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                    Åäºñ·ÕÁ¡¾È¾×  TOBILONG EYE DROP[Allantoin , Chlorpheniramine Maleate , Chondroitin Sodium Sulfate , Dipotassium glycyrrhizinate , Neostigmine   
                    
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    | µ¶¼ºÁ¤º¸ | 
    Chlorpheniramine¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
Magnesium¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
Potassium¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
Pyridoxine¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
  Ãâó: ±¹¸³µ¶¼º°úÇпø µ¶¼º¹°ÁúÁ¤º¸DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do  | 
   
  
   
    | Mechanism of Action | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
  Neostigmine¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It does not cross the blood-brain barrier.
  Potassium¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential?”a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.
  magnesium¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Not Available
  Pyridoxine¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA). 
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    | Pharmacology | 
     
       Chlorpheniramine¿¡ ´ëÇÑ Pharmacology Á¤º¸ In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
  Neostigmine¿¡ ´ëÇÑ Pharmacology Á¤º¸ Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
  Potassium¿¡ ´ëÇÑ Pharmacology Á¤º¸ Not Available
  Pyridoxine¿¡ ´ëÇÑ Pharmacology Á¤º¸ Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities. 
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    | Protein Binding | 
    
       Chlorpheniramine¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ 72%
  Neostigmine¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ Protein binding to human serum albumin ranges from 15 to 25 percent.
  Pyridoxine¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ 22% 
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    | Half-life | 
    
       Chlorpheniramine¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 21-27 hours
  Neostigmine¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ The half-life ranged from 42 to 60 minutes with a mean half-life of 52 minutes.
  Pyridoxine¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 15-20 days 
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    | Absorption | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Absorption Á¤º¸ Well absorbed in the gastrointestinal tract.
  Neostigmine¿¡ ´ëÇÑ Absorption Á¤º¸ Neostigmine bromide is poorly absorbed from the gastrointestinal tract following oral administration
  Potassium¿¡ ´ëÇÑ Absorption Á¤º¸ Not Available
  Pyridoxine¿¡ ´ëÇÑ Absorption Á¤º¸ The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum. 
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    | Pharmacokinetics | 
    
       Pyridoxine HClÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
- Èí¼ö : À§Àå°üÀ¸·ÎºÎÅÍ Àß Èí¼öµÈ´Ù.
 - ´ë»ç : °£¿¡¼ 4-pyridoxic acid·Î ´ë»çµÈ´Ù.
 - ¹Ý°¨±â : 15-20ÀÏ
 - Ç÷ÁßÃÖ°í³óµµ µµ´Þ½Ã°£ : °æ±¸ : 1.25 ½Ã°£
 - ¼Ò½Ç : 4-pyridoxic acid·Î ½Å¹è¼³µÇ¸ç, ¼Ò·® (¾à 2%)Àº ´ãÁóÀ» ÅëÇØ ¹è¼³µÈ´Ù.
  
 Neostigmine MethylsulfateÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
- ÀÛ¿ë¹ßÇö½Ã°£ :
	
	- °æ±¸ : 45-75ºÐ
	
 - ±ÙÀ°ÁÖ»ç : 20-30ºÐ
	
 - Á¤¸ÆÁÖ»ç : 4-8ºÐ
	
  
 - ÀÛ¿ëÁö¼Ó½Ã°£ : °æ±¸, ±ÙÀ°ÁÖ»ç, Á¤¸ÆÁÖ»ç : 2-4 ½Ã°£
 - Èí¼ö : °æ±¸ : Àß Èí¼öµÇÁö ¾ÊÀ½ (2% À̳»)
 - ´Ü¹é°áÇÕ : 15-25%
 - ´ë»ç : Cholinesterase¿¡ ÀÇÇØ °¡¼öºÐÇØ, °£¿¡¼ ´ë»çµÊ
 - ¹Ý°¨±â : Á¤»ó ½Å±â´É : 0.5-2.1 ½Ã°£  (¸»±â½ÅÁúȯ¿¡¼´Â ¿¬ÀåµÊ)
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 Chlorpheniramine MaleateÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
	- ´Ü¹é°áÇÕ : 69-72%
	
 - ´ë»ç : °£´ë»ç
	
 - ¹Ý°¨±â : 20-24 ½Ã°£
	
 - ¼Ò½Ç : ´ë»çü, ¾à¹°(3-4%)ÀÌ ½Å¹è¼³µÇ¸ç, 48½Ã°£³»¿¡ ÀüüÀÇ 35%°¡ ¼Ò½ÇµÈ´Ù.
  
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    | Biotransformation | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Biotransformation Á¤º¸ Primarily hepatic via Cytochrome P450 (CYP450) enzymes.
  Neostigmine¿¡ ´ëÇÑ Biotransformation Á¤º¸ Neostigmine undergoes hydrolysis by cholinesterase and is also metabolized by microsomal enzymes in the liver. 
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    | Toxicity | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Toxicity Á¤º¸ LD50 = 306 mg/kg in humans, mild reproductive toxin to women of childbearing age.
  Neostigmine¿¡ ´ëÇÑ Toxicity Á¤º¸ Overdosage of Neostigmine can cause cholinergic crisis, which is characterized by increasing muscle weakness, and through involvement of the muscles of respiration, may result in death. The LD 50 of neostigmine methylsulfate in mice is 0.3 ¡¾ 0.02 mg/kg intravenously, 0.54 ¡¾ 0.03 mg/kg subcutaneously, and 0.395 ¡¾ 0.025 mg/kg intramuscularly; in rats the LD 50 is 0.315 ¡¾ 0.019 mg/kg intravenously, 0.445 ¡¾ 0.032 mg/kg subcutaneously, and 0.423 ¡¾ 0.032 mg/kg intramuscularly.
  Potassium¿¡ ´ëÇÑ Toxicity Á¤º¸ Not Available
  Pyridoxine¿¡ ´ëÇÑ Toxicity Á¤º¸ Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness. 
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    | Drug Interactions | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Donepezil	Possible antagonism of actionGalantamine	Possible antagonism of actionRivastigmine	Possible antagonism of actionEthotoin	The antihistamine increases the effect of hydantoinFosphenytoin	The antihistamine increases the effect of hydantoinMephenytoin	The antihistamine increases the effect of hydantoinPhenytoin	The antihistamine increases the effect of hydantoin
  Neostigmine¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available
  Potassium¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Amiloride	Increased risk of hyperkaliemiaBenazepril	Increased risk of hyperkaliemiaCandesartan	Increased risk of hyperkaliemiaCaptopril	Increased risk of hyperkaliemiaCilazapril	Increased risk of hyperkaliemiaDrospirenone	Increased risk of hyperkaliemiaEnalapril	Increased risk of hyperkaliemiaEplerenone	This association presents an increased risk of hyperkaliemiaEprosartan	Increased risk of hyperkaliemiaForasartan	Increased risk of hyperkaliemiaFosinopril	Increased risk of hyperkaliemiaIrbesartan	Increased risk of hyperkaliemiaLisinopril	Increased risk of hyperkaliemiaLosartan	Increased risk of hyperkaliemiaMoexipril	Increased risk of hyperkaliemiaPerindopril	Increased risk of hyperkaliemiaPolystyrene sulfonate	Antagonism of actionQuinapril	Increased risk of hyperkaliemiaRamipril	Increased risk of hyperkaliemiaSaprisartan	Increased risk of hyperkaliemiaSpirapril	Increased risk of hyperkaliemiaSpironolactone	Increased risk of hyperkaliemiaTasosartan	Increased risk of hyperkaliemiaTelmisartan	Increased risk of hyperkaliemiaTrandolapril	Increased risk of hyperkaliemiaTriamterene	Increased risk of hyperkaliemiaValsartan	Increased risk of hyperkaliemia
  magnesium¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Alendronate	Formation of non-absorbable complexesCiprofloxacin	Formation of non-absorbable complexesClodronate	Formation of non-absorbable complexesDemeclocycline	Formation of non-absorbable complexesDoxycycline	Formation of non-absorbable complexesEnoxacin	Formation of non-absorbable complexesEtidronic acid	Formation of non-absorbable complexesGatifloxacin	Formation of non-absorbable complexesGemifloxacin	Formation of non-absorbable complexesGrepafloxacin	Formation of non-absorbable complexesIbandronate	Formation of non-absorbable complexesLevofloxacin	Formation of non-absorbable complexesLomefloxacin	Formation of non-absorbable complexesMethacycline	Formation of non-absorbable complexesMinocycline	Formation of non-absorbable complexesMoxifloxacin	Formation of non-absorbable complexesNorfloxacin	Formation of non-absorbable complexesOfloxacin	Formation of non-absorbable complexesOxytetracycline	Formation of non-absorbable complexesPefloxacin	Formation of non-absorbable complexesRisedronate	Formation of non-absorbable complexesTrovafloxacin	Formation of non-absorbable complexesTetracycline	Formation of non-absorbable complexesTemafloxacin	Formation of non-absorbable complexesAmprenavir	The antiacid decreases the absorption of amprenavirChloroquine	The antiacid decreases the absorption of chloroquineAtazanavir	This gastric pH modifier decreases the levels/effects of atazanavirDelavirdine	The antiacid decreases the absorption of delavirdineDihydroquinidine barbiturate	The antiacid decreases the absorption of quinidineFosamprenavir	The antiacid decreases the absorption of amprenavirIndinavir	The antiacid decreases the absorption of indinavirQuinidine	The antiacid decreases the absorption of quindineQuinidine barbiturate	The antiacid decreases the absorption of quinidinePolystyrene sulfonate	Risk of alkalosis in renal impairmentRosuvastatin	The antiacid decreases the absorption of rosuvastatin
  Pyridoxine¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available 
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    CYP450  Drug Interaction | 
    
      [CYP450 TableÁ÷Á¢Á¶È¸] Chlorpheniramine¿¡ ´ëÇÑ P450 table
  SUBSTRATES 
CYP 2D6 
Beta Blockers: 
S-metoprolol 
propafenone 
timolol 
Antidepressants: 
amitriptyline 
clomipramine 
desipramine 
imipramine 
paroxetine 
Antipsychotics: 
haloperidol 
risperidone 
thioridazine 
aripiprazole 
codeine 
dextromethorphan 
duloxetine 
flecainide 
mexiletine 
ondansetron 
tamoxifen 
tramadol 
venlafaxine 
 INHIBITORS 
CYP 2D6 
amiodarone 
buproprion 
**chlorpheniramine** 
cimetidine 
clomipramine 
duloxetine 
fluoxetine 
haloperidol 
methadone 
mibefradil 
paroxetine 
quinidine 
ritonavir 
 INDUCERS 
CYP 2D6 
N/A 
 
     | 
   
  
   
    | Description | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Description Á¤º¸ A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]
  Neostigmine¿¡ ´ëÇÑ Description Á¤º¸ A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. [PubChem]
  Potassium¿¡ ´ëÇÑ Description Á¤º¸ Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential?”a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.
  magnesium¿¡ ´ëÇÑ Description Á¤º¸ Magnesium hydroxide is used primarily in "Milk of Magnesia", a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents.
  Pyridoxine¿¡ ´ëÇÑ Description Á¤º¸ The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.  Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). [PubChem] 
     | 
   
  
   
    | Dosage Form | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Syrup	OralTablet	OralTablet, extended release	Oral
  Neostigmine¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Liquid	IntramuscularLiquid	IntravenousTablet	Oral
  Potassium¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Aerosol	OralCapsule	OralCapsule, extended release	OralElixir	OralLiquid	IntravenousLiquid	OralLiquid	SublingualPowder	OralPowder, for solution	OralSolution	IntravenousSolution	OralSolution / drops	OralTablet	OralTablet, extended release	Oral
  magnesium¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Aerosol	OralCapsule	OralLiquid	IntramuscularLiquid	IntravenousLiquid	OralOintment	TopicalPellet	OralPowder	OralSolution	IntramuscularSolution	IntravenousSolution	OralSolution / drops	OralSuspension	OralSyrup	OralTablet	Oral
  Pyridoxine¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Liquid	IntramuscularSolution	IntramuscularSolution / drops	OralTablet	Oral 
     | 
   
  
   
    | Drug Category | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Drug_Category Á¤º¸ Anti-Allergic AgentsAntihistaminesAntipruriticsHistamine H1 Antagonists
  Neostigmine¿¡ ´ëÇÑ Drug_Category Á¤º¸ Cholinesterase InhibitorsParasympathomimetics
  magnesium¿¡ ´ëÇÑ Drug_Category Á¤º¸ Not Available
  Pyridoxine¿¡ ´ëÇÑ Drug_Category Á¤º¸ Anti-inflammatory AgentsEssential VitaminVitamin B ComplexVitamins (Vitamin B Complex) 
     | 
   
  
   
    | Smiles String Canonical | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1
  Neostigmine¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CN(C)C(=O)OC1=CC(=CC=C1)[N+](C)(C)C
  Potassium¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ Not Available
  magnesium¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ [Mg++]
  Pyridoxine¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CC1=NC=C(CO)C(CO)=C1O 
     | 
   
  
   
    | Smiles String Isomeric | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CN(C)CC[C@H](C1=CC=C(Cl)C=C1)C1=CC=CC=N1
  Neostigmine¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CN(C)C(=O)OC1=CC(=CC=C1)[N+](C)(C)C
  Potassium¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ Not Available
  magnesium¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ [Mg++]
  Pyridoxine¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CC1=NC=C(CO)C(CO)=C1O 
     | 
   
  
   
    | InChI Identifier | 
    
       Chlorpheniramine¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
  Neostigmine¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1
  Potassium¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ Not Available
  magnesium¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/Mg/q+2
  Pyridoxine¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3 
     | 
   
  
   
    | Chemical IUPAC Name | 
    
       Chlorpheniramine¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
  Neostigmine¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium
  Potassium¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ Not Available
  magnesium¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ magnesium(+2) cation
  Pyridoxine¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol 
     | 
   
  
   
    | Drug-Induced Toxicity Related Proteins | 
    
      MALEATE ÀÇ Drug-Induced Toxicity Related ProteinÁ¤º¸ Replated Protein:Intercellular adhesion molecule 1  Drug:maleate Toxicity:hepatic injury.  [¹Ù·Î°¡±â] 
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