드러그인포 약품요약정보 - 리카엘연질캅셀

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

비급여
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

유백색의 내용물이든 진한갈색의 장방형 연질캅셀 [제형정보 확인]

포장·유통단위

300C

효능효과

[적응증 별 검색]

간기능 저하로 인한 소화불량의 보조치료

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
성인 통상 1일 4캅셀을 분복한다.
※복용시 참고사항

아침에 2캅셀, 저녁에 2캅셀씩 복용한다.

식사전·후와 관계없으나 가급적 식사 1시간전에 복용하는 것이 약물 흡수가 더 잘 된다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

[복용을 잊은 경우 대처법]

신중투여

시스틴뇨증 환자

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	담즙산분비촉진제 & 간보호제 (Cholelitholitics & Hepatic Protectors)
ATC 코드	Liver therapy / A05BA [코드분류상세설명] [ATC코드예측]
복지부분류코드	399 (따로 분류되지 않는 대사성 의약품 )
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	비급여 [상병코드조회] [질병코드집 다운로드]
제품성상	유백색의 내용물이든 진한갈색의 장방형 연질캅셀 [제형정보 확인]
포장·유통단위	300C
보관방법	기밀용기, 실온보관, 24개월

복약정보

항목	내용
LACTmed 바로가기	[바로가기]
약리작용	유료정보입니다.
복약지도	유료정보입니다.
병용금기 및 연령대금기 근거조회	[병용금기 및 연령대금기 근거조회]
보관상 주의
조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
Mechanism of Action	Choline에 대한 Mechanism_Of_Action 정보 Choline is a major part of the polar head group of phosphatidylcholine. Phosphatidylcholine's role in the maintenance of cell membrane integrity is vital to all of the basic biological processes: information flow, intracellular communication and bioenergetics. Inadequate choline intake would negatively affect all these processes. Choline is also a major part of another membrane phospholipid, sphingomyelin, also important for the maintenance of cell structure and function. It is noteworthy and not surprising that choline deficiency in cell culture causes apoptosis or programmed cell death. This appears to be due to abnormalities in cell membrane phosphatidylcholine content and an increase in ceramide, a precursor, as well as a metabolite, of sphingomyelin. Ceramide accumulation, which is caused by choline deficiency, appears to activate Caspase, a type of enzyme that mediates apoptosis. Betaine or trimethylglycine is derived from choline via an oxidation reaction. Betaine is one of the factors that maintains low levels of homocysteine by resynthesizing L-methionine from homocysteine. Elevated homocysteine levels are a significant risk factor for atherosclerosis, as well as other cardiovascular and neurological disorders. Acetylcholine is one of the major neurotransmitters and requires choline for its synthesis. Adequate acetylcholine levels in the brain are believed to be protective against certain types of dementia, including Alzheimer's disease. L-cysteine에 대한 Mechanism_Of_Action 정보 Although classified as a non-essential amino acid cysteine may be essential for infants, the elderly, and individuals with certain metabolic disease or who suffer from malabsorption syndromes. Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Due to the ability of thiols to undergo redox reactions, cysteine has antioxidant properties. Cysteine's antioxidant properties are typically expressed in the tripeptide glutathione, which occurs in humans as well as other organisms. The systemic availability of oral glutathione (GSH) is negligible; so it must be biosynthesized from its constituent amino acids, cysteine, glycine, and glutamic acid. Glutamic acid and glycine are readily available in the diets of most industrialized countries, but the availability of cysteine can be the limiting substrate. Cysteine is also an important source of sulfide in human metabolism. The sulfide in iron-sulfur clusters and in nitrogenase is extracted from cysteine, which is converted to alanine in the process. In a 1994 report released by five top cigarette companies, cysteine is one of the 599 additives to cigarettes. Its use or purpose, however, is unknown, like most cigarette additives. Its inclusion in cigarettes could offer two benefits: Acting as an expectorant, since smoking increases mucus production in the lungs; and increasing the beneficial antioxidant glutathione (which is diminished in smokers).
Pharmacology	Choline에 대한 Pharmacology 정보 This compound is needed for good nerve conduction throughout the CNS (central nervous system) as it is a precursor to acetylcholine (ACh). Choline is also needed for gallbladder regulation, liver function and lecithin (a key lipid) formation. Choline also aids in fat and cholesterol metabolism and prevents excessive fat build up in the liver. Choline has been used to mitigate the effects of Parkinsonism and tardive dyskinesia. Choline deficiencies may result in excessive build-up of fat in the liver, high blood pressure, gastric ulcers, kidney and liver dysfunction and stunted growth. L-cysteine에 대한 Pharmacology 정보 Due to this ability to undergo redox reactions, cysteine has antioxidant properties. Cysteine is an important source of sulfur in human metabolism, and although it is classified as a non-essential amino acid, cysteine may be essential for infants, the elderly, and individuals with certain metabolic disease or who suffer from malabsorption syndromes. Cysteine may at some point be recognized as an essential or conditionally essential amino acid.
Metabolism	Choline에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cholinesterase L-cysteine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Not Available
Absorption	Choline에 대한 Absorption 정보 Not Available
Biotransformation	L-cysteine에 대한 Biotransformation 정보 Not Available
Toxicity	Choline에 대한 Toxicity 정보 Oral rat LD₅₀: 3400 mg/kg L-cysteine에 대한 Toxicity 정보 Not Available
Drug Interactions	Choline에 대한 Drug_Interactions 정보 Not Available L-cysteine에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회]
Drug Target	[Drug Target]
Description	Choline에 대한 Description 정보 A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [PubChem] L-cysteine에 대한 Description 정보 A thiol-containing non-essential amino acid that is oxidized to form cystine. [PubChem]
Dosage Form	Choline에 대한 Dosage_Form 정보 Tablet Oral L-cysteine에 대한 Dosage_Form 정보 Not Available
Drug Category	Choline에 대한 Drug_Category 정보 Dietary supplementLipotropic AgentsMicronutrientNootropic Agents L-cysteine에 대한 Drug_Category 정보 Dietary supplementNutritional Supplement
Smiles String Canonical	Choline에 대한 Smiles_String_canonical 정보 C[N+](C)(C)CCO L-cysteine에 대한 Smiles_String_canonical 정보 NC(CS)C(O)=O
Smiles String Isomeric	Choline에 대한 Smiles_String_isomeric 정보 C[N+](C)(C)CCO L-cysteine에 대한 Smiles_String_isomeric 정보 N[C@@H](CS)C(O)=O
InChI Identifier	Choline에 대한 InChI_Identifier 정보 InChI=1/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 L-cysteine에 대한 InChI_Identifier 정보 InChI=1/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1/f/h5H
Chemical IUPAC Name	Choline에 대한 Chemical_IUPAC_Name 정보 2-hydroxyethyl-trimethylazanium L-cysteine에 대한 Chemical_IUPAC_Name 정보 (2R)-2-amino-3-sulfanylpropanoic acid

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