| 항목 |
내용 |
| DUR (의약품사용평가) |
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| 독성정보 |
Glycerin에 대한 독성정보 : 정보보기
Nitroglycerin에 대한 독성정보 : 정보보기
출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do |
| Mechanism of Action |
Nitroglycerin에 대한 Mechanism_Of_Action 정보
Similar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
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| Pharmacology |
Nitroglycerin에 대한 Pharmacology 정보
Nitroglycerin, an organic nitrate, is available in many forms as a vasodilator. Nitroglycerin is used in the treatement of angina pectoris and perioperative hypertension, to produce controlled hypotension during surgical procedures, to treat hypertensive emergencies, and to treat congestive heart failure associated with myocardial infarction.
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| Metabolism |
Nitroglycerin에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Not Available
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| Protein Binding |
Nitroglycerin에 대한 단백결합 정보
Not Available
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| Half-life |
Nitroglycerin에 대한 반감기 정보
3 minutes
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| Absorption |
Nitroglycerin에 대한 Absorption 정보
Not Available
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| Pharmacokinetics |
Nitroglycerin의 약물동력학자료
- 작용발현시간 및 작용지속시간 : 제형에 따라 다름
- 단백결합 : 60%
- 대사 : 초회통과효과 큼
- 반감기 : 1-4분
- 소실 : 뇨를 통해 비활성형 대사체로 배설
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| Biotransformation |
Nitroglycerin에 대한 Biotransformation 정보
Hepatic, cytochrome P450 (P450) is a key enzyme of organic nitrate biotransformation
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| Toxicity |
Nitroglycerin에 대한 Toxicity 정보
Increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
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| Drug Interactions |
Nitroglycerin에 대한 Drug_Interactions 정보
Alteplase IV nitroglycerin decreases the effect of alteplaseDihydroergotamine Possible antagonism of actionDihydroergotoxine Possible antagonism of actionErgonovine Possible antagonism of actionErgotamine Possible antagonism of actionMethylergonovine Possible antagonism of actionMethysergide Possible antagonism of actionSildenafil Possible significant hypotension with this combinationTadalafil Possible significant hypotension with this combinationVardenafil Possible significant hypotension with this combination
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CYP450
Drug Interaction |
[CYP450 Table직접조회]
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| Food Interaction |
Nitroglycerin에 대한 Food Interaction 정보
Avoid alcohol.Take on empty stomach: 1 hour before or 2 hours after meals.Dissolve under the tongue.
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| Drug Target |
[Drug Target]
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| Description |
Nitroglycerin에 대한 Description 정보
A volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. [PubChem]
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| Drug Category |
Nitroglycerin에 대한 Drug_Category 정보
Explosive AgentsNitrates and NitritesTocolytic AgentsVasodilator Agents
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| Smiles String Canonical |
Nitroglycerin에 대한 Smiles_String_canonical 정보
[O-][N+](=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O
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| Smiles String Isomeric |
Nitroglycerin에 대한 Smiles_String_isomeric 정보
[O-][N+](=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O
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| InChI Identifier |
Nitroglycerin에 대한 InChI_Identifier 정보
InChI=1/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2
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| Chemical IUPAC Name |
Nitroglycerin에 대한 Chemical_IUPAC_Name 정보
1,3-dinitrooxypropan-2-yl nitrate
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전문/일반
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