Cimetidine¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
Pharmacology
Cimetidine¿¡ ´ëÇÑ Pharmacology Á¤º¸ Cimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Cimetidine¿¡ ´ëÇÑ Toxicity Á¤º¸ Symptoms of overdose include nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat.
Drug Interactions
Cimetidine¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Alfentanil Increases the effect of the narcoticAlprazolam Increases the effect of the benzodiazepineAminophylline Increases the effect of theophyllineAmitriptyline Increases the effect of tricyclic agentAmoxapine Increases the effect of tricyclic agentAnisindione The ANTI-H2 increases the anticoagulant effectAstemizole Increased risk of cardiotoxicity and arrhythmiasAtazanavir This gastric pH modifier decreases the levels/effects of atazanavirCarbamazepine Increases the effect of carbamazepineCarmustine Increases myelosuppression caused by carmustineChlordiazepoxide Increases the effect of the benzodiazepineClomipramine Increases the effect of tricyclic agentClonazepam Increases the effect of the benzodiazepineClorazepate Increases the effect of the benzodiazepineClozapine Increases the effect of clozapineCodeine Increases the effect of the narcoticDesipramine Increases the effect of tricyclic agentDiazepam Increases the effect of the benzodiazepineDicumarol The anti-H2 increases the anticoagulant effectDihydroquinidine barbiturate Increases the effect of quinidineDyphylline Increases the effect of theophyllineDofetilide Increases effect/toxicity of dofetilideDonepezil Possible antagonism of actionDoxepin Increases the effect of tricyclic agentDyphylline Increases the effect of theophyllineEnoxacin The agent decreases the absorption of enoxacinEpirubicin Cimetidine can increase epirubicin levelsEstazolam Increases the effect of the benzodiazepineEthotoin Increases the effect of hydantoinFentanyl Increases the effect of the narcoticFlecainide Increases serum levels of flecainideFluorouracil Increases the effect of and toxicity of fluorouacilFlurazepam Increases the effect of the benzodiazepineFosphenytoin Increases the effect of hydantoinGalantamine Possible antagonism of actionHalazepam Increases the effect of the benzodiazepineHydrocodone Increases the effect of the narcoticHydromorphone Increases the effect of the narcoticImipramine Increases the effect of tricyclic agentItraconazole The anti-H2 decreases the absorption of the imidazoleLevorphanol Increases the effect of the narcoticKetoconazole The anti-H2 decreases the absorption of the imidazoleLidocaine Increases the effect and toxicity of lidocaineMeperidine Increases the effect of the narcoticMephenytoin Increases the effect of hydantoinMetformin Increases the effect of metforminMethadone Increases the effect of the narcoticMetoprolol Increases the effect of the beta-blockerMidazolam Increases the effect of the benzodiazepineMoclobemide Increases the effect of moclobemideMorphine Increases the effect of the narcoticNalbuphine Increases the effect of the narcoticAcenocoumarol The anti-H2 increases the anticoagulant effectNimodipine Increases the effect of the calcium channel blockerNifedipine Increases the effect of the calcium channel blockerNitrendipine Increases the effect of the calcium channel blockerNortriptyline Increases the effect of tricyclic agentOxtriphylline Increases the effect of theophyllineOxycodone Increases the effect of the narcoticOxymorphone Increases the effect of the narcoticPentazocine Increases the effect of the narcoticPhenytoin Increases the effect of hydantoinPosaconazole Significant decrease of posaconazole levelsPramipexole Increases the effect and toxicity of pramipexolePropoxyphene Increases the effect of the narcoticProcainamide The histamine H2-receptor antagonist increases the effect of procainamidePropranolol Increases the effect of the beta-blockerProtriptyline Increases the effect of tricyclic agentQuinidine Increases the effect of quinidineQuinidine barbiturate Increases the effect of quinidineRivastigmine Possible antagonism of actionSildenafil Increases the effect and toxicity of sildenafilSufentanil Increases the effect of the narcoticTacrine Increases the effect and toxicity of tacrineTerfenadine Increased risk of cardiotoxicity and arrhythmiasTheophylline Increases the effect of theophyllineTimolol Increases the effect of the beta-blockerTolazoline Anticipated loss of efficacy of tolazolineTriazolam Increases the effect of the benzodiazepineTrimipramine Increases the effect of tricyclic agentWarfarin The anti-H2 increases the anticoagulant effectZaleplon Increases the effect and toxicity of zaleplonHeroin Cimetidine increases the effect of the narcoticKetazolam Cimetidine increases the effect of the benzodiazepineLabetalol Cimetidine increases the effect of the beta-blockerPrazepam Cimetidine increases the effect of the benzodiazepineQuazepam Cimetidine increases the effect of the benzodiazepine
Cimetidine¿¡ ´ëÇÑ Description Á¤º¸ A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. [PubChem]