드러그인포 약품요약정보

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

[A33001651] [보험코드에 따른 약품기본정보 직접조회]
\0 원/1g(2005.03.01)(현재약가)
\97 원/1g(2001.08.08)(변경전약가)
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

효능효과

[적응증 별 검색]

코르티코이드에 반응하는 2차 감염성 피부질환

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
1일 2~4회 적당량을 환부(질환부위)에 얇게 바른다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

주요약물 상호작용

[조회]

금기

1) 세균(결핵, 매독 등)·진균(칸디다증, 백선 등)·바이러스(대상포진, 단순포진, 수두, 종두증 등)·동물(옴, 사면발이 등)성 피부감염증 환자(증상이 악화될 수 있다.)

2) 이 약 또는 이 약 성분에 과민증 및 그 병력이 있는 환자

3) 고막천공(뚫림)이 있는 습진성 외이도(바깥귀길)염 환자(천공(뚫림)부위의 치유지연이 나타날 수 있다.)

4) 궤양(베체트병 제외), 제2도 심재성(드러나지 않는) 이상의 화상·동상 환자(피부재생이 억제되어 치유가 지연될 수 있다.)

5) 입주위피부염, 보통여드름, 주사(rosacea)환자

6) 유·소아

7) 눈 주위

신중투여

임부 또는 임신하고 있을 가능성이 있는 부인 및 수유부

이상반응

1) 피부

① 감염증 : 피부의 세균성(전염성 농가진(고름딱지증), 모낭염 등) 및 진균성(칸디다증, 백선 등) 감염증이 나타날 수 있다.〔밀봉붕대법(ODT)의 경우 나타나기쉽다.〕 이와 같은 증상이 나타날 경우에는 적절한 항균제나 항진균제 등을 병용(함께 사용)하고 증상이 신속히 개선되지 않을 경우에는 사용을 중지한다.

② 일반적 피부증상 : 모낭염, 부스럼, 피부자극, 자통(찌르는 것 같은 아픔), 발열, 작열감(화끈감), 발진, 발적(충혈되어 붉어짐), 홍조, 가려움, 피부건조, 농포(고름물집)성피부염, 알레르기성 접촉피부염, 땀띠, 상처악화, 욕창, 농포(고름물집)증, 2차감염, 색소침착감소, 미란(짓무름) 등이 나타날 수 있으며, 이러한 증상이 나타날 경우에는 사용을 중지한다.

③ 장기연용(계속 사용) : 스테로이드성 여드름, 스테로이드성 피부(피부위축, 모세혈관확장, 자반(자주색반점)), 스테로이드성 주사, 입주위피부염(입주위·안면전체에 홍반(붉은 반점), 구진, 모세혈관확장, 딱지, 인설(비늘, 껍질)), 어린선양 피부변화, 다모(털과다), 색소탈실, 선조(튼살), 수포(물집)성피부염, 아토피피부염, 피부출혈 등이 나타날 수 있다. 이러한 증상이 나타날 경우에는 천천히 사용량을 줄여 코르티코이드를 함유하지 않는 약으로 바꾸어 사용한다.

④ 네오마이신은 때때로 피부과민증을 유발한다. 네오마이신, 바시트라신, 폴리믹신비를 포함하는 항생물질 복합제의 국소적 사용으로 부작용이 나타날 수 있다. 가장 빈번하게 발생하는 반응은 알레르기성 과민증이다. 한 임상연구에 의하면 20% 네오마이신 패취 사용시 0.09%에서 네오마이신에 의한 알레르기성 피부반응을 나타냈으며 다른 연구에서는 약 1% 나타난 것으로 보고되었다.

2) 내분비계 : 대량 또는 장기간에 걸친 광범위한 사용, 밀봉붕대법에 의해 코르티코이드 전신 투여와 같은 뇌하수체·부신(콩팥위샘) 피질계 기능의 억제를 가져올 수 있으므로 주의한다.

3) 눈 : 안검(눈꺼풀)피부에 사용시 안압 상승, 녹내장을 일으킬 수 있으므로 주의한다. 대량 또는 장기간에 걸친 광범위한 사용, 특히 밀봉붕대법을 사용할 경우 후 낭하백내장, 녹내장 등이 나타날 수 있다. 빈도불명의 시야흐림이 나타날 수 있다.

[주요 이상반응정보]

Off-label Usage

[조회]

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BACITRACIN-NEOMYCIN-POLYMYXIN W/ HYDROCORTISONE ACETATE (BACITRACIN; HYDROCORTISONE ACETATE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
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LANABIOTIC (BACITRACIN ZINC; LIDOCAINE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
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POLY-RX (POLYMYXIN B SULFATE)
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CORDRAN-N (FLURANDRENOLIDE; NEOMYCIN SULFATE)
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MYTREX A (NEOMYCIN SULFATE; TRIAMCINOLONE ACETONIDE)
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NEO-CORT-DOME (ACETIC ACID, GLACIAL; HYDROCORTISONE; NEOMYCIN SULFATE)
NEO-CORTEF (HYDROCORTISONE ACETATE; NEOMYCIN SULFATE)
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NEO-FRADIN (NEOMYCIN SULFATE)
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NEO-MEDROL (METHYLPREDNISOLONE; NEOMYCIN SULFATE)
NEO-MEDROL ACETATE (METHYLPREDNISOLONE ACETATE; NEOMYCIN SULFATE)
NEOMYCIN SULFATE (NEOMYCIN SULFATE)
NEOMYCIN SULFATE AND DEXAMETHASONE SODIUM PHOSPHATE (DEXAMETHASONE SODIUM PHOSPHATE; NEOMYCIN SULFATE)
NEOMYCIN SULFATE-DEXAMETHASONE SODIUM PHOSPHATE (DEXAMETHASONE SODIUM PHOSPHATE; NEOMYCIN SULFATE)
NEOMYCIN SULFATE-TRIAMCINOLONE ACETONIDE (NEOMYCIN SULFATE; TRIAMCINOLONE ACETONIDE)
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NEO-SYNALAR (FLUOCINOLONE ACETONIDE; NEOMYCIN SULFATE)
기준 성분:HYDROCORTISONE
ACETASOL HC (ACETIC ACID, GLACIAL; HYDROCORTISONE)
ACETIC ACID W/ HYDROCORTISONE (ACETIC ACID, GLACIAL; HYDROCORTISONE)
ACHROMYCIN (HYDROCORTISONE; TETRACYCLINE HYDROCHLORIDE)
ACTICORT (HYDROCORTISONE)
ACYCLOVIR AND HYDROCORTISONE (ACYCLOVIR; HYDROCORTISONE)
AEROSEB-HC (HYDROCORTISONE)
A-HYDROCORT (HYDROCORTISONE SODIUM SUCCINATE)
ALA-CORT (HYDROCORTISONE)
ALA-SCALP (HYDROCORTISONE)
ALPHADERM (HYDROCORTISONE; UREA)
ANUSOL HC (HYDROCORTISONE)
BALNEOL-HC (HYDROCORTISONE)
BETA-HC (HYDROCORTISONE)
CALMURID HC (HYDROCORTISONE; UREA)
CARMOL HC (HYDROCORTISONE ACETATE; UREA)
CETACORT (HYDROCORTISONE)
CHLOROMYCETIN HYDROCORTISONE (CHLORAMPHENICOL; HYDROCORTISONE ACETATE)
CIPRO HC (CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE)
COLOCORT (HYDROCORTISONE)
CORT-DOME (HYDROCORTISONE)
CORTEF (HYDROCORTISONE)
CORTEF ACETATE (HYDROCORTISONE ACETATE)
CORTENEMA (HYDROCORTISONE)
CORTIFOAM (HYDROCORTISONE ACETATE)
CORTRIL (HYDROCORTISONE)
DERMACORT (HYDROCORTISONE)
DRICORT (HYDROCORTISONE ACETATE)
ELDECORT (HYDROCORTISONE)
EPICORT (HYDROCORTISONE)
EPIFOAM (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
FLEXICORT (HYDROCORTISONE)
GLYCORT (HYDROCORTISONE)
HC #1 (HYDROCORTISONE)
HC #4 (HYDROCORTISONE)
HC (HYDROCORTISONE) (HYDROCORTISONE)
H-CORT (HYDROCORTISONE)
HEMSOL-HC (HYDROCORTISONE ACETATE)
HI-COR (HYDROCORTISONE)
HYDROCORTISONE (HYDROCORTISONE)
HYDROCORTISONE ACETATE (HYDROCORTISONE ACETATE)
HYDROCORTISONE ACETATE 1% AND PRAMOXINE HYDROCHLORIDE 1% (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
HYDROCORTISONE AND ACETIC ACID (ACETIC ACID, GLACIAL; HYDROCORTISONE)
HYDROCORTISONE BUTYRATE (HYDROCORTISONE BUTYRATE)
HYDROCORTISONE IN ABSORBASE (HYDROCORTISONE)
HYDROCORTISONE SODIUM PHOSPHATE (HYDROCORTISONE SODIUM PHOSPHATE)
HYDROCORTISONE SODIUM SUCCINATE (HYDROCORTISONE SODIUM SUCCINATE)
HYDROCORTISONE VALERATE (HYDROCORTISONE VALERATE)
HYDROCORTONE (HYDROCORTISONE)
HYDRO-RX (HYDROCORTISONE)
HYTONE (HYDROCORTISONE)
LOCOID (HYDROCORTISONE BUTYRATE)
LOCOID LIPOCREAM (HYDROCORTISONE BUTYRATE)
MICORT-HC (HYDROCORTISONE ACETATE)
NOGENIC HC (HYDROCORTISONE)
NUTRACORT (HYDROCORTISONE)
ORABASE HCA (HYDROCORTISONE ACETATE)
ORLEX HC (ACETIC ACID, GLACIAL; HYDROCORTISONE)
PANDEL (HYDROCORTISONE PROBUTATE)
PENECORT (HYDROCORTISONE)
PRAMOSONE (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
PROCTOCORT (HYDROCORTISONE)
PROCTOFOAM HC (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
SOLU-CORTEF (HYDROCORTISONE SODIUM SUCCINATE)
STIE-CORT (HYDROCORTISONE)
SYNACORT (HYDROCORTISONE)
TERRA-CORTRIL (HYDROCORTISONE ACETATE; OXYTETRACYCLINE HYDROCHLORIDE)
TEXACORT (HYDROCORTISONE)
U-CORT (HYDROCORTISONE ACETATE; UREA)
VOSOL HC (ACETIC ACID, GLACIAL; HYDROCORTISONE)
WESTCORT (HYDROCORTISONE VALERATE)
기준 성분:BACITRACIN ZINC
ZIBA-RX (BACITRACIN ZINC)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	감염증치료제 : 외용복합 (Anti-infectives /with steroids)
ATC 코드	Hydrocortisone and antibiotics / D07CA01 [코드분류상세설명] [ATC코드예측]
복지부분류코드	263 (화농성질환용제 )
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	[A33001651] [보험코드에 따른 약품기본정보 직접조회] \0 원/1g(2005.03.01)(최신약가) \97 원/1g(2001.08.08)(변경전약가) [상병코드조회] [질병코드집 다운로드]
동일주성분코드 검색순위	유료정보입니다.

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임부에대한투여

*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : C등급

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

신장애, 간장애시
용량조절

유료정보입니다.

Pharmacokinetics

유료정보입니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

제형별 복약지도

[연고]

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Bacitracin에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Bacitracin에 대한 Mechanism_Of_Action 정보 Bacitracin intereferes with the dephosphorylation of the 55-carbon, biphosphate lipid transport molecule, which carries the building blocks of the peptidoglycan bacterial cell wall outside the inner membrane for construction. zinc에 대한 Mechanism_Of_Action 정보 Not Available Hydrocortisone에 대한 Mechanism_Of_Action 정보 Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In another words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Neomycin에 대한 Mechanism_Of_Action 정보 Aminoglycosides like neomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Pharmacology	Bacitracin에 대한 Pharmacology 정보 Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. As a polypeptide, toxic, and difficult to use chemical, Bacitracin doesn't work well orally, however is very effective topically. Bacitracin exerts pronounced antibacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. However, among systemic diseases, only staphylococcal infections qualify for consideration of bacitracin therapy. zinc에 대한 Pharmacology 정보 Not Available Hydrocortisone에 대한 Pharmacology 정보 Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated. Neomycin에 대한 Pharmacology 정보 Neomycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Metabolism	Bacitracin에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Not Available Hydrocortisone에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 3A4 (CYP3A4) Neomycin에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Not Available
Protein Binding	Bacitracin에 대한 단백결합 정보 Not Available Hydrocortisone에 대한 단백결합 정보 95% Neomycin에 대한 단백결합 정보 Protein binding studies have shown that the degree of aminoglycoside protein binding is low and, depending upon the methods used for testing, may be between 0% and 30%.
Half-life	Bacitracin에 대한 반감기 정보 Not Available Hydrocortisone에 대한 반감기 정보 6-8 hours Neomycin에 대한 반감기 정보 2 to 3 hours
Absorption	Bacitracin에 대한 Absorption 정보 Absorption of bacitracin following intramuscular injection is rapid and complete. Absorption from the gastrointestinal tract following oral administration is not appreciable. Absorption following topical application is negligible. zinc에 대한 Absorption 정보 Not Available Hydrocortisone에 대한 Absorption 정보 Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Neomycin에 대한 Absorption 정보 Poorly absorbed from the normal gastrointestinal tract. Although only approximately 3% of neomycin is absorbed through intact intestinal mucosa, significant amounts may be absorbed through ulcerated or denuded mucosa or if inflammation is present.
Pharmacokinetics	Hydrocortisone의 약물동력학자료 흡수 : 직장을 제외한 모든 투여경로에서 빠르게 흡수된다. 대사 : 간에서 대사된다. 생리적 반감기 : 8∼12시간 소실 : 주로 17-hydroxysteroids와 17-ketosteroids의 형태로 신배설된다. 용해성이 큰 다른 약물과 비교했을 때 hydrocortisone acetate는 작용발현시간은 느리지만 작용지속시간이 길다. Hydrocortisone sodium succinate는 물에 쉽게 녹아 빨리 활성화된다. Neomycin Sulfate의 약물동력학자료 흡수 : 경구, 경피 : 흡수되는 양이 미미하다. (3%) 분포 : 분포용적 : 0.36 L/kg 대사 : 소량이 간에서 대사된다. 반감기 : 3 시간 (나이와 신기능에 의존) 혈중최고농도 도달시간 : 경구 : 1-4 시간 근육주사 : 2 시간 이내 소실 : 주사제 : 신배설 (30-50%가 미변화체로 배설) 경구 : 97%가 미변화체로 변배설 Polymyxin B Sulfate의 약물동력학자료 흡수 : 복막에서 잘 흡수된다. 위장관(신생아 제외), 점막, 피부에서는 잘 흡수되지 않는다. 분포 : 뇌척수액으로의 분포는 미미하다. 태반통과 반감기 : 4.5-6 시간, 신기능 저하시 연장된다. 혈중최고농도 도달시간 : IM : 2시간 이내 소실 : 사구체 여과를 통해 60% 이상이 미변화체로 신배설된다. Bacitracin zinc의 약물동력학자료 작용지속시간 : 6-8시간 흡수 : 외용 : 점막, 정상 피부, 손상된 피부로부터 거의 흡수되지 않는다. IM : 빠르게 흡수된다. 방광 관주 : 거의 흡수되지 않는다. 복막 세척, 종격동 세척 : 흡수된다. 분포 : 뇌수막염시에도 뇌척수액으로의 분포는 미미하다. 단백결합 : 혈중 단백에 거의 결합하지 않는다. 혈중최고농도 도달시간 : IM : 1-2시간 소실 : 24시간 이내에 10-40%가 천천히 신배설
Biotransformation	Bacitracin에 대한 Biotransformation 정보 Not Available Hydrocortisone에 대한 Biotransformation 정보 Primarily hepatic via CYP3A4 Neomycin에 대한 Biotransformation 정보 Neomycin undergoes negligible biotransformation after parenteral administration.
Toxicity	Bacitracin에 대한 Toxicity 정보 Oral, mouse: LD₅₀ = >3750 mg/kg. zinc에 대한 Toxicity 정보 Not Available Hydrocortisone에 대한 Toxicity 정보 Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing Neomycin에 대한 Toxicity 정보 LD₅₀ = 200 mg/kg (rat). Because of low absorption, it is unlikely that acute overdosage would occur with oral neomycin. However, prolonged administration could result in sufficient systemic drug levels to produce neurotoxicity, ototoxicity and/or nephrotoxicity.
Drug Interactions	Bacitracin에 대한 Drug_Interactions 정보 Not Available zinc에 대한 Drug_Interactions 정보 Not Available Hydrocortisone에 대한 Drug_Interactions 정보 Ambenonium The corticosteroid decreases the effect of anticholinesterasesEdrophonium The corticosteroid decreases the effect of anticholinesterasesNeostigmine The corticosteroid decreases the effect of anticholinesterasesPyridostigmine The corticosteroid decreases the effect of anticholinesterasesAspirin The corticosteroid decreases the effect of salicylatesBismuth Subsalicylate The corticosteroid decreases the effect of salicylatesSalicylate-magnesium The corticosteroid decreases the effect of salicylatesSalicylate-sodium The corticosteroid decreases the effect of salicylatesSalsalate The corticosteroid decreases the effect of salicylatesTrisalicylate-choline The corticosteroid decreases the effect of salicylatesWarfarin The corticosteroid alters the anticoagulant effectAcenocoumarol The corticosteroid alters the anticoagulant effectDicumarol The corticosteroid alters the anticoagulant effectAnisindione The corticosteroid alters the anticoagulant effectCholestyramine Cholestyramine decreases the effect of hydrocortisoneColestipol Cholestyramine decreases the effect of hydrocortisoneAmobarbital The barbiturate decreases the effect of the corticosteroidAprobarbital The barbiturate decreases the effect of the corticosteroidButabarbital The barbiturate decreases the effect of the corticosteroidButalbital The barbiturate decreases the effect of the corticosteroidButethal The barbiturate decreases the effect of the corticosteroidDihydroquinidine barbiturate The barbiturate decreases the effect of the corticosteroidHeptabarbital The barbiturate decreases the effect of the corticosteroidHexobarbital The barbiturate decreases the effect of the corticosteroidMethohexital The barbiturate decreases the effect of the corticosteroidMethylphenobarbital The barbiturate decreases the effect of the corticosteroidPentobarbital The barbiturate decreases the effect of the corticosteroidPhenobarbital The barbiturate decreases the effect of the corticosteroidPrimidone The barbiturate decreases the effect of the corticosteroidQuinidine barbiturate The barbiturate decreases the effect of the corticosteroidSecobarbital The barbiturate decreases the effect of the corticosteroidTalbutal The barbiturate decreases the effect of the corticosteroidRifampin The enzyme inducer decreases the effect of the corticosteroidPhenytoin The enzyme inducer decreases the effect of the corticosteroidMephenytoin The enzyme inducer decreases the effect of the corticosteroidFosphenytoin The enzyme inducer decreases the effect of the corticosteroidEthotoin The enzyme inducer decreases the effect of the corticosteroidMidodrine Increased arterial pressure Neomycin에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회]
Food Interaction	Bacitracin에 대한 Food Interaction 정보 Not Available Hydrocortisone에 대한 Food Interaction 정보 Take with food to reduce irritation. Calcium, phosphorous, potassium, Vitamin A, C, D and zinc needs increased with long term use. Neomycin에 대한 Food Interaction 정보 Not Available
Drug Target	[Drug Target]
Description	Bacitracin에 대한 Description 정보 Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesn't work well orally. However, it is very effective topically.Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis. zinc에 대한 Description 정보 A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is known by the symbol Zn. Hydrocortisone에 대한 Description 정보 The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [PubChem] Neomycin에 대한 Description 정보 A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Dosage Form	Bacitracin에 대한 Dosage_Form 정보 Ointment TopicalPowder, for solution Intramuscular zinc에 대한 Dosage_Form 정보 Aerosol OralCapsule OralCream TopicalDressing TopicalLiquid OralLiquid SublingualLiquid TopicalLotion TopicalLozenge OralOintment RectalOintment TopicalPaste TopicalPowder OralPowder TopicalSolution IntravenousSolution / drops OralSuppository RectalTablet OralTablet, extended release Oral Hydrocortisone에 대한 Dosage_Form 정보 Aerosol RectalCream TopicalEnema RectalLiquid TopicalLotion TopicalOintment OphthalmicOintment TopicalPowder, for solution IntramuscularPowder, for solution IntravenousTablet Oral Neomycin에 대한 Dosage_Form 정보 Dressing TopicalOintment OphthalmicSolution / drops Ophthalmic
Drug Category	Bacitracin에 대한 Drug_Category 정보 Anti-Bacterial AgentsAnti-Infective Agents, Local zinc에 대한 Drug_Category 정보 Trace Elements Hydrocortisone에 대한 Drug_Category 정보 Anti-inflammatory Agents Neomycin에 대한 Drug_Category 정보 Anti-Bacterial AgentsAntibiotics
Smiles String Canonical	Bacitracin에 대한 Smiles_String_canonical 정보 CCC(C)C(N)C1=NCC(S1)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)CC)C(=O)NC1CCCCNC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(NC(=O)C(CCCN)NC1=O)C(C)CC zinc에 대한 Smiles_String_canonical 정보 [Zn] Hydrocortisone에 대한 Smiles_String_canonical 정보 CC12CCC(=O)C=C1CCC1C3CCC(O)(C(=O)CO)C3(C)CC(O)C21 Neomycin에 대한 Smiles_String_canonical 정보 NCC1OC(OC2C(N)CC(N)C(O)C2OC2OC(CO)C(OC3OC(CN)C(O)C(O)C3N)C2O)C(N)C(O)C1O
Smiles String Isomeric	Bacitracin에 대한 Smiles_String_isomeric 정보 CC[C@@H](C)[C@H](N)C1=NC[C@@H](S1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@H](C)CC)C(=O)N[C@H]1CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC1=O)[C@H](C)CC zinc에 대한 Smiles_String_isomeric 정보 [Zn] Hydrocortisone에 대한 Smiles_String_isomeric 정보 C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@H]21 Neomycin에 대한 Smiles_String_isomeric 정보 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
InChI Identifier	Bacitracin에 대한 InChI_Identifier 정보 InChI=1/C66H103N17O16S/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-13-12-14-19-38)81-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)74-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,73)(H,71,89)(H,74,90)(H,75,93)(H,76,98)(H,77,94)(H,78,96)(H,79,95)(H,80,97)(H,81,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36?,37?,40-,41+,42+,43-,44+,45-,46-,47+,48?,52-,53-,54-/m0/s1/f/h71,73-83,85,87H,68H2 zinc에 대한 InChI_Identifier 정보 InChI=1/Zn Hydrocortisone에 대한 InChI_Identifier 정보 InChI=1/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 Neomycin에 대한 InChI_Identifier 정보 InChI=1/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
Chemical IUPAC Name	Bacitracin에 대한 Chemical_IUPAC_Name 정보 (4R)-4-[[(2S)-2-[[2-[(1S)-1-amino-2-methylbutyl]4,5-dihydro-1,3-thiazole-5-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-15-butan-2-yl-6-(carboxymethyl)-9-(3H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-12-(phenylmethyl)-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid zinc에 대한 Chemical_IUPAC_Name 정보 zinc Hydrocortisone에 대한 Chemical_IUPAC_Name 정보 (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one Neomycin에 대한 Chemical_IUPAC_Name 정보 (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
Drug-Induced Toxicity Related Proteins	HYDROCORTISONE 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Interleukin-8 Drug:hydrocortisone Toxicity:inflammation. [바로가기] NEOMYCIN 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:NMDA receptor-regulated protein Drug:neomycin Toxicity:excitotoxic activation. [바로가기]

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