드러그인포 약품 상세정보

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

653701780[A11850351] [보험코드에 따른 약품기본정보 직접조회]
\0 원/1정(2007.03.01)(현재약가)
\9 원/1정(2001.01.01)(변경전약가)
[상병코드조회]
[질병코드집 다운로드] [우리집건강주치의 바로가기]

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요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

대표코드

8806537017809

약리작용

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효능효과

[적응증 별 검색]

1. 폐색성혈전혈관염(버거병)에 의한 궤양, 동통, 냉감 등의 허혈성 증상의 개선 2. 후천성 요부척추관협착증(SLR시험에서 정상이고, 양측성의 간헐파행을 보이는 환자)에 의한 자각증상(하지동통, 하지저림) 및 보행능력의 개선
[Drugbank 의 성분정보열람]
[Isoniazid][Vitamin B6 (Pyridoxine)]

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
[주성분코드:311900ATB 에 따른 심사지침열람]

폐색성혈전혈관염(버거병)에 의한 궤양, 동통, 냉감 등의 허혈성 증상의 개선에는 통상 성인에 리마프로스트로서 1일 30㎍을 3회 분할 경구투여 한다. 연령, 증상에 따라 적절히 증감한다.

후천성 요부척추관협착증(SLR시험에서 정상이고, 양측성 간헐파행을 보이는 환자)에 의한 자각증상(하지동통, 하지저림) 및 보행 능력의 개선에는 통상 성인에 리마프로스트로서 1일 15㎍을 3회 분할 경구투여한다.
연령, 증상에 따라 적절히 증감한다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

[피해야 할 음식] [복용을 잊은 경우 대처법]

금기

임부 또는 임신하고 있을 가능성이 있는 부인

Related FDA Approved Drug

기준 성분:PYRIDOXINE HYDROCHLORIDE
BENDECTIN (DOXYLAMINE SUCCINATE; PYRIDOXINE HYDROCHLORIDE)
BEROCCA PN (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN E)
HEXA-BETALIN (PYRIDOXINE HYDROCHLORIDE)
INFUVITE ADULT (ALPHA-TOCOPHEROL ACETATE; ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN K)
M.V.C. 9+3 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I. ADULT (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K)
M.V.I. ADULT (PHARMACY BULK PACKAGE) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K)
M.V.I. PEDIATRIC (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I.-12 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I.-12 (WITHOUT VITAMIN K) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
MVC PLUS (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
PYRIDOXINE HYDROCHLORIDE (PYRIDOXINE HYDROCHLORIDE)
TPN (NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; TYROSINE)
기준 성분:ISONIAZID
DOW-ISONIAZID (ISONIAZID)
HYZYD (ISONIAZID)
INH (ISONIAZID)
ISONIAZID (ISONIAZID)
LANIAZID (ISONIAZID)
NYDRAZID (ISONIAZID)
RIFAMATE (ISONIAZID; RIFAMPIN)
RIFAMPIN AND ISONIAZID (ISONIAZID; RIFAMPIN)
RIFATER (ISONIAZID; PYRAZINAMIDE; RIFAMPIN)
RIMIFON (ISONIAZID)
STANOZIDE (ISONIAZID)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
대표코드	8806537017809
BIT 약효분류	결핵치료제 (Antitubercular Agents)
ATC 코드	Isoniazid, combinations / J04AC51 [코드분류상세설명] [ATC코드예측]
복지부분류코드	622 (항결핵제 )
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	653701780[A11850351] [보험코드에 따른 약품기본정보 직접조회] \0 원/1정(2007.03.01)(최신약가) \9 원/1정(2001.01.01)(변경전약가) [상병코드조회] [질병코드집 다운로드]
동일주성분코드 검색순위	유료정보입니다.

복약정보

항목

내용

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약리작용

유료정보입니다.

복약지도

유료정보입니다.

임부에대한투여

*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : C등급
(isoniazid )

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

Pharmacokinetics

유료정보입니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Isoniazid에 대한 독성정보 : 정보보기 Pyridoxine에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Isoniazid에 대한 Mechanism_Of_Action 정보 Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Specifically isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA. Pyridoxine에 대한 Mechanism_Of_Action 정보 Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Pharmacology	Isoniazid에 대한 Pharmacology 정보 Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a highly specific agent, ineffective against other microorganisms. Isoniazid is bactericidal to rapidly-dividing mycobacteria, but is bacteriostatic if the mycobacterium is slow-growing. Pyridoxine에 대한 Pharmacology 정보 Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Metabolism	Isoniazid에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 2E1 (CYP2E1) Pyridoxine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Methylenetetrahydrofolate reductase
Protein Binding	Isoniazid에 대한 단백결합 정보 Very low (0-10%) Pyridoxine에 대한 단백결합 정보 22%
Half-life	Isoniazid에 대한 반감기 정보 Fast acetylators: 0.5 to 1.6 hours. Slow acetylators: 2 to 5 hours. Pyridoxine에 대한 반감기 정보 15-20 days
Absorption	Isoniazid에 대한 Absorption 정보 Readily absorbed following oral administration; however, may undergo significant first pass metabolism. Absorption and bioavailability are reduced when isoniazid is administered with food. Pyridoxine에 대한 Absorption 정보 The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
Pharmacokinetics	Isoniazid의 약물동력학자료 최고 혈중 농도 도달 시간 : 1-2 시간 흡수: 위장관에서 매우 잘 흡수되나 음식에 의해서 흡수가 감소 생체내이용률 : 90 % 분포: 뇌척수액을 포함한 신체 전반에 분포 단백결합률: 10-15 % 대사: 유전적인 acetylation phenytype에 의존적으로 간대사 배설: 소실반감기는 fast acetylators는 30-100 분, slow acetylators에서는 2-5 시간 75-95%가 뇨배설 Pyridoxine HCl의 약물동력학자료 흡수 : 위장관으로부터 잘 흡수된다. 대사 : 간에서 4-pyridoxic acid로 대사된다. 반감기 : 15-20일 혈중최고농도 도달시간 : 경구 : 1.25 시간 소실 : 4-pyridoxic acid로 신배설되며, 소량 (약 2%)은 담즙을 통해 배설된다.
Biotransformation	Isoniazid에 대한 Biotransformation 정보 Primarily hepatic. Isoniazid is acetylated by N -acetyl transferase to N -acetylisoniazid; it is then biotransformed to isonicotinic acid and monoacetylhydrazine. Monoacetylhydrazine is associated with hepatotoxicity via formation of a reactive intermediate metabolite when N-hydroxylated by the cytochrome P450 mixed oxidase system. The rate of acetylation is genetically determined. Slow acetylators are characterized by a relative lack of hepatic N -acetyltransferase.
Toxicity	Isoniazid에 대한 Toxicity 정보 LD₅₀ 100 mg/kg (Human, oral). Adverse reactions include rash, abnormal liver function tests, hepatitis, peripheral neuropathy, mild central nervous system (CNS) effects. In vivo, Isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits generation of pyridoxal phosphate. Isoniazid also combines with pyridoxal phosphate; high doses interfere with the coenzyme function of the latter. Pyridoxine에 대한 Toxicity 정보 Oral Rat LD₅₀ = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Drug Interactions	Isoniazid에 대한 Drug_Interactions 정보 Acetaminophen Risk of hepatotoxicityAminophylline Increases the effect and toxicity of theophyllineDyphylline Increases the effect and toxicity of theophyllineOxtriphylline Increases the effect and toxicity of theophyllineTheophylline Increases the effect and toxicity of theophyllinePhenytoin Isoniazid increases the effect of phenytoin in 20% of patientsMephenytoin Isoniazid increases the effect of phenytoin in 20% of patientsFosphenytoin Isoniazid increases the effect of phenytoin in 20% of patientsEthotoin Isoniazid increases the effect of phenytoin in 20% of patientsMeperidine Possible episodes of hypotensionKetoconazole Isoniazid decreases the effect of ketoconazoleWarfarin The agent increases the effect of anticoagulantAcenocoumarol The agent increases the effect of anticoagulantDicumarol The agent increases the effect of anticoagulantAnisindione The agent increases the effect of anticoagulantCarbamazepine Carbamazepine effect is increased as is isoniazid toxicityDisulfiram Increased risk of CNS adverse effects Pyridoxine에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회] Isoniazid에 대한 P450 table SUBSTRATES CYP 2C9 NSAIDs: diclofenac ibuprofen piroxicam Oral Hypoglycemic Agents: tolbutamide glipizide Angiotensin II Blockers: NOT candesartan irbesartan losartan NOT valsartan celecoxib fluvastatin naproxen phenytoin sulfamethoxazole tamoxifen tolbutamide torsemide warfarin INHIBITORS CYP 2C9 amiodarone fluconazole isoniazid INDUCERS CYP 2C9 rifampin secobarbital SUBSTRATES CYP 2E1 acetaminophen chlorzoxazone ethanol INHIBITORS CYP 2E1 disulfiram INDUCERS CYP 2E1 ethanol isoniazid
Food Interaction	Isoniazid에 대한 Food Interaction 정보 Avoid aged foods (cheese, red wine), pickled foods, cured foods (bacon/ham), chocolate, fava beans, beer, unless approved by your physician.Take on empty stomach: 1 hour before or 2 hours after meals.Avoid alcohol.Take with a full glass of water.Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.
Drug Target	[Drug Target]
SNP 정보	Name:Isoniazid (DB00951) Interacting Gene/Enzyme:Cytochrome P450 2E1 (Gene symbol = CYP2E1) Swissprot P05181 SNP(s):CYP2E1 1A rs6413419 (G Allele, homozygote) Effect:Hepatotoxicity Reference(s):*Vuilleumier N, Rossier MF, Chiappe A, Degoumois F, Dayer P, Mermillod B, Nicod L, Desmeules J, Hochstrasser D: CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. Eur J Clin Pharmacol. 2006 Jun;62(6):423-9. Epub 2006 Apr 27. [PubMed]
Description	Isoniazid에 대한 Description 정보 Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. [PubChem] Pyridoxine에 대한 Description 정보 The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). [PubChem]
Dosage Form	Isoniazid에 대한 Dosage_Form 정보 Powder OralSyrup OralTablet Oral Pyridoxine에 대한 Dosage_Form 정보 Liquid IntramuscularSolution IntramuscularSolution / drops OralTablet Oral
Drug Category	Isoniazid에 대한 Drug_Category 정보 Antitubercular AgentsFatty Acid Synthesis Inhibitors Pyridoxine에 대한 Drug_Category 정보 Anti-inflammatory AgentsEssential VitaminVitamin B ComplexVitamins (Vitamin B Complex)
Smiles String Canonical	Isoniazid에 대한 Smiles_String_canonical 정보 NNC(=O)C1=CC=NC=C1 Pyridoxine에 대한 Smiles_String_canonical 정보 CC1=NC=C(CO)C(CO)=C1O
Smiles String Isomeric	Isoniazid에 대한 Smiles_String_isomeric 정보 NNC(=O)C1=CC=NC=C1 Pyridoxine에 대한 Smiles_String_isomeric 정보 CC1=NC=C(CO)C(CO)=C1O
InChI Identifier	Isoniazid에 대한 InChI_Identifier 정보 InChI=1/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)/f/h9H Pyridoxine에 대한 InChI_Identifier 정보 InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
Chemical IUPAC Name	Isoniazid에 대한 Chemical_IUPAC_Name 정보 pyridine-4-carbohydrazide Pyridoxine에 대한 Chemical_IUPAC_Name 정보 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Drug-Induced Toxicity Related Proteins	ISONIAZID 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:N-acetyltransferase Drug:isoniazid Toxicity:erythematosus. [바로가기] Replated Protein:N-acetyltransferase 5 Drug:Isoniazid Toxicity:idiosyncratic hepatotoxicity. [바로가기]

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