드러그인포 약품요약정보 - 엔슈어액(바닐라향,커피향,딸기향)

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

644200350[E01860051] [보험코드에 따른 약품기본정보 직접조회]
\0 원/1ml(2016.06.01)(현재약가)
\11 원/1ml(2014.02.01)(변경전약가)
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

바닐라향, 커피향 : 바닐라향 또는 커피향이 나는 담갈색의 현탁액 딸기향 : 딸기향이 나는 분홍색의 현탁액 [제형정보 확인]

포장·유통단위

250ml, 500ml

포장·코드단위

약품규격	단위	포장형태	대표코드	표준코드	비고
250밀리리터	1 개	캔	8806442003508	8806442003553	딸기향(캔)
500밀리리터	1 개	백	8806442003508	8806442003560	딸기향(백)
250밀리리터	1 개	캔	8806442003508	8806442003515	바닐라향
500밀리리터	1 개	백	8806442003508	8806442003522	바닐라향
250밀리리터	1 개	캔	8806442003508	8806442003539	커피향
500밀리리터	1 개	백	8806442003508	8806442003546	커피향

주성분코드

304700ALQ [동일한 주성분코드를 가진 오리지날 또는 제네릭 의약품 조회]

허가사항 원문조회

[허가사항 원문조회]

효능효과

[적응증 별 검색]

(현탁제)
일반적으로 수술 후 환자의 영양유지에 사용한다. 특히, 장기간 경구적으로 식사섭취가 곤란한 경우의 경관영양보급에 사용한다.

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
[주성분코드:304700ALQ 에 따른 심사지침열람]

(현탁제)
○성인표준량 : 1일 1,500～2,250 mL (1,500～2,250 kcal)을 경관 및 경구 투여한다. 1 mL당 1 kcal이다.
연령 및 증상에 따라 적의 증감한다.
○경관투여 속도 : 1시간에 100～150 mL
지속적으로 1일 1회 또는수회로 나누어서 투여한다.
○초기량은 표준량의 1/3～1/2량으로물의 양을 약 배량으로 하여 희석시켜 투여한다(0.5 kcal/mL).
이후에는 환자의 상태에 따라 천천히 농도 및 양을 증가시켜 표준량으로 한다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

[피해야 할 음식] [복용을 잊은 경우 대처법]

주요약물 상호작용

[조회]

금기

1) 우유에 과민하거나 알레르기 병력이 있는 환자(이 약은 우유 단백질을 함유하므로, 아나필락시를 일으킬 수 있다.)
2) 본제의 성분에 대하여 과민증의 병력이 있는 환자

업데이트일:2009-02-19/ 업데이트종류:허가사항변경지시

신중투여

1) 단장(短腸) 증후군 환자 또는 중증의 장관기능장애환자(설사의 악화를 초래할 수 있다.)
2) 당대사이상 환자(고혈당이 생길 수 있다.)
3) 수분의 보급에 주의를 요하는 다음의 환자(탈수 증상이 나타날 수 있다.)
(1) 혼수상태의 환자
(2) 의식불명의 환자
(3) 구갈을 호소할 수 없는 환자
(4) 고열을 수반하는 환자
(5) 심각한 설사를 보이는 탈수증 환자
(6) 신장애 환자
4) 임부 또는 임신하고 있을 가능성이 있는 여성
외국에서임신 전 3개월로부터 임신 초기 3개월까지 비타민 A를 1일 10,000 IU 이상섭취한 여성으로부터 태어난 아이에서 능형뇌(菱型腦, hindbrain: 배아발생초기 신경관의 내강이 확장되어 형성되는 부분) 등을 중심으로 하는 기형발현 증가가추정된다는 역학조사 결과가 있으므로 임신 3개월 이내 또는 임신하고 있을 가능성이 있는 여성에게는 비타민 A 결핍증 치료에 사용하는 경우를 제외하고는 이 약을 투여하지 말 것. 또한비타민 A 보급을 목적으로 이 약을 사용하는 경우는 식품 등으로부터의 섭취량에 주의하고 이 약에 의한비타민 A 투여는 1 일5,000 IU 미만에 머물도록 하는 등 적절한 주의를 할 것.

업데이트일:2009-02-19/ 업데이트종류:허가사항변경지시

이상반응

상담시 가능한 한 이 첨부문서를 소지할 것.
1)중대한 부작용 : 쇼크, 유사아나필락시스 반응을 일으키는 경우가 있으므로 충분히 관찰하고, 혈압저하, 의식장애, 호흡곤란, 청색증, 구역, 흉부압박감, 안면홍조, 가려움증, 발한, 발진, 발작, 두드러기 등이 나타난 경우에는 즉시 투여를 중지하고 적절히처치한다.
2) 간장계 : AST(GOT)상승, ALT(GPT)상승, r-GTP상승, ALP상승 등 간기능 이상이 있을 수 있으므로 주의 깊게 관찰한다.
3) 소화기계 : 설사 때때로 복부팽만감, 복통,구역, 구토, 가슴쓰림 등이 나타난다. 그런 증상이 나타나는 경우에는 감량하고 주입속도를 지연시키거나 또는 농도를 저하시키고 휴약하는 등의 적절한처치를 한다.
4) 혈액계 : 때때로 칼륨, BUN 농도가 상승하는 경우가 있으므로 주의깊게관찰한다.
5) 과민반응 : 발진, 발적, 두드러기등이 나타날 수 있으므로 이러한 경우 즉시 투여를 중단한다.

업데이트일:2009-02-19/ 업데이트종류:허가사항변경지시

[주요 이상반응정보] [즉시 알려야 하는 이상반응]

Off-label Usage

[조회]

Related FDA Approved Drug

기준 성분:CHOLINE
ANECTINE (SUCCINYLCHOLINE CHLORIDE)
MIOCHOL (ACETYLCHOLINE CHLORIDE)
MIOCHOL-E (ACETYLCHOLINE CHLORIDE)
PROVOCHOLINE (METHACHOLINE CHLORIDE)
QUELICIN (SUCCINYLCHOLINE CHLORIDE)
QUELICIN PRESERVATIVE FREE (SUCCINYLCHOLINE CHLORIDE)
SUCCINYLCHOLINE CHLORIDE (SUCCINYLCHOLINE CHLORIDE)
SUCOSTRIN (SUCCINYLCHOLINE CHLORIDE)
TRILIPIX (CHOLINE FENOFIBRATE)
기준 성분:CHOLECALCIFEROL
CERNEVIT-12 (ALPHA-TOCOPHEROL; ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; FOLIC ACID; NIACINAMIDE; PANTOTHENIC ACID; PYRIDOXINE; RIBOFLAVIN; THIAMINE; VITAMIN A)
FOSAMAX PLUS D (ALENDRONATE SODIUM; CHOLECALCIFEROL)
INFUVITE ADULT (ALPHA-TOCOPHEROL ACETATE; ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN K)
INFUVITE PEDIATRIC (ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K)
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE) (ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K)
기준 성분:CALCIUM PANTOTHENATE
기준 성분:BIOTIN
BEROCCA PN (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN E)
M.V.C. 9+3 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I. ADULT (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K)
M.V.I. ADULT (PHARMACY BULK PACKAGE) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K)
M.V.I. PEDIATRIC (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I.-12 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I.-12 (WITHOUT VITAMIN K) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I.-12 LYOPHILIZED (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE; VITAMIN A; VITAMIN E)
MVC PLUS (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
VITAPED (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PANTOTHENIC ACID; PHYTONADIONE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; VITAMIN A PALMITATE; VITAMIN E)
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정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
성분코드	M071118/제삼인산칼슘 120.00밀리그램 / M040558/염산치아민 0.17밀리그램 / M040133/리보플라빈 0.17밀리그램 / M093880/분리대두단백질 0.52밀리그램 / M085717/카제인나트륨 2.36그램 / M040757/피토나디온(비타민케이) 7.0마이크로그램 / M040594/콜레칼시페롤 0.50마이크로그램 / M040354/아스코르빈산 15.2밀리그램 / M040442/엽산 20마이크로그램 / M084248/염화망간 0.72밀리그램 / M088483/팔미틴산레티놀 137.60마이크로그램 / M091152/대두인지질 0.16그램 / M040799/황산동 0.39밀리그램 / M096429/시아노코발라민 0.60마이크로그램 / M093879/카제인나트륨칼슘 1.08밀리그램 / M040438/염화칼륨 120.00밀리그램 / M040449/옥수수기름 3.32그램 / M040648/초산토코페롤 3.29밀리그램 / M040679/판토텐산칼슘 0.54밀리그램 / M040442/엽산 20.00마이크로그램 / M040085/덱스트린 9.80그램 / M040034/구연산나트륨 156밀리그램 / M040631/탄산수소나트륨 30.6마이크로그램 / M051111/염화마그네슘 164.00밀리그램 / M040751/염산피리독신 0.24밀리그램 / M040802/황산아연 6.60밀리그램 / M040064/니코틴산아미드 2.00밀리그램 / M040438/염화칼륨 120밀리그램 / M071118/제삼인산칼슘 120밀리그램 / M080391/구연산칼륨 184.00밀리그램 / M040210/정제백당 3.92그램 / M051111/염화마그네슘 164밀리그램 / M070934/염화콜린 0.06그램 / M040804/황산철 4.48밀리그램 / M050704/비오틴 15.20마이크로그램 / M040631/탄산수소나트륨 30.60마이크로그램 / M040802/황산아연 6.6밀리그램 /
주성분코드	304700ALQ [동일한 주성분코드를 가진 오리지날 또는 제네릭 의약품 조회]
대표코드	8806442003508
BIT 약효분류	경장영양제(Enteral Nutritional Products)
ATC 코드	Other combinations of nutrients / V06DX [코드분류상세설명] [ATC코드예측]
복지부분류코드	325 (단백아미노산제제 )
의약품 바코드정보	내용보기 엔슈어액(바닐라향커피향딸기향)/E01860051 제품규격:250밀리리터/제품수량:1/제형:개 폼목기준코드:199203397 /대표코드:8806442003508/표준코드:8806442003515 구바코드:-/비고:바닐라향(캔) 엔슈어액(바닐라향커피향딸기향)/E01860051 제품규격:500밀리리터/제품수량:1/제형:개 폼목기준코드:199203397 /대표코드:8806442003508/표준코드:8806442003522 구바코드:-/비고:바닐라향(백) 엔슈어액(바닐라향커피향딸기향)/E01860051 제품규격:250밀리리터/제품수량:1/제형:개 폼목기준코드:199203397 /대표코드:8806442003508/표준코드:8806442003539 구바코드:-/비고:커피향(캔) 엔슈어액(바닐라향커피향딸기향)/E01860051 제품규격:500밀리리터/제품수량:1/제형:개 폼목기준코드:199203397 /대표코드:8806442003508/표준코드:8806442003546 구바코드:-/비고:커피향(백) 엔슈어액(바닐라향커피향딸기향)/E01860051 제품규격:250밀리리터/제품수량:1/제형:개 폼목기준코드:199203397 /대표코드:8806442003508/표준코드:8806442003553 구바코드:-/비고:딸기향(캔) 엔슈어액(바닐라향커피향딸기향)/E01860051 제품규격:500밀리리터/제품수량:1/제형:개 폼목기준코드:199203397 /대표코드:8806442003508/표준코드:8806442003560 구바코드:-/비고:딸기향(백)
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
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제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	644200350[E01860051] [보험코드에 따른 약품기본정보 직접조회] \0 원/1ml(2016.06.01)(최신약가) \11 원/1ml(2014.02.01)(변경전약가) [상병코드조회] [질병코드집 다운로드]
제품성상	바닐라향, 커피향 : 바닐라향 또는 커피향이 나는 담갈색의 현탁액 딸기향 : 딸기향이 나는 분홍색의 현탁액 [제형정보 확인]
포장·유통단위	250ml, 500ml
보관방법	밀봉용기, 실온보관
동일주성분코드 검색순위	유료정보입니다.

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*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : A등급
(ascorbic acid;cyanocobalamin;ferrous sulfate;folic acid; )

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Ascorbic Acid에 대한 독성정보 : 정보보기 Biotin에 대한 독성정보 : 정보보기 Calcium에 대한 독성정보 : 정보보기 Choline chloride에 대한 독성정보 : 정보보기 Cyanocobalamin에 대한 독성정보 : 정보보기 Folic acid에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Biotin에 대한 Mechanism_Of_Action 정보 Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids. Calcium에 대한 Mechanism_Of_Action 정보 Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available. Cholecalciferol에 대한 Mechanism_Of_Action 정보 The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed by the 25-hydroxylase in the liver and then by other enzymes. The mitochondrial sterol 27-hydroxylase catalyses the first reaction in the oxidation of the side chain of sterol intermediates. The active form of vitamin D3 (calcitriol) binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. Calcitriol increases the serum calcium concentrations by: increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium. Calcitriol appears to promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein. Choline에 대한 Mechanism_Of_Action 정보 Choline is a major part of the polar head group of phosphatidylcholine. Phosphatidylcholine's role in the maintenance of cell membrane integrity is vital to all of the basic biological processes: information flow, intracellular communication and bioenergetics. Inadequate choline intake would negatively affect all these processes. Choline is also a major part of another membrane phospholipid, sphingomyelin, also important for the maintenance of cell structure and function. It is noteworthy and not surprising that choline deficiency in cell culture causes apoptosis or programmed cell death. This appears to be due to abnormalities in cell membrane phosphatidylcholine content and an increase in ceramide, a precursor, as well as a metabolite, of sphingomyelin. Ceramide accumulation, which is caused by choline deficiency, appears to activate Caspase, a type of enzyme that mediates apoptosis. Betaine or trimethylglycine is derived from choline via an oxidation reaction. Betaine is one of the factors that maintains low levels of homocysteine by resynthesizing L-methionine from homocysteine. Elevated homocysteine levels are a significant risk factor for atherosclerosis, as well as other cardiovascular and neurological disorders. Acetylcholine is one of the major neurotransmitters and requires choline for its synthesis. Adequate acetylcholine levels in the brain are believed to be protective against certain types of dementia, including Alzheimer's disease. Cyanocobalamin에 대한 Mechanism_Of_Action 정보 Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
Pharmacology	Biotin에 대한 Pharmacology 정보 Biotin is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is used in cell growth, the production of fatty acids, metabolism of fats, and amino acids. It plays a role in the Kreb cycle, which is the process in which energy is released from food. Biotin not only assists in various metabolic chemical conversions, but also helps with the transfer of carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequenty, it is found in many cosmetic and health products for the hair and skin. Biotin deficiency is a rare nutritional disorder caused by a deficiency of biotin. Initial symptoms of biotin deficiency include: Dry skin, Seborrheic dermatitis, Fungal infections, rashes including erythematous periorofacial macular rash, fine and brittle hair, and hair loss or total alopecia. If left untreated, neurological symptoms can develop, including mild depression, which may progress to profound lassitude and, eventually, to somnolence; changes in mental status, generalized muscular pains (myalgias), hyperesthesias and paresthesias. The treatment for biotin deficiency is to simply start taking some biotin supplements. A lack of biotin in infants will lead to a condition called seborrheic dermatitis or "cradle cap". Biotin deficiencies are extremely rare in adults but if it does occur, it will lead to anemia, depression, hair loss, high blood sugar levels, muscle pain, nausea, loss of appetite and inflamed mucous membranes. Cholecalciferol에 대한 Pharmacology 정보 Cholecalciferol (vitamin D3) is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of Vitamin A. The classical manifestations of vitamin D deficiency is rickets, which is seen in children and results in bony deformaties including bowed long bones. Deficiency in adults leads to the disease osteomalacia. Both rickets and osteomalacia reflect impaired mineralization of newly synthesized bone matrix, and usually result from a combination of inadequate exposure to sunlight and decreased dietary intake of vitamin D. Common causes of vitamin D deficiency include genetic defects in the vitamin D receptor, severe liver or kidney disease, and insufficient exposure to sunlight. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma. Choline에 대한 Pharmacology 정보 This compound is needed for good nerve conduction throughout the CNS (central nervous system) as it is a precursor to acetylcholine (ACh). Choline is also needed for gallbladder regulation, liver function and lecithin (a key lipid) formation. Choline also aids in fat and cholesterol metabolism and prevents excessive fat build up in the liver. Choline has been used to mitigate the effects of Parkinsonism and tardive dyskinesia. Choline deficiencies may result in excessive build-up of fat in the liver, high blood pressure, gastric ulcers, kidney and liver dysfunction and stunted growth. Cyanocobalamin에 대한 Pharmacology 정보 Cyanocobalamin (Vitamin B12) is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It is needed for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.
Metabolism	Cholecalciferol에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 24A1 (CYP24A1)Cytochrome P450 11A1 (CYP11A1) Choline에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cholinesterase Cyanocobalamin에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Methylenetetrahydrofolate reductase
Protein Binding	Cholecalciferol에 대한 단백결합 정보 50% to 80% Cyanocobalamin에 대한 단백결합 정보 Very high (to specific plasma proteins called transcobalamins); binding of hydroxocobalamin is slightly higher than cyanocobalamin.
Half-life	Cholecalciferol에 대한 반감기 정보 Several weeks Cyanocobalamin에 대한 반감기 정보 Approximately 6 days (400 days in the liver).
Absorption	Biotin에 대한 Absorption 정보 Systemic - approximately 50% Cholecalciferol에 대한 Absorption 정보 Readily absorbed Choline에 대한 Absorption 정보 Not Available Cyanocobalamin에 대한 Absorption 정보 Readily absorbed in the lower half of the ileum.
Biotransformation	Biotin에 대한 Biotransformation 정보 Not Available Cholecalciferol에 대한 Biotransformation 정보 Within the liver, cholecalciferal is hydroxylated to calcidiol (25-hydroxycholecalciferol) by the enzyme 25-hydroxylase. Within the kidney, calcidiol serves as a substrate for 1-alpha-hydroxylase, yielding calcitriol (1,25-dihydroxycholecalciferol), the biologically active form of vitamin D3. Cyanocobalamin에 대한 Biotransformation 정보 Hepatic
Toxicity	Biotin에 대한 Toxicity 정보 Prolonged skin contact may cause irritation. Cholecalciferol에 대한 Toxicity 정보 Hypercalcemia - Early symptoms of hypercalcemia, include nausea and vomiting, weakness, headache, somnolence, dry mouth, constipation, metallic taste, muscle pain and bone pain. Late symptoms and signs of hypercalcemia, include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritis, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated ALT (SGPT) and AST (SGOT), ectopic calcification, nephrocalcinosis, hypertension and cardiac arrhythmias. Choline에 대한 Toxicity 정보 Oral rat LD₅₀: 3400 mg/kg Cyanocobalamin에 대한 Toxicity 정보 Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD₅₀ > 8000 mg/kg
Drug Interactions	Biotin에 대한 Drug_Interactions 정보 Not Available Calcium에 대한 Drug_Interactions 정보 Alendronate Formation of non-absorbable complexesAmprenavir The antiacid decreases the absorption of amprenavirAtazanavir This gastric pH modifier decreases the levels/effects of atazanavirChloroquine The antiacid decreases the absorption of chloroquineCiprofloxacin Formation of non-absorbable complexesDapsone Formation of non-absorbable complexesDelavirdine The antiacid decreases the effect of delavirdineDemeclocycline Formation of non-absorbable complexesDoxycycline Formation of non-absorbable complexesEnoxacin Formation of non-absorbable complexesFosamprenavir The antiacid decreases the absorption of amprenavirGrepafloxacin Formation of non-absorbable complexesIbandronate Formation of non-absorbable complexesIndinavir The antiacid decreases the absorption of indinavirItraconazole The antacid decreases the effect of the imidazoleKetoconazole The antacid decreases the effect of the imidazoleLevofloxacin Formation of non-absorbable complexesLevothyroxine Calcium decreases absorption of levothyroxineLomefloxacin Formation of non-absorbable complexesMethacycline Formation of non-absorbable complexesMinocycline Formation of non-absorbable complexesMoxifloxacin Formation of non-absorbable complexesNorfloxacin Formation of non-absorbable complexesOfloxacin Formation of non-absorbable complexesOxytetracycline Formation of non-absorbable complexesPefloxacin Formation of non-absorbable complexesPolystyrene sulfonate Formation of non-absorbable complexesRisedronate Formation of non-absorbable complexesTetracycline Formation of non-absorbable complexesTrovafloxacin Formation of non-absorbable complexesClodronate Formation of non-absorbable complexesEtidronic acid Formation of non-absorbable complexesMycophenolate mofetil Formation of non-absorbable complexesTemafloxacin Formation of non-absorbable complexes Cholecalciferol에 대한 Drug_Interactions 정보 Not Available Choline에 대한 Drug_Interactions 정보 Not Available Cyanocobalamin에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회]
Drug Target	[Drug Target]
Description	Biotin에 대한 Description 정보 A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. [PubChem] Calcium에 대한 Description 정보 Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. Cholecalciferol에 대한 Description 정보 Derivative of 7-dehydroxycholesterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from ergocalciferol in having a single bond between C22 and C23 and lacking a methyl group at C24. [PubChem] Choline에 대한 Description 정보 A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [PubChem] Cyanocobalamin에 대한 Description 정보 Cyanocobalamin (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Cyanocobalamin's structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Cyanocobalamin cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of cyanocobalamin are bacteria and archaea. Higher plants do not concentrate cyanocobalamin from the soil and so are a poor source of the substance as compared with animal tissues. Cyanocobalamin is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products. [HMDB]
Dosage Form	Biotin에 대한 Dosage_Form 정보 Powder, for solution OralTablet Oral Calcium에 대한 Dosage_Form 정보 Capsule OralLiquid DentalLiquid IntravenousLiquid OralLiquid SublingualPaste DentalPowder OralPowder, for solution OralSolution IntramuscularSolution IntravenousSolution OralSolution / drops OralSyrup OralTablet OralTablet, chewable Oral Cholecalciferol에 대한 Dosage_Form 정보 Capsule OralTablet Oral Choline에 대한 Dosage_Form 정보 Tablet Oral Cyanocobalamin에 대한 Dosage_Form 정보 Capsule OralLiquid IntramuscularLiquid OralPowder OralSolution IntramuscularTablet OralTablet, extended release Oral
Drug Category	Biotin에 대한 Drug_Category 정보 Dietary supplementMicronutrientVitamin B ComplexVitamins (Vitamin B Complex) Cholecalciferol에 대한 Drug_Category 정보 Antihypocalcemic AgentsAntihypoparathyroid AgentsBone Density Conservation AgentsEssential VitaminVitaminsVitamins (Vitamin D) Choline에 대한 Drug_Category 정보 Dietary supplementLipotropic AgentsMicronutrientNootropic Agents Cyanocobalamin에 대한 Drug_Category 정보 Antianemic AgentsEssential VitaminVitamins (Vitamin B Complex)
Smiles String Canonical	Biotin에 대한 Smiles_String_canonical 정보 OC(=O)CCCCC1SCC2NC(=O)NC12 Calcium에 대한 Smiles_String_canonical 정보 Not Available Cholecalciferol에 대한 Smiles_String_canonical 정보 CC(C)CCCC(C)C1CCC2C(CCCC12C)=CC=C1CC(O)CCC1=C Choline에 대한 Smiles_String_canonical 정보 C[N+](C)(C)CCO Cyanocobalamin에 대한 Smiles_String_canonical 정보 [Co+3].[C-]
Smiles String Isomeric	Biotin에 대한 Smiles_String_isomeric 정보 OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 Calcium에 대한 Smiles_String_isomeric 정보 Not Available Cholecalciferol에 대한 Smiles_String_isomeric 정보 CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@]1(C)CCC\C2=C/C=C1\C[C@@H](O)CCC1=C Choline에 대한 Smiles_String_isomeric 정보 C[N+](C)(C)CCO Cyanocobalamin에 대한 Smiles_String_isomeric 정보 [Co+3].[C-]
InChI Identifier	Biotin에 대한 InChI_Identifier 정보 InChI=1/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1/f/h11-13H Calcium에 대한 InChI_Identifier 정보 Not Available Cholecalciferol에 대한 InChI_Identifier 정보 InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/t21-,24+,25-,26+,27-/m1/s1 Choline에 대한 InChI_Identifier 정보 InChI=1/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 Cyanocobalamin에 대한 InChI_Identifier 정보 InChI=1/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;-1;+3/p-1/t31?,34-,35-,36-,37+,41+,52?,53?,56?,57+,59-,60+,61+,62+;;/m1../s1/fC62H89N13O14P.CN.Co/h69,85H,63-68H2;;/q-1;2m/b42-23-,54-32-,55-33-;;
Chemical IUPAC Name	Biotin에 대한 Chemical_IUPAC_Name 정보 5-[(3aR,6S,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]pentanoic acid Calcium에 대한 Chemical_IUPAC_Name 정보 Not Available Cholecalciferol에 대한 Chemical_IUPAC_Name 정보 (1S)-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol Choline에 대한 Chemical_IUPAC_Name 정보 2-hydroxyethyl-trimethylazanium Cyanocobalamin에 대한 Chemical_IUPAC_Name 정보 Not Available
Drug-Induced Toxicity Related Proteins	COPPER 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Metallothionein Drug:copper Toxicity:abnormal metallothionein gene regulation . [바로가기]

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