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                    Ƽ³ªº½Å©¸²  TINABOM CREAM[Crotamiton , Glycylic acid , Lidocaine , Salicylic Acid , Tolnaftate]  
                    
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                     ÀϹÝÀǾàǰ | ºñ±Þ¿©  
                        
                    	
                    
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    8806459048707 | 
   
  
  
  
  
  
  
   
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[Drugbank ÀÇ ¼ººÐÁ¤º¸¿¶÷] [Crotamiton][Lidocaine]
      
      
      
      
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      * Àý´ë ÀÓÀǺ¹¿ëÇÏÁö ¸¶½Ã°í ¹Ýµå½Ã ÀÇ»ç ¶Ç´Â ¾à»ç¿Í »ó´ãÇϽñ⠹ٶø´Ï´Ù. 
    
     
      
      
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    | µ¶¼ºÁ¤º¸ | 
    Lidocaine¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
Salicylic acid¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
  Ãâó: ±¹¸³µ¶¼º°úÇпø µ¶¼º¹°ÁúÁ¤º¸DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do  | 
   
  
   
    | Mechanism of Action | 
    
       Crotamiton¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Crotamiton relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your body's attention away from the itching.
  Lidocaine¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.
  Tolnaftate¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Topical - Fungicidal; exact mechanism unknown; however, it has been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. 
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    | Pharmacology | 
     
       Crotamiton¿¡ ´ëÇÑ Pharmacology Á¤º¸ Crotamiton is usually used to treat pruritis (itching of the skin) caused by scabies or sunburn. Crotamiton relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your body's attention away from the itching. Due to this cooling effect it is also effective for the relief of sunburn. The drug is also believed to kill scabies through an unknown mechanism.
  Lidocaine¿¡ ´ëÇÑ Pharmacology Á¤º¸ Lidocaine is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Lidocaine appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, Lidocaine in therapeutic doses does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, lidocaine may produce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide.
  Tolnaftate¿¡ ´ëÇÑ Pharmacology Á¤º¸ Tolnaftate is a synthetic over-the-counter anti-fungal agent. 
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    | Metabolism | 
    
       Crotamiton¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Not Available
  Lidocaine¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Cytochrome P450 1A2 (CYP1A2)Cytochrome P450 2D6 (CYP2D6) 
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    | Protein Binding | 
    
       Crotamiton¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ Not Available
  Lidocaine¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ 60-80%
  Tolnaftate¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ Not Available 
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    | Half-life | 
    
       Crotamiton¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ Not Available
  Lidocaine¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 109 minutes
  Tolnaftate¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ Not Available 
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    | Absorption | 
    
       Crotamiton¿¡ ´ëÇÑ Absorption Á¤º¸ 10 % absorbed when applied locally.
  Lidocaine¿¡ ´ëÇÑ Absorption Á¤º¸ Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent.
  Tolnaftate¿¡ ´ëÇÑ Absorption Á¤º¸ Not Available 
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    | Pharmacokinetics | 
    
       TolnaftateÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
-  ÀÛ¿ë¹ßÇö½Ã°£ : Ä¡·á¸¦ ½ÃÀÛÇÑ Áö 24-72 ½Ã°£ À̳»¿¡ ¹ÝÀÀÀÌ ³ªÅ¸³´Ù.
    LidocaineÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
	- È¿°ú¹ßÇö½Ã°£ (1ȸ bolus ¿ë·®À¸·Î¼) : 45-90ÃÊ
	
 - ÀÛ¿ëÁö¼Ó½Ã°£ : 10-25ºÐ
	
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		- Ȱ¼ºÇü ´ë»çüÀÎ  monoethylglycinexylidide(MEGX)¿Í glycinexylidide(GX)°¡ ÃàÀûµÇ¾î ÁßÃ߽Űæ°è µ¶¼ºÀ» À¯¹ßÇÒ ¼ö ÀÖ´Ù.
 
	  
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 Salicylic AcidÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
- »ýü³»ÀÌ¿ë·ü : methyl salicylate ¿¬°íÁ¦ : 15-22%
 - ºÐÆ÷ : ºÐÆ÷¿ëÀû : 0.17 L/kg
 - ´Ü¹é°áÇÕ : 50-80%
 - Ç÷ÁßÃÖ°í³óµµ µµ´Þ½Ã°£ : ¿Ü¿ë : ¹ÐºÀÆ÷´ë¹ý Àû¿ë½Ã 5½Ã°£ À̳»
 - ¼Ò½Ç : ´¢Áß ¹è¼³ÇüÅ´ °æ±¸¿Í´Â ¾à°£ ´Þ¶ó¼, ¿Ü¿ë½Ã glucuronide Æ÷ÇÕü (42%)°¡ »ó´ëÀûÀ¸·Î ¸¹À¸¸ç, salicyluric acid (52%)¿Í ¹Ìº¯Èü (6%)´Â »ó´ëÀûÀ¸·Î Àû´Ù.
  
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    | Biotransformation | 
    
       Crotamiton¿¡ ´ëÇÑ Biotransformation Á¤º¸ Not Available
  Lidocaine¿¡ ´ëÇÑ Biotransformation Á¤º¸ Primarily hepatic. 
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    | Toxicity | 
    
       Crotamiton¿¡ ´ëÇÑ Toxicity Á¤º¸ Not Available
  Lidocaine¿¡ ´ëÇÑ Toxicity Á¤º¸ The oral LD 50 of lidocaine HCl in non-fasted female rats is 459 (346-773) mg/kg (as the salt) and 214 (159-324) mg/kg (as the salt) in fasted female rats. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
  Tolnaftate¿¡ ´ëÇÑ Toxicity Á¤º¸ Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector. 
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    | Drug Interactions | 
    
       Crotamiton¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Acetohexamide	The beta-blocker decreases the symptoms of hypoglycemiaChlorpropamide	The beta-blocker decreases the symptoms of hypoglycemiaCimetidine	Cimetidine increases the effect of the beta-blockerClonidine	Increased hypertension when clonidine stoppedDisopyramide	The beta-blocker increases toxicity of disopyramideGliclazide	The beta-blocker decreases the symptoms of hypoglycemiaGlipizide	The beta-blocker decreases the symptoms of hypoglycemiaGlisoxepide	The beta-blocker decreases the symptoms of hypoglycemiaGlibenclamide	The beta-blocker decreases the symptoms of hypoglycemiaGlycodiazine	The beta-blocker decreases the symptoms of hypoglycemiaInsulin	The beta-blocker decreases the symptoms of hypoglycemiaLidocaine	The beta-blocker increases the effect and toxicity of lidocainePropafenone	Propafenone increases the effect of beta-blockerRepaglinide	The beta-blocker decreases the symptoms of hypoglycemiaRifampin	Rifampin decreases the effect of the metabolized beta-blockerTelithromycin	Telithromycin may possibly increase metoprolol effectTolazamide	The beta-blocker decreases the symptoms of hypoglycemiaTolbutamide	The beta-blocker decreases the symptoms of hypoglycemiaAmobarbital	The barbiturate decreases the effect of metabolized beta-blockerAprobarbital	The barbiturate decreases the effect of metabolized beta-blockerButalbital	The barbiturate decreases the effect of metabolized beta-blockerButabarbital	The barbiturate decreases the effect of metabolized beta-blockerButethal	The barbiturate decreases the effect of metabolized beta-blockerDihydroquinidine barbiturate	The barbiturate decreases the effect of metabolized beta-blockerHeptabarbital	The barbiturate decreases the effect of metabolized beta-blockerHexobarbital	The barbiturate decreases the effect of metabolized beta-blockerMethohexital	The barbiturate decreases the effect of metabolized beta-blockerMethylphenobarbital	The barbiturate decreases the effect of metabolized beta-blockerPentobarbital	The barbiturate decreases the effect of metabolized beta-blockerPhenobarbital	The barbiturate decreases the effect of metabolized beta-blockerPrimidone	The barbiturate decreases the effect of metabolized beta-blockerQuinidine barbiturate	The barbiturate decreases the effect of metabolized beta-blockerSecobarbital	The barbiturate decreases the effect of metabolized beta-blockerTalbutal	The barbiturate decreases the effect of metabolized beta-blockerCitalopram	The SSRI increases the effect of the beta-blockerEscitalopram	The SSRI increases the effect of the beta-blockerFluoxetine	The SSRI increases the effect of the beta-blockerSertraline	The SSRI increases the effect of the beta-blockerParoxetine	The SSRI increases the effect of the beta-blockerDihydroergotamine	Ischemia with risk of gangreneDihydroergotoxine	Ischemia with risk of gangreneErgonovine	Ischemia with risk of gangreneErgotamine	Ischemia with risk of gangreneMethysergide	Ischemia with risk of gangreneVerapamil	Increased effect of both drugsHydralazine	Increased effect of both drugsDiltiazem	Increased risk of bradycardiaEpinephrine	Hypertension, then bradycardiaFenoterol	AntagonismFormoterol	AntagonismIsoproterenol	AntagonismOrciprenaline	AntagonismPirbuterol	AntagonismPrazosin	Risk of hypotension at the beginning of therapyProcaterol	AntagonismSalbutamol	AntagonismSalmeterol	AntagonismTerbutaline	AntagonismIbuprofen	Risk of inhibition of renal prostaglandinsIndomethacin	Risk of inhibition of renal prostaglandinsPiroxicam	Risk of inhibition of renal prostaglandins
  Lidocaine¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available
  Tolnaftate¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available 
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    CYP450  Drug Interaction | 
    
      [CYP450 TableÁ÷Á¢Á¶È¸] 
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    | Food Interaction | 
    
       Crotamiton¿¡ ´ëÇÑ Food Interaction Á¤º¸ Not Available
  Lidocaine¿¡ ´ëÇÑ Food Interaction Á¤º¸ Not Available
  Tolnaftate¿¡ ´ëÇÑ Food Interaction Á¤º¸ Not Available 
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    | Drug Target | 
    
      
      [Drug Target]
     | 
   
  
   
    | Description | 
    
       Crotamiton¿¡ ´ëÇÑ Description Á¤º¸ Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol.
  Lidocaine¿¡ ´ëÇÑ Description Á¤º¸ A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. [PubChem]
  Tolnaftate¿¡ ´ëÇÑ Description Á¤º¸ Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin (Schering-Plough Corporation) and Odor Eaters (Combe Incorporated). Other brands are Absorbine, Aftate, Desenex, Genaspor, NP 27, and Ting. 
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    | Dosage Form | 
    
       Crotamiton¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Cream	Topical
  Lidocaine¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Aerosol	TopicalAerosol, metered	TopicalCream	TopicalGel	TopicalJelly	TopicalJelly	UrethralLiquid	BuccalLiquid	DentalLiquid	InfiltrationLiquid	IntravenousLiquid	OralLiquid	TopicalLotion	TopicalOintment	TopicalSolution	InfiltrationSolution	IntramuscularSolution	IntravenousSolution	OralSolution	TopicalSpray	TopicalSwab	Topical
  Tolnaftate¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Aerosol	TopicalCream	TopicalGel	TopicalLiquid	TopicalPowder	TopicalSpray	TopicalSwab	Topical 
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    | Drug Category | 
    
       Crotamiton¿¡ ´ëÇÑ Drug_Category Á¤º¸ Antiparasitic AgentsAntipruriticsPesticidesScabicides
  Lidocaine¿¡ ´ëÇÑ Drug_Category Á¤º¸ AnestheticsAnesthetics, LocalAnti-Arrhythmia AgentsAntiarrhythmic Agents
  Tolnaftate¿¡ ´ëÇÑ Drug_Category Á¤º¸ Antifungal Agents 
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    | Smiles String Canonical | 
    
       Crotamiton¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CCN(C(=O)C=CC)C1=CC=CC=C1C
  Lidocaine¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
  Tolnaftate¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1 
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    | Smiles String Isomeric | 
    
       Crotamiton¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CCN(C(=O)\C=C\C)C1=CC=CC=C1C
  Lidocaine¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
  Tolnaftate¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1 
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    | InChI Identifier | 
    
       Crotamiton¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3
  Lidocaine¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)/f/h15H
  Tolnaftate¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3 
     | 
   
  
   
    | Chemical IUPAC Name | 
    
       Crotamiton¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ N-ethyl-N-(2-methylphenyl)but-2-enamide
  Lidocaine¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ 2-diethylamino-N-(2,6-dimethylphenyl)acetamide
  Tolnaftate¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ O-naphthalen-2-yl [methyl-(3-methylphenyl)amino]methanethioate 
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    | Drug-Induced Toxicity Related Proteins | 
    
      DOCA ÀÇ Drug-Induced Toxicity Related ProteinÁ¤º¸ Replated Protein:Aquaporin-2 Drug:DOCA Toxicity:hypertension.  [¹Ù·Î°¡±â] LIDOCAINE ÀÇ Drug-Induced Toxicity Related ProteinÁ¤º¸ Replated Protein:glucose-regulated protein  Drug:lidocaine Toxicity:intestinal disorder.  [¹Ù·Î°¡±â] Replated Protein:Alkaline phosphatase Drug:lidocaine  Toxicity:lidocaine induced hepatitis.  [¹Ù·Î°¡±â] Replated Protein:C-reactive protein Drug:lidocaine  Toxicity:fever.  [¹Ù·Î°¡±â] Replated Protein:C-reactive protein Drug:lidocaine  Toxicity:lidocaine induced hepatitis.  [¹Ù·Î°¡±â] Replated Protein:Alpha-1-acid glycoprotein Drug:lidocaine  Toxicity:lidocaine tolerance.  [¹Ù·Î°¡±â] Replated Protein:Gamma-glutamyltranspeptidase  Drug:lidocaine  Toxicity:fever.  [¹Ù·Î°¡±â] Replated Protein:Alkaline phosphatase Drug:lidocaine  Toxicity:fever.  [¹Ù·Î°¡±â] Replated Protein:Gamma-glutamyltranspeptidase  Drug:lidocaine  Toxicity:lidocaine induced hepatitis.  [¹Ù·Î°¡±â] 
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