| 항목 |
내용 |
| DUR (의약품사용평가) |
병용금기 :
고시된 병용금기 내용은 없습니다.
[상호작용/병용금기검색]
연령대금기 :
고시된 연령금기 내용은 없습니다.
[연령대금기상세검색]
|
| 화학구조 및 물성 |
[Pheniramine maleate]
[Pheniramine maleate]
CAS number/86-21-5
ATC code/R06AB05
PubChem/4761
Formula/C16H20N2
Mol. mass/240.343 g/mol
Bioavailability/ ?
Metabolism/Hepatic hydroxylation, demethylation and glucuronidation
Excretion/Renal
Pregnancy cat./
?
Legal status/
Routes/Oral
|
| Mechanism of Action |
Pheniramine에 대한 Mechanism_Of_Action 정보
Antihistamines such as pheniramine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
|
| Pharmacology |
Pheniramine에 대한 Pharmacology 정보
Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria. It is generally sold in combination with other medications, rather than as a stand-alone drug.
|
| Pharmacokinetics |
Naphazoline HCl의 약물동력학자료
- 충혈제거작용 발현시간 : 국소 : 10분 이내
- 작용지속시간 : 2-6 시간
- 소실 : 미확립
Pheniramine maleate의 약물동력학자료
- 흡수 : 경구 투여시 신속하게 잘 흡수됨
- 최고혈중농도 도달시간 : 경구 : 1-2.5 시간
- 분포용적 : 약 150 L
- 반감기 : 16-19 시간
- 대사 : 간대사 (chlorpheniramine, brompheniramine보다는 간대사를 받는 비율이 더 적을 것으로 여겨짐)
- 소실 : 50-80%가 뇨를 통해 (24-43%는 미변화체로서) 배설됨
|
| Biotransformation |
Pheniramine에 대한 Biotransformation 정보
Hepatic hydroxylation, demethylation and glucuronidation.
|
| Toxicity |
Pheniramine에 대한 Toxicity 정보
Not Available
|
| Drug Interactions |
Pheniramine에 대한 Drug_Interactions 정보
Not Available
|
CYP450
Drug Interaction |
[CYP450 Table직접조회]
|
| Food Interaction |
Pheniramine에 대한 Food Interaction 정보
Not Available
|
| Drug Target |
[Drug Target]
|
| Description |
Pheniramine에 대한 Description 정보
One of the histamine H1 antagonists with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. [PubChem]
|
| Dosage Form |
Pheniramine에 대한 Dosage_Form 정보
Powder OralSolution OralSolution / drops OralTablet Oral
|
| Drug Category |
Pheniramine에 대한 Drug_Category 정보
Anti-Allergic AgentsAntipruritic AgentsAntipruriticsHistamine H1 Antagonists
|
| Smiles String Canonical |
Pheniramine에 대한 Smiles_String_canonical 정보
CN(C)CCC(C1=CC=CC=C1)C1=CC=CC=N1
|
| Smiles String Isomeric |
Pheniramine에 대한 Smiles_String_isomeric 정보
CN(C)CC[C@H](C1=CC=CC=C1)C1=CC=CC=N1
|
| InChI Identifier |
Pheniramine에 대한 InChI_Identifier 정보
InChI=1/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3
|
| Chemical IUPAC Name |
Pheniramine에 대한 Chemical_IUPAC_Name 정보
N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
|
| Drug-Induced Toxicity Related Proteins |
MALEATE 의 Drug-Induced Toxicity Related Protein정보
Replated Protein:Intercellular adhesion molecule 1
Drug:maleate
Toxicity:hepatic injury.
[바로가기]
|
전문/일반
내용보기
