드러그인포 약품요약정보

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

644000081[644000080] [보험코드에 따른 약품기본정보 직접조회]
[비급여]
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

감미를 가진 엷은 황색의 시럽제 [제형정보 확인]

포장·유통단위

6mL/포 *2

주성분코드

E46500ASY [동일한 주성분코드를 가진 오리지날 또는 제네릭 의약품 조회]

허가사항 원문조회

[허가사항 원문조회]

효능효과

[적응증 별 검색]

멀미에 의한 어지러움·구토·두통의 예방 및 완화

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
만 15세 이상 : 1회 1포 (6mL)
만 13세 이상 ～ 만 15세 미만 : 1회 ⅔포 (4mL)
멀미의 예방에는 승차 30분 전에 1회 복용량을 복용한다. 또 필요시 추가복용 할 경우에는 1회 복용량을 4시간 이상의 간격을 두고 복용한다. 1일 복용횟수는 3회를 한도로 한다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

금기

(1) 만 3세 미만의 영ㆍ유아

(2) 만 12 세 이하의 어린이

신중투여

(1) 약으로 알레르기 증상(발진,충혈되어 붉어짐, 가려움 등)을 일으킨 일이 있는 사람

(2) 임부 또는 임신하고 있을 가능성이 있는 여성, 수유부

(3) 녹내장(눈의 통증, 눈의 침침함 등) 환자, 배뇨장애 환자

(4) 다른 약물을 복용하고 있는 사람

(5) 폐기종 혹은 만성 기관지염과 같은 호흡기 질환을 앓고 있는 환자

(6) 고령자(일반적으로 고령자는 생리기능이 저하되어 있으므로 감량하는 등 주의한다.)

이상반응

다음과 같은 경우 이 약의 복용을 즉각 중지하고 의사, 치과의사, 약사와 상의할 것.상담시 가능한한 이 첨부문서를 소지할 것.

(1) 이 약을 복용함으로써 발진, 충혈되서 붉어짐, 가려움 등이 나타날 경우

(2) 이 약을 복용로써 구갈(목마름)이 나타나는 경우

[주요 이상반응정보]

상호작용

이 약을 복용하는 동안 다음의 약을 복용(사용)하지 말 것

(1) 다른 진토제, 감기약, 해열진통제, 항히스타민제, 진정제, 진해거담제 등

Off-label Usage

[조회]

Related FDA Approved Drug

기준 성분:PYRIDOXINE HYDROCHLORIDE
BENDECTIN (DOXYLAMINE SUCCINATE; PYRIDOXINE HYDROCHLORIDE)
BEROCCA PN (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN E)
HEXA-BETALIN (PYRIDOXINE HYDROCHLORIDE)
INFUVITE ADULT (ALPHA-TOCOPHEROL ACETATE; ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN K)
M.V.C. 9+3 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I. ADULT (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K)
M.V.I. ADULT (PHARMACY BULK PACKAGE) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K)
M.V.I. PEDIATRIC (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I.-12 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
M.V.I.-12 (WITHOUT VITAMIN K) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
MVC PLUS (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E)
PYRIDOXINE HYDROCHLORIDE (PYRIDOXINE HYDROCHLORIDE)
TPN (NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; TYROSINE)
기준 성분:MECLIZINE HYDROCHLORIDE
ANTIVERT (MECLIZINE HYDROCHLORIDE)
MECLIZINE HYDROCHLORIDE (MECLIZINE HYDROCHLORIDE)
기준 성분:CHLORPHENIRAMINE MALEATE
ADVIL ALLERGY SINUS (CHLORPHENIRAMINE MALEATE; IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
ANTAGONATE (CHLORPHENIRAMINE MALEATE)
CHILDREN'S ADVIL ALLERGY SINUS (CHLORPHENIRAMINE MALEATE; IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
CHLOROHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE)
CHLORPHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CHLOR-TRIMETON (CHLORPHENIRAMINE MALEATE)
CODIMAL-L.A. 12 (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
COLD CAPSULE IV (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
COLD CAPSULE V (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CONTAC (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CONTAC 12 HOUR (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
DEMAZIN (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
DEXCHLORPHENIRAMINE MALEATE (DEXCHLORPHENIRAMINE MALEATE)
DRIZE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
EFIDAC 24 CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE)
ISOCLOR (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
KLOROMIN (CHLORPHENIRAMINE MALEATE)
ORNADE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
PHENETRON (CHLORPHENIRAMINE MALEATE)
PHENYLPROPANOLAMINE HYDROCHLORIDE W/ CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
POLARAMINE (DEXCHLORPHENIRAMINE MALEATE)
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
PYRIDAMAL 100 (CHLORPHENIRAMINE MALEATE)
TELDRIN (CHLORPHENIRAMINE MALEATE)
TRIAMINIC-12 (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
기준 성분:CAFFEINE ANHYDROUS

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
주성분코드	E46500ASY [동일한 주성분코드를 가진 오리지날 또는 제네릭 의약품 조회]
대표코드	8806440000806
BIT 약효분류	항현훈제(Antivertigo drug)
ATC 코드	Other antiemetics / A04AD [코드분류상세설명] [ATC코드예측]
복지부분류코드	235 (최토제, 진토제 )
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	644000081[644000080] [보험코드에 따른 약품기본정보 직접조회] [비급여] [상병코드조회] [질병코드집 다운로드]
제품성상	감미를 가진 엷은 황색의 시럽제 [제형정보 확인]
포장·유통단위	6mL/포 *2
보관방법	기밀용기, 실온(1～30℃)보관

복약정보

항목

내용

LACTmed 바로가기

[바로가기]

약리작용

유료정보입니다.

복약지도

유료정보입니다.

임부에대한투여

*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : C등급

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

Pharmacokinetics

유료정보입니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Chlorpheniramine에 대한 독성정보 : 정보보기 Pyridoxine에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Caffeine에 대한 Mechanism_Of_Action 정보 Caffeine stimulates medullary, vagal, vasomotor, and respiratory centers, promoting bradycardia, vasoconstriction, and increased respiratory rate. This action was previously believed to be due primarily to increased intracellular cyclic 3′,5′-adenosine monophosphate (cyclic AMP) following inhibition of phosphodiesterase, the enzyme that degrades cyclic AMP. It is now thought that xanthines such as caffeine act as agonists at adenosine-receptors within the plasma membrane of virtually every cell. As adenosine acts as an autocoid, inhibiting the release of neurotransmitters from presynaptic sites but augmenting the actions of norepinephrine or angiotensin, antagonism of adenosine receptors promotes neurotransmitter release. This explains the stimulatory effects of caffeine. Blockade of the adenosine A1 receptor in the heart leads to the accelerated, pronounced "pounding" of the heart upon caffeine intake. Chlorpheniramine에 대한 Mechanism_Of_Action 정보 Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Meclizine에 대한 Mechanism_Of_Action 정보 Along with its actions as an antagonist at H₁-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone. Pyridoxine에 대한 Mechanism_Of_Action 정보 Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Pharmacology	Caffeine에 대한 Pharmacology 정보 Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain. Chlorpheniramine에 대한 Pharmacology 정보 In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. Meclizine에 대한 Pharmacology 정보 Meclizine, a piperazine-derivative H₁-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus. Pyridoxine에 대한 Pharmacology 정보 Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Metabolism	Caffeine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 1A2 (CYP1A2) Chlorpheniramine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 3A4 (CYP3A4)Cytochrome P450 2D6 (CYP2D6) Meclizine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Monoamine oxidase type B (MAO-B) Pyridoxine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Methylenetetrahydrofolate reductase
Protein Binding	Caffeine에 대한 단백결합 정보 Low (25 to 36%). Chlorpheniramine에 대한 단백결합 정보 72% Meclizine에 대한 단백결합 정보 Not Available Pyridoxine에 대한 단백결합 정보 22%
Half-life	Caffeine에 대한 반감기 정보 3 to 7 hours in adults, 65 to 130 hours in neonates Chlorpheniramine에 대한 반감기 정보 21-27 hours Meclizine에 대한 반감기 정보 6 hours Pyridoxine에 대한 반감기 정보 15-20 days
Absorption	Caffeine에 대한 Absorption 정보 Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours. Chlorpheniramine에 대한 Absorption 정보 Well absorbed in the gastrointestinal tract. Meclizine에 대한 Absorption 정보 Well absorbed Pyridoxine에 대한 Absorption 정보 The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
Pharmacokinetics	Pyridoxine HCl의 약물동력학자료 흡수 : 위장관으로부터 잘 흡수된다. 대사 : 간에서 4-pyridoxic acid로 대사된다. 반감기 : 15-20일 혈중최고농도 도달시간 : 경구 : 1.25 시간 소실 : 4-pyridoxic acid로 신배설되며, 소량 (약 2%)은 담즙을 통해 배설된다. Caffeine anhydrous의 약물동력학자료 흡수 : 경구 : 신속하게, 완전히 흡수됨 (99%) 분포 : 모든 체액에 분포하며, 뇌혈관장벽, 태반을 통과하고, 유즙으로도 분비됨 분포용적 : 신생아 : 0.92 L/kg 성인 : 0.58 L/kg 단백결합 : 15-35% 대사 : 성인 : 거의 대부분이 간에서 대사되며, 탈메틸화되어 paraxanthine (72%), theobromine (20%), theophylline (8%)으로 대사됨 반감기 : 미숙아 : 65-103 시간 완숙아 : 82시간 3-4개월 영아 : 14.4 시간 5-6개월 영아 : 2.6 시간 성인 : 3-7.5 시간 (평균 4.9 시간) 임신부 : 18시간까지 혈중최고농도 도달시간 : 15-45분 소실 : 성인 : 미변화체로 신배설되는 양은 0.5-3.5% 신생아 : 거의 대부분 미변화체로 신배설됨 Chlorpheniramine Maleate의 약물동력학자료 단백결합 : 69-72% 대사 : 간대사 반감기 : 20-24 시간 소실 : 대사체, 약물(3-4%)이 신배설되며, 48시간내에 전체의 35%가 소실된다. Meclizine HCl의 약물동력학자료 효과발현시간 : 경구 투여시 1시간 이내 작용지속시간 : 8-24시간 대사 : 간대사 반감기 : 6시간 소실 : 대사체는 신배설되고 대사받지 않은 약물은 변으로 배설
Biotransformation	Caffeine에 대한 Biotransformation 정보 Hepatic cytochrome P450 1A2 (CYP 1A2) is involved in caffeine biotransformation. About 80% of a dose of caffeine is metabolized to paraxanthine (1,7-dimethylxanthine), 10% to theobromine (3,7-dimethylxanthine), and 4% to theophylline (1,3-dimethylxanthine). Chlorpheniramine에 대한 Biotransformation 정보 Primarily hepatic via Cytochrome P450 (CYP450) enzymes.
Toxicity	Caffeine에 대한 Toxicity 정보 LD₅₀=127 mg/kg (orally in mice) Chlorpheniramine에 대한 Toxicity 정보 LD₅₀ = 306 mg/kg in humans, mild reproductive toxin to women of childbearing age. Meclizine에 대한 Toxicity 정보 Symptoms of overdose include drowsiness and anticholinergic effects. LD₅₀=mg/kg (orally in rat). Pyridoxine에 대한 Toxicity 정보 Oral Rat LD₅₀ = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Drug Interactions	Caffeine에 대한 Drug_Interactions 정보 Not Available Chlorpheniramine에 대한 Drug_Interactions 정보 Donepezil Possible antagonism of actionGalantamine Possible antagonism of actionRivastigmine Possible antagonism of actionEthotoin The antihistamine increases the effect of hydantoinFosphenytoin The antihistamine increases the effect of hydantoinMephenytoin The antihistamine increases the effect of hydantoinPhenytoin The antihistamine increases the effect of hydantoin Meclizine에 대한 Drug_Interactions 정보 Donepezil Possible antagonism of actionGalantamine Possible antagonism of actionRivastigmine Possible antagonism of action Pyridoxine에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회] Chlorpheniramine에 대한 P450 table SUBSTRATES CYP 2D6 Beta Blockers: S-metoprolol propafenone timolol Antidepressants: amitriptyline clomipramine desipramine imipramine paroxetine Antipsychotics: haloperidol risperidone thioridazine aripiprazole codeine dextromethorphan duloxetine flecainide mexiletine ondansetron tamoxifen tramadol venlafaxine INHIBITORS CYP 2D6 amiodarone buproprion chlorpheniramine cimetidine clomipramine duloxetine fluoxetine haloperidol methadone mibefradil paroxetine quinidine ritonavir INDUCERS CYP 2D6 N/A
Food Interaction	Chlorpheniramine에 대한 Food Interaction 정보 Take with food.Avoid alcohol. Meclizine에 대한 Food Interaction 정보 Take with food to reduce irritation. Avoid alcohol.
Drug Target	[Drug Target]
SNP 정보	Name:Caffeine (DB00201) Interacting Gene/Enzyme:Cytochrome P450 1A2 (Gene symbol = CYP1A2) Swissprot P05177 SNP(s):rs762551 (C allele) Effect:Myocardial infarction Reference(s):Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H: Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006 Mar 8;295(10):1135-41. [PubMed]
Description	Caffeine에 대한 Description 정보 A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine& Chlorpheniramine에 대한 Description 정보 A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem] Meclizine에 대한 Description 정보 A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem] Pyridoxine에 대한 Description 정보 The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). [PubChem]
Dosage Form	Caffeine에 대한 Dosage_Form 정보 Capsule OralElixir OralLiquid OralPill OralSolution OralSolution / drops OralSuppository RectalSuspension OralSyrup OralTablet OralTablet, extended release Oral Chlorpheniramine에 대한 Dosage_Form 정보 Syrup OralTablet OralTablet, extended release Oral Meclizine에 대한 Dosage_Form 정보 Tablet, chewable Oral Pyridoxine에 대한 Dosage_Form 정보 Liquid IntramuscularSolution IntramuscularSolution / drops OralTablet Oral
Drug Category	Caffeine에 대한 Drug_Category 정보 Anorexigenic AgentsCentral Nervous System StimulantsPhosphodiesterase Inhibitors Chlorpheniramine에 대한 Drug_Category 정보 Anti-Allergic AgentsAntihistaminesAntipruriticsHistamine H1 Antagonists Meclizine에 대한 Drug_Category 정보 Anti-Allergic AgentsAntiemeticsAntihistaminesHistamine H1 Antagonists Pyridoxine에 대한 Drug_Category 정보 Anti-inflammatory AgentsEssential VitaminVitamin B ComplexVitamins (Vitamin B Complex)
Smiles String Canonical	Caffeine에 대한 Smiles_String_canonical 정보 CN1C=NC2=C1C(=O)N(C)C(=O)N2C Chlorpheniramine에 대한 Smiles_String_canonical 정보 CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1 Meclizine에 대한 Smiles_String_canonical 정보 CC1=CC(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1 Pyridoxine에 대한 Smiles_String_canonical 정보 CC1=NC=C(CO)C(CO)=C1O
Smiles String Isomeric	Caffeine에 대한 Smiles_String_isomeric 정보 CN1C=NC2=C1C(=O)N(C)C(=O)N2C Chlorpheniramine에 대한 Smiles_String_isomeric 정보 CN(C)CC[C@H](C1=CC=C(Cl)C=C1)C1=CC=CC=N1 Meclizine에 대한 Smiles_String_isomeric 정보 CC1=CC(CN2CCN(CC2)[C@H](C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1 Pyridoxine에 대한 Smiles_String_isomeric 정보 CC1=NC=C(CO)C(CO)=C1O
InChI Identifier	Caffeine에 대한 InChI_Identifier 정보 InChI=1/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 Chlorpheniramine에 대한 InChI_Identifier 정보 InChI=1/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 Meclizine에 대한 InChI_Identifier 정보 InChI=1/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3 Pyridoxine에 대한 InChI_Identifier 정보 InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
Chemical IUPAC Name	Caffeine에 대한 Chemical_IUPAC_Name 정보 1,3,7-trimethylpurine-2,6-dione Chlorpheniramine에 대한 Chemical_IUPAC_Name 정보 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine Meclizine에 대한 Chemical_IUPAC_Name 정보 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Pyridoxine에 대한 Chemical_IUPAC_Name 정보 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Drug-Induced Toxicity Related Proteins	CAFFEINE 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Metallothionein Drug:caffeine Toxicity:hepatotoxicity. [바로가기] MALEATE 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Intercellular adhesion molecule 1 Drug:maleate Toxicity:hepatic injury. [바로가기]

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