Phenylephrine에 대한 Mechanism_Of_Action 정보 Phenylephrine produces its ophthalmic and systemic actions by acting on alpha 1 adrenergic receptors in the pupillary dilator muscle and the vascular smooth musle, resulting in contraction of the dilator muscle and contraction of the smooth muscle in the arterioles of the conjunctiva and peripheral vasoconstriction. Phenylephrine decreases nasal congestion by acting on alpha 1 adrenergic receptors in the arterioles of the nasal mucosa to produce constriction.
Pharmacology
Phenylephrine에 대한 Pharmacology 정보 Phenylephrine is a powerful vasoconstrictor. It is used as a mydriatic, nasal decongestant, and cardiotonic agent. Phenylephrine is a postsynaptic alpha-receptor stimulant with little effect on the beta receptors of the heart. Parenteral administration of Phenylephrine causes a rise in systolic and diastolic pressures, cardiac output is slightly decreased and peripheral resistance is considerably increased, most vascular beds are constricted; renal, splanchnic, cutaneous, and limb blood flows are reduced but coronary blood flow is increased. Pulmonary vessels are constricted, and pulmonary arterial pressure is raised. This alpha receptor sympathetic agonist is also used locally because its vasoconstrictor and mydriatic action.
Protein Binding
Phenylephrine에 대한 단백결합 정보 95% binding-plasma proteins
Half-life
Phenylephrine에 대한 반감기 정보 2.1 to 3.4 hours
Absorption
Phenylephrine에 대한 Absorption 정보 Reduced bioavailability (compared to pseudoephedrine) following oral administration due to significant first-pass metabolism.
Pharmacokinetics
Phenylephrine HCl의 약물동력학자료
효과발현시간
근육주사, 피하주사 : 10~15분 이내
정맥주사 : 즉시
효과지속시간
근육주사 : 30분 ~ 2시간
정맥주사 : 15~30분
피하주사 : 1시간
대사 : Phenolic 포합체로 대사됨. Monoamine oxidase에 의해 간과 장에서 대사됨.
반감기 : 2.5 시간
소실 : 신배설 (90%)
Biotransformation
Phenylephrine에 대한 Biotransformation 정보 Oral phenylephrine is extensively metabolised by monoamine oxidase, an enzyme which is present in the stomach and liver.
Toxicity
Phenylephrine에 대한 Toxicity 정보 Not Available
Drug Interactions
Phenylephrine에 대한 Drug_Interactions 정보 Alseroxylon Increased arterial pressureIsocarboxazid Increased arterial pressureDeserpidine Increased arterial pressureGuanethidine The agent decreases the effect of guanethidineRasagiline Increased arterial pressureMethyldopa Increased arterial pressureMidodrine Increased arterial pressurePargyline Increased arterial pressurePhenelzine Increased arterial pressureReserpine Increased arterial pressureTranylcypromine Increased arterial pressureOxytocin Possible marked increase of arterial pressureMethylergonovine Possible marked increase of arterial pressureLinezolid Possible increase of arterial pressureErgonovine Possible marked increase of arterial pressureTrimipramine The tricyclic increases the sympathomimetic effectProtriptyline The tricyclic increases the sympathomimetic effectNortriptyline The tricyclic increases the sympathomimetic effectClomipramine The tricyclic increases the sympathomimetic effectAmitriptyline The tricyclic increases the sympathomimetic effectAmoxapine The tricyclic increases the sympathomimetic effectDesipramine The tricyclic increases the sympathomimetic effectDoxepin The tricyclic increases the sympathomimetic effectImipramine The tricyclic increases the sympathomimetic effectMoclobemide Moclobemide increases the sympathomimetic effect
Phenylephrine에 대한 Description 정보 An alpha-adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent. [PubChem]
Dosage Form
Phenylephrine에 대한 Dosage_Form 정보 Liquid IntramuscularLiquid IntravenousLiquid OphthalmicOintment TopicalSolution IntravenousSolution / drops OphthalmicStrip OralTablet Oral
Drug Category
Phenylephrine에 대한 Drug_Category 정보 Adrenergic alpha-AgonistsCardiotonic AgentsMydriaticsNasal DecongestantsSympathomimeticsVasoconstrictor Agents
Smiles String Canonical
Phenylephrine에 대한 Smiles_String_canonical 정보 CNCC(O)C1=CC(O)=CC=C1
Smiles String Isomeric
Phenylephrine에 대한 Smiles_String_isomeric 정보 CNC[C@H](O)C1=CC(O)=CC=C1
InChI Identifier
Phenylephrine에 대한 InChI_Identifier 정보 InChI=1/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1
Chemical IUPAC Name
Phenylephrine에 대한 Chemical_IUPAC_Name 정보 3-[(1R)-1-hydroxy-2-methylaminoethyl]phenol
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항목
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최근정보수정일 2023-09-01
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