드러그인포 약품요약정보 - 프록토세딜연고

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

652101560[A07403311] [보험코드에 따른 약품기본정보 직접조회]
\0 원/1g(2006.11.01)(현재약가)
\146 원/1g(2003.10.01)(변경전약가)
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

백색내지 미황색의 기름기가 있는 반투명한 무취연고. [제형정보 확인]

포장·유통단위

2g,10g(2gx5),15g,24g(2gx12)

포장·코드단위

약품규격	단위	포장형태	대표코드	표준코드	비고
15그램	1 개	튜브	8806521015606	8806521015620	수출용
15그램	1 개	튜브	8806521015606	8806521015613

주성분코드

337600COM [동일한 주성분코드를 가진 오리지날 또는 제네릭 의약품 조회]

허가사항 원문조회

[허가사항 원문조회]

효능효과

[적응증 별 검색]

다음 경우의 완화 : 치핵 및 항문주위의 부종, 동통, 가려움, 염증, 치열

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
[주성분코드:337600COM 에 따른 심사지침열람]
아침, 저녁 및 배변 후에 1일 1-3회 소량씩 환부에 직접 바른다.
직장내 적용할 경우 주입기를 튜브에 끼우고 직장내 삽입한 후 주입기내의 양을 완전히 짜 넣는다.
[제형별복약지도]

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

[피해야 할 음식] [복용을 잊은 경우 대처법]

주요약물 상호작용

[조회]

금기

환부에 결핵성 감염증 또는 바이러스성 질환 환자
환부에 진균증(칸디다증, 백선 등) 환자
환부가 화농되어 있는 환자
이 약 및 이 약 성분에 과민증 환자
스트렙토마이신, 가나마이신, 겐타마이신, 네오마이신 등 아미노글루코사이드계 항생물질에 대해 과민증이 있는 환자

신중투여

의사의 치료를 받고있는 환자

이상반응

1) 피부감염증 : 피부 및 음부에 진균성(칸디다증, 백선 등) 또는 바이러스성 질환이 나타날 수 있다. 이러한 증상이 나타날 경우 사용을 중지한다.
2) 과민증 : 피부자극감, 가려움, 발적(충혈되어 붉어짐), 종창(부기), 구진, 소수포(물집), 두드러기 등이 나타날 경우 사용을 중지한다.
3) 뇌하수체·부신피질계 기능 : 대량투여 또는 장기사용에 의해 뇌하수체·부신피질계 기능 억제를 일으킬 수 있으므로 주의한다.
4) 장기 연용(계속사용) : 장기 연용(계속사용)에 따라 드물게 전신투여와 같은 증상이 나타날 수 있으므로 장기 연용(계속사용)을 피한다.
5) 눈 : 빈도불명의 시야흐림이 나타날 수 있다.

[주요 이상반응정보]

Related FDA Approved Drug

기준 성분:NEOMYCIN SULFATE
BACITRACIN ZINC-NEOMYCIN SULFATE-POLYMYXIN B SULFATE (BACITRACIN ZINC; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
BACITRACIN-NEOMYCIN-POLYMYXIN (BACITRACIN ZINC; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
BACITRACIN-NEOMYCIN-POLYMYXIN W/ HYDROCORTISONE ACETATE (BACITRACIN; HYDROCORTISONE ACETATE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
COLY-MYCIN S (COLISTIN SULFATE; HYDROCORTISONE ACETATE; NEOMYCIN SULFATE; THONZONIUM BROMIDE)
CORDRAN-N (FLURANDRENOLIDE; NEOMYCIN SULFATE)
COR-OTICIN (HYDROCORTISONE ACETATE; NEOMYCIN SULFATE)
CORTISPORIN (BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
DEXACIDIN (DEXAMETHASONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
DEXASPORIN (DEXAMETHASONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
LANABIOTIC (BACITRACIN ZINC; LIDOCAINE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
MAXITROL (DEXAMETHASONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
MYCIFRADIN (NEOMYCIN SULFATE)
MYCITRACIN (BACITRACIN; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
MYTREX A (NEOMYCIN SULFATE; TRIAMCINOLONE ACETONIDE)
NEOBIOTIC (NEOMYCIN SULFATE)
NEO-CORT-DOME (ACETIC ACID, GLACIAL; HYDROCORTISONE; NEOMYCIN SULFATE)
NEO-CORTEF (HYDROCORTISONE ACETATE; NEOMYCIN SULFATE)
NEODECADRON (DEXAMETHASONE SODIUM PHOSPHATE; NEOMYCIN SULFATE)
NEO-DELTA-CORTEF (NEOMYCIN SULFATE; PREDNISOLONE ACETATE)
NEO-FRADIN (NEOMYCIN SULFATE)
NEO-HYDELTRASOL (NEOMYCIN SULFATE; PREDNISOLONE SODIUM PHOSPHATE)
NEO-MEDROL (METHYLPREDNISOLONE; NEOMYCIN SULFATE)
NEO-MEDROL ACETATE (METHYLPREDNISOLONE ACETATE; NEOMYCIN SULFATE)
NEOMYCIN & POLYMYXIN B SULFATES & BACITRACIN ZINC & HYDROCORTISONE (BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN AND POLYMYXIN B SULFATE (NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN AND POLYMYXIN B SULFATE AND BACITRACIN ZINC (BACITRACIN ZINC; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC (BACITRACIN ZINC; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN AND POLYMYXIN B SULFATES AND DEXAMETHASONE (DEXAMETHASONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN (GRAMICIDIN; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN AND POLYMYXIN B SULFATES AND HYDROCORTISONE (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN AND POLYMYXIN B SULFATES, BACITRACIN ZINC AND HYDROCORTISONE (BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN SULFATE (NEOMYCIN SULFATE)
NEOMYCIN SULFATE AND DEXAMETHASONE SODIUM PHOSPHATE (DEXAMETHASONE SODIUM PHOSPHATE; NEOMYCIN SULFATE)
NEOMYCIN SULFATE AND POLYMYXIN B SULFATE GRAMICIDIN (GRAMICIDIN; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN SULFATE, POLYMYXIN B SULFATE & HYDROCORTISONE (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN SULFATE-DEXAMETHASONE SODIUM PHOSPHATE (DEXAMETHASONE SODIUM PHOSPHATE; NEOMYCIN SULFATE)
NEOMYCIN SULFATE-POLYMYXIN B SULFATE-HYDROCORTISONE (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOMYCIN SULFATE-TRIAMCINOLONE ACETONIDE (NEOMYCIN SULFATE; TRIAMCINOLONE ACETONIDE)
NEO-POLYCIN (BACITRACIN ZINC; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEO-RX (NEOMYCIN SULFATE)
NEOSPORIN (BACITRACIN ZINC; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEOSPORIN G.U. IRRIGANT (NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
NEO-SYNALAR (FLUOCINOLONE ACETONIDE; NEOMYCIN SULFATE)
OTICAIR (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
OTOBIONE (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
OTOCORT (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
PEDIOTIC (HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
POLY-PRED (NEOMYCIN SULFATE; POLYMYXIN B SULFATE; PREDNISOLONE ACETATE)
STATROL (NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
ZINC BACITRACIN,NEOMYCIN SULFATE,POLYMYXIN B SULFATE & HYDROCORTISONE (BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
기준 성분:HYDROCORTISONE
ACETASOL HC (ACETIC ACID, GLACIAL; HYDROCORTISONE)
ACETIC ACID W/ HYDROCORTISONE (ACETIC ACID, GLACIAL; HYDROCORTISONE)
ACHROMYCIN (HYDROCORTISONE; TETRACYCLINE HYDROCHLORIDE)
ACTICORT (HYDROCORTISONE)
ACYCLOVIR AND HYDROCORTISONE (ACYCLOVIR; HYDROCORTISONE)
AEROSEB-HC (HYDROCORTISONE)
A-HYDROCORT (HYDROCORTISONE SODIUM SUCCINATE)
ALA-CORT (HYDROCORTISONE)
ALA-SCALP (HYDROCORTISONE)
ALPHADERM (HYDROCORTISONE; UREA)
ANUSOL HC (HYDROCORTISONE)
BALNEOL-HC (HYDROCORTISONE)
BETA-HC (HYDROCORTISONE)
CALMURID HC (HYDROCORTISONE; UREA)
CARMOL HC (HYDROCORTISONE ACETATE; UREA)
CETACORT (HYDROCORTISONE)
CHLOROMYCETIN HYDROCORTISONE (CHLORAMPHENICOL; HYDROCORTISONE ACETATE)
CIPRO HC (CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE)
COLOCORT (HYDROCORTISONE)
CORT-DOME (HYDROCORTISONE)
CORTEF (HYDROCORTISONE)
CORTEF ACETATE (HYDROCORTISONE ACETATE)
CORTENEMA (HYDROCORTISONE)
CORTIFOAM (HYDROCORTISONE ACETATE)
CORTRIL (HYDROCORTISONE)
DERMACORT (HYDROCORTISONE)
DRICORT (HYDROCORTISONE ACETATE)
ELDECORT (HYDROCORTISONE)
EPICORT (HYDROCORTISONE)
EPIFOAM (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
FLEXICORT (HYDROCORTISONE)
GLYCORT (HYDROCORTISONE)
HC #1 (HYDROCORTISONE)
HC #4 (HYDROCORTISONE)
HC (HYDROCORTISONE) (HYDROCORTISONE)
H-CORT (HYDROCORTISONE)
HEMSOL-HC (HYDROCORTISONE ACETATE)
HI-COR (HYDROCORTISONE)
HYDROCORTISONE (HYDROCORTISONE)
HYDROCORTISONE ACETATE (HYDROCORTISONE ACETATE)
HYDROCORTISONE ACETATE 1% AND PRAMOXINE HYDROCHLORIDE 1% (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
HYDROCORTISONE AND ACETIC ACID (ACETIC ACID, GLACIAL; HYDROCORTISONE)
HYDROCORTISONE BUTYRATE (HYDROCORTISONE BUTYRATE)
HYDROCORTISONE IN ABSORBASE (HYDROCORTISONE)
HYDROCORTISONE SODIUM PHOSPHATE (HYDROCORTISONE SODIUM PHOSPHATE)
HYDROCORTISONE SODIUM SUCCINATE (HYDROCORTISONE SODIUM SUCCINATE)
HYDROCORTISONE VALERATE (HYDROCORTISONE VALERATE)
HYDROCORTONE (HYDROCORTISONE)
HYDRO-RX (HYDROCORTISONE)
HYTONE (HYDROCORTISONE)
LOCOID (HYDROCORTISONE BUTYRATE)
LOCOID LIPOCREAM (HYDROCORTISONE BUTYRATE)
MICORT-HC (HYDROCORTISONE ACETATE)
NOGENIC HC (HYDROCORTISONE)
NUTRACORT (HYDROCORTISONE)
OPHTHOCORT (CHLORAMPHENICOL; HYDROCORTISONE ACETATE; POLYMYXIN B SULFATE)
ORABASE HCA (HYDROCORTISONE ACETATE)
ORLEX HC (ACETIC ACID, GLACIAL; HYDROCORTISONE)
OTOBIOTIC (HYDROCORTISONE; POLYMYXIN B SULFATE)
PANDEL (HYDROCORTISONE PROBUTATE)
PENECORT (HYDROCORTISONE)
PRAMOSONE (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
PROCTOCORT (HYDROCORTISONE)
PROCTOFOAM HC (HYDROCORTISONE ACETATE; PRAMOXINE HYDROCHLORIDE)
PYOCIDIN (HYDROCORTISONE; POLYMYXIN B SULFATE)
SOLU-CORTEF (HYDROCORTISONE SODIUM SUCCINATE)
STIE-CORT (HYDROCORTISONE)
SYNACORT (HYDROCORTISONE)
TERRA-CORTRIL (HYDROCORTISONE ACETATE; OXYTETRACYCLINE HYDROCHLORIDE)
TEXACORT (HYDROCORTISONE)
U-CORT (HYDROCORTISONE ACETATE; UREA)
VOSOL HC (ACETIC ACID, GLACIAL; HYDROCORTISONE)
WESTCORT (HYDROCORTISONE VALERATE)
기준 성분:ESCULOSIDE
기준 성분:DIBUCAINE HYDROCHLORIDE
HEAVY SOLUTION NUPERCAINE (DIBUCAINE HYDROCHLORIDE)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
주성분코드	337600COM [동일한 주성분코드를 가진 오리지날 또는 제네릭 의약품 조회]
대표코드	8806521015606
BIT 약효분류	혈관강화제, 정맥류 치료제, 치질약(Capillary stabilizer, Phlebitis, Varicose veins, Hemorrhoidal)
ATC 코드	Other preparations, combinations / C05AX03 [코드분류상세설명] [ATC코드예측]
복지부분류코드	256 (치질용제 )
의약품 바코드정보	내용보기 프록토세딜연고/A07403311 제품규격:15그램/제품수량:1/제형:개 폼목기준코드:198800713 /대표코드:8806521015606/표준코드:8806521015613 구바코드:-/비고:-
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	652101560[A07403311] [보험코드에 따른 약품기본정보 직접조회] \0 원/1g(2006.11.01)(최신약가) \146 원/1g(2003.10.01)(변경전약가) [상병코드조회] [질병코드집 다운로드]
제품성상	백색내지 미황색의 기름기가 있는 반투명한 무취연고. [제형정보 확인]
포장·유통단위	2g,10g(2gx5),15g,24g(2gx12)
보관방법	기밀용기, 실온보관.
동일주성분코드 검색순위	유료정보입니다.

복약정보

항목

내용

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약리작용

유료정보입니다.

축약복약지도

유료정보입니다.

복약지도

유료정보입니다.

임부에대한투여

*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : D등급

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

Pharmacokinetics

유료정보입니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
Mechanism of Action	Dibucaine에 대한 Mechanism_Of_Action 정보 Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Hydrocortisone에 대한 Mechanism_Of_Action 정보 Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In another words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Neomycin에 대한 Mechanism_Of_Action 정보 Aminoglycosides like neomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Pharmacology	Dibucaine에 대한 Pharmacology 정보 Dibucaine is an amide-type local anesthetic, similar to lidocaine. Hydrocortisone에 대한 Pharmacology 정보 Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated. Neomycin에 대한 Pharmacology 정보 Neomycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Metabolism	Dibucaine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 1A2 (CYP1A2)Cytochrome P450 2D6 (CYP2D6)Cholinesterase Hydrocortisone에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 3A4 (CYP3A4) Neomycin에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Not Available
Protein Binding	Dibucaine에 대한 단백결합 정보 Not Available Hydrocortisone에 대한 단백결합 정보 95% Neomycin에 대한 단백결합 정보 Protein binding studies have shown that the degree of aminoglycoside protein binding is low and, depending upon the methods used for testing, may be between 0% and 30%.
Half-life	Dibucaine에 대한 반감기 정보 Not Available Hydrocortisone에 대한 반감기 정보 6-8 hours Neomycin에 대한 반감기 정보 2 to 3 hours
Absorption	Dibucaine에 대한 Absorption 정보 In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation. Hydrocortisone에 대한 Absorption 정보 Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Neomycin에 대한 Absorption 정보 Poorly absorbed from the normal gastrointestinal tract. Although only approximately 3% of neomycin is absorbed through intact intestinal mucosa, significant amounts may be absorbed through ulcerated or denuded mucosa or if inflammation is present.
Pharmacokinetics	Neomycin Sulfate의 약물동력학자료 흡수 : 경구, 경피 : 흡수되는 양이 미미하다. (3%) 분포 : 분포용적 : 0.36 L/kg 대사 : 소량이 간에서 대사된다. 반감기 : 3 시간 (나이와 신기능에 의존) 혈중최고농도 도달시간 : 경구 : 1-4 시간 근육주사 : 2 시간 이내 소실 : 주사제 : 신배설 (30-50%가 미변화체로 배설) 경구 : 97%가 미변화체로 변배설 Dibucaine HCl의 약물동력학자료 작용발현시간 : 15분 이내 작용지속시간 : 2-4 시간 흡수 : 손상되지 않은 피부에 적용시 흡수는 매우 적지만, 점막이나 손상된 피부로부터는 잘 흡수된다. Hydrocortisone의 약물동력학자료 흡수 : 직장을 제외한 모든 투여경로에서 빠르게 흡수된다. 대사 : 간에서 대사된다. 생리적 반감기 : 8∼12시간 소실 : 주로 17-hydroxysteroids와 17-ketosteroids의 형태로 신배설된다. 용해성이 큰 다른 약물과 비교했을 때 hydrocortisone acetate는 작용발현시간은 느리지만 작용지속시간이 길다. Hydrocortisone sodium succinate는 물에 쉽게 녹아 빨리 활성화된다.
Biotransformation	Dibucaine에 대한 Biotransformation 정보 Primarily hepatic. Hydrocortisone에 대한 Biotransformation 정보 Primarily hepatic via CYP3A4 Neomycin에 대한 Biotransformation 정보 Neomycin undergoes negligible biotransformation after parenteral administration.
Toxicity	Dibucaine에 대한 Toxicity 정보 Subcutaneous LD₅₀ in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest. Hydrocortisone에 대한 Toxicity 정보 Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing Neomycin에 대한 Toxicity 정보 LD₅₀ = 200 mg/kg (rat). Because of low absorption, it is unlikely that acute overdosage would occur with oral neomycin. However, prolonged administration could result in sufficient systemic drug levels to produce neurotoxicity, ototoxicity and/or nephrotoxicity.
Drug Interactions	Dibucaine에 대한 Drug_Interactions 정보 Methotrexate The NSAID increases the effect and toxicity of methotrexateLithium The NSAID increases serum levels of lithiumAcenocoumarol The NSAID increases the anticoagulant effect Hydrocortisone에 대한 Drug_Interactions 정보 Ambenonium The corticosteroid decreases the effect of anticholinesterasesEdrophonium The corticosteroid decreases the effect of anticholinesterasesNeostigmine The corticosteroid decreases the effect of anticholinesterasesPyridostigmine The corticosteroid decreases the effect of anticholinesterasesAspirin The corticosteroid decreases the effect of salicylatesBismuth Subsalicylate The corticosteroid decreases the effect of salicylatesSalicylate-magnesium The corticosteroid decreases the effect of salicylatesSalicylate-sodium The corticosteroid decreases the effect of salicylatesSalsalate The corticosteroid decreases the effect of salicylatesTrisalicylate-choline The corticosteroid decreases the effect of salicylatesWarfarin The corticosteroid alters the anticoagulant effectAcenocoumarol The corticosteroid alters the anticoagulant effectDicumarol The corticosteroid alters the anticoagulant effectAnisindione The corticosteroid alters the anticoagulant effectCholestyramine Cholestyramine decreases the effect of hydrocortisoneColestipol Cholestyramine decreases the effect of hydrocortisoneAmobarbital The barbiturate decreases the effect of the corticosteroidAprobarbital The barbiturate decreases the effect of the corticosteroidButabarbital The barbiturate decreases the effect of the corticosteroidButalbital The barbiturate decreases the effect of the corticosteroidButethal The barbiturate decreases the effect of the corticosteroidDihydroquinidine barbiturate The barbiturate decreases the effect of the corticosteroidHeptabarbital The barbiturate decreases the effect of the corticosteroidHexobarbital The barbiturate decreases the effect of the corticosteroidMethohexital The barbiturate decreases the effect of the corticosteroidMethylphenobarbital The barbiturate decreases the effect of the corticosteroidPentobarbital The barbiturate decreases the effect of the corticosteroidPhenobarbital The barbiturate decreases the effect of the corticosteroidPrimidone The barbiturate decreases the effect of the corticosteroidQuinidine barbiturate The barbiturate decreases the effect of the corticosteroidSecobarbital The barbiturate decreases the effect of the corticosteroidTalbutal The barbiturate decreases the effect of the corticosteroidRifampin The enzyme inducer decreases the effect of the corticosteroidPhenytoin The enzyme inducer decreases the effect of the corticosteroidMephenytoin The enzyme inducer decreases the effect of the corticosteroidFosphenytoin The enzyme inducer decreases the effect of the corticosteroidEthotoin The enzyme inducer decreases the effect of the corticosteroidMidodrine Increased arterial pressure Neomycin에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회]
Food Interaction	Hydrocortisone에 대한 Food Interaction 정보 Take with food to reduce irritation. Calcium, phosphorous, potassium, Vitamin A, C, D and zinc needs increased with long term use. Neomycin에 대한 Food Interaction 정보 Not Available
Drug Target	[Drug Target]
Description	Dibucaine에 대한 Description 정보 A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006) Hydrocortisone에 대한 Description 정보 The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [PubChem] Neomycin에 대한 Description 정보 A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Dosage Form	Dibucaine에 대한 Dosage_Form 정보 Ointment Rectal Hydrocortisone에 대한 Dosage_Form 정보 Aerosol RectalCream TopicalEnema RectalLiquid TopicalLotion TopicalOintment OphthalmicOintment TopicalPowder, for solution IntramuscularPowder, for solution IntravenousTablet Oral Neomycin에 대한 Dosage_Form 정보 Dressing TopicalOintment OphthalmicSolution / drops Ophthalmic
Drug Category	Dibucaine에 대한 Drug_Category 정보 Anesthetics, Local Hydrocortisone에 대한 Drug_Category 정보 Anti-inflammatory Agents Neomycin에 대한 Drug_Category 정보 Anti-Bacterial AgentsAntibiotics
Smiles String Canonical	Dibucaine에 대한 Smiles_String_canonical 정보 CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC Hydrocortisone에 대한 Smiles_String_canonical 정보 CC12CCC(=O)C=C1CCC1C3CCC(O)(C(=O)CO)C3(C)CC(O)C21 Neomycin에 대한 Smiles_String_canonical 정보 NCC1OC(OC2C(N)CC(N)C(O)C2OC2OC(CO)C(OC3OC(CN)C(O)C(O)C3N)C2O)C(N)C(O)C1O
Smiles String Isomeric	Dibucaine에 대한 Smiles_String_isomeric 정보 CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC Hydrocortisone에 대한 Smiles_String_isomeric 정보 C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@H]21 Neomycin에 대한 Smiles_String_isomeric 정보 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
InChI Identifier	Dibucaine에 대한 InChI_Identifier 정보 InChI=1/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)/f/h21H Hydrocortisone에 대한 InChI_Identifier 정보 InChI=1/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 Neomycin에 대한 InChI_Identifier 정보 InChI=1/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
Chemical IUPAC Name	Dibucaine에 대한 Chemical_IUPAC_Name 정보 2-butoxy-N-(2-diethylaminoethyl)quinoline-4-carboxamide Hydrocortisone에 대한 Chemical_IUPAC_Name 정보 (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one Neomycin에 대한 Chemical_IUPAC_Name 정보 (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
Drug-Induced Toxicity Related Proteins	HYDROCORTISONE 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Interleukin-8 Drug:hydrocortisone Toxicity:inflammation. [바로가기] NEOMYCIN 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:NMDA receptor-regulated protein Drug:neomycin Toxicity:excitotoxic activation. [바로가기]

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