드러그인포 약품요약정보

허가정보

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청구코드(KD코드)
비급여점검코드
상한금액

[A21901841] [보험코드에 따른 약품기본정보 직접조회]
\0 원/1캅셀(2005.06.01)(현재약가)
\26 원/1캅셀(2001.11.18)(변경전약가)
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

효능효과

[적응증 별 검색]

위장경련, 위 십이지장염, 유문경련, 담관담낭의 경련성질환 수뇨관의 경련.

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
[주성분코드:257600ACH 에 따른 심사지침열람]
[TDM 대상약물]
Anticonvulsants Phenobarbital
유효혈청농도: 15~40 ㎍/㎖

보통 성인 1회 1캅셀씩, 1일 3회 식전 또는 식후 복용
변비가 있을 경우 완하제 복용

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

금기

뇨정체, 협착성 소화궤양, 유문 및 십이지장 협착에는 복용을 금함.

이상반응

감수성이 예민한 환자에 있어 구강건조, 현기, 피로, 시력몽롱, 발진, 구토, 두통, 배뇨곤란이 일어날 수 있다.

[주요 이상반응정보]

Related FDA Approved Drug

기준 성분:DICYCLOMINE HYDROCHLORIDE
BENTYL (DICYCLOMINE HYDROCHLORIDE)
BENTYL PRESERVATIVE FREE (DICYCLOMINE HYDROCHLORIDE)
DICYCLOMINE HYDROCHLORIDE (DICYCLOMINE HYDROCHLORIDE)
DICYCLOMINE HYDROCHLORIDE (PRESERVATIVE-FREE) (DICYCLOMINE HYDROCHLORIDE)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	위장운동조절 및 진경제 (GI Tract Regulators & Antispasmodics)
ATC 코드	Synthetic anticholinergic agents in combination with psycholeptics / A03CA [코드분류상세설명] [ATC코드예측]
복지부분류코드	124 (진경제 )
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	[A21901841] [보험코드에 따른 약품기본정보 직접조회] \0 원/1캅셀(2005.06.01)(최신약가) \26 원/1캅셀(2001.11.18)(변경전약가) [상병코드조회] [질병코드집 다운로드]

복약정보

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약리작용

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복약지도

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임부에대한투여

*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : D등급
(phenobarbital )

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

신장애, 간장애시
용량조절

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Pharmacokinetics

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병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Phenobarbital에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Dicyclomine에 대한 Mechanism_Of_Action 정보 Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic). Phenobarbital에 대한 Mechanism_Of_Action 정보 Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal.
Pharmacology	Dicyclomine에 대한 Pharmacology 정보 Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Dicyclomine inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. Phenobarbital에 대한 Pharmacology 정보 Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal).
Metabolism	Phenobarbital에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 2C19 (CYP2C19)
Protein Binding	Dicyclomine에 대한 단백결합 정보 >99% Phenobarbital에 대한 단백결합 정보 20 to 45%
Half-life	Dicyclomine에 대한 반감기 정보 Not Available Phenobarbital에 대한 반감기 정보 53 to 118 hours (mean 79 hours)
Absorption	Dicyclomine에 대한 Absorption 정보 Not Available Phenobarbital에 대한 Absorption 정보 Absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach.
Pharmacokinetics	Dicyclomine HCl의 약물동력학자료 작용발현시간 : 1-2시간 작용지속시간 : 4시간까지 흡수 : 경구 : 잘 흡수됨 분포 : Vd : 3.65 L/kg 대사 : 대사 큼 반감기 초기 상(phase) : 1.8시간 말기 상 : 9-10시간 소실 : 미변화체로서 소량만이 뇨를 통해 배설됨 Phenobarbital의 약물동력학자료 경구 : 수면효과 발현시간 : 20-60분 이내 작용지속시간 : 6-10 시간 정맥투여 : 작용발현시간 : 5분 이내 최대효과 발현시간 : 30분 이내 작용지속시간 : 4-10 시간 흡수 : 경구 : 70-90% 단백결합 : 20-45%, 신생아에서는 감소됨 대사 : 간에서 hydroxylation되고 glucuronide 포합됨 반감기 : 신생아 : 45-500 시간 영아 : 20-133 시간 소아 : 37-73 시간 성인 : 53-140 시간 혈중최고농도 도달시간 : 경구 : 1-6 시간 이내 소실 : 20-50%가 소변으로 미변화 배설됨
Biotransformation	Phenobarbital에 대한 Biotransformation 정보 Hepatic (mostly via CYP2C19).
Toxicity	Dicyclomine에 대한 Toxicity 정보 Not Available Phenobarbital에 대한 Toxicity 정보 CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.
Drug Interactions	Dicyclomine에 대한 Drug_Interactions 정보 Donepezil Possible antagonism of actionGalantamine Possible antagonism of actionRivastigmine Possible antagonism of actionHaloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia Phenobarbital에 대한 Drug_Interactions 정보 Aminophylline The barbiturate decreases the effect of theophyllineDyphylline The barbiturate decreases the effect of theophyllineOxtriphylline The barbiturate decreases the effect of theophyllineTheophylline The barbiturate decreases the effect of theophyllineAnisindione The barbiturate decreases the anticoagulant effectAcenocoumarol The barbiturate decreases the anticoagulant effectDicumarol The barbiturate decreases the anticoagulant effectWarfarin The barbiturate decreases the anticoagulant effectBetamethasone The barbiturate decreases the effect of the corticosteroidCortisone acetate The barbiturate decreases the effect of the corticosteroidCyclosporine The barbiturate decreases the effect of cyclosporineDasatinib Decreased levels/efficacy of ddasatinibDelavirdine The anticonvulsant decreases the effect of delavirdineDexamethasone The barbiturate decreases the effect of the corticosteroidDisopyramide Phenobarbital decreases levels of disopyramideDoxycycline The anticonvulsant decreases the effect of doxycyclineFelbamate Felbamate increases the effect and toxicity of phenobarbital/primidoneFelodipine The barbiturate decreases the effect of felodipineFludrocortisone The barbiturate decreases the effect of the corticosteroidFolic Acid Folic acid decreases the effect of anticonvulsantGefitinib This CYP3A4 inducer may reduce gefitinib plasma concentrations and pharmacological effectsGriseofulvin The barbiturate decreases the effect of griseofulvinHydrocortisone The barbiturate decreases the effect of the corticosteroidItraconazole The barbiturate decreases the effect of itraconazoleMethadone The barbiturate decreases the effect of methadoneMethylprednisolone The barbiturate decreases the effect of the corticosteroidPrednisolone The barbiturate decreases the effect of the corticosteroidPrednisone The barbiturate decreases the effect of the corticosteroidParamethasone The barbiturate decreases the effect of the corticosteroidTriamcinolone The barbiturate decreases the effect of the corticosteroidVoriconazole The barbiturate decreases the effect of voriconazoleVerapamil The barbiturate decreases the effect of the calcium channel blockerSunitinib Possible decrease in sunitinib levelsPropranolol The barbiturate decreases the effect of the metabolized beta-blockerMetoprolol The barbiturate decreases the effect of the metabolized beta-blockerMethoxyflurane The barbiturate increases the renal toxicity of methoxyfluraneMetronidazole The barbiturate decreases the effect of metronidazoleNifedipine The barbiturate decreases the effect of the calcium channel blockerQuinidine The anticonvulsant decreases the effect of quinidineDivalproex sodium Valproic acid increases the effect of barbiturateChlorotrianisene The enzyme inducer decreases the effect of hormonesClomifene The enzyme inducer decreases the effect of hormonesDiethylstilbestrol The enzyme inducer decreases the effect of hormonesEstradiol The enzyme inducer decreases the effect of hormonesEstriol The enzyme inducer decreases the effect of hormonesConjugated Estrogens The enzyme inducer decreases the effect of hormonesEstrone The enzyme inducer decreases the effect of hormonesEstropipate The enzyme inducer decreases the effect of hormonesImatinib Phenobarbital decreases levels of imatinibLevonorgestrel Phenobarbital decreases the effect of levonorgestrelMedroxyprogesterone The enzyme inducer decreases the effect of hormonesMegestrol The enzyme inducer decreases the effect of hormonesQuinestrol The enzyme inducer decreases the effect of hormonesNorethindrone This product may cause a slight decrease of contraceptive effectMestranol This product may cause a slight decrease of contraceptive effectEthinyl Estradiol This product may cause a slight decrease of contraceptive effect
CYP450 Drug Interaction	[CYP450 Table직접조회] Phenobarbital에 대한 P450 table SUBSTRATES CYP 2B6 bupropion cyclophosphamide efavirenz ifosfamide methadone INHIBITORS CYP 2B6 thiotepa ticlopidine INDUCERS CYP 2B6 phenobarbital phenytoin rifampin SUBSTRATES CYP 3A4/3A5/3A7 Macrolide antibiotics: clarithromycin erythromycin NOT azithromycin telithromycin Anti-arrhythmics: quinidine Benzodiazepines: alprazolam diazepam midazolam triazolam Immune Modulators: cyclosporine tacrolimus (FK506) HIV Protease Inhibitors: indinavir ritonavir saquinavir Prokinetic: cisapride Antihistamines: astemizole chlorpheniramine Calcium Channel Blockers: amlodipine diltiazem felodipine nifedipine nisoldipine nitrendipine verapamil HMG CoA Reductase Inhibitors: atorvastatin cerivastatin lovastatin NOT pravastatin simvastatin aripiprazole buspirone gleevec haloperidol (in part) methadone pimozide quinine NOT rosuvastatin sildenafil tamoxifen trazodone vincristine INHIBITORS CYP 3A4/3A5/3A7 HIV Protease Inhibitors: indinavir nelfinavir ritonavir amiodarone NOT azithromycin cimetidine clarithromycin diltiazem erythromycin fluvoxamine grapefruit juice itraconazole ketoconazole mibefradil nefazodone troleandomycin verapamil INDUCERS CYP 3A4/3A5/3A7 carbamazepine phenobarbital phenytoin rifabutin rifampin St. John's wort troglitazone
Food Interaction	Dicyclomine에 대한 Food Interaction 정보 Avoid alcohol.Take this medication 30 minutes before meals. Phenobarbital에 대한 Food Interaction 정보 Avoid alcohol.Avoid excessive quantities of coffee or tea (Caffeine).Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.Take on an empty stomach for quicker absorption
Drug Target	[Drug Target]
Description	Dicyclomine에 대한 Description 정보 A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. [PubChem] Phenobarbital에 대한 Description 정보 A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. [PubChem]
Dosage Form	Dicyclomine에 대한 Dosage_Form 정보 Capsule OralSolution IntramuscularSyrup OralTablet Oral Phenobarbital에 대한 Dosage_Form 정보 Elixir OralSolution IntramuscularTablet Oral
Drug Category	Dicyclomine에 대한 Drug_Category 정보 Anticholinergic AgentsAntimuscarinicsAntispasmodicsMuscarinic AntagonistsParasympatholytics Phenobarbital에 대한 Drug_Category 정보 AnticonvulsantsExcitatory Amino Acid AntagonistsGABA ModulatorsHypnotics and Sedatives
Smiles String Canonical	Dicyclomine에 대한 Smiles_String_canonical 정보 CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1 Phenobarbital에 대한 Smiles_String_canonical 정보 CCC1(C(=O)NC(=O)NC1=O)C1=CC=CC=C1
Smiles String Isomeric	Dicyclomine에 대한 Smiles_String_isomeric 정보 CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1 Phenobarbital에 대한 Smiles_String_isomeric 정보 CCC1(C(=O)NC(=O)NC1=O)C1=CC=CC=C1
InChI Identifier	Dicyclomine에 대한 InChI_Identifier 정보 InChI=1/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3 Phenobarbital에 대한 InChI_Identifier 정보 InChI=1/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17)/f/h13-14H
Chemical IUPAC Name	Dicyclomine에 대한 Chemical_IUPAC_Name 정보 2-diethylaminoethyl 1-cyclohexylcyclohexane-1-carboxylate Phenobarbital에 대한 Chemical_IUPAC_Name 정보 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione

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