Pseudoephedrine에 대한 Mechanism_Of_Action 정보 Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. Triprolidine에 대한 Mechanism_Of_Action 정보 Triprolidine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Pharmacology
Pseudoephedrine에 대한 Pharmacology 정보 Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa). Triprolidine에 대한 Pharmacology 정보 In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Triprolidine, is a histamine H1 antagonist that competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Metabolism
Pseudoephedrine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Monoamine oxidase type A (MAO-A) Triprolidine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Not Available
Protein Binding
Pseudoephedrine에 대한 단백결합 정보 Pseudoephedrine does not bind to human plasma proteins over the concentration range of 50 to 2000 ng/mL Triprolidine에 대한 단백결합 정보 Not Available
Half-life
Pseudoephedrine에 대한 반감기 정보 9-16 hours Triprolidine에 대한 반감기 정보 4 to 6 hours.
Absorption
Pseudoephedrine에 대한 Absorption 정보 Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism. Triprolidine에 대한 Absorption 정보 Rapidly absorbed in the intestinal tract.
Pseudoephedrine에 대한 Biotransformation 정보 Hepatic. Triprolidine에 대한 Biotransformation 정보 Not Available
Toxicity
Pseudoephedrine에 대한 Toxicity 정보 Common adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness. Triprolidine에 대한 Toxicity 정보 Symptoms of overdose include drowsiness, weakness, inco-ordination, difficulty with micturition, respiratory depression, hypotension, agitation, irritability, convulsions, hypertension, palpitation and tachycardia.
Drug Interactions
Pseudoephedrine에 대한 Drug_Interactions 정보 Alseroxylon Increased arterial pressureIsocarboxazid Increased arterial pressureLinezolid Possible increase of arterial pressureMethyldopa Increased arterial pressureBromocriptine The sympathomimetic increases the toxicity of bromocriptineTranylcypromine Increased arterial pressureMidodrine Increased arterial pressureMoclobemide Moclobemide increases the sympathomimetic effectPargyline Increased arterial pressurePhenelzine Increased arterial pressureRasagiline Increased arterial pressureReserpine Increased arterial pressureTrimipramine The tricyclic increases the sympathomimetic effectProtriptyline The tricyclic increases the sympathomimetic effectNortriptyline The tricyclic increases the sympathomimetic effectAmitriptyline The tricyclic increases the sympathomimetic effectAmoxapine The tricyclic increases the sympathomimetic effectClomipramine The tricyclic increases the sympathomimetic effectImipramine The tricyclic increases the sympathomimetic effectDesipramine The tricyclic increases the sympathomimetic effectDoxepin The tricyclic increases the sympathomimetic effectDeserpidine Increased arterial pressureGuanethidine The agent decreases the effect of guanethidine Triprolidine에 대한 Drug_Interactions 정보 Not Available
Pseudoephedrine에 대한 Description 정보 An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem] Triprolidine에 대한 Description 정보 Histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and COLD medicines. It may cause drowsiness. [PubChem]
Drug Category
Pseudoephedrine에 대한 Drug_Category 정보 Adrenergic AgentsBronchodilator AgentsCentral Nervous System AgentsNasal DecongestantsSympathomimeticsVasoconstrictor Agents Triprolidine에 대한 Drug_Category 정보 Anti-Allergic AgentsHistamine H1 Antagonists
Smiles String Canonical
Pseudoephedrine에 대한 Smiles_String_canonical 정보 CNC(C)C(O)C1=CC=CC=C1 Triprolidine에 대한 Smiles_String_canonical 정보 CC1=CC=C(C=C1)C(=CCN1CCCC1)C1=CC=CC=N1
Smiles String Isomeric
Pseudoephedrine에 대한 Smiles_String_isomeric 정보 CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 Triprolidine에 대한 Smiles_String_isomeric 정보 CC1=CC=C(C=C1)C(=C/CN1CCCC1)\C1=CC=CC=N1
InChI Identifier
Pseudoephedrine에 대한 InChI_Identifier 정보 InChI=1/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1 Triprolidine에 대한 InChI_Identifier 정보 InChI=1/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
Chemical IUPAC Name
Pseudoephedrine에 대한 Chemical_IUPAC_Name 정보 (1S,2S)-2-methylamino-1-phenylpropan-1-ol Triprolidine에 대한 Chemical_IUPAC_Name 정보 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
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최근정보수정일 2025-11-03
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