|   | 
                  
                       | 
                      | 
                    
                        
                            
                                | 
                                  
                                 | 
                             
                             |  
                            
                                
                                    
                                        
  
    
	  | 
   
  
    
        
          |   | 
          
              
                | 
                    ¿¡¸®ÇÇ¿ÂÁ¤  [Erythromycin propionate]  
                    
                 | 
               
              
                | 
                     Àü¹®ÀǾàǰ | ºñ±Þ¿©  
                        
                    	
                    
                 | 
               
              
                | 
					  
                  
				  
                 | 
               
              
              
              
              
              |   |  
              
                
                    
                        | 
                      ¾Ë¸²:  | 
                      µå·°ÀÎÆ÷¿¡¼´Â ÀǾàǰ ÀÎÅÍ³Ý ÆÇ¸Å¸¦ ÇÏÁö ¾Ê½À´Ï´Ù. | 
                     
                    | 
               
            
              
                
                   
                   
                   
                   
		   
                 | 
               
              
                | 
                  
                  
                 | 
               
              | 
            | 
         
       
       | 
   
    |  
  
    | 
      
     | 
     
  |                   
                                        | 
                                             | 
                                         
                            
                                
                            
                            
                              
                                                        
                              
                                                
                            
 |   
    | 
      
     | 
 
 |  
    
   
    | 
       
        À¯·áȸ¿ø °áÀç½Ã¿¡´Â º¸´Ù ´Ù¾çÇÑ ¾à¹°Á¤º¸¸¦
        ÀÌ¿ëÇÏ½Ç ¼ö ÀÖ½À´Ï´Ù.
        À¯·áÁ¤º¸¸ñ·ÏÀº Àü¹®È¸¿øÀ¸·Î
        ·Î±×ÀÎ ÇϽøé È®ÀÎ °¡´ÉÇÕ´Ï´Ù.
       
     | 
   
  
     | 
   
  
  
    
      
  
    
       |  
      
        
          
            
                | Çã°¡Á¤º¸ | 
             
           
         | 
       
       |  
      
  
    | Ç׸ñ | 
    ³»¿ë | 
   
  
  
  
  
   
    û±¸ÄÚµå(KDÄÚµå) ºñ±Þ¿©Á¡°ËÄÚµå  »óÇÑ±Ý¾× | 
    
      
      
        
        646802210[A03802771]  
	    
	    
            [º¸ÇèÄڵ忡 µû¸¥ ¾àǰ±âº»Á¤º¸ Á÷Á¢Á¶È¸] 
          
        
        
        
          
          
            \0 ¿ø/1Á¤(2004.01.16)(ÇöÀç¾à°¡)
            \0 ¿ø/1Á¤(2002.05.11)(º¯°æÀü¾à°¡)
        
          
            
	 
  	   
  	   
       
      
       
       
     
      
      
     
      
    
    
    
      
     [»óº´ÄÚµåÁ¶È¸]
      
      [Áúº´ÄÚµåÁ¶È¸]
     
     | 
   
   
    | ºü¸¥Á¶È¸ | 
    
      
     |   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
 
  
  
    
  
  
  
  
  
  
  
  
  
  
 
  
  
  
 
  
  
  
  
  
  
   
    | Çã°¡»çÇ× ¿ø¹®Á¶È¸ | 
    
      
	    [Çã°¡»çÇ× ¿ø¹®Á¶È¸] 
     | 
   
  
  
  
  
     
  
  
  
   
    | È¿´ÉÈ¿°ú | 
    
    [ÀûÀÀÁõ º° °Ë»ö] 
      
    
     
	 
      ¡Û À¯È¿±ÕÁ¾ 
   ¿¬¼â±¸±Õ, Ȳ»öÆ÷µµ±¸±Õ. Æó·Å¿¬¼â±¸±Õ, ¹ÌÄÚÇö󽺸¶, ÀÓ±Õ, ÀÎÇ÷翣ÀÚ±Õ, µðÇÁÅ׸®¾Æ±Õ, ¸Åµ¶±Õ, ¼ö¸·¿°±Õ, ¸®½ºÅ׸®¾Æ ¸ð³ë»çÀÌÅäÁ¦´Ï½º, ¿¬¼ºÇϰ¨±Õ  
¡Û ÀûÀÀÁõ  
  - Àεο°, Èĵο°, Æó·Å, ±â°üÁöÈ®ÀåÁõ(°¨¿° ½Ã), ³óÈä 
  - µðÇÁÅ׸®¾Æ 
  - ¿ËÁ¾, Á¾±â, ¿¬Á¶Á÷¿°, »ýÀμÕ, ´Üµ¶, ³ó°¡Áø, ¿©µå¸§, ÇÇÇϳó¾ç   
  - ¸Åµ¶ 
  - ¸®½ºÅ׸®¾ÆÁõ 
  - â»ó. È»ó. ¼ö¼ú ÈÄ 2Â÷°¨¿° 
  - ¿ÜÀ̵µ¿°, ºÎºñµ¿¿° 
  - Àڱó»°¨¿°, Àڱúμӱ⿰, ¿¬¼ºÇϰ¨ 
      
     | 
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
    | 1ÀÏ ÃÖ´ë Åõ¿©·® | 
    
       
      À¯·áÁ¤º¸ÀÔ´Ï´Ù.
       
     | 
      
  
  
  
  
    
  
  
  
  
  
   
    | ¿ë¹ý¿ë·® | 
    
      * Àý´ë ÀÓÀǺ¹¿ëÇÏÁö ¸¶½Ã°í ¹Ýµå½Ã ÀÇ»ç ¶Ç´Â ¾à»ç¿Í »ó´ãÇϽñ⠹ٶø´Ï´Ù. 
    
     
      
      
      [󹿾à¾î] 
      ¡Û ¼ºÀÎ : ¿¡¸®½º·Î¸¶À̽ÅÀ¸·Î¼ 1ȸ 500mg(¿ª°¡) 1ÀÏ 2ȸ(¾ÆÄ§, Àú³á) °æ±¸Åõ¿©ÇÑ´Ù. 
   Áõ»ó¿¡ µû¶ó 1ȸ 500mg(¿ª°¡) 1ÀÏ 3ȸ(¾ÆÄ§, ³·, Àú³á) ¶Ç´Â 1ȸ 1000mg(¿ª°¡) 1ÀÏ 2ȸ(¾ÆÄ§, Àú³á)·Î Áõ·® Åõ¿©ÇÒ ¼ö ÀÖ´Ù. 
¡Û ¼Ò¾Æ : 1ÀÏ Ã¼Áß Kg´ç 25¢¦50mg(¿ª°¡)À» 4¢¦6ȸ ºÐÇÒ Åõ¿©ÇÑ´Ù.      
      	
     | 
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
    | ±Ý±â | 
    1) ÀÌ ¾à¿¡ °ú¹Î¹ÝÀÀ ¶Ç´Â ±× º´·ÂÀÌ Àִ ȯÀÚ 
 2)Å׸£Æä³ªµò, ¾Æ½ºÅ×¹ÌÁ¹, ½Ã»çÇÁ¸®µå, ¹ÌÁ¹¶ó½ºÆ¾, ÇǸðÁþ, º£ÇÁ¸®µô µîÀ» Åõ¿© Áß ÀΠȯÀÚ<¡¸»óÈ£Àۿ롹Ç× ÂüÁ¶> 
 3) ¿¡¸£°íÆ®¾ËÄ®·ÎÀ̵å(¿¡¸£°íŸ¹Î, µðÈ÷µå·Î¿¡¸£°íŸ¹Î ÇÔÀ¯Á¦Á¦)¸¦ Åõ¿© ÁßÀΠȯÀÚ(¸»ÃÊÇ÷°ü°æ·Ã, »çÁöÇãÇ÷, °¨°¢ÀÌ»óÀ» ÀÏÀ¸Å³ ¼ö ÀÖ´Ù.)(¡¸»óÈ£Àۿ롹Ç× ÂüÁ¶) 
 4) Ŭ·Î¶÷Æä´ÏÄÝ, Ŭ¸°´Ù¸¶À̽Å, ¸°ÄÚ¸¶À̽ÅÀ» Åõ¿©ÁßÀΠȯÀÚ(¡¸»óÈ£Àۿ롹Ç× ÂüÁ¶) 
 5) CYP3A4¿¡ ÀÇÇØ ´ë»çµÇ´Â HMG-CoA reductase ¾ïÁ¦Á¦ : ½É¹Ù½ºÅ¸Æ¾, ·Î¹Ù½ºÅ¸Æ¾(¡¸»óÈ£Àۿ롹Ç× ÂüÁ¶)  | 
   
  
  
  
  
   
    | ½ÅÁßÅõ¿© | 
     1) °£Àå¾Ö ¶Ç´Â ±× º´·ÂÀÌ Àִ ȯÀÚ 
 2) ½ÅºÎÀü ȯÀÚ 
 3) ºê·Î¸ðÅ©¸³Æ¾, Ä«¹ö°ñ¸°, ºÎ½ºÇÇ·Ð, Ä«¸£¹Ù¸¶Á¦ÇÉ, ½ÃŬ·Î½ºÆ÷¸°, Ÿũ·Î¸®¹«½º, ¿¡¹Ù½ºÆ¾, Å׿ÀÇʸ°, ¾Æ¹Ì³ëÇʸ°, Æ®¸®¾ÆÁ¹¶÷, ÅçÅ׷εò µîÀ» Åõ¿© ÁßÀΠȯÀÚ
 | 
   
  
    
  
  
  
  
  
   
    | ÀÌ»ó¹ÝÀÀ | 
    
        1) °ú¹Î¹ÝÀÀ : µÎµå·¯±â ¹× ÇǺΠ¹ßÁø°ú °°Àº °¡º¿î Áõ»óÀÌ ³ªÅ¸³¯ ¼ö ÀÖÀ¸¸ç ½ÉÇÑ °æ¿ì ¾Æ³ªÇʶô½Ã°¡ ³ªÅ¸³´Ù. 
 2) ¼Òȱâ°è : µå¹°°Ô ½Ä¿åºÎÁø, ±¸¿ª, ±¸Åä, À§Åë, ¼³»ç, º¹ºÎÆØ¸¸°¨, À§ºÎºÒÄè°¨, º¯ºñ, º¹ºÎ°æ·Ã µîÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù. 
 3) °£Àå : µå¹°°Ô ALP »ó½Â ¶Ç´Â Æ®¶õ½º¾Æ¹Ì³ªÁ¦ Áõ°¡¸¦ µ¿¹ÝÇÑ °£¼Õ»ó, °£¿° µîÀÌ ¹ß¿, Ȳ´ÞÀ» µ¿¹ÝÇÏ¿© ³ªÅ¸³¯ ¼ö ÀÖÀ¸¸ç ±Þ¼º º¹ÅëÀÌ ³ªÅ¸³¯ ¼ö ÀÖÀ¸¹Ç·Î ÃæºÐÈ÷ °üÂûÇÏ°í °£±â´É¿¡ ÀÌ»óÀÌ ÀÎÁ¤µÇ´Â °æ¿ì¿¡´Â Åõ¿©¸¦ ÁßÁöÇÑ´Ù.  
 4) ½ÅÀå : ±Þ¼º ½ÅºÎÀü(±Þ¼º °£Áú¼º ½Å¿°)ÀÌ ³ªÅ¸³¯ ¼ö ÀÖÀ¸¹Ç·Î Á¤±âÀûÀÎ °Ë»ç¸¦ ½Ç½ÃÇϸç ÀÌ»óÀÌ ÀÖÀ» °æ¿ì¿¡´Â Åõ¿©¸¦ ÁßÁöÇÑ´Ù. 
 5) ÇǺΠ: ¾àÇÑ ¹ßÁø¿¡¼ ´ÙÇüÈ«¹Ý, ½ºÆ¼ºì½º-Á¸½¼ÁõÈıº, µ¶¼ºÇ¥ÇDZ«»ç¿ëÇØ¿¡ À̸£´Â ÇǺιÝÀÀÀº µå¹°°Ô ³ªÅ¸³¯ ¼ö ÀÖ´Ù. 
 6) ÁßÁõ ±Ù¹«·ÂÁõ ȯÀÚÀÇ ¹«·ÂÁõÀ» ¾ÇȽÃų ¼ö ÀÖ´Ù. 
      
     | 
   
        
  
  
    
   
    | »óÈ£ÀÛ¿ë | 
     1) ÀÌ ¾àÀº °£Àå¿¡¼ ´ë»çµÇ´Â °¢Á¾ ÀǾàǰÀÇ ´ë»ç¸¦ ¾ïÁ¦ÇÏ¿© ´ÙÀ½ ÀǾàǰÀÇ Ç÷Á߳󵵸¦ ³ôÀÎ´Ù°í º¸°íµÇ¾î ÀÖ´Ù.  
  (1) ´ÙÀ½ ¾à°úÀÇ º´¿ë¿¡ ÀÇÇØ µå¹°°Ô QT ¿¬Àå, ½É½ÇºÎÁ¤¸Æ(Torsades de pointes Æ÷ÇÔ), ½ÉÁ¤Áö(»ç¸Á Æ÷ÇÔ) µîÀÇ ½ÉÇ÷°ü°è ÀÌ»ó¹ÝÀÀÀÌ ³ªÅ¸³¯ ¼ö ÀÖÀ¸¹Ç·Î º´¿ëÅõ¿©ÇÏÁö ¾Ê´Â´Ù : Å׸£Æä³ªµò, ¾Æ½ºÅ×¹ÌÁ¹, ¹ÌÁ¹¶ó½ºÆ¾, ½Ã»çÇÁ¸®µå, ÇǸðÁþ, º£ÇÁ¸®µô,(¡¸±Ý±â¡¹Ç× ÂüÁ¶) 
  (2) ´ÙÀ½ ¾àµé°ú º´¿ëÇÏ´Â °æ¿ì¿¡´Â ±× ¾àµéÀ» °¨·®ÇÏ´Â µî ½ÅÁßÈ÷ Åõ¿©ÇÑ´Ù : Å׿ÀÇʸ°, ¹Ì´ÙÁ¹¶÷, Ä«¸£¹Ù¸¶Á¦ÇÉ, ½ÃŬ·Î½ºÆ÷¸°, µð°î½Å, Æ®¸®¾ÆÁ¹¶÷, µð¼ÒÇǶó¹Ìµå, Ÿũ·Î¸®¹«½º ¼öȹ°, Æç·ÎµðÇÉ, ¹ßÇÁ·Ð»ê, ºê·Î¸ðÅ©¸³Æ¾, µµ¼¼Å¹¼¿ ¼öȹ°  
 2) ½Ã¸ÞƼµò : ¿¡¸®½º·Î¸¶À̽ÅÀÇ Ç÷Áß³óµµ°¡ »ó½ÂÇß´Ù´Â º¸°í°¡ ÀÖ´Ù. 
 3) Ȳ»ê ºóºí¶ó½ºÆ¾ : Ȳ»ê ºóºí¶ó½ºÆ¾ÀÇ ÀÛ¿ëÀÌ Áõ°µÇ¾ú´Ù´Â º¸°í°¡ ÀÖ´Ù. 
 4) ¿¡¸£°íÆ® ¾ËÄ®·ÎÀ̵å(¿¡¸£°íŸ¹Î, µðÈ÷µå·Î¿¡¸£°íŸ¹Î) : ÁßÁßÀÇ ¸»ÃÊÇ÷°ü°æ·Ã, »çÁöÇãÇ÷, °¨°¢ÀÌ»ó°ú °°Àº ±Þ¼º ¿¡¸£°íÆ® µ¶¼ºÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù.(¡¸±Ý±â¡¹Ç× ÂüÁ¶) 
 5) ¾ËÆæÅ¸´Ò : ÀÌ ¾àÀÇ °£´ë»çÀÇ °¨¼Ò·Î È£Èí¾ïÁ¦È¿°ú°¡ Áõ°¡ÇÑ´Ù. ¿¡¸®½º·Î¸¶À̽Űú º´¿ëÅõ¿©ÇÒ °æ¿ì¿¡´Â ÀÌ ¾àÀÇ ¿ë·®À» ÀûÀýÈ÷ Á¶ÀýÇÑ´Ù. 
 6) HMG-CoA ȯ¿øÈ¿¼Ò ÀúÇØÁ¦(·Î¹Ù½ºÅ¸Æ¾, ½É¹Ù½ºÅ¸Æ¾, ¾ÆÅ丣¹Ù½ºÅ¸Æ¾ µî) : Ⱦ¹®±ÙÀ¶Çذ¡ Áõ°µÉ ¼ö ÀÖÀ¸¹Ç·Î ¿¡¸®½º·Î¸¶À̽Űú º´¿ëÅõ¿©ÇÑ È¯ÀÚ´Â Creatine Kinase(CK)¿Í Ç÷û Æ®·£½º¾Æ¹Ì³ªÁ¦ ³óµµ¸¦ ÁÖÀDZí°Ô °üÂûÇØ¾ß ÇÑ´Ù. ·Î¹Ù½ºÅ¸Æ¾°ú ½É¹Ù½ºÅ¸Æ¾Àº º´¿ëÅõ¿©ÇÏÁö ¾Ê´Â´Ù.(¡¸±Ý±â¡¹Ç× ÂüÁ¶) 
 7) ¸®¼ö¸®µå : ¸®¼ö¸®µåÀÇ Ç÷Àå³óµµ Áõ°¡¿Í ÇÔ²² µµÆÄ¹Î¼º °ú·®Åõ¿© ¡ÈÄ(±¸¿ª, ±¸Åä, Á¹À½, ¹«·ÂÁõ)°¡ ³ªÅ¸³¯ ¼ö ÀÖ´Ù. 
 8) ½Çµ¥³ªÇÊ : ½Çµ¥³ªÇÊÀÇ Ç÷Àå³óµµ Áõ°¡¿Í ÇÔ²² ÀúÇ÷¾ÐÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù. 
 9) INR(±¹Á¦Á¤»óȺñÀ²)ÀÇ º¯È : ÀÌ ¾àÀ» Æ÷ÇÔÇÑ Ç×»ý¹°ÁúÀ» Ç×ÀÀ°íÁ¦¿Í µ¿½Ã¿¡ Åõ¿©¹ÞÀº ȯÀÚ¿¡¼ Ç×ÀÀ°í Ȱ¼ºÀÇ Áõ°¡°¡ º¸°íµÇ¾ú´Ù. °¨¿°¼º Áúȯ(±×¸®°í ¿°Áõ¼º °úÁ¤À» µ¿¹ÝÇÑ) ȯÀÚÀÇ ¿¬·É°ú ÀϹÝÀûÀÎ »óÅ´ À§Çè¿ä¼Ò°¡ µÈ´Ù. ºñ·Ï ÀÌ ¾à°ú ¿ÍÆÄ¸°ÀÇ »óÈ£ÀÛ¿ëÀÌ ÀÓ»ó½ÃÇèÀ» ÅëÇØ ¹àÇôÁöÁö´Â ¾Ê¾ÒÁö¸¸ INR ¸ð´ÏÅ͸µÀ» ½Ç½ÃÇÏ¿©¾ß Çϰí, ÇÊ¿äÇÑ °æ¿ì °æ±¸¿ë Ç×ÀÀ°íÁ¦ÀÇ ¿ë·®À» ÀûÀýÈ÷ Á¶ÀýÇÑ´Ù. Ç×»ý¹°ÁúÀÇ ÀϺΠÁ¾·ùµé, ƯÈ÷ Ç÷ç¿À·ÎÄû³î·Ð, ¸¶ÀÌÅ©·Î¶óÀ̵å, »çÀÌŬ¸°, ÄÚÆ®¸®¸ñ»çÁ¹°ú ÀϺΠ¼¼ÆÈ·Î½ºÆ÷¸°ÀÇ °æ¿ì´Â ´õ ½ÉÇÏ´Ù. 
10) Ŭ·Î¶÷Æä´ÏÄÝ, Ŭ¸°´Ù¸¶À̽Å, ¸°ÄÚ¸¶À̽Š: ÀÌ ¾à°ú Ŭ¸°´Ù¸¶À̽Š¶Ç´Â ¸°ÄÚ¸¶À̽Űú º´¿ëÇϸé, ±æÇ×ÀÛ¿ë(antagonism)¿¡ ÀÇÇØ º´¿ë¿¡ ÀÇÇÑ È¿°ú°¡ ³ªÅ¸³ªÁö ¾ÊÀ¸¹Ç·Î º´¿ëÅõ¿©ÇÏÁö ¾Ê´Â´Ù. Ŭ·Î¶÷Æä´ÏÄݰú º´¿ëÇÏ´Â °æ¿ì¿¡µµ, µÎ ¾à¹°Àº ¼·Î °æÀï ÀúÇØÇÒ ¼ö ÀÖÀ¸¹Ç·Î º´¿ëÅõ¿©ÇÏÁö ¾Ê´Â´Ù.(¡¸±Ý±â¡¹Ç× ÂüÁ¶) 
 | 
   
  
    
  
  
       	
  
     
  
  
  
  
  
  
  |  
     
   
  
    
       |  
      
        
          
            
                | Á¤º¸¿ä¾à |         
             
           
         | 
             	    
       |  
      | 
  
    µå·°ÀÎÆ÷ ÀǾàǰ ¿ä¾à/»ó¼¼Á¤º¸
    
  
  
    
  
   |  
     
   
  
    
       |  
      
        
          
            
                | ÄÚµå ¹× ºÐ·ùÁ¤º¸ |         
             
           
         | 
             	    
       |  
      | 	 |  
     
   
  
    
       |  
      
        
          
            
                | Á¦Ç°Á¤º¸ |            
             
           
         | 
             	  
       |  
       |  
     
   
  
    
       |  
      
        
          
            
                | º¹¾àÁ¤º¸ |            
             
           
         | 
             	  
       |  
      
  
    | Ç׸ñ | 
    ³»¿ë | 
   
   
    | LACTmed ¹Ù·Î°¡±â | 
    
      
        [¹Ù·Î°¡±â]
     | 
     
  
  
  
  
   
    | Ãà¾àº¹¾àÁöµµ | 
    
     
    À¯·áÁ¤º¸ÀÔ´Ï´Ù.
    
     | 
   
       
  
  
   
    | º¹¾àÁöµµ | 
    
     
    À¯·áÁ¤º¸ÀÔ´Ï´Ù.
    
     | 
   
                                                          															
  
   
  
  
   
    | ÀӺο¡´ëÇÑÅõ¿© | 
    
      
      
        
	      
	      
	        | *  | 
	        
	          ÀüüÀӽŠ±â°£º°·Î ¿©·¯µî±ÞÀÌ Á¸ÀçÇÒ ¼ö ÀÖÀ¸¸ç °¡Àå À§Çèµµ°¡ ³ôÀº Á¤º¸¸¸ º¸¿©Áý´Ï´Ù. ´Ü, º¹ÇÕÁ¦ÀÇ °æ¿ì ¸ðµç º¹ÇÕÁ¦¼ººÐ¿¡ ´ëÇÑ ÀÓºÎÅõ¿©µî±ÞÀÌ Ç¥½ÃµÈ°ÍÀº Àý´ë ¾Æ´Ï¸ç Ç¥½ÃµÈ°ÍÁß¿¡ °¡Àå À§Çèµµ°¡ ³ôÀº Á¤º¸¸¸ ³ªÅ¸³³´Ï´Ù. 
	         | 
	         
	       
	       | 
	   
	  
	    |   | 
	   
	  
	    
	      FDA : Bµî±Þ 
				        	
					  
					
	   | 
	  
	  
	  
	     
	     
	     
	     
	     
	     
	   | 
	 
	
	  
	      
	      
	        | *  | 
	        
	          »ó±â ÀÓºÎÅõ¿©¿¡ ´ëÇÑ Á¤º¸´Â Àü»êó¸® µÇ¸é¼ ÀÔ·Â ¿À·ù °¡´É¼ºÀÌ Á¸ÀçÇÕ´Ï´Ù. ¿À·ù °¡´É¼ºÀ» ÃÖ¼ÒÈÇϱâ À§ÇÏ¿© ¸¹Àº ³ë·ÂÀ» ±â¿ïÀ̰í ÀÖÀ¸³ª, ±× Á¤È®¼º¿¡ ´ëÇÏ¿© È®½ÅÀ» µå¸± ¼ö ¾ø½À´Ï´Ù. ÀÌ¿¡ ´ëÇØ ȸ»ç´Â Ã¥ÀÓÀ» ÁöÁö ¾Ê½À´Ï´Ù.
	         | 
	         
	      
	        | *  | 
	        
	          ¹Ýµå½Ã °ø½Å·Â ÀÖ´Â ¹®ÇåÀ» ´Ù½Ã Çѹø Âü°í ÇϽñ⠹ٶó¸ç ÀÇ»ç ¶Ç´Â ¾à»çÀÇ ÆÇ´Ü¿¡ µû¶ó Åõ¿©¿©ºÎ°¡ °áÁ¤µÇ¾î¾ß ÇÕ´Ï´Ù.
	         | 
	         
	       
	   | 
	 
       
     | 
   
  
  
  	   
  
  	   
  
  	   
  
  
  
  
  
  
  
  
   
    | º´¿ë±Ý±â ¹× ¿¬·É´ë±Ý±â ±Ù°ÅÁ¶È¸ | 
    
      [º´¿ë±Ý±â ¹× ¿¬·É´ë±Ý±â ±Ù°ÅÁ¶È¸]
     | 
   
  	
  
  
  
   
    | º¹¾à¶óº§ | 
    
    
    
      | À̹ÌÁö | 
      º¹¾à¼³¸í | 
     
    
    
        | 
      º¯ºñ°¡ »ý±æ¼ö ÀÖ½À´Ï´Ù. | 
     
    
       | 
     
    
     |  
    
      
	
	  
            | *  | 
	    º¹¾àÀ̹ÌÁö´Â ¸ðµç º¹¾àÁöµµ »çÇ×À» Ç¥½ÃÇѰÍÀº ¾Æ´Ï¸ç, Ãß°¡ÀûÀ¸·Î ¾÷µ¥ÀÌÆ®µÇ°Å³ª ¼öÁ¤µÉ ¼ö ÀÖ½À´Ï´Ù. | 
	   
	  
            | *  | 
	    º¹¾àÀ̹ÌÁöÀÇ Ç¥½Ã¿©ºÎ´Â ½ÇÁ¦ ¾à¹°º¹¿ë½Ã Á߿䵵¿¡ µû¸¥°ÍÀº ¾Æ´Ï¸ç ´Ü¼øÈ÷ Çã°¡Á¤º¸»ó Ű¿öµå¸¦ ±âÁØÀ¸·Î µî·ÏµÇ¾ú½À´Ï´Ù. | 
	   
	  
            | *  | 
	    ±ÍÇϰ¡ º¹¾àÀ̹ÌÁö Á¤º¸¸¦ ½Å·ÚÇÔÀº ÀüÀûÀ¸·Î ±ÍÇÏÀÇ Ã¥ÀÓÀÔ´Ï´Ù. µå·°ÀÎÆ÷´Â ÀÌ¿¡ ´ëÇÑ ¾î¶°ÇÑ º¸Áõµµ ÇÏÁö ¾Ê½À´Ï´Ù. | 
	   
	   
     |   
     | 
   
  	
  
  
  
   
    | º¸°ü»ó ÁÖÀÇ | 
    
      
    	
     | 
   
  
  
   
    | Á¶Á¦½Ã ÁÖÀÇ | 
    
      
    	
     | 
      
 
 |  
     
   
  
    
       |  
      
        
          
            
                | ½É»çÁ¤º¸ |            
             
           
         | 
             	  
       |  
      
  
    | Ç׸ñ | 
    ³»¿ë | 
   
  
  
 
  
  
   
    | ½É»ç»ç·Ê | 
    
    ¸¸¼ºÈ£Èí±âÁúȯ¿¡ Àå±â Åõ¿©µÈ macrolide °è¿ Á¦Á¦¿¡ ´ëÇÏ¿© 
 ¡á ½ÉÀÇ¹è°æ 
    ÇöÀç macrolide°è¿(clarithromycin, erythromycin, roxithromycin, azithromycin) Á¦Á¦¸¦ ¸¸¼ºÈ£Èí±â Áúȯ¿¡¼ Àå±â Åõ¿©ÇÏ´Â »ç·Ê°¡ ¹ß»ýÇϰí ÀÖ¾î ÀÌÀÇ ÀÇÇÐÀû Ÿ´ç¼º¿¡ ´ëÇØ ½ÉÀÇÇÔ. 
 ¡á Âü°í 
   ¡Û Clarithromycin °æ±¸Á¦ (ǰ¸í:Ŭ·¡¸®½ÃµåÇʸ§ÄÚÆÃÁ¤250mg µî) ÀÎÁ¤±âÁØ (º¸°Çº¹ÁöºÎ°í½Ã Á¦2010-20È£, 2010.05.01) 
   ¡Û ½ÄǰÀǾàǰ¾ÈÀüû Çã°¡»çÇ× 
   ¡Û ±èÁ¾¼±. À̺ñÀÎÈİúÇÐ(´ëÇÑÀ̺ñÀÎÈİúÇÐȸ Æí). ÀÏÁ¶°¢. 2002. 
   ¡Û ´ëÇѰ¨¿°ÇÐȸ. Ç×»ýÁ¦ÀÇ ±æÀâÀÌ, Á¦3ÆÇ. 2008. 
   ¡Û ±è¿µÈ¯ ¿Ü. ±â°üÁöÈ®ÀåÁõ¿¡¼ ErythromycinÀÇ ¼Ò·® Àå±âÅõ¿© È¿°ú. °áÇÙ ¹× È£Èí±âÁúȯ 
 ¡á ½ÉÀdz»¿ë 
    Macrolide°è¿(clarithromycin, erythromycin, roxithromycin, azithromycin)Á¦Á¦°¡ ¸¸¼ºÈ£Èí±â Áúȯ¿¡¼ Àå±â Åõ¿©µÇ´Â »ç·Ê°¡ ¹ß»ýÇϰí ÀÌ¿Í °ü·ÃÇÑ ³í¹®µéÀÌ ³ª¿À°í ÀÖÀ¸³ª, Àú¿ë·® Àå±â¿ä¹ýÀÇ °æ¿ì Ç×»ýÁ¦ ³»¼º À¯¹ß µîÀÇ ½É°¢ÇÑ ¹®Á¦¸¦ ¾ß±âÇÒ ¼ö ÀÖ´Â Á¡À» °í·ÁÇØº¼ ¶§ chronic sinusitis, bronchiectasis, COPD µî¿¡¼ macrolide°è Á¦Á¦ÀÇ Àå±â»ç¿ë¿¡ ´ëÇÑ Ä¡·áÈ¿°ú ¹× ÀÇÇÐÀû Ÿ´ç¼º¿¡ ´ëÇÏ¿© ü°èÀû ¹®Çå°íÂûÀÌ ÇÊ¿äÇÏ´Ù´Â ÀǰßÀÌ Á¦±âµÇ¾î(¡®08.3.28 ³»°ú¥³ºÐÀ§) EBH¿¡ ¹®Çå°íÂûÀ» ¿äûÇÏ¿© ³íÀÇÇÑ °á°ú 
   ¡®¸¸¼ºÈ£Èí±âÁúȯ¿¡ Àú¿ë·® Àå±â Åõ¿©(low-dose, long-term therapy)µÈ macrolides°è¿ Á¦Á¦ÀÇ ÀÓ»óÀû À¯¿ë¼º ¹× ¾ÈÀü¼ºÀ» ÀÔÁõÇÒ ¸¸ÇÑ ±Ù°Å´Â ÇöÀç±îÁö ÃæºÐÇÏÁö ¾Ê´Ù°í ÆÇ´ÜµÈ´Ù.¡¯´Â EBH º¸°í¼¸¦ ÂüÁ¶½Ã Â÷ÈÄ macrolides°è Á¦Á¦ÀÇ Àú¿ë·® Àå±â Åõ¿©·Î ÀÎÇÑ ³»¼º±Õ ÃâÇöÀ̳ª ±Õ±³´ëÇö»ó µî ¾ÈÀü¼º ¹× À¯È¿¼º¿¡ ´ëÇÑ ÃæºÐÇÑ ±Ù°Å°¡ È®¸³µÉ ¶§±îÁö ¸¸¼ºÈ£Èí±âÁúȯ¿¡ macrolides°è¿ Á¦Á¦ÀÇ Àú¿ë·® Àå±âÅõ¿©´Â ÇöÇà´ë·Î ½Ä¾àû Çã°¡»çÇ×(¿ë¹ý¿ë·®) µîÀ» ÃʰúÇÑ °æ¿ì·Î º¸¾Æ ÀÎÁ¤ÇÏÁö ¾Æ´ÏÇÔ. 
[2010.06.07 Áø·á½É»çÆò°¡À§¿øÈ¸]  
     | 
   
  
  
   
    | DUR °ü·Ã °í½Ã | 
    
      
        [º´¿ë¿¬·É±Ý±â ÀǾàǰ / ÀӺαݱâ ÀǾàǰ / ºñ¿ëÈ¿°úÀû ÇÔ·® ÀǾàǰ / ¾ÈÀü¼º °ü·Ã ±Þ¿©ÁßÁö ÀǾàǰ]
      
     | 
       
  |  
     
     
  
    
       |  
      
        
          
            
                | ÇмúÁ¤º¸ |          
             
           
         | 
             	  
       |  
      
  
    | Ç׸ñ | 
    ³»¿ë | 
   
  
    | DUR (ÀǾàǰ»ç¿ëÆò°¡) | 
    º´¿ë±Ý±â :
     
	 °í½ÃµÈ º´¿ë±Ý±â ³»¿ëÀº ¾ø½À´Ï´Ù.
	 
	  [»óÈ£ÀÛ¿ë/º´¿ë±Ý±â°Ë»ö]										
	  ¿¬·É´ë±Ý±â :
      °í½ÃµÈ ¿¬·É±Ý±â ³»¿ëÀº ¾ø½À´Ï´Ù.
      
       [¿¬·É´ë±Ý±â»ó¼¼°Ë»ö]
       
       
        
        
     | 
   
  
   
    | Mechanism of Action | 
    
       Erythromycin¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the ¡°P¡± or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the ¡°A¡± or acceptor site to the ¡°P¡± or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug. 
     | 
   
  
   
    | Pharmacology | 
     
       Erythromycin¿¡ ´ëÇÑ Pharmacology Á¤º¸ Erythromycin is produced by a strain of Streptomyces erythraeus and belongs to the macrolide group of antibiotics. After absorption, erythromycin diffuses readily into most body fluids. In the absence of meningeal inflammation, low concentrations are normally achieved in the spinal fluid, but the passage of the drug across the blood-brain barrier increases in meningitis. Erythromycin is excreted in breast milk. The drug crosses the placental barrier, but fetal plasma levels are low. Erythromycin is not removed by peritoneal dialysis or hemodialysis. 
     | 
   
  
   
    | Metabolism | 
    
       Erythromycin¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Adenosine deaminaseCytochrome P450 3A4 (CYP3A4) 
     | 
   
  
   
    | Protein Binding | 
    
       Erythromycin¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ Erythromycin is largely bound to plasma proteins, and the freely dissociating bound fraction after administration of erythromycin base represents 90% of the total erythromycin absorbed. 
     | 
   
  
   
    | Half-life | 
    
       Erythromycin¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 1.5 hours 
     | 
   
  
   
    | Absorption | 
    
       Erythromycin¿¡ ´ëÇÑ Absorption Á¤º¸ Orally administered erythromycin base and its salts are readily absorbed in the microbiologically active form. Topical application of the ophthalmic ointment to the eye may result in absorption into the cornea and aqueous humor. 
     | 
   
  
   
    | Biotransformation | 
    
       Erythromycin¿¡ ´ëÇÑ Biotransformation Á¤º¸ Hepatic. Extensively metabolized - after oral administration, less than 5% of the administered dose can be recovered in the active form in the urine. 
     | 
   
  
   
    | Toxicity | 
    
       Erythromycin¿¡ ´ëÇÑ Toxicity Á¤º¸ Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting. 
     | 
   
  
   
    | Drug Interactions | 
    
       Erythromycin¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Alfentanil	The macrolide increases the effect and toxicity of alfentanilAlprazolam	The macrolide increases the effect of the benzodiazepineAminophylline	The macrolide increases the effect and toxicity of theophyllineAmiodarone	Increased risk of cardiotoxicity and arrhythmiasAnisindione	The macrolide increases anticoagulant effectAprepitant	This CYP3A4 inhibitor increases effect and toxicity of aprepitantAstemizole	Increased risk of cardiotoxicity and arrhythmiasAtorvastatin	The macrolide possibly increases the statin toxicityBretylium	Increased risk of cardiotoxicity and arryhthmiasBromocriptine	Erythromycin increases serum levels of bromocriptineBuspirone	The macrolide increases the effect and toxicity of buspironeCabergoline	Erythromycin increases serum levels and toxicity of cabergolineCarbamazepine	The macrolide increases the effect of carbamazepineCerivastatin	The macrolide possibly increases the statin toxicityCilostazol	Erythromycin increases the effect of cilostazolCinacalcet	This macrolide increases the serum levels and toxicity of cinacalcetCisapride	Increased risk of cardiotoxicity and arrhythmiasCitalopram	Possible serotoninergic syndrome with this combinationClozapine	Erythromycin increases the effect of clozapineColchicine	Severe colchicine toxicity can occurCyclosporine	The macrolide increases the effect of cyclosporineDiazepam	The macrolide increases the effect of the benzodiazepineDicumarol	The macrolide increases anticoagulant effectDigoxin	The macrolide increases the effect of digoxin in 10% of patientsDihydroergotamine	Possible ergotism and severe ischemia with this combinationDihydroergotoxine	Possible ergotism and severe ischemia with this combinationDyphylline	The macrolide increases the effect and toxicity of theophyllineDisopyramide	Increased risk of cardiotoxicity and arrhythmiasDivalproex sodium	Erythromycin increases the effect of valproic acidDocetaxel	The agent increases the serum levels and toxicity of docetaxelDofetilide	Increased risk of cardiotoxicity and arrhythmiasEletriptan	The macrolide increases the effect and toxicity of eletriptanEplerenone	This CYP3A4 inhibitor increases the effect and toxicity of eplerenoneErgotamine	Possible ergotism and severe ischemia with this combinationErlotinib	This CYP3A4 inhibitor increases levels/toxicity of erlotinibImatinib	The macrolide increases levels of imatinibFelodipine	Erythromycin increases the effect of felodipineFluoxetine	Possible serotoninergic syndrome with this combinationGefitinib	This CYP3A4 inhibitor increases levels/toxicity of gefitinibGrepafloxacin	Increased risk of cardiotoxicity and arrhythmiasItraconazole	The macrolide increases the effect and toxicity of itraconazoleLevofloxacin	Increased risk of cardiotoxicity and arrhythmiasMesoridazine	Increased risk of cardiotoxicity and arrhythmiasMethylergonovine	Possible ergotism and severe ischemia with this combinationLovastatin	The macrolide possibly increases the statin toxicityMethylprednisolone	The macrolide increases the effect of corticosteroidMethysergide	Possible ergotism and severe ischemia with this combinationMidazolam	The macrolide increases the efect of the benzodiazepineMoxifloxacin	Increased risk of cardiotoxicity and arrhythmiasOxtriphylline	The macrolide increases the effect and toxicity of theophyllinePimozide	Increased risk of cardiotoxicity and arrhythmiasQuetiapine	This macrolide increases the effect/toxicity of quetiapineQuinidine	Increased risk of cardiotoxicity and arrhythmiasQuinidine barbiturate	Increased risk of cardiotoxicity and arrhythmiasQuinupristin	This combination presents an increased risk of toxicityRanolazine	Increased levels of ranolazine - risk of toxicityRepaglinide	This macrolide increases effect of repaglinideRifabutin	The rifamycin decreases the effect of the macrolideRifampin	The rifamycin decreases the effect of the macrolideRitonavir	Increased toxicity of both agentsSertraline	Possible serotoninergic syndrome with this combinationSibutramine	Erythromycin increases the effect and toxicity of sibutramineSildenafil	The macrolide increases the effect and toxicity of sildenafilSimvastatin	The macrolide possibly increases the statin toxicitySirolimus	The macrolide increases sirolimus levelsSotalol	Increased risk of cardiotoxicity and arrhythmiasSparfloxacin	Increased risk of cardiotoxicity and arrhythmiasTacrolimus	Erythromycin increases the effect and toxicity of tacrolimusTerfenadine	Increased risk of cardiotoxicity and arrhythmiasTheophylline	The macrolide increases the effect and toxicity of theophyllineThioridazine	Increased risk of cardiotoxicity and arrhythmiasVerapamil	Increased risk of cardiotoxicity and arrhythmiasTriazolam	The macrolide increases the effect of the benzodiazepineVardenafil	The macrolide increases the effect and toxicity of vardenafilVinblastine	Erythromycin increases vinblastine toxicityWarfarin	The macrolide increases anticoagulant effectZafirlukast	Erythromycin decreases the effect of zafirlukastErgonovine	Possible ergotism and severe ischemia with this combinationEverolimus	The macrolide increases everolimus levels/toxicityLincomycin	Possible antagonism of action with this combinationAcenocoumarol	The macrolide increases anticoagulant effect 
     | 
   
  
   
    CYP450  Drug Interaction | 
    
      [CYP450 TableÁ÷Á¢Á¶È¸] Erythromycin¿¡ ´ëÇÑ P450 table
  SUBSTRATES 
CYP 3A4/3A5/3A7 
Macrolide antibiotics: 
clarithromycin 
**erythromycin** 
NOT azithromycin 
telithromycin 
Anti-arrhythmics: 
quinidine 
Benzodiazepines: 
alprazolam 
diazepam 
midazolam 
triazolam 
Immune Modulators: 
cyclosporine 
tacrolimus (FK506) 
HIV Protease Inhibitors: 
indinavir 
ritonavir 
saquinavir 
Prokinetic: 
cisapride 
Antihistamines: 
astemizole 
chlorpheniramine 
Calcium Channel Blockers: 
amlodipine 
diltiazem 
felodipine 
nifedipine 
nisoldipine 
nitrendipine 
verapamil 
HMG CoA Reductase Inhibitors: 
atorvastatin 
cerivastatin 
lovastatin 
NOT pravastatin 
simvastatin 
aripiprazole 
buspirone 
gleevec 
haloperidol (in part) 
methadone 
pimozide 
quinine 
NOT rosuvastatin 
sildenafil 
tamoxifen 
trazodone 
vincristine 
 INHIBITORS 
CYP 3A4/3A5/3A7 
HIV Protease Inhibitors: 
indinavir 
nelfinavir 
ritonavir 
amiodarone 
NOT azithromycin 
cimetidine 
clarithromycin 
diltiazem 
**erythromycin** 
fluvoxamine 
grapefruit juice 
itraconazole 
ketoconazole 
mibefradil 
nefazodone 
troleandomycin 
verapamil 
 INDUCERS 
CYP 3A4/3A5/3A7 
carbamazepine 
phenobarbital 
phenytoin 
rifabutin 
rifampin 
St. John's wort 
troglitazone 
  SUBSTRATES 
CYP 3A4/3A5/3A7 
Macrolide antibiotics: 
clarithromycin 
**erythromycin** 
NOT azithromycin 
telithromycin 
Anti-arrhythmics: 
quinidine 
Benzodiazepines: 
alprazolam 
diazepam 
midazolam 
triazolam 
Immune Modulators: 
cyclosporine 
tacrolimus (FK506) 
HIV Protease Inhibitors: 
indinavir 
ritonavir 
saquinavir 
Prokinetic: 
cisapride 
Antihistamines: 
astemizole 
chlorpheniramine 
Calcium Channel Blockers: 
amlodipine 
diltiazem 
felodipine 
nifedipine 
nisoldipine 
nitrendipine 
verapamil 
HMG CoA Reductase Inhibitors: 
atorvastatin 
cerivastatin 
lovastatin 
NOT pravastatin 
simvastatin 
aripiprazole 
buspirone 
gleevec 
haloperidol (in part) 
methadone 
pimozide 
quinine 
NOT rosuvastatin 
sildenafil 
tamoxifen 
trazodone 
vincristine 
 INHIBITORS 
CYP 3A4/3A5/3A7 
HIV Protease Inhibitors: 
indinavir 
nelfinavir 
ritonavir 
amiodarone 
NOT azithromycin 
cimetidine 
clarithromycin 
diltiazem 
**erythromycin** 
fluvoxamine 
grapefruit juice 
itraconazole 
ketoconazole 
mibefradil 
nefazodone 
troleandomycin 
verapamil 
 INDUCERS 
CYP 3A4/3A5/3A7 
carbamazepine 
phenobarbital 
phenytoin 
rifabutin 
rifampin 
St. John's wort 
troglitazone 
     | 
   
  
   
    | Food Interaction | 
    
       Erythromycin¿¡ ´ëÇÑ Food Interaction Á¤º¸ Avoid alcohol.Take on empty stomach: 1 hour before or 2 hours after meals.Take with a full glass of water Avoid taking with grapefruit juice. 
     | 
   
  
   
    | Drug Target | 
    
      
      [Drug Target]
     | 
   
  
   
    | Description | 
    
       Erythromycin¿¡ ´ëÇÑ Description Á¤º¸ Erythromycin is a bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. [PubChem] 
     | 
   
  
   
    | Drug Category | 
    
       Erythromycin¿¡ ´ëÇÑ Drug_Category Á¤º¸ Anti-Bacterial Agents 
     | 
   
  
   
    | Smiles String Canonical | 
    
       Erythromycin¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(C2O)N(C)C)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O 
     | 
   
  
   
    | Smiles String Isomeric | 
    
       Erythromycin¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 
     | 
   
  
   
    | InChI Identifier | 
    
       Erythromycin¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 
     | 
   
  
   
    | Chemical IUPAC Name | 
    
       Erythromycin¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione 
     | 
   
  
   
    | Drug-Induced Toxicity Related Proteins | 
    
      ERYTHROMYCIN ÀÇ Drug-Induced Toxicity Related ProteinÁ¤º¸ Replated Protein:Misshapen-like kinase(Mink) Drug:Erythromycin Toxicity:torsade de pointes.  [¹Ù·Î°¡±â] Replated Protein:Potassium voltage-gated channel subfamily KQT member 1 (KvLQT1) Drug:Erythromycin Toxicity:torsade de pointes.  [¹Ù·Î°¡±â] Replated Protein:Intercellular adhesion molecule 1  Drug:erythromycin Toxicity:pathogenesis of infusion phlebitis.  [¹Ù·Î°¡±â] Replated Protein:HERG Drug:Erythromycin Toxicity:torsade de pointes.  [¹Ù·Î°¡±â] Replated Protein:Alanine aminotransferase Drug:erythromycin  Toxicity:adverse gastrointestinal effects.  [¹Ù·Î°¡±â] 
     | 
   
    
  |  
     
     
  
    
       |  
      
        
          
            
                | »ç¿ëÀÚÄÁÅÙÃ÷ |           
             
           
         | 
             	  
       |  
       |  
     
         
 
     | 
   
   
     | 
   
  
    
      
        
          
            
              - 
                ÃÖ±ÙÁ¤º¸¼öÁ¤ÀÏ 2021-12-09
              
 
              - 
                
                 º» ¼öÁ¤ÀÏ Á¤º¸´Â Çã°¡Á¤º¸ ÀÌ¿ÜÀÇ ±âŸÁ¤º¸ ¼öÁ¤ÀÏÀ» ÀǹÌÇϹǷÎ, Çã°¡Á¤º¸¼öÁ¤ÀÏÀº º»¹®¿¡ Ç¥±âµÈ ³¯Â¥¸¦ ÂüÁ¶ÇϽñ⠹ٶø´Ï´Ù.
                
              
     
             
         |                 
       
     |       
          
                
                    
                       ¾Ë¸² | 
                       
                      »ó¼¼Á¤º¸´Â ½ÄǰÀǾàǰ¾ÈÀüóÀÇ Á¦Ç°Çã°¡»çÇ×À» Åä´ë·Î ÀÛ¼ºµÇ¾úÀ¸¸ç ¿ä¾àÁ¤º¸´Â »ó¼¼Á¤º¸ ¹× ±âŸ¹®ÇåÀ» ±â¹ÝÀ¸·Î µå·°ÀÎÆ÷¿¡¼ ÆíÁýÇÑ ³»¿ëÀÔ´Ï´Ù. Á¦Ç°Çã°¡»çÇ×ÀÇ ¸ñÂ÷¿Í ´Ù¼Ò »óÀÌÇÒ ¼ö ÀÖ½À´Ï´Ù.  | 
                    
                    | 
               
      
      
                
                    
                       °æ°í | 
                     
                      µå·°ÀÎÆ÷ ÀǾàÇмúÁ¤º¸´Â ½ÄǰÀǾàǰ¾ÈÀüóÀÇ Á¦Ç°Çã°¡»çÇ×, Çмú¹®Çå, Á¦¾àȸ»ç Á¦°øÁ¤º¸ µîÀ» ±Ù°Å·Î ÀÛ¼ºµÈ Âü°í Á¤º¸ÀÔ´Ï´Ù. 
                          Á¤º¸ÀÇ Á¤È®¼ºÀ» À§ÇØ ³ë·ÂÇϰí ÀÖÀ¸³ª ÆíÁý»óÀÇ ¿À·ù, Çã°¡»çÇ× º¯°æ, Ãß°¡ÀûÀÎ Çмú¿¬±¸ ¶Ç´Â Àӻ󿬱¸ ¹ßÇ¥ µîÀ¸·Î ÀÎÇØ ¹ß»ýÇÏ´Â ¹®Á¦¿¡ ´ëÇØ µå·°ÀÎÆ÷´Â 
                          Ã¥ÀÓÀ» ÁöÁö ¾Ê½À´Ï´Ù. ÀÚ¼¼ÇÑ ³»¿ëÀº ¡°Ã¥ÀÓÀÇ ÇÑ°è ¹× ¹ýÀû°íÁö¡±¸¦ ÂüÁ¶ÇØ ÁֽʽÿÀ.
                            ¹Ýµå½Ã Á¦Á¶¡¤¼öÀÔ»ç, ÆÇ¸Å»ç, ÀÇ»ç, ¾à»ç¿¡°Ô ÃÖÁ¾ÀûÀ¸·Î È®ÀÎÇϽñ⠹ٶø´Ï´Ù.
                          ÀüÈ: 02-3486-1061 ¤Ó À̸ÞÀÏ: webmaster@druginfo.co.kr
 | 
  
                    | 
               
  
 
  
    ¾Æ·¡ÀÇ ³»¿ëÀ» Æ÷ÇÔÇÑ Àüü µ¥ÀÌÅ͸¦ º¸½Ã·Á¸é 
    ¿©±â·Î À̵¿ÇϽñ⠹ٶø´Ï´Ù.
   
  The database contains the following fields: The generic name of each chemical For module A10 (liver enzyme composite module): Overall activity category for each compound (A for active, M for marginally active, or I for inactive) based on the number of active and marginally active scores for each compound at the five individual endpoints (see research article for full description of method) Number of endpoints at which each compound is marginally active (M) Number of endpoints at which each compound is active (A) For modules A11 to A15 (alkaline phosphatase increased, SGOT increased, SGPT increased, LDH increased, and GGT increased, respectively): Overall activity category for each compound (A for active, M for marginally active, or I for inactive) based on the RI and ADR values (see the research article for full description of method) Number of ADR reports for each compound, given as <4 or ¡Ã4 Reporting Index value for each compound, except where no shipping units were available (NSU) Group 1 comprises of compounds for which ADR data were available for the first five years of marketing, so when no ADR reports were listed during this period the compounds were evaluated as inactive. Group 2 comprises of compounds for which a 'steady state' period of ADR data were available (1992-1996). In cases where no ADR reports were filed during this period, the compounds were scored as 'NA' (data not available) since they may have had one or more ADR reports during their first five years of marketing which should not be negated by a lack of ADR reports during the steady-state period. ERYTHROMYCIN PROPIONATE[GGT Increase][Composite Activity](Score)  A(Marginal)  0(Active)  3[Alkaline Phosphatase Increase](Activity Score)  A(Number of Rpts)  ¡Ã4(Index value)  7.3[SGOT Increase](Activity Score)  A(Number of Rpts)  ¡Ã4(Index value)  7.9[SGPT Increase](Activity Score)  A(Number of Rpts)  ¡Ã4(Index value)  8.5[LDH Increase](Activity Score)  NA(Number of Rpts)  NA(Index value)  NA[GGT Increase](Activity Score)  NA(Number of Rpts)  NA(Index value)  NA
 
  º´¿ë±Ý±â ¹× ƯÁ¤¿¬·É´ë ±Ý±â ¼ººÐ
 
  [ÀǾàǰº´¿ë/¿¬·É´ë±Ý±â °í½Ã±Ù°Å·Î ¹Ù·Î°¡±â]       Á¦¸ñ ¾øÀ½ 
 
    
    2008³â 8¿ù 1ÀÏ ¾à°¡ÈÀÏ»ó 8¿ù´Þ ½Å±ÔµîÀç ¹× »èÁ¦µÇ´Â ǰ¸ñ Æ÷ÇÔÇÑ º´¿ë¿¬·É ±Ý±â ǰ¸ñ¸®½ºÆ® ±âÁØ
    
    1. ÇöÀç °Ë»öÇÑ Á¦Ç°¿¡ ´ëÇÑ  º´¿ë±Ý±â Á¦Ç° Á¸Àç¿©ºÎ ¹× °Ë»ö
    ÇöÀç ÀÌÁ¦Ç°¿¡ ´ëÇÑ º´¿ë±Ý±â¿¡ ÇØ´çÇϴ û±¸Äڵ庰 Á¦Ç°³»¿ª °øÁö³»¿ëÀÌ ¾ø½À´Ï´Ù
          
    
    
    
    2. ¿¬·É´ë±Ý±â Á¸Àç¿©ºÎ
    ÇöÀç ÀÌÁ¦Ç°¿¡ ´ëÇÑ ¿¬·É±Ý±â¿¡ ÇØ´çÇϴ û±¸Äڵ庰 °øÁö³»¿ëÀÌ ¾ø½À´Ï´Ù
 
 
 
   
  |  
                           
                         | 
                       
                      | 
                   |