드러그인포 약품요약정보

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

비급여
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

포장·유통단위

1EA

효능효과

[적응증 별 검색]

족부 백선, 체부 백선, 완선
[Drugbank 의 성분정보열람]
[Ciclopirox][Lidocaine]

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
환부를 청결히 하고 1일 2-3회 적당량을 바른다.
[제형별복약지도]

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

금기

눈과 눈주위, 점막(구강, 비강, 질 등), 음낭 등
습진

신중투여

현재, 의약품 또는 화장품에 의한 알레르기 증상(발진, 발적, 가려움, 옻등)이 발생한 사람 또는 지금까지 발생한 경우가 있는 사람.
환부가 암면부이거나 광범위한 사람
[습진] 또는 [족부백선, 체부백선, 완선] 인지 여부가 명확히 구분되지 않는 사람
환부에 화농, 습진, 진무름이 심한 사람

Related FDA Approved Drug

기준 성분:LIDOCAINE
AKTEN (LIDOCAINE HYDROCHLORIDE)
ALPHACAINE (LIDOCAINE)
ALPHACAINE HYDROCHLORIDE (LIDOCAINE HYDROCHLORIDE)
ALPHACAINE HYDROCHLORIDE W/ EPINEPHRINE (EPINEPHRINE; LIDOCAINE HYDROCHLORIDE)
ANESTACON (LIDOCAINE HYDROCHLORIDE)
DECADRON W/ XYLOCAINE (DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE)
DENTIPATCH (LIDOCAINE)
DUOCAINE (BUPIVACAINE HYDROCHLORIDE; LIDOCAINE HYDROCHLORIDE)
EMBOLEX (DIHYDROERGOTAMINE MESYLATE; HEPARIN SODIUM; LIDOCAINE HYDROCHLORIDE)
EMLA (LIDOCAINE; PRILOCAINE)
IONTOCAINE (EPINEPHRINE; LIDOCAINE HYDROCHLORIDE)
LANABIOTIC (BACITRACIN ZINC; LIDOCAINE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE)
LARYNG-O-JET KIT (LIDOCAINE HYDROCHLORIDE)
LARYNGOTRACHEAL ANESTHESIA KIT (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE (LIDOCAINE)
LIDOCAINE AND PRILOCAINE (LIDOCAINE; PRILOCAINE)
LIDOCAINE AND TETRACAINE (LIDOCAINE; TETRACAINE)
LIDOCAINE HYDROCHLORIDE (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 0.1% AND DEXTROSE 5% IN PLASTIC CONTAINER (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% IN PLASTIC CONTAINER (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 0.4% IN DEXTROSE 5% (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 0.4% IN DEXTROSE 5% IN PLASTIC CONTAINER (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINER (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 0.8% IN DEXTROSE 5% IN PLASTIC CONTAINER (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE 5% AND DEXTROSE 7.5% (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (EPINEPHRINE; LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE IN PLASTIC CONTAINER (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE IN PLASTIC CONTAINER (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE VISCOUS (LIDOCAINE HYDROCHLORIDE)
LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE (EPINEPHRINE; LIDOCAINE HYDROCHLORIDE)
LIDOCAINE VISCOUS (LIDOCAINE HYDROCHLORIDE)
LIDOCATON (EPINEPHRINE; LIDOCAINE HYDROCHLORIDE)
LIDODERM (LIDOCAINE)
LIDOPEN (LIDOCAINE HYDROCHLORIDE)
LIDOSITE TOPICAL SYSTEM KIT (EPINEPHRINE; LIDOCAINE HYDROCHLORIDE)
LIGNOSPAN FORTE (EPINEPHRINE BITARTRATE; LIDOCAINE HYDROCHLORIDE)
LIGNOSPAN STANDARD (EPINEPHRINE BITARTRATE; LIDOCAINE HYDROCHLORIDE)
LTA II KIT (LIDOCAINE HYDROCHLORIDE)
OCTOCAINE (EPINEPHRINE; LIDOCAINE HYDROCHLORIDE)
ORAQIX (LIDOCAINE; PRILOCAINE)
PEDIATRIC LTA KIT (LIDOCAINE HYDROCHLORIDE)
ROCEPHIN KIT (CEFTRIAXONE SODIUM; LIDOCAINE)
SYNERA (LIDOCAINE; TETRACAINE)
TERRAMYCIN (LIDOCAINE HYDROCHLORIDE; OXYTETRACYCLINE)
XYLOCAINE (LIDOCAINE)
XYLOCAINE 1.5% W/ DEXTROSE 7.5% (LIDOCAINE HYDROCHLORIDE)
XYLOCAINE 4% PRESERVATIVE FREE (LIDOCAINE HYDROCHLORIDE)
XYLOCAINE 5% W/ GLUCOSE 7.5% (LIDOCAINE HYDROCHLORIDE)
XYLOCAINE DENTAL (LIDOCAINE HYDROCHLORIDE)
XYLOCAINE DENTAL WITH EPINEPHRINE (EPINEPHRINE; LIDOCAINE HYDROCHLORIDE)
XYLOCAINE PRESERVATIVE FREE (LIDOCAINE HYDROCHLORIDE)
XYLOCAINE VISCOUS (LIDOCAINE HYDROCHLORIDE)
XYLOCAINE W/ EPINEPHRINE (EPINEPHRINE; LIDOCAINE HYDROCHLORIDE)
ZINGO (LIDOCAINE HYDROCHLORIDE)
기준 성분:CICLOPIROX OLAMINE

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	외용 항진균제 (Antifungals : Skin & Mucous Membrane)
ATC 코드	Other antifungals for topical use / D01AE [코드분류상세설명] [ATC코드예측]
복지부분류코드	265 (기생성 피부질환용제 )
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	비급여 [상병코드조회] [질병코드집 다운로드]
포장·유통단위	1EA

복약정보

항목

내용

LACTmed 바로가기

[바로가기]

약리작용

유료정보입니다.

복약지도

유료정보입니다.

임부에대한투여

*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : B등급
(ciclopirox;lidocaine; )

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

신장애, 간장애시
용량조절

유료정보입니다.

Pharmacokinetics

유료정보입니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

제형별 복약지도

[크림]

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Lidocaine에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Ciclopirox에 대한 Mechanism_Of_Action 정보 Unlike antifungals such as itraconazole and terbinafine, which affect sterol synthesis, ciclopirox is thought to act through the chelation of polyvalent metal cations, such as Fe³⁺ and Al³⁺. These cations inhibit many enzymes, including cytochromes, thus disrupting cellular activities such as mitochondrial electron transport processes and energy production. Ciclopirox also appears to modify the plasma membrane of fungi, resulting in the disorganization of internal structures. The anti-inflammatory action of ciclopirox is most likely due to inhibition of 5-lipoxygenase and cyclooxygenase. Lidocaine에 대한 Mechanism_Of_Action 정보 Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.
Pharmacology	Ciclopirox에 대한 Pharmacology 정보 Ciclopirox is a broad-spectrum antifungal medication that also has antibacterial and anti-inflammatory properties. Its main mode of action is thought to be its high affinity for trivalent cations, which inhibit essential co-factors in enzymes. Ciclopirox exhibits either fungistatic or fungicidal activity in vitro against a broad spectrum of fungal organisms, such as dermatophytes, yeasts, dimorphic fungi, eumycetes, and actinomycetes. In addition to its broad spectrum of action, ciclopirox also exerts antibacterial activity against many Gram-positive and Gram-negative bacteria. Furthermore, the anti-inflammatory effects of ciclopirox have been demonstrated in human polymorphonuclear cells, where ciclopirox has inhibited the synthesis of prostaglandin and leukotriene. Ciclopirox can also exhibit its anti-inflammatory effects by inhibiting the formation of 5-lipoxygenase and cyclooxygenase. Lidocaine에 대한 Pharmacology 정보 Lidocaine is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Lidocaine appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, Lidocaine in therapeutic doses does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, lidocaine may produce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide.
Metabolism	Lidocaine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 1A2 (CYP1A2)Cytochrome P450 2D6 (CYP2D6)
Protein Binding	Ciclopirox에 대한 단백결합 정보 Protein binding is 94-97% following topical administration. Lidocaine에 대한 단백결합 정보 60-80%
Half-life	Ciclopirox에 대한 반감기 정보 1.7 hours for 1% topical solution. Lidocaine에 대한 반감기 정보 109 minutes
Absorption	Ciclopirox에 대한 Absorption 정보 Rapidly absorbed after oral administration. Mean absorption of ciclopirox after application to nails of all twenty digits and adjacent 5 millimeters of skin once daily for 6 months in patients with dermatophytic onychomycoses was less than 5% of the applied dose. Ciclopirox olamine also penetrates into hair and through the epidermis and hair follicles into sebaceous glands and dermis. Lidocaine에 대한 Absorption 정보 Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent.
Pharmacokinetics	Ciclopirox Olamine의 약물동력학자료 흡수 : 외용 : 정상 피부 : 2% 미만 단백결합 : 94-98% 반감기 : 1.7시간 소실 : 흡수된 소량의 약물은 주로 신배설되고, 소량이 변배설된다. Lidocaine의 약물동력학자료 효과발현시간 (1회 bolus 용량으로서) : 45-90초 작용지속시간 : 10-25분 분포 (Vd) : 많은 요인에 따라 변화되며, 울혈성 심부전과 간질환에서는 분포용적이 감소됨 단백결합 : 60-80%, α₁-acid glycoprotein과 결합 대사 : 간에서 90% 대사 활성형 대사체인 monoethylglycinexylidide(MEGX)와 glycinexylidide(GX)가 축적되어 중추신경계 독성을 유발할 수 있다. 반감기 (biphasic) : 울혈성 심부전, 간질환, 쇼크, 중증의 신질환에서 증가 초기 : 7-30분 말기 : 영아, 미숙아 : 3.2시간, 성인 : 1.5-2시간
Biotransformation	Ciclopirox에 대한 Biotransformation 정보 Glucuronidation is the main metabolic pathway of ciclopirox. Lidocaine에 대한 Biotransformation 정보 Primarily hepatic.
Toxicity	Ciclopirox에 대한 Toxicity 정보 Oral LD₅₀ in rat is >10 ml/kg. Symptoms of overexposure include drowsiness and headache. Lidocaine에 대한 Toxicity 정보 The oral LD 50 of lidocaine HCl in non-fasted female rats is 459 (346-773) mg/kg (as the salt) and 214 (159-324) mg/kg (as the salt) in fasted female rats. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
Drug Interactions	Ciclopirox에 대한 Drug_Interactions 정보 Not Available Lidocaine에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회]
Food Interaction	Lidocaine에 대한 Food Interaction 정보 Not Available
Drug Target	[Drug Target]
Description	Ciclopirox에 대한 Description 정보 Ciclopirox (also called Loprox짰, Penlac짰 and Stieprox짰) is a synthetic antifungal agent for topical dermatologic use. [Wikipedia] Lidocaine에 대한 Description 정보 A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. [PubChem]
Dosage Form	Ciclopirox에 대한 Dosage_Form 정보 Cream TopicalLotion TopicalShampoo TopicalSolution Topical Lidocaine에 대한 Dosage_Form 정보 Aerosol TopicalAerosol, metered TopicalCream TopicalGel TopicalJelly TopicalJelly UrethralLiquid BuccalLiquid DentalLiquid InfiltrationLiquid IntravenousLiquid OralLiquid TopicalLotion TopicalOintment TopicalSolution InfiltrationSolution IntramuscularSolution IntravenousSolution OralSolution TopicalSpray TopicalSwab Topical
Drug Category	Ciclopirox에 대한 Drug_Category 정보 Antifungal Agents Lidocaine에 대한 Drug_Category 정보 AnestheticsAnesthetics, LocalAnti-Arrhythmia AgentsAntiarrhythmic Agents
Smiles String Canonical	Ciclopirox에 대한 Smiles_String_canonical 정보 CC1=CC(=O)N(O)C(=C1)C1CCCCC1 Lidocaine에 대한 Smiles_String_canonical 정보 CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
Smiles String Isomeric	Ciclopirox에 대한 Smiles_String_isomeric 정보 CC1=CC(=O)N(O)C(=C1)C1CCCCC1 Lidocaine에 대한 Smiles_String_isomeric 정보 CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
InChI Identifier	Ciclopirox에 대한 InChI_Identifier 정보 InChI=1/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3 Lidocaine에 대한 InChI_Identifier 정보 InChI=1/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)/f/h15H
Chemical IUPAC Name	Ciclopirox에 대한 Chemical_IUPAC_Name 정보 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one Lidocaine에 대한 Chemical_IUPAC_Name 정보 2-diethylamino-N-(2,6-dimethylphenyl)acetamide
Drug-Induced Toxicity Related Proteins	DOCA 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Aquaporin-2 Drug:DOCA Toxicity:hypertension. [바로가기] LIDOCAINE 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:glucose-regulated protein Drug:lidocaine Toxicity:intestinal disorder. [바로가기] Replated Protein:Alkaline phosphatase Drug:lidocaine Toxicity:lidocaine induced hepatitis. [바로가기] Replated Protein:C-reactive protein Drug:lidocaine Toxicity:fever. [바로가기] Replated Protein:C-reactive protein Drug:lidocaine Toxicity:lidocaine induced hepatitis. [바로가기] Replated Protein:Alpha-1-acid glycoprotein Drug:lidocaine Toxicity:lidocaine tolerance. [바로가기] Replated Protein:Gamma-glutamyltranspeptidase Drug:lidocaine Toxicity:fever. [바로가기] Replated Protein:Alkaline phosphatase Drug:lidocaine Toxicity:fever. [바로가기] Replated Protein:Gamma-glutamyltranspeptidase Drug:lidocaine Toxicity:lidocaine induced hepatitis. [바로가기]

사용자컨텐츠

항목

내용

핵심 요약 정보