| 항목 |
내용 |
| DUR (의약품사용평가) |
병용금기 :
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연령대금기 :
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| Mechanism of Action |
Oxymetazoline에 대한 Mechanism_Of_Action 정보
Oxymetazoline is a direct acting sympathomimetic amine, which acts on alpha-adrenergic receptors in the arterioles of the conjunctiva and nasal mucosa. It produces vasoconstriction, resulting in decreased conjunctival congestion in ophthalmic. In nasal it produces constriction, resulting in decreased blood flow and decreased nasal congestion.
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| Pharmacology |
Oxymetazoline에 대한 Pharmacology 정보
Oxymetazoline a adrenergic alpha-agonists, direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion The sympathomimetic action of oxymetazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (up to 12 hours), gentle and decongesting effect. Oxymetazoline elicits relief of conjunctival hyperemia by causing vasoconstriction of superficial conjunctival blood vessels. The drug's action has been demonstrated in acute allergic conjunctivitis and in chemical (chloride) conjunctivitis.
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| Metabolism |
Oxymetazoline에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Not Available
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| Protein Binding |
Oxymetazoline에 대한 단백결합 정보
Not Available
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| Half-life |
Oxymetazoline에 대한 반감기 정보
Not Available
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| Absorption |
Oxymetazoline에 대한 Absorption 정보
Not Available
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| Pharmacokinetics |
Oxymetazoline HCl의 약물동력학자료
- 효과발현시간 : 비강내 투여 : 5~10분 이내
- 효과지속시간 : 5~6 시간
- 대사 : 알려져 있지 않음
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| Biotransformation |
Oxymetazoline에 대한 Biotransformation 정보
Not Available
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| Toxicity |
Oxymetazoline에 대한 Toxicity 정보
Not Available
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| Drug Interactions |
Oxymetazoline에 대한 Drug_Interactions 정보
Cisapride Increased risk of cardiotoxicity and arrhythmiasMesoridazine Increased risk of cardiotoxicity and arrhythmiasThioridazine Increased risk of cardiotoxicity and arrhythmiasDonepezil Possible antagonism of actionGalantamine Possible antagonism of actionRivastigmine Possible antagonism of actionPropranolol Propranolol increases the serum levels of cisapride
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CYP450
Drug Interaction |
[CYP450 Table직접조회]
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| Food Interaction |
Oxymetazoline에 대한 Food Interaction 정보
Not Available
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| Drug Target |
[Drug Target]
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| Description |
Oxymetazoline에 대한 Description 정보
A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
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| Dosage Form |
Oxymetazoline에 대한 Dosage_Form 정보
Liquid NasalSolution NasalSolution Respiratory (inhalation)Solution / drops OphthalmicSpray Nasal
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| Drug Category |
Oxymetazoline에 대한 Drug_Category 정보
Adrenergic alpha-AgonistsNasal DecongestantsSympathomimetics
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| Smiles String Canonical |
Oxymetazoline에 대한 Smiles_String_canonical 정보
CC1=CC(=C(O)C(C)=C1CC1=NCCN1)C(C)(C)C
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| Smiles String Isomeric |
Oxymetazoline에 대한 Smiles_String_isomeric 정보
CC1=CC(=C(O)C(C)=C1CC1=NCCN1)C(C)(C)C
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| InChI Identifier |
Oxymetazoline에 대한 InChI_Identifier 정보
InChI=1/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)/f/h17H
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| Chemical IUPAC Name |
Oxymetazoline에 대한 Chemical_IUPAC_Name 정보
6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
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전문/일반
