드러그인포 약품요약정보

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

비급여
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

백색분말이 충진된 상부 녹색, 하부 연녹색의 경질캅셀제 [제형정보 확인]

효능효과

[적응증 별 검색]

기침, 가래
[Drugbank 의 성분정보열람]
[Aminophylline][Dextromethorphan]

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
성인 1회 1캅셀 1일 2회(아침, 저녁) 복용한다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

신중투여

본인 또는 양친, 형제 등이 두드러기, 접촉성 피부염, 알레르기성 비염, 편두통, 음식물 알레르기 등을 일으키기 쉬운 체질을 갖고 있는 사람
약이나 달걀에 의해 알레르기 증상을 일으킨 일이 있는 환자
간장애, 신장애, 갑상선질환, 당뇨병 등 병이 있는 환자. 고열환자, 허약자
간장애 및 고혈압 환자, 고령자
임부 또는 임신하고 있을 가능성이 있는 부인, 수유부
다른 약물을 투여받고 있는 환자

이상반응

이 약을 투여하는 동안 발진, 발적, 구역, 구토, 식욕부진, 어지러움 등이 나타날 경우에는 투여를 중지하고 약사 또는 의사와 상의한다.

[주요 이상반응정보]

상호작용

다음 약들과 병용투여하지 않는다.
- 다른 진해거담제, 감기약, 항히스타민제, 진정제, 알코올 등

Off-label Usage

[조회]

Related FDA Approved Drug

기준 성분:AMINOPHYLLINE
AMINOPHYLLIN (AMINOPHYLLINE)
AMINOPHYLLINE (AMINOPHYLLINE)
AMINOPHYLLINE DYE FREE (AMINOPHYLLINE)
AMINOPHYLLINE IN SODIUM CHLORIDE 0.45% (AMINOPHYLLINE)
AMINOPHYLLINE IN SODIUM CHLORIDE 0.45% IN PLASTIC CONTAINER (AMINOPHYLLINE)
PHYLLOCONTIN (AMINOPHYLLINE)
SOMOPHYLLIN (AMINOPHYLLINE)
SOMOPHYLLIN-DF (AMINOPHYLLINE)
TRUPHYLLINE (AMINOPHYLLINE)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	진해거담제 & 기침감기약 (Cough & Cold remedies)
ATC 코드	Diprophylline, combinations / R03DA51 [코드분류상세설명] [ATC코드예측]
복지부분류코드	222 (진해거담제 )
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	비급여 [상병코드조회] [질병코드집 다운로드]
제품성상	백색분말이 충진된 상부 녹색, 하부 연녹색의 경질캅셀제 [제형정보 확인]
보관방법	기밀용기

복약정보

항목

내용

LACTmed 바로가기

[바로가기]

약리작용

유료정보입니다.

복약지도

유료정보입니다.

Pharmacokinetics

유료정보입니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

복약라벨

이미지

복약설명

어지러움이 있을수 있습니다.

*	복약이미지는 모든 복약지도 사항을 표시한것은 아니며, 추가적으로 업데이트되거나 수정될 수 있습니다.
*	복약이미지의 표시여부는 실제 약물복용시 중요도에 따른것은 아니며 단순히 허가정보상 키워드를 기준으로 등록되었습니다.
*	귀하가 복약이미지 정보를 신뢰함은 전적으로 귀하의 책임입니다. 드럭인포는 이에 대한 어떠한 보증도 하지 않습니다.

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목

내용

DUR (의약품사용평가)

병용금기 : 고시된 병용금기 내용은 없습니다.
[상호작용/병용금기검색]
연령대금기 : 고시된 연령금기 내용은 없습니다.
[연령대금기상세검색]

독성정보

Dextromethorphan에 대한 독성정보 : 정보보기
Lysozyme에 대한 독성정보 : 정보보기

출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do

Mechanism of Action

Aminophylline에 대한 Mechanism_Of_Action 정보
Theophylline is structurally related to theobromine and caffeine. The precise mechanism of action of theophylline is not known.

Dextromethorphan에 대한 Mechanism_Of_Action 정보
Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan.

Pharmacology

Aminophylline에 대한 Pharmacology 정보
Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi, produces diuresis, and causes an increase in gastric secretion.

Dextromethorphan에 대한 Pharmacology 정보
Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.

Metabolism

Aminophylline에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Not Available

Dextromethorphan에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Cytochrome P450 2D6 (CYP2D6)

Protein Binding

Aminophylline에 대한 단백결합 정보
60%

Half-life

Aminophylline에 대한 반감기 정보
7-9 hours

Dextromethorphan에 대한 반감기 정보
3-6 hours

Absorption

Aminophylline에 대한 Absorption 정보
Not Available

Dextromethorphan에 대한 Absorption 정보
Rapidly absorbed from the gastrointestinal tract.

Pharmacokinetics

Aminophylline의 약물동력학자료
1.분포 Vd = 0.45L/kg
2.모유로 거의 혈중농도와 같은 정도로 분포하며 태반도 통과
3.대사 : 간에서 demethylation, oxidation
4.반감기 : 나이, 간 기능, 심 기능, 폐 질환, 흡연력에 따라 매우 다양

■ Aminophylline의 반감기

환자군

반감기(hr)

신생아

미숙아

30

정상분만

24

영아

4-52주

4-30

소아/청소년

1-9세

2-10 (평균4)

9-16세

4-16

성인

비흡연자

흡연자

4.4

심질환,간부전

20-30

■ Aminophylline의 역동학/약력학

제형

최고혈중농도 도달시간

투여 간격

나정/시럽

2시간

6시간

장용정

5시간

12시간

츄잉정

1-1.5시간

6시간

서방정

4-7시간

12시간

주사제

30분이하

5.소실 : 소변
6.성인은 10%가 미변화체로 배설되고 신생아는 더 많은 양(50%까지)이 미변화체로 신배설된다.

Dextromethorphan HBr의 약물동력학자료

진해작용 발현시간 : 15~30분 이내
작용지속시간 : 6시간까지
대사 : 간대사
소실 : 주로 신배설

Biotransformation

Aminophylline에 대한 Biotransformation 정보
Not Available

Dextromethorphan에 대한 Biotransformation 정보
Hepatic. Rapidly and extensively metabolized to dextrorphan (active metabolite). One well known metabolic catalyst involved is a specific cytochrome P450 enzyme known as 2D6, or CYP2D6.

Toxicity

Aminophylline에 대한 Toxicity 정보
Not Available

Dextromethorphan에 대한 Toxicity 정보
Not Available

Drug Interactions

Aminophylline에 대한 Drug_Interactions 정보
Aciclovir Acyclovir increases the effect and toxicity of theophyllineAdenosine This xanthine decreases the effect of adenosineButabarbital The barbiturate decreases the effect of theophyllineButalbital The barbiturate decreases the effect of theophyllineDihydroquinidine barbiturate The barbiturate decreases the effect of theophyllineAtracurium Theophylline decreases the effect of muscle relaxantCarbamazepine Carbamazepine increases or decreases the effect of theophyllineCarteolol Antagonism of action and increased effect of theophyllineCimetidine Cimetidine increases the effect of theophyllineCiprofloxacin The quinolone increases the effect of theophyllineClarithromycin Clarithromycin increases the effect amd toxicity of theophyllineDisulfiram Disulfiram increases the effect and toxicity of theophyllineDoxacurium Theophylline decreases the effect of muscle relaxantEnoxacin The quinolone increases the effect of theophyllineErythromycin The macrolide increases the effect and toxicity of theophyllineEthinyl Estradiol The contraceptive increases the effect and toxicity of theophyllineEthotoin Decreased effect of both productsFluvoxamine Fluvoxamine increases the effect and toxicity of theophyllineFosphenytoin Decreased effect of both productsGallamine Triethiodide Theophylline decreases the effect of muscle relaxantGrepafloxacin The quinolone increases the effect of theophyllineHalothane Increased risk of cardiac arrhythmiaInterferon Alfa-2a, Recombinant Interferon increases the effect and toxicity of theophyllineInterferon Alfa-2b, Recombinant Interferon increases the effect and toxicity of theophyllineInterferon alfa-n1 Interferon increases the effect and toxicity of theophyllineIsoniazid Isoniazid increases the effect and toxicity of theophhyllineJosamycin The macrolide increases the effect and toxicity of theophyllineMephenytoin Decreased effect of both productsMethohexital The barbiturate decreases the effect of theophyllineMetocurine Theophylline decreases the effect of muscle relaxantMexiletine Mexiletine increases the effect and toxicity of theophyllineMivacurium Theophylline decreases the effect of muscle relaxantNadolol Antagonism of action and increased effect of theophyllineNorfloxacin The quinolone increases the effect of theophyllinePancuronium Theophylline decreases the effect of muscle relaxantPefloxacin The quinolone increases the effect of theophyllinePeginterferon alfa-2a Interferon increases the effect and toxicity of theophyllinePeginterferon alfa-2b Interferon increases the effect and toxicity of theophyllinePentobarbital The barbiturate decreases the effect of theophyllinePentoxifylline Pentoxyfylline increases the effect and toxicity of theophyllinePhenytoin Decreased effect of both productsPindolol Antagonism of action and increased effect of theophyllinePrimidone The barbiturate decreases the effect of theophyllinePropafenone Propafenone increases the effect of theophyllinePropranolol Antagonism of action and increased effect of theophyllineQuinidine barbiturate The barbiturate decreases the effect of theophyllineRifampin Rifampin decreases the effect of theophyllineRitonavir Ritonavir decreases the effect of theophyllineRofecoxib Rofecoxib increases the effect and toxicity of theophyllineSecobarbital The barbiturate decreases the effect of theophyllineSotalol Antagonism of action and increased effect of theophyllineSt. John's Wort St. John's Wort decreases the effect of theophyllineTacrine Tacrine increases the effect and toxicity of theophyllineTalbutal The barbiturate decreases the effect of theophyllineTerbinafine Terbinafine increases the effect and toxicity of theophyllineThiabendazole Thiabendazole increases the effect and toxicity of theophyllineTiclopidine Ticlopidine increases the effect and toxicity of theophyllineTimolol Antagonism of action and increased effect of theophyllineTubocurarine Theophylline decreases the effect of muscle relaxantVecuronium Theophylline decreases the effect of muscle relaxantZileuton Zileuton increases the effect and toxicity of theophyllineVerapamil Verapamil increases the effect of theophyllineAmobarbital The barbiturate decreases the effect of theophyllineAprobarbital The barbiturate decreases the effect of theophyllineButethal The barbiturate decreases the effect of theophyllineHeptabarbital The barbiturate decreases the effect of theophyllineHexobarbital The barbiturate decreases the effect of theophyllineLithium Theophylline decreases serum levels of lithiumMestranol The contraceptive increases the effect and toxicity of theophyllineMethylphenobarbital The barbiturate decreases the effect of theophyllinePenbutolol Antagonism of action and increased effect of theophyllinePhenobarbital The barbiturate decreases the effect of theophyllineTroleandomycin The macrolide increases the effect and toxicity of theophylline

Dextromethorphan에 대한 Drug_Interactions 정보
Dihydroquinidine barbiturate Quinidine increases the toxicity of dextromethorphanQuinidine Quinidine increases the toxicity of dextromethorphanQuinidine barbiturate Quinidine increases the toxicity of dextromethorphanFluoxetine Combination associated with possible serotoninergic syndromeIsocarboxazid Possible severe adverse reactionMemantine Increased risk of CNS adverse effectsMoclobemide Increased CNS toxicityParoxetine Combination associated with possible serotoninergic syndromePhenelzine Possible severe adverse reactionRasagiline Possible severe adverse reactionSelegiline Combination associated with possible serotoninergic syndromeSibutramine Combination associated with possible serotoninergic syndromeTerbinafine Terbinafine increases dextromethorphan levelsTranylcypromine Possible severe adverse reaction

CYP450
Drug Interaction

[CYP450 Table직접조회]
Dextromethorphan에 대한 P450 table

SUBSTRATES
CYP 2D6
Beta Blockers:
S-metoprolol
propafenone
timolol
Antidepressants:
amitriptyline
clomipramine
desipramine
imipramine
paroxetine
Antipsychotics:
haloperidol
risperidone
thioridazine
aripiprazole
codeine
**dextromethorphan**
duloxetine
flecainide
mexiletine
ondansetron
tamoxifen
tramadol
venlafaxine

INHIBITORS
CYP 2D6
amiodarone
buproprion
chlorpheniramine
cimetidine
clomipramine
duloxetine
fluoxetine
haloperidol
methadone
mibefradil
paroxetine
quinidine
ritonavir

INDUCERS
CYP 2D6
N/A

Food Interaction

Aminophylline에 대한 Food Interaction 정보
Take with food.Limit caffeine intake.Vitamin B6 needs increased, supplement recommended.

Drug Target

[Drug Target]

SNP 정보

Name:Dextromethorphan (DB00514)
Interacting Gene/Enzyme:Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635
SNP(s):CYP2D6*6 rs5030655 (T deletion, homozygote)
Effect:Poor drug metabolizer, lower dose requirements
Reference(s):Bradford LD, Gaedigk A, Leeder JS: High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data. Psychopharmacol Bull. 1998;34(4):797-804. [PubMed]

Description

Aminophylline에 대한 Description 정보
Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio. [Wikipedia]

Dextromethorphan에 대한 Description 정보
The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. [PubChem]

Dosage Form

Aminophylline에 대한 Dosage_Form 정보
Solution IntravenousTablet OralTablet, extended release Oral

Dextromethorphan에 대한 Dosage_Form 정보
Capsule OralLiquid OralLozenge OralStrip OralSuspension OralSyrup OralTablet Oral

Drug Category

Aminophylline에 대한 Drug_Category 정보
Bronchodilator AgentsCardiotonic AgentsPhosphodiesterase InhibitorsRespiratory Smooth Muscle Relaxants

Dextromethorphan에 대한 Drug_Category 정보
Analgesics, OpioidAntitussive AgentsExcitatory Amino Acid Antagonists

Smiles String Canonical

Aminophylline에 대한 Smiles_String_canonical 정보
NCCN.CN1C(=O)N(C)C2=C(NC=N2)C1=O.CN1C(=O)N(C)C2=C(NC=N2)C1=O

Dextromethorphan에 대한 Smiles_String_canonical 정보
COC1=CC2=C(CC3C4CCCCC24CCN3C)C=C1

Smiles String Isomeric

Aminophylline에 대한 Smiles_String_isomeric 정보
NCCN.CN1C(=O)N(C)C2=C(NC=N2)C1=O.CN1C(=O)N(C)C2=C(NC=N2)C1=O

Dextromethorphan에 대한 Smiles_String_isomeric 정보
COC1=CC2=C(C[C@H]3[C@H]4CCCC[C@@]24CCN3C)C=C1

InChI Identifier

Aminophylline에 대한 InChI_Identifier 정보
InChI=1/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2/f/h2*8H;

Dextromethorphan에 대한 InChI_Identifier 정보
InChI=1/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18-/m1/s1

Chemical IUPAC Name

Aminophylline에 대한 Chemical_IUPAC_Name 정보
1,3-dimethyl-7H-purine-2,6-dione; 1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine

Dextromethorphan에 대한 Chemical_IUPAC_Name 정보
Not Available

사용자컨텐츠

항목

내용

핵심 요약 정보