드러그인포 약품요약정보 - 시프로손점이액

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

[A22552721] [보험코드에 따른 약품기본정보 직접조회]
\0 원/1ml(2004.03.01)(현재약가)
\1,326 원/1ml(2003.06.01)(변경전약가)
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

효능효과

[적응증 별 검색]

Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa 등에 의한 급성 외이염의 치료

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]

소아(1세 이상) 및 성인 : 이 약 3방울을 1일 2회씩 7일 동안 감염된 귀 안에 점적한다.

사용하기 직전 잘 흔들어서 사용한다.
차가운 용액을 귀 안으로 점적하면 현기증이 일어날 수도 있으므로 이를 피하기 위하여 용기를 1-2분정도 손으로 잡아 따뜻하게 한 후 투여한다. 환자는 감염된 귀가 위쪽으로 향하도록 누운 자세에서 본제를 점적하여야 한다. 약물이 보다 쉽게 귀 안으로 흡수될 수 있도록 이러한 자세를 30-60초간 유지하여야 한다. 필요하다면 반대쪽 귀에도 투여한다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

[피해야 할 음식] [복용을 잊은 경우 대처법]

주요약물 상호작용

[조회]

금기

1) 히드로코르티손이나 시프로플록사신, 기타 퀴놀론계 항균제에 과민증이 있는 환자 또는 이 약의 구성성분에 과민증이 있는 환자

2) 고막 천공이 있는 환자

3) 수두나 단순 포진 감염증 등 외이도의 바이러스 감염증이 있는 환자

이상반응

1) 편두통, 지각 감퇴증, 감각 이상증, 피부 진균증, 기침, 발진, 담마진, 탈모증 등이 나타날 수 있다.

2) 두통, 소양증 등이 때때로 나타날 수 있다.

3) 시판 후 보고된 매우 드문 이상반응으로 외이도에 약물이 잔류하여 귀의 감각둔화, 청력장애, 귀의 통증이 보고되었다.

4) 국내에서 재심사를 위하여 6년 동안 1658명을 대상으로 실시한 시판후 조사결과 8명에서 9건의 이상반응이 보고되었다. 귀의 통증이 4건으로 가장 많았으며, 두통 2건, 오심, 현훈, 피부진균증이 각 1건씩 보고되었다.

5) 눈 : 빈도불명의 시야흐림이 나타날 수 있다.

[주요 이상반응정보] [즉시 알려야 하는 이상반응]

상호작용

1) 이 약의 사용에 있어서 특정한 약물의 상호작용은 연구되지 않았다.

2) 타 점이용 의약품과의 동시 사용은 피하도록 한다.

Related FDA Approved Drug

기준 성분:HYDROCORTISONE
ACETASOL HC (ACETIC ACID, GLACIAL; HYDROCORTISONE)
ACETIC ACID W/ HYDROCORTISONE (ACETIC ACID, GLACIAL; HYDROCORTISONE)
ACHROMYCIN (HYDROCORTISONE; TETRACYCLINE HYDROCHLORIDE)
ACTICORT (HYDROCORTISONE)
ACYCLOVIR AND HYDROCORTISONE (ACYCLOVIR; HYDROCORTISONE)
AEROSEB-HC (HYDROCORTISONE)
A-HYDROCORT (HYDROCORTISONE SODIUM SUCCINATE)
ALA-CORT (HYDROCORTISONE)
ALA-SCALP (HYDROCORTISONE)
ALPHADERM (HYDROCORTISONE; UREA)
ANUSOL HC (HYDROCORTISONE)
BACITRACIN-NEOMYCIN-POLYMYXIN W/ HYDROCORTISONE ACETATE (BACITRACIN; HYDROCORTISONE ACETATE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
BALNEOL-HC (HYDROCORTISONE)
BETA-HC (HYDROCORTISONE)
CALMURID HC (HYDROCORTISONE; UREA)
CARMOL HC (HYDROCORTISONE ACETATE; UREA)
CETACORT (HYDROCORTISONE)
CHLOROMYCETIN HYDROCORTISONE (CHLORAMPHENICOL; HYDROCORTISONE ACETATE)
CIPRO HC (CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE)
COLOCORT (HYDROCORTISONE)
COLY-MYCIN S (COLISTIN SULFATE; HYDROCORTISONE ACETATE; NEOMYCIN SULFATE; THONZONIUM BROMIDE)
COR-OTICIN (HYDROCORTISONE ACETATE; NEOMYCIN SULFATE)
CORT-DOME (HYDROCORTISONE)
CORTEF (HYDROCORTISONE)
CORTEF ACETATE (HYDROCORTISONE ACETATE)
CORTENEMA (HYDROCORTISONE)
CORTIFOAM (HYDROCORTISONE ACETATE)
CORTISPORIN (BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
CORTRIL (HYDROCORTISONE)
DERMACORT (HYDROCORTISONE)
DRICORT (HYDROCORTISONE ACETATE)
ELDECORT (HYDROCORTISONE)
EPICORT (HYDROCORTISONE)
EPIFOAM (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
FLEXICORT (HYDROCORTISONE)
GLYCORT (HYDROCORTISONE)
HC #1 (HYDROCORTISONE)
HC #4 (HYDROCORTISONE)
HC (HYDROCORTISONE) (HYDROCORTISONE)
H-CORT (HYDROCORTISONE)
HEMSOL-HC (HYDROCORTISONE ACETATE)
HI-COR (HYDROCORTISONE)
HYDROCORTISONE (HYDROCORTISONE)
HYDROCORTISONE ACETATE (HYDROCORTISONE ACETATE)
HYDROCORTISONE ACETATE 1% AND PRAMOXINE HYDROCHLORIDE 1% (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
HYDROCORTISONE AND ACETIC ACID (ACETIC ACID, GLACIAL; HYDROCORTISONE)
HYDROCORTISONE BUTYRATE (HYDROCORTISONE BUTYRATE)
HYDROCORTISONE IN ABSORBASE (HYDROCORTISONE)
HYDROCORTISONE SODIUM PHOSPHATE (HYDROCORTISONE SODIUM PHOSPHATE)
HYDROCORTISONE SODIUM SUCCINATE (HYDROCORTISONE SODIUM SUCCINATE)
HYDROCORTISONE VALERATE (HYDROCORTISONE VALERATE)
HYDROCORTONE (HYDROCORTISONE)
HYDRO-RX (HYDROCORTISONE)
HYTONE (HYDROCORTISONE)
LOCOID (HYDROCORTISONE BUTYRATE)
LOCOID LIPOCREAM (HYDROCORTISONE BUTYRATE)
MICORT-HC (HYDROCORTISONE ACETATE)
NEO-CORT-DOME (ACETIC ACID, GLACIAL; HYDROCORTISONE; NEOMYCIN SULFATE)
NEO-CORTEF (HYDROCORTISONE ACETATE; NEOMYCIN SULFATE)
NEOMYCIN & POLYMYXIN B SULFATES & BACITRACIN ZINC & HYDROCORTISONE (BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN AND POLYMYXIN B SULFATES AND HYDROCORTISONE (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN AND POLYMYXIN B SULFATES, BACITRACIN ZINC AND HYDROCORTISONE (BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN SULFATE, POLYMYXIN B SULFATE & HYDROCORTISONE (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN SULFATE-POLYMYXIN B SULFATE-HYDROCORTISONE (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NOGENIC HC (HYDROCORTISONE)
NUTRACORT (HYDROCORTISONE)
OPHTHOCORT (CHLORAMPHENICOL; HYDROCORTISONE ACETATE; POLYMYXIN B SULFATE)
ORABASE HCA (HYDROCORTISONE ACETATE)
ORLEX HC (ACETIC ACID, GLACIAL; HYDROCORTISONE)
OTICAIR (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
OTOBIONE (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
OTOBIOTIC (HYDROCORTISONE; POLYMYXIN B SULFATE)
OTOCORT (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
PANDEL (HYDROCORTISONE PROBUTATE)
PEDIOTIC (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
PENECORT (HYDROCORTISONE)
PRAMOSONE (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
PROCTOCORT (HYDROCORTISONE)
PROCTOFOAM HC (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
PYOCIDIN (HYDROCORTISONE; POLYMYXIN B SULFATE)
SOLU-CORTEF (HYDROCORTISONE SODIUM SUCCINATE)
STIE-CORT (HYDROCORTISONE)
SYNACORT (HYDROCORTISONE)
TERRA-CORTRIL (HYDROCORTISONE ACETATE; OXYTETRACYCLINE HYDROCHLORIDE)
TEXACORT (HYDROCORTISONE)
U-CORT (HYDROCORTISONE ACETATE; UREA)
VOSOL HC (ACETIC ACID, GLACIAL; HYDROCORTISONE)
WESTCORT (HYDROCORTISONE VALERATE)
ZINC BACITRACIN,NEOMYCIN SULFATE,POLYMYXIN B SULFATE & HYDROCORTISONE (BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
기준 성분:CIPROFLOXACIN HYDROCHLORIDE
CETRAXAL (CIPROFLOXACIN HYDROCHLORIDE)
CILOXAN (CIPROFLOXACIN HYDROCHLORIDE)
CIPRO (CIPROFLOXACIN HYDROCHLORIDE)
CIPRO XR (CIPROFLOXACIN; CIPROFLOXACIN HYDROCHLORIDE)
CIPROFLOXACIN EXTENDED RELEASE (CIPROFLOXACIN; CIPROFLOXACIN HYDROCHLORIDE)
CIPROFLOXACIN HYDROCHLORIDE (CIPROFLOXACIN HYDROCHLORIDE)
PROQUIN XR (CIPROFLOXACIN HYDROCHLORIDE)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	Ear anti-infectives/ with steroides
ATC 코드	Hydrocortisone and antiinfectives / S02CA03 [코드분류상세설명] [ATC코드예측]
복지부분류코드	132 (이비과용제 )
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	[A22552721] [보험코드에 따른 약품기본정보 직접조회] \0 원/1ml(2004.03.01)(최신약가) \1,326 원/1ml(2003.06.01)(변경전약가) [상병코드조회] [질병코드집 다운로드]

복약정보

항목

내용

LACTmed 바로가기

[바로가기]

약리작용

유료정보입니다.

축약복약지도

유료정보입니다.

복약지도

유료정보입니다.

임부에대한투여

*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : D등급
(cortisone; )

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

Pharmacokinetics

유료정보입니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

복약라벨

이미지

복약설명

어지러움이 있을수 있습니다.

*	복약이미지는 모든 복약지도 사항을 표시한것은 아니며, 추가적으로 업데이트되거나 수정될 수 있습니다.
*	복약이미지의 표시여부는 실제 약물복용시 중요도에 따른것은 아니며 단순히 허가정보상 키워드를 기준으로 등록되었습니다.
*	귀하가 복약이미지 정보를 신뢰함은 전적으로 귀하의 책임입니다. 드럭인포는 이에 대한 어떠한 보증도 하지 않습니다.

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
Mechanism of Action	Ciprofloxacin에 대한 Mechanism_Of_Action 정보 The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Hydrocortisone에 대한 Mechanism_Of_Action 정보 Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In another words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Pharmacology	Ciprofloxacin에 대한 Pharmacology 정보 Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Hydrocortisone에 대한 Pharmacology 정보 Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.
Metabolism	Ciprofloxacin에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 1A2 (CYP1A2) Hydrocortisone에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 3A4 (CYP3A4)
Protein Binding	Ciprofloxacin에 대한 단백결합 정보 20 to 40% Hydrocortisone에 대한 단백결합 정보 95%
Half-life	Ciprofloxacin에 대한 반감기 정보 4 hours Hydrocortisone에 대한 반감기 정보 6-8 hours
Absorption	Ciprofloxacin에 대한 Absorption 정보 Rapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism. Hydrocortisone에 대한 Absorption 정보 Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.
Pharmacokinetics	Ciprofloxacin HCl의 약물동력학자료 흡수 : 경구 : 위장관에서 빠르게 흡수된다. 생체내이용률 : 50-80% 분포 : 태반 통과, 유즙 분비, 체내에 널리 분포 흔히 조직농도가 혈중농도보다 높다. 신장, 방광, 간, 폐, 부인과적 조직, 전립선에 높은 농도로 분포한다. 뇌척수액 대 혈액의 농도비 (%) 정상 뇌막 : 10 염증성 뇌막 : 14-37 단백결합 : 16-43% 대사 : 부분적으로 간대사 반감기 : 소아 : 2.5시간 정상 신기능의 성인 : 3-5 시간 혈중최고농도 도달시간 : 경구 : 0.5-2 시간 소실 : 30-50%가 미변화체로 신배설, 20-40%가 담즙을 통해 변배설 Hydrocortisone의 약물동력학자료 흡수 : 직장을 제외한 모든 투여경로에서 빠르게 흡수된다. 대사 : 간에서 대사된다. 생리적 반감기 : 8∼12시간 소실 : 주로 17-hydroxysteroids와 17-ketosteroids의 형태로 신배설된다. 용해성이 큰 다른 약물과 비교했을 때 hydrocortisone acetate는 작용발현시간은 느리지만 작용지속시간이 길다. Hydrocortisone sodium succinate는 물에 쉽게 녹아 빨리 활성화된다.
Biotransformation	Ciprofloxacin에 대한 Biotransformation 정보 Hepatic. Four metabolites have been identified in human urine which together account for approximately 15% of an oral dose. The metabolites have antimicrobial activity, but are less active than unchanged ciprofloxacin. Hydrocortisone에 대한 Biotransformation 정보 Primarily hepatic via CYP3A4
Toxicity	Ciprofloxacin에 대한 Toxicity 정보 The major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics. Hydrocortisone에 대한 Toxicity 정보 Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing
Drug Interactions	Ciprofloxacin에 대한 Drug_Interactions 정보 Aluminium Formation of non-absorbable complexesMethotrexate Increases methotrexate toxicity Aminophylline The quinolone increases the effect of theophyllineAnisindione The quinolone increases the anticoagulant effectBismuth Formation of non-absorbable complexesCaffeine The quinolone increases the effect and toxicity of caffeineCalcium Formation of non-absorbable complexesClozapine Ciprofloxacin may increase clozapine serum levelsCyclosporine The quinolone increases the effect and toxicity of cyclosporineDicumarol The quinolone increases the anticoagulant effectDihydroxyaluminium Formation of non-absorbable complexesDyphylline The quinolone increases the effect of theophyllineDuloxetine Increases the effect/toxicity of duloxetineDyphylline The quinolone increases the effect of theophyllineEthotoin Decreases the hydantoin effectFoscarnet Increased risk of convulsionsFosphenytoin Decreases the hydantoin effectMagnesium oxide Formation of non-absorbable complexesMagnesium Formation of non-absorbable complexesMephenytoin Decreases the hydantoin effectAcenocoumarol The quinolone increases the anticoagulant effectOxtriphylline The quinolone increases the effect of theophyllinePhenytoin Decreases the hydantoin effectProcainamide The quinolone increases the effect of procainamideRasagiline Increases effect/toxicity of rasagilineRopinirole The quinolone increases the effect and toxicity of ropiniroleSevelamer Sevelamer decreases ciprofloxacin bioavailabilitySildenafil The quinolone increases sildenafil levelsSucralfate Formation of non-absorbable complexesTheophylline The quinolone increases the effect of theophyllineTizanidine Increases the effect/toxicity of tizanidineWarfarin The quinolone increases the anticoagulant effectIron Formation of non-absorbable complexesZinc Formation of non-absorbable complexes Hydrocortisone에 대한 Drug_Interactions 정보 Ambenonium The corticosteroid decreases the effect of anticholinesterasesEdrophonium The corticosteroid decreases the effect of anticholinesterasesNeostigmine The corticosteroid decreases the effect of anticholinesterasesPyridostigmine The corticosteroid decreases the effect of anticholinesterasesAspirin The corticosteroid decreases the effect of salicylatesBismuth Subsalicylate The corticosteroid decreases the effect of salicylatesSalicylate-magnesium The corticosteroid decreases the effect of salicylatesSalicylate-sodium The corticosteroid decreases the effect of salicylatesSalsalate The corticosteroid decreases the effect of salicylatesTrisalicylate-choline The corticosteroid decreases the effect of salicylatesWarfarin The corticosteroid alters the anticoagulant effectAcenocoumarol The corticosteroid alters the anticoagulant effectDicumarol The corticosteroid alters the anticoagulant effectAnisindione The corticosteroid alters the anticoagulant effectCholestyramine Cholestyramine decreases the effect of hydrocortisoneColestipol Cholestyramine decreases the effect of hydrocortisoneAmobarbital The barbiturate decreases the effect of the corticosteroidAprobarbital The barbiturate decreases the effect of the corticosteroidButabarbital The barbiturate decreases the effect of the corticosteroidButalbital The barbiturate decreases the effect of the corticosteroidButethal The barbiturate decreases the effect of the corticosteroidDihydroquinidine barbiturate The barbiturate decreases the effect of the corticosteroidHeptabarbital The barbiturate decreases the effect of the corticosteroidHexobarbital The barbiturate decreases the effect of the corticosteroidMethohexital The barbiturate decreases the effect of the corticosteroidMethylphenobarbital The barbiturate decreases the effect of the corticosteroidPentobarbital The barbiturate decreases the effect of the corticosteroidPhenobarbital The barbiturate decreases the effect of the corticosteroidPrimidone The barbiturate decreases the effect of the corticosteroidQuinidine barbiturate The barbiturate decreases the effect of the corticosteroidSecobarbital The barbiturate decreases the effect of the corticosteroidTalbutal The barbiturate decreases the effect of the corticosteroidRifampin The enzyme inducer decreases the effect of the corticosteroidPhenytoin The enzyme inducer decreases the effect of the corticosteroidMephenytoin The enzyme inducer decreases the effect of the corticosteroidFosphenytoin The enzyme inducer decreases the effect of the corticosteroidEthotoin The enzyme inducer decreases the effect of the corticosteroidMidodrine Increased arterial pressure
CYP450 Drug Interaction	[CYP450 Table직접조회]
Food Interaction	Ciprofloxacin에 대한 Food Interaction 정보 Take without regard to meals.Avoid milk, calcium containing dairy products, iron, magnesium, zinc, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.Take with a full glass of water.Avoid excessive quantities of coffee or tea (Caffeine). Hydrocortisone에 대한 Food Interaction 정보 Take with food to reduce irritation. Calcium, phosphorous, potassium, Vitamin A, C, D and zinc needs increased with long term use.
Drug Target	[Drug Target]
Description	Ciprofloxacin에 대한 Description 정보 A broad-spectrum antimicrobial carboxyfluoroquinoline. [PubChem] Hydrocortisone에 대한 Description 정보 The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [PubChem]
Dosage Form	Ciprofloxacin에 대한 Dosage_Form 정보 Ointment OphthalmicSolution IntravenousSolution OphthalmicSuspension OralTablet OralTablet, extended release Oral Hydrocortisone에 대한 Dosage_Form 정보 Aerosol RectalCream TopicalEnema RectalLiquid TopicalLotion TopicalOintment OphthalmicOintment TopicalPowder, for solution IntramuscularPowder, for solution IntravenousTablet Oral
Drug Category	Ciprofloxacin에 대한 Drug_Category 정보 Anti-Infective AgentsAnti-InfectivesNucleic Acid Synthesis InhibitorsQuinolones Hydrocortisone에 대한 Drug_Category 정보 Anti-inflammatory Agents
Smiles String Canonical	Ciprofloxacin에 대한 Smiles_String_canonical 정보 OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O Hydrocortisone에 대한 Smiles_String_canonical 정보 CC12CCC(=O)C=C1CCC1C3CCC(O)(C(=O)CO)C3(C)CC(O)C21
Smiles String Isomeric	Ciprofloxacin에 대한 Smiles_String_isomeric 정보 OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O Hydrocortisone에 대한 Smiles_String_isomeric 정보 C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@H]21
InChI Identifier	Ciprofloxacin에 대한 InChI_Identifier 정보 InChI=1/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)/f/h23H Hydrocortisone에 대한 InChI_Identifier 정보 InChI=1/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Chemical IUPAC Name	Ciprofloxacin에 대한 Chemical_IUPAC_Name 정보 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid Hydrocortisone에 대한 Chemical_IUPAC_Name 정보 (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Drug-Induced Toxicity Related Proteins	CIPROFLOXACIN 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Alanine aminotransferase Drug:ciprofloxacin Toxicity:Fulminant hepatic failure. [바로가기] Replated Protein:Alanine aminotransferase Drug:ciprofloxacin Toxicity:significant haematological or biochemical toxicity. [바로가기] Replated Protein:Aspartate aminotransferase Drug:ciprofloxacin Toxicity:Fulminant hepatic failure. [바로가기] HYDROCORTISONE 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Interleukin-8 Drug:hydrocortisone Toxicity:inflammation. [바로가기]

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