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The database contains the following fields:
The generic name of each chemical
For module A10 (liver enzyme composite module):
Overall activity category for each compound (A for active, M for marginally active, or I for inactive) based on the number of active and marginally active scores for each compound at the five individual endpoints (see research article for full description of method)
Number of endpoints at which each compound is marginally active (M)
Number of endpoints at which each compound is active (A)
For modules A11 to A15 (alkaline phosphatase increased, SGOT increased, SGPT increased, LDH increased, and GGT increased, respectively):
Overall activity category for each compound (A for active, M for marginally active, or I for inactive) based on the RI and ADR values (see the research article for full description of method)
Number of ADR reports for each compound, given as <4 or ¡Ã4
Reporting Index value for each compound, except where no shipping units were available (NSU)
Group 1 comprises of compounds for which ADR data were available for the first five years of marketing, so when no ADR reports were listed during this period the compounds were evaluated as inactive. Group 2 comprises of compounds for which a 'steady state' period of ADR data were available (1992-1996). In cases where no ADR reports were filed during this period, the compounds were scored as 'NA' (data not available) since they may have had one or more ADR reports during their first five years of marketing which should not be negated by a lack of ADR reports during the steady-state period.
LORATADINE
[GGT Increase]
[Composite Activity]
(Score)  I
(Marginal)  0
(Active)  0

[Alkaline Phosphatase Increase]
(Activity Score)  I
(Number of Rpts)  ¡Ã4
(Index value)  0.7

[SGOT Increase]
(Activity Score)  I
(Number of Rpts)  ¡Ã4
(Index value)  0.9

[SGPT Increase]
(Activity Score)  I
(Number of Rpts)  ¡Ã4
(Index value)  0.6

[LDH Increase]
(Activity Score)  I
(Number of Rpts)  <4
(Index value)  0.2

[GGT Increase]
(Activity Score)  I
(Number of Rpts)  ¡Ã4
(Index value)  0.5

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