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9) °£Àå : ¶§¶§·Î AST, ALT, LDH »ó½Â, µå¹°°Ô °£¿°(°£¼¼Æ÷¼º ¶Ç´Â ÄÝ·¹½ºÅ׷Ѽº), °£ºÎÀü, Ȳ´Þ, ÃéÀå¿°ÀÌ ³ªÅ¸³¯ ¼ö ÀÖÀ¸¹Ç·Î °üÂûÀ» ÃæºÐÈ÷ Çϰí ÀÌ»óÀÌ ÀÎÁ¤µÇ´Â °æ¿ì¿¡´Â Åõ¿©¸¦ ÁßÁöÇÑ´Ù.
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¨ç È£Áß±¸ °¨¼Ò, ÀûÇ÷±¸ ħ°¼Óµµ(ESR) »ó½Â, È£»ê±¸ Áõ°¡Áõ, ¹éÇ÷±¸ Áõ°¡Áõ, ¹«°ú¸³¼¼Æ÷Áõ, ¸²ÇÁ¼±Á¾, ÀÚ°¡¸é¿ªÁúȯÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù. ´Ù¸¥ ACE ÀúÇØÁ¦ÀΠİÅäÇÁ¸±¿¡ ÀÇÇÏ¿© ¹«°ú¸³¼¼Æ÷Áõ ¹× °ñ¼ö¾ïÁ¦°¡ ºñº´¹ß¼º ȯÀÚ¿¡¼´Â µå¹°°Ô ³ªÅ¸³ª³ª ½ÅÀå¾Ö ȯÀÚ (ƯÈ÷, ±³¿ø¼º Ç÷°üÁúȯÀÌ ÀÖ´Â)¿¡¼´Â ´õ ³ôÀº ºóµµ·Î ³ªÅ¸³µ´Ù. ÀÌ ¾àÀÌ ÀÌ¿Í À¯»çÇÑ ºóµµ·Î ¹«°ú¸³¼¼Æ÷ÁõÀ» ÀÏÀ¸Å°Áö ¾Ê´Â´Ù´Â °ÍÀ» ÀÔÁõÇÒ ¸¸ÇÑ ÀÚ·á´Â ÃæºÐÇÏÁö ¾ÊÀ¸¹Ç·Î ±³¿ø´Ü¹é Ç÷°üÁúȯ ¹× ½ÅÁúȯÀÌ Àִ ȯÀÚ´Â Á¤±âÀûÀ¸·Î ¹éÇ÷±¸ ¼ö¸¦ ÃøÁ¤¹Þ´Â´Ù.
¨è ÀÌ ¾àÀ» Åõ¿©¹ÞÀº ȯÀÚ¿¡¼ ÀûÇ÷±¸, Çì¸ð±Û·Îºó°ú Ç츶ÅäÅ©¸®Æ®°¡ ¾à°£ °¨¼ÒµÇ¾úÀ¸³ª, º¸Åë ºóÇ÷À» ÀÏÀ¸Å³ ¼ÒÁö°¡ ¾ø´Â ȯÀÚ¿¡¼´Â ÀÓ»óÀûÀ¸·Î Áß¿äÇÏÁö ¾Ê´Ù.
¨é ¿ëÇ÷¼ººóÇ÷, Ç÷¼ÒÆÇ °¨¼Ò°¡ ³ªÅ¸³¯ ¼ö ÀÖÀ¸¹Ç·Î °üÂûÀ» ÃæºÐÈ÷ Çϰí ÀÌ»óÀÌ ÀÎÁ¤µÇ´Â °æ¿ì¿¡´Â, ÀÌ ¾àÀÇ Åõ¿©¸¦ ÁßÁöÇÏ´Â µî ÀûÀýÇÑ Ã³Ä¡¸¦ ÇÑ´Ù.
11) ÇǺΠ¹× ºÎ¼Ó±â°è : õÆ÷âÀ» Æ÷ÇÔÇÏ´Â ½É°¢ÇÑ ÇǺÎÁúȯ, µ¶¼º ÇǺα«»ç, ÇǺÎÁ¡¸·¾ÈÁõÈıº(Stevens Johnson syndrome)ÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù.
12) °ú¹ÎÁõ : Å»¸ð, ´ÙÇüÈ«¹Ý, ¹ßÁø, °¡·Á¿òÁõ, µÎµå·¯±â, ´ë»óÆ÷Áø, ±¤°ú¹ÎÁõ, ¼Õ¹ßÅé ¹Ú¸®, °Ç¼± µîÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù.
13) ±âŸ : °¨°¢ÀÌ»ó, ¹èÅë(back pain), ½Ã·Â ºÒ¼±¸í µîÀÇ ½Ã°¢Àå¾Ö, °¡·Á¿ò, ÇǺιßÁø, ¿ä·Î°¨¿°Áõ, ÇÏÁö ¸Æ°ü¿°, û»öÁõ, ¿°¨, ¼³ÇÏ․ÀÔ¼ú․¼Õ°¡¶ô ¸¶ºñ°¨, ÇÇ·Î, Àϰú¼º ÇãÇ÷¹ßÀÛ, ·¹À̳ëÁõ»óÀÇ ¾ÇÈ, À̸í, ½Ã°¢Àå¾Ö, ¹Ì°¢ÀÌ»ó, Ç×ÇÙÇ×ü(ANA)¾ç¼º ¶§¶§·Î ±Çۨ, ¹«·Â°¨ÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù. ¶ÇÇÑ, ÀÌ ¾à°úÀÇ Àΰú°ü°è°¡ ºÒºÐ¸íÇÑ ÀÌ»ó¹ÝÀÀÀ¸·Î µå¹°°Ô °£È¿¼Ò, Ç÷ûºô¸®·çºóÀÇ Áõ°¡, ¿ëÇ÷¼º ºóÇ÷ÀÌ ³ªÅ¸³µ´Ù´Â º¸°í°¡ ÀÖ´Ù.
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1) ÀÌ´¢Á¦ ¶Ç´Â ¥â-Â÷´ÜÁ¦ µîÀÇ ´Ù¸¥ Ç÷¾Ð°ÇÏÁ¦¿Í º´¿ëÅõ¿©½Ã Ç÷¾Ð°ÇÏÀÛ¿ëÀÌ Áõ°¡ÇϹǷΠÁÖÀÇÇÑ´Ù. ±Û¸®¼¼¸± Æ®¸®´ÏÆ®·¹ÀÌÆ®¿Í ´Ù¸¥ Áú»ê¿° Á¦Á¦, ¶Ç´Â ´Ù¸¥ Ç÷°üÈ®ÀåÁ¦¸¦ º´¿ë Åõ¿©ÇÒ °æ¿ì Ç÷¾ÐÀÌ ´õ¿í °Ç쵃 ¼ö ÀÖ´Ù. ÀÌ ¾àÀ¸·Î Ä¡·á¸¦ ½ÃÀÛÇϱâ Àü¿¡ ÀÌ´¢Á¦ Åõ¿©¸¦ Áß´ÜÇÒ °æ¿ì ¾à¿¡ ÀÇÇØ Àü½Å ÀúÇ÷¾ÐÀÌ ¹ßÇöµÉ °¡´É¼ºÀ» ÃÖ¼ÒÈÇÒ ¼ö ÀÖ´Ù.
2) ¾Æ¼¼Æ¿»ì¸®½Ç»ê (1ÀÏ 3g ÀÌ»ó), Àεµ¸ÞŸ½Å µîÀÇ ºñ½ºÅ×·ÎÀ̵强 ¼Ò¿°ÁøÅëÁ¦ ¹× Ç×·ù¸¶Æ¼½º ¾à¹°°ú º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â Ç÷¾Ð°ÇÏÀÛ¿ëÀÌ ¾à°£ °¨¼ÒÇÏ¿´´Ù´Â º¸°í°¡ ÀÖ´Ù. NSAID°è ¾à¹°°ú ACE ÀúÇØÁ¦´Â Ç÷û Ä®·ý ¼öÄ¡ Áõ°¡¿¡ ÀÖ¾î »ó°¡Àû È¿°ú¸¦ ³ªÅ¸³»¸ç, ½Å±â´ÉÀ» ¾ÇȽÃų ¼ö ÀÖ´Ù. ÀÌ·¯ÇÑ È¿°ú´Â º¸Åë °¡¿ªÀûÀÌ´Ù. µå¹°°Ô, ±Þ¼º ½ÅºÎÀüÀÌ ³ªÅ¸³¯ ¼ö ÀÖÀ¸¸ç, ƯÈ÷ °í·É ¶Ç´Â Å»¼ö ȯÀÚ¿Í °°ÀÌ ½Å±â´ÉÀÌ ¾àÈµÈ °æ¿ì¿¡ ´õ¿í ±×·¯ÇÏ´Ù.
3) ACE ÀúÇØÁ¦¿Í Ç÷û Ä®·ýÀ» »ó½Â½ÃŰ´Â ¾à¹° (½ºÇǷγë¶ôÅæ, ¾Æ¹Ð·Î¶óÀ̵å, Æ®¸®¾ÏÅ×·» µîÀÇ Ä®·ýº¸Á¸¼º ÀÌ´¢Á¦, Ä®·ýº¸±ÞÁ¦, Ä®·ýÇÔÀ¯ ¿°´ë¿ëǰ, ÇìÆÄ¸° µî)À» º´¿ëÅõ¿© ¹Þ°í Àִ ȯÀÚ¿¡¼ °íÄ®·ýÇ÷ÁõÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù. ¶ÇÇÑ ÀÌ ¾àÀº Ä¡¾ÆÁþ°è ÀÌ´¢Á¦¿¡ ÀÇÇØ ÀϾ´Â Ä®·ý¼Õ½ÇÀ» °¨¼Ò½ÃŲ´Ù.
4) ¸®Æ¬°ú ACE ÀúÇØÁ¦¸¦ º´¿ëÇÏ´Â °æ¿ì¿¡´Â ¸®Æ¬µ¶¼ºÀÇ À§ÇèÀÌ ÀÖÀ¸¹Ç·Î Ç÷Áß ¸®Æ¬³óµµ¸¦ ½ÅÁßÈ÷ ¸ð´ÏÅÍÇÏ°í ¿ë·®À» Á¶ÀýÇÑ´Ù (¸®Æ¬ÀÇ ¹è¼³À» °¨¼Ò½ÃÄÑ Ç÷Áß ¸®Æ¬³óµµ°¡ Áõ°¡ÇÑ´Ù).
5) ¾ËÄڿðú º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â ¾ËÄÚ¿Ã ÀÛ¿ëÀÌ »ó½ÂÇÒ ¼ö ÀÖÀ¸¹Ç·Î ÁÖÀÇÇÑ´Ù.
6) ¸é¿ª¾ïÁ¦Á¦, ¼¼Æ÷Áõ½Ä¾ïÁ¦Á¦, ¾Ë·ÎǪ¸®³î, ÄÚ¸£Æ¼ÄÚÀ̵å¿Í º´¿ë Åõ¿©ÇÏ´Â °æ¿ì¿¡´Â Ç÷±¸¼öÀÇ º¯È°¡ ³ªÅ¸³ª¹Ç·Î ÁÖÀÇÇÑ´Ù.
7) ¿ªÇÐÀû ¿¬±¸ °á°ú, Àν¶¸° ¶Ç´Â °æ±¸¿ë Ç÷´ç°ÇÏÁ¦¿Í º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â Ç÷´ç °ÇÏÀÛ¿ëÀÌ Áõ°¡µÇ¾î ÀúÇ÷´çÀÇ À§Çèµµ°¡ Áõ°¡µÉ ¼ö ÀÖ´Ù´Â º¸°í°¡ ÀÖ´Ù. ÀÌ·¯ÇÑ Çö»óÀº º´¿ë Ä¡·á ù ÁÖ¿Í ½ÅºÎÀü ȯÀÚ¿¡¼ ´õ¿í Áõ°¡ÇÏ´Â °æÇâÀÌ ÀÖ´Ù.
8) ÀÌ ¾àÀ» ¸¶ÃëÁ¦ °è¿ÀÇ ¾à¹°, 3ȯ°è Ç׿ì¿ïÁ¦, ±×¸®°í Ç×Á¤½Åº´ ¾à¹°À» º´¿ë½Ã Ç÷¾ÐÀÌ ´õ¿í °Ç쵃 ¼ö ÀÖ´Ù.
9) ±³°¨½Å°æÈïºÐÁ¦´Â ACE ÀúÇØÁ¦ÀÇ °¾Ð È¿°ú¸¦ °¨¼Ò½Ãų ¼ö ÀÖ´Ù.
10) ÀÌ ¾àÀ» Áú»ê¿°, µð°î½Å, ÇÁ·ÎÇÁ¶ó³î·Ñ ¹× È÷µå·ÎŬ·Î·ÎÄ¡¾ÆÁþ, ¾Æ¼¼Æ¿»ì¸®½Ç»ê (½ÉÀåÇÐÀû ¿ë·®), Ç÷Àü¿ëÇØÁ¦, º£Å¸Â÷´ÜÁ¦¿Í º´¿ë½Ã ÀÓ»óÀûÀ¸·Î À¯ÇØÇÑ »óÈ£ÀÛ¿ëÀº ¾ø¾ú´Ù.
11) ¾ÈÁö¿ÀÅٽмö¿ëü Â÷´ÜÁ¦(ARB), ¾ÈÁö¿ÀÅٽŠÀüȯ È¿¼Ò(ACE) ¾ïÁ¦Á¦ ¶Ç´Â ·¹´Ñ¾ïÁ¦Á¦(¾Ë¸®½ºÅ°·»)ÀÇ º´¿ëÅõ¿©¿¡ ÀÇÇÑ ·¹´Ñ-¾ÈÁö¿ÀÅٽŰè(RAS)ÀÇ ÀÌÁßÂ÷´ÜÀº ÀúÇ÷¾Ð, ½Ç½Å, °íÄ®·ýÇ÷Áõ ¹× ½Å±â´ÉÀÇ ÀúÇÏ(±Þ¼º½ÅºÎÀüÁõ Æ÷ÇÔ)¿Í °°Àº ÀÌ»ó»ç·ÊÀÇ ºóµµ°¡ ·¹´Ñ-¾ÈÁö¿ÀÅٽŰè(RAS)¿¡ ¿µÇâÀ» ¹ÌÄ¡´Â ¾àÁ¦ÀÇ ´Üµ¶ »ç¿ë½Ã¿¡ ºñÇØ ³ô´Ù. ÀÌ ¾à°ú ·¹´Ñ¾ïÁ¦Á¦(¾Ë¸®½ºÅ°·») ÇÔÀ¯ Á¦Á¦ÀÇ º´¿ëÀº ±ÇÀåµÇÁö ¾ÊÀ¸¸ç, ´ç´¢º´À̳ª Áߵ¡ÁßÁõÀÇ ½ÅÀå¾Ö ȯÀÚ(GFR <60 ml/min/1.73§³)´Â º´¿ëÅõ¿©Çؼ´Â ¾ÈµÈ´Ù. ÀÌ ¾à°ú ¾ÈÁö¿ÀÅٽмö¿ëü Â÷´ÜÁ¦(ARB)ÀÇ º´¿ëÀº ±ÇÀåµÇÁö ¾ÊÀ¸¸ç, ´ç´¢º´¼º ½ÅÁõ ȯÀÚ´Â º´¿ëÅõ¿©Çؼ´Â ¾ÈµÈ´Ù.
12) mTOR(mammalian target of rapamycin) ÀúÇØÁ¦(¿¹, Å۽÷Ѹ®¹«½º, ½Ã·Ñ¸®¹«½º, ¿¡º£·Î¸®¹«½º)¿Í º´¿ëÅõ¿©Çϴ ȯÀÚ¿¡¼ Ç÷°üºÎÁ¾ÀÇ À§ÇèÀÌ Áõ°¡ÇÒ ¼ö ÀÖ´Ù.
13) ³×ÇÁ¸±¸®½Å(Neutral endopeptidase; NEP) ÀúÇØÁ¦(¿¹, »çÄíºñÆ®¸±, ¶ó¼¼Ä«µµÆ®¸±)¿Í º´¿ëÅõ¿©Çϴ ȯÀÚ¿¡¼ Ç÷°üºÎÁ¾ÀÇ À§ÇèÀÌ Áõ°¡ÇÒ ¼ö ÀÖ´Ù.
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[Lisinopril]
> [Lisinopril] CAS number/83915-83-7 ATC code/C09AA03 PubChem/5362119 DrugBank/APRD00560 Formula/C21H31N3O5 Mol. mass/405.488 g/mol Bioavailability/approx. 25%, but wide range between individuals (6 to 60%) Metabolism/None Excretion/Eliminated unchanged in Urine Pregnancy cat./
D - teratogenic Legal status/
℞ Prescription only Routes/? Protein binding/0
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| Mechanism of Action |
Lisinopril¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Lisinopril competes with angiotensin I for its binding site on the angiotensin-converting enzyme (ACE), an enzyme which converts angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II plasma levels result in decreased blood pressure and increased plasma renin activity. Baroreceptor reflex mechanisms, stimulated by the fall in blood pressure, release kininase II, an enzyme identical to ACE that degrades bradykinin, a vasodilator.
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| Pharmacology |
Lisinopril¿¡ ´ëÇÑ Pharmacology Á¤º¸ Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension, congestive heart failure (CHF), postmyocardial infarction, and diabetic nephropathy or retinopathy. Although it is the lysine ester of enalaprilat, the active form of the prodrug enalapril, lisinopril is active unchanged.
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| Protein Binding |
Lisinopril¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ Lisinopril does not appear to be bound to other serum proteins
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| Half-life |
Lisinopril¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 12 hours
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| Absorption |
Lisinopril¿¡ ´ëÇÑ Absorption Á¤º¸ Approximately 25%, but widely variable between individuals (6 to 60%)
|
| Pharmacokinetics |
LisinoprilÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á
- ÃÖ´ëÈ¿°ú ¹ßÇö½Ã°£ : 6½Ã°£ À̳»
- Èí¼ö : Àß Èí¼öµÊ. À½½ÄÀÇ ¿µÇâÀ» ¹ÞÁö ¾ÊÀ½.
- ´Ü¹é°áÇÕ : 25%
- ¹Ý°¨±â : 11-12 ½Ã°£
- ¼Ò½Ç : °ÅÀÇ ¸ðµÎ°¡ ¹Ìº¯Èü·Î ´¢¸¦ ÅëÇØ ¹è¼³µÊ.
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| Biotransformation |
Lisinopril¿¡ ´ëÇÑ Biotransformation Á¤º¸ Lisinopril does not undergo metabolism and is excreted unchanged entirely in the urine
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| Toxicity |
Lisinopril¿¡ ´ëÇÑ Toxicity Á¤º¸ hypotension, LD50= 2000 mg/kg(orally in rat)
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| Drug Interactions |
Lisinopril¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Amiloride Increased risk of hyperkaliemiaTriamterene Increased risk of hyperkaliemiaSpironolactone Increased risk of hyperkaliemiaPotassium Increased risk of hyperkaliemiaDrospirenone Increased risk of hyperkaliemiaClozapine Increases the effect and toxicity of clozapineLithium The ACE inhibitor increases serum levels of lithiumTizanidine Tizanidine increases the risk of hypotension with the ACE inhibitor
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CYP450 Drug Interaction |
[CYP450 TableÁ÷Á¢Á¶È¸]
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| Food Interaction |
Lisinopril¿¡ ´ëÇÑ Food Interaction Á¤º¸ Avoid alcohol.Avoid excess salt/sodium unless otherwise instructed by your physician.Avoid salt substitutes containing potassium.Avoid natural licorice.Take without regard to meals.
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| Drug Target |
[Drug Target]
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| Description |
Lisinopril¿¡ ´ëÇÑ Description Á¤º¸ One of the angiotensin-converting enzyme inhibitors (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure. [PubChem]
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| Drug Category |
Lisinopril¿¡ ´ëÇÑ Drug_Category Á¤º¸ Angiotensin-converting Enzyme InhibitorsAntihypertensive AgentsCardiotonic Agents
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| Smiles String Canonical |
Lisinopril¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ NCCCCC(NC(CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCCC1C(O)=O
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| Smiles String Isomeric |
Lisinopril¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ NCCCC[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O
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| InChI Identifier |
Lisinopril¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17-,18-/m0/s1/f/h26,28H
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| Chemical IUPAC Name |
Lisinopril¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ (2S)-1-[(2S)-6-amino-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
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| Drug-Induced Toxicity Related Proteins |
LISINOPRIL ÀÇ Drug-Induced Toxicity Related ProteinÁ¤º¸ Replated Protein:Angiotensin-converting enzyme(ACE) Drug:Lisinopril Toxicity:blood-pressure reduction and reduction in left ventricular mass. [¹Ù·Î°¡±â] Replated Protein:B2 bradykinin receptor Drug:Lisinopril Toxicity:cough. [¹Ù·Î°¡±â]
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ÀüÈ: 02-3486-1061 ¤Ó À̸ÞÀÏ: webmaster@druginfo.co.kr
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The database contains the following fields: The generic name of each chemical For module A10 (liver enzyme composite module): Overall activity category for each compound (A for active, M for marginally active, or I for inactive) based on the number of active and marginally active scores for each compound at the five individual endpoints (see research article for full description of method) Number of endpoints at which each compound is marginally active (M) Number of endpoints at which each compound is active (A) For modules A11 to A15 (alkaline phosphatase increased, SGOT increased, SGPT increased, LDH increased, and GGT increased, respectively): Overall activity category for each compound (A for active, M for marginally active, or I for inactive) based on the RI and ADR values (see the research article for full description of method) Number of ADR reports for each compound, given as <4 or ¡Ã4 Reporting Index value for each compound, except where no shipping units were available (NSU) Group 1 comprises of compounds for which ADR data were available for the first five years of marketing, so when no ADR reports were listed during this period the compounds were evaluated as inactive. Group 2 comprises of compounds for which a 'steady state' period of ADR data were available (1992-1996). In cases where no ADR reports were filed during this period, the compounds were scored as 'NA' (data not available) since they may have had one or more ADR reports during their first five years of marketing which should not be negated by a lack of ADR reports during the steady-state period. LISINOPRIL[GGT Increase][Composite Activity](Score) I(Marginal) 0(Active) 0[Alkaline Phosphatase Increase](Activity Score) I(Number of Rpts) ¡Ã4(Index value) 2[SGOT Increase](Activity Score) I(Number of Rpts) ¡Ã4(Index value) 1.5[SGPT Increase](Activity Score) I(Number of Rpts) ¡Ã4(Index value) 1.4[LDH Increase](Activity Score) I(Number of Rpts) ¡Ã4(Index value) 1.2[GGT Increase](Activity Score) I(Number of Rpts) ¡Ã4(Index value) 1
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