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1. ¾Æ³ªÇʶô½Ã½º ¼îÅ©, ÃÖ±ÙÀÇ ½É±Ù°æ»ö
2. ÆóºÎÁ¾(µ¶¼º¹°ÁúÀÇ ÈíÀÔ, À§¾× ÈíÀÔ, ħ½À ÈÄ)
3. ½ÅÀå ÀÌ½Ä ÈÄ °ÅºÎ¹ÝÀÀ
4. ÁßÁõÀÇ ±Þ¼º õ½Ä »óÅÂ
5. ±Þ¼º ³úºÎÁ¾
6. ±Þ¼º ÁßÁõ ÇǺΠÁúȯ : ½É»ó¼º õÆ÷â, È«ÇÇÁõ
7. ±Þ¼º Ç÷¾× Áúȯ : ±Þ¼º ¿ëÇ÷¼º ºóÇ÷, ±Þ¼º Ç÷¼ÒÆÇ°¨¼Ò¼º Àڹݺ´
8. ±Þ¼º ºÎ½ÅÇÇÁúºÎÀüÁõ : ¾Öµð½¼º´
9. ÁßÁõ °¨¿° Áúȯ(Ç×»ý¹°Áú°ú º´¿ë)
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* Àý´ë ÀÓÀǺ¹¿ëÇÏÁö ¸¶½Ã°í ¹Ýµå½Ã ÀÇ»ç ¶Ç´Â ¾à»ç¿Í »ó´ãÇϽñ⠹ٶø´Ï´Ù.
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±Þ¼ºÁúȯ½Ã ´ëºÎºÐ Á¤¸ÆÁÖ»çÇϳª ±ÙÀ°Áֻ絵 °¡´ÉÇÏ´Ù.
1. ¾Æ³ªÇʶô½Ã½º ¼îÅ©, ÃÖ±ÙÀÇ ½É±Ù°æ»ö :
1) ¾Æ³ªÇʶô½Ã½º ¼îÅ© : ¿ì¼± ¾Æµå·¹³¯¸°À» Á¤¸ÆÁÖ»çÇÑ´Ù(½ÃÆÇ ¾Æµå·¹³¯¸° ¿ë¾×ÀÇ 1.0 mL¸¦ 1 : 1,000ºñ°¡ µÇµµ·Ï »ý¸®½Ä¿° ÁÖ»ç¾× ¶Ç´Â Ç÷¾×À¸·Î Èñ¼®ÇÏ¿© 10 mL¸¦ ¸¸µé¾î¼ ºÎÁ¤¸Æ¿¡ ÁÖÀÇÇÏ¸é¼ ÇÊ¿äÇÑ ¾çÀ» ÀÇ»çÀÇ °üÂû ÇÏ¿¡ 1 mL¾¿ õõÈ÷ ÁÖ»çÇÑ´Ù). ±× ´ÙÀ½, Ä«Å×Å͸¦ »ðÀÔÇÑ Ã¤·Î ÇÁ·¹µå´Ï¼Ö·Ð¼÷½Ã³×ÀÌÆ®³ªÆ®·ý 1 g(¼Ò¾Æ´Â 250 mg)À» ¿ë·® ġȯÇÏ¿© Åõ¿©ÇÑ´Ù. ¾Æµå·¹³¯¸°°ú ÀÌ ¾àÀ» ¹Ýº¹ Åõ¿©ÇÑ´Ù(Ä®½·, µð±âÅ»¸®½º, ½ºÆ®·ÎÆÇƾ Á¦Á¦´Â ¾Æµå·¹³¯¸°°ú º´¿ëÅõ¿©ÇÏÁö ¾Ê´Â´Ù).
2) ÃÖ±ÙÀÇ ½É±Ù°æ»ö : ÀÌ ¾àÀ¸·Î¼ 1ÀÏ 50 mgÀ» Åõ¿©Çϰí ÁÖÀÇÇÏ¿© ¿ë·®À» °¨¼ÒÇÏ¿© Åõ¿©ÇÑ´Ù.
2. ÆóºÎÁ¾(µ¶¼º¹°ÁúÀÇ ÈíÀÔ, À§¾× ÈíÀÔ, ħ½À ÈÄ) : µ¶¼º¹°ÁúÀÇ ÈíÀÔ¿¡ ÀÇÇÑ ÆóºÎÁ¾ÀÌ ¹ß»ýÇß´Ù¸é ÀÌ ¾àÀ¸·Î¼ 1,000 mg¿ë·®À¸·Î ½ÃÀÛÇÏ°í °¡´ÉÇÑ 6, 12, 24½Ã°£ ¹Ýº¹ÇÑ´Ù.
ÀÌÈÄ ÀÌ ¾àÀ¸·Î¼ 2Àϰ£ 150 mg, Ãß°¡ 2Àϰ£ 75 mgÀ» Åõ¿©ÇÏ°í ¼¼È÷ ÈíÀÔ Ä¡·á·Î ÀüȯÇÑ´Ù.
3. ½ÅÀå ÀÌ½Ä ÈÄ °ÅºÎ¹ÝÀÀ : ÀÌ ¾àÀ¸·Î¼ 1 gÀÇ ´ÜÀÏ ´ëÀÀ·®À» ±âÃÊ¿ä¹ý¿¡ Ãß°¡ÇÏ¿© Åõ¿©Çϰí, ȯÀÚÀÇ »óÅ¿¡ µû¶ó 3 ¢¦ 7ÀÏ ¿¬¼Ó Åõ¿©ÇÑ´Ù.
4. ÁßÁõ ±Þ¼º õ½Ä »óÅ : ÀÌ ¾àÀ¸·Î¼ 100 ¢¦ 500 mgÀ» Ãʱ⠿뷮À¸·Î Åõ¿©Çϰí ÀÌÈÄ °°Àº ¿ë·® ¶Ç´Â ³·Àº ¿ë·®À» 6½Ã°£ °£°ÝÀ¸·Î Åõ¿©ÇÑ´Ù. ±× ´ÙÀ½ À¯Áö·®¿¡ µµ´ÞÇÒ ¶§±îÁö ¿ë·®À» õõÈ÷ °¨¼Ò½ÃŲ´Ù.
5. ±Þ¼º ³úºÎÁ¾ : ÀÌ ¾àÀ¸·Î¼ 250 ¢¦ 1,000 mgÀ» ÃʱâÅõ¿©Çϰí ÀÌÈÄ 2 ¢¦ 6½Ã°£ °£°ÝÀ» µÎ°í µ¦»ç¸ÞŸ¼ÕÁÖ 8 ¢¦ 16 mgÀ¸·Î Ä¡·áÇÑ´Ù.
6. ±Þ¼º ÁßÁõ ÇǺΠÁúȯ ¹× ±Þ¼º Ç÷¾× Áúȯ : ÀÌ ¾àÀ¸·Î¼ 1ÀÏ 40 ¢¦ 250 mgÀ» Åõ¿©ÇÑ´Ù. ÇÊ¿ä ½Ã 1ÀÏ 400 mg ÀÌ»ó Åõ¿©ÇÒ ¼ö ÀÖ´Ù.
7. ¾Öµð½¼º´°ú °°Àº ±Þ¼º ºÎ½ÅÇÇÁúºÎÀüÁõ : Ãʱâ¿ë·®À¸·Î ÀÌ ¾àÀ¸·Î¼ 25 ¢¦ 50 mgÀ» Åõ¿©ÇÑ´Ù.
8. ÁßÁõ °¨¿°¼º Áúȯ : Ç×»ý¹°Áú ¿ä¹ý°ú º´¿ëÇÏ¿© ÀÌ ¾àÀ¸·Î¼ 1ÀÏ 100 ¢¦ 500 mgÀ» Åõ¿©ÇÑ´Ù.
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1) ÀÌ ¾à ¶Ç´Â ÀÌ ¾à ±¸¼º¼ººÐ¿¡ °ú¹Î¹ÝÀÀ ¹× ±× º´·ÂÀÌ Àִ ȯÀÚ
2) À¯È¿ÇÑ Ç×±ÕÁ¦°¡ ¾ø´Â °¨¿°Áõ, Àü½Å Áø±Õ °¨¿°Áõ ȯÀÚ(¸é¿ª±â´É ¾ïÁ¦ÀÛ¿ë¿¡ ÀÇÇØ °¨¿°ÁõÀ» ¾ÇȽÃų ¼ö ÀÖ´Ù)
3) ´Ü¼øÆ÷Áø, ´ë»óÆ÷Áø, ¼öµÎ ȯÀÚ
4) °üÀý°³», Á¡¾×³¶³», °ÇÃʳ» ¶Ç´Â °ÇÁÖÀ§¿¡ °¨¿°ÁõÀÌ Àִ ȯÀÚ(¸é¿ª±â´É ¾ïÁ¦ÀÛ¿ë¿¡ ÀÇÇØ °¨¿°ÁõÀ» ¾ÇȽÃų ¼ö ÀÖ´Ù)
5) °üÀý°³»°¡ ºÒ¾ÈÁ¤ÇÑ È¯ÀÚ(°üÀýÁõ»óÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
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1) Åõ¿©ÇÏÁö ¾Ê´Â °ÍÀ» ¿øÄ¢À¸·Î ÇÏÁö¸¸ ´ÙÀ½ ȯÀÚ¿¡´Â ƯÈ÷ ÇÊ¿äÇÑ °æ¿ì¿¡ ÇÑÇÏ¿© ½ÅÁßÈ÷ Åõ¿©ÇÑ´Ù.
(1) ³ì³»Àå ȯÀÚ(¾È¾ÐÀÌ »ó½ÂÇÏ¿© ³ì³»ÀåÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
(2) °áÇÙ¼º Áúȯ, ´Ü¼øÆ÷Áø¼º °¢¸·¿° ȯÀÚ(¸é¿ª±â´É ¾ïÁ¦ÀÛ¿ë¿¡ ÀÇÇØ Áõ»óÀ» ¾ÇȽÃų ¼ö ÀÖ´Ù)
(3) Èij¶ÇÏ ¹é³»Àå ȯÀÚ(Áõ»óÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
(4) ÀüÇØÁú ÀÌ»ó ȯÀÚ, °íÇ÷¾Ð ȯÀÚ(ÀüÇØÁú´ë»çÀÛ¿ë¿¡ ÀÇÇØ Áõ»óÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
(5) Ç÷ÀüÁõ ȯÀÚ(Ç÷¾×ÀÀ°íÃËÁøÀÛ¿ë¿¡ ÀÇÇØ Ç÷ÀüÁõÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
(6) ÃÖ±Ù Àå¹®ÇÕ¼úÀ» ¹ÞÀº ȯÀÚ(»óóġÀ¯Áö¿¬ÀÌ ÀϾ ¼ö ÀÖ´Ù)
(7) ±Þ¼º ½É±Ù°æ»öÀ» ÀÏÀ¸Å² ÀûÀÌ Àִ ȯÀÚ(½ÉÆÄ¿À» ÀÏÀ¸Ä×´Ù´Â º¸°í°¡ ÀÖ´Ù)
(8) ¼Òȼº ±Ë¾ç ȯÀÚ(¼ÒȰüº¸È£ÀÛ¿ëÀ» °¨¾à½Ã۰í, Á¶Á÷ÀÇ ¼öº¹À» ¹æÇØÇϹǷΠÁõ»óÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
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2) °¨¿°ÁõÀÌ Àִ ȯÀÚ(¸é¿ª±â´É¾ïÁ¦ÀÛ¿ë¿¡ ÀÇÇØ °¨¿°ÁõÀ» ¾ÇȽÃų ¼ö ÀÖ´Ù)
3) ´ç´¢º´ ȯÀÚ(´ç½Å»ýÀÛ¿ë¿¡ ÀÇÇØ Ç÷´çÄ¡°¡ »ó½ÂÇÏ¿© ´ç´¢º´ÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
4) °ñ´Ù°øÁõ ȯÀÚ
5) ½ÅºÎÀü, ¿ïÇ÷½ÉºÎÀü ȯÀÚ(¹è¼³ÀÌ Áö¿¬µÇ¾î ÀÌ»ó¹ÝÀÀÀÌ ³ªÅ¸³ª±â ½±´Ù)
6) °©»ó»ù±â´ÉÀúÇÏÁõ ȯÀÚ(ÄÚ¸£Æ¼ÄÚÀ̵åÀÇ Ç÷Áß ¹Ý°¨±â°¡ ¿¬ÀåµÇ¾ú´Ù´Â º¸°í°¡ ÀÖ´Ù)
7) °£°æº¯ ȯÀÚ(´ë»çÈ¿¼ÒȰ¼ºÀÇ ÀúÇÏ µî¿¡ ÀÇÇØ ÀÌ»ó¹ÝÀÀ¿¡ ³ªÅ¸³ª±â ½±´Ù)
8) Áö¹æ°£ ȯÀÚ(°£¿¡ Áö¹æÄ§ÂøÀÌ Áõ°¡ÇÏ¿© Áö¹æ°£ÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
9) Áö¹æ»öÀüÁõ ȯÀÚ(ÄÚ¸£Æ¼ÄÚÀÌµå °ú·®Åõ¿©¿¡ ÀÇÇØ Áö¹æ»öÀüÁõÀÌ ³ªÅ¸³µ´Ù´Â º¸°í°¡ ÀÖ´Ù)
10) ÁßÁõ ±Ù¹«·ÂÁõ ȯÀÚ(»ç¿ëÃʱ⿡ ÀϽÃÀûÀ¸·Î Áõ»óÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
11) °í·ÉÀÚ
12) °£ÁúȯÀÚ
13) °ñ´Ù°øÁõ, °íÇ÷¾Ð, ¿ïÇ÷½ÉºÎÀü, ½É°¢ÇÑ °¨Á¤ÀÌ»ó, ´ç´¢º´, °áÇÙ, ³ì³»Àå, °£Àå¾Ö, ½ÉºÎÀü, °£Áú, ¼Òȼº ±Ë¾çÀÇ º´·ÂÀÌ Àִ ȯÀÚ(º´ÀÌ ¾Ç鵃 ¼ö ÀÖ´Ù)
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´ÙÀ½ Áõ»óÀÌ ³ªÅ¸³¯ ¼ö ÀÖÀ¸¹Ç·Î ÃæºÐÈ÷ °üÂûÇϰí, ÀÌ·¯ÇÑ Áõ»óÀÌ ³ªÅ¸³ª´Â °æ¿ì¿¡´Â ÀûÀýÇÑ Ã³Ä¡¸¦ ÇÑ´Ù.
1) °¨¿° : °¨¿°ÁõÀÇ À¯¹ß, °¨¿°ÁõÀÇ ¾ÇÈ, BÇü°£¿°¹ÙÀÌ·¯½º Áõ½Ä¿¡ ÀÇÇÑ °£¿°
2) ³»ºÐºñ°è : ¼Ó¹ß¼º ºÎ½ÅÇÇÁú±â´ÉºÎÀü, ´ç´¢º´, ¿ù°æÀÌ»ó, Äí½ÌÁõÈıº(¿ù»ó¾È), buffalo hump µî
3) ¼Òȱâ°è : ¼Òȼº ±Ë¾ç, ÃéÀå¿°, ¼³»ç, ±¸¿ª, ±¸Åä, À§Åë, °¡½¿¾²¸², º¹ºÎÆØ¸¸°¨, ±¸°¥, ½Ä¿åºÎÁø, ½Ä¿åÇ×Áø, ¼Ò¾ÆÀÇ ¼ºÀå¾ïÁ¦ µî
4) Á¤½Å½Å°æ°è : Á¤½ÅÀå¾Ö, ¿ì¿ïÁõ, ´ÙÇà°¨, ºÒ¸é, µÎÅë, ¾îÁö·³, °æ·Ã, ÈïºÐ, Ä¡·á ÈÄ À¯µÎºÎÁ¾(°¡³úÁ¾¾ç)À» ¼ö¹ÝÇÑ µÎ°³³»¾ÐÀÇ »ó½Â µî
5) ±Ù․°ñ°Ý°è : °ñ´Ù°øÁõ, ´ëÅð°ñ ¹× »ó¿Ï°ñ ¸»´ÜÀÇ ¹«±Õ¼º ±«»ç, ±Ùº´Áõ, ôÃ߾йڰñÀý, ±ÙÀ°½ÇÁúÀÇ ¼Õ½Ç, Àå°ñÀÇ º´¸®Àû °ñÀý, ±ÙÀ°Åë, °üÀýÅë, ±ÙÀ°¾àÈ µî
6) ÁöÁú․´Ü¹éÁú ´ë»ç : À½¼ºÁú¼ÒÆòÇü, Áö¹æ°£ µî
7) ü¾×․ÀüÇØÁú : ºÎÁ¾, ü¾×Àú·ù, ³ªÆ®·ýÀú·ù, Ä®½·¼Ò½Ç, °¨¼ö¼ºÈ¯ÀÚ¿¡ ÀÖ¾î¼ ¿ïÇ÷¼º ½ÉºÎÀü, Ç÷¾Ð»ó½Â, ÀúÄ®·ý¼º ¾ËÄ®¸®Ç÷Áõ µî
8) ´« : ¿¬¿ë¿¡ ÀÇÇØ ¾È¾ÐÇ×Áø, ³ì³»Àå, Èij¶ÇÏ ¹é³»Àå, °õÆÎÀ̳ª ¹ÙÀÌ·¯½º¿¡ ÀÇÇÑ ´«ÀÇ 2Â÷ °¨¿°À» ÃÊ·¡ÇÒ ¼ö ÀÖÀ¸¹Ç·Î Á¤±âÀûÀ¸·Î °Ë»ç¸¦ ÇÏ´Â °ÍÀÌ ¹Ù¶÷Á÷ÇÏ´Ù. Á߽ɼº Àå¾×¼º ¸Æ¶ô¸Á¸·Áõ µî¿¡ ÀÇÇØ ¸Á¸·Àå¾Ö, ¾È±¸µ¹ÃâµîÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù. ºóµµºÒ¸íÀÇ ½Ã¾ßÈ帲ÀÌ ³ªÅ¸³¯ ¼ö ÀÖ´Ù.
9) Ç÷¾× : ¹éÇ÷±¸ Áõ°¡, Ç÷ÀüÁõ µî
10) ÇǺΠ: ¿©µå¸§, ´Ù¸ð, Å»¸ð, »ö¼ÒÄ§Âø, Á¡»óÃâÇ÷ ¹× ¹Ý»óÃâÇ÷, ÀÚ¹Ý, ¼±Á¶, °¡·Á¿ò, ¹ßÇÑÀÌ»ó, ¾È¸éÈ«¹Ý, â»óÄ¡À¯Áö¿¬, ¾ã°í ¿¬¾àÇÑ ÇǺΠµî
11) °ú¹Î¹ÝÀÀ : °ú¹ÎÁõ»óÀÌ ³ªÅ¸³ª´Â °æ¿ì¿¡´Â Åõ¿©¸¦ ÁßÁöÇÑ´Ù.
12) ±âŸ : ¹ß¿, ÇǷΰ¨, ½ºÅ×·ÎÀ̵强 ½ÅÁõ, üÁßÁõ°¡, Á¤ÀÚ¼ö ¹× ±× ¿Ü ¿îµ¿¼ºÀÇ Áõ°¨ µî
13) ¼îÅ©․¾Æ³ªÇʶô½Ã½º°¡ ³ªÅ¸³¯ ¼ö ÀÖÀ¸¹Ç·Î °üÂûÀ» ÃæºÐÈ÷ Çϰí È£Èí°ï¶õ, Àü½ÅÈ«Á¶, Ç÷°üºÎÁ¾, µÎµå·¯±â µîÀÇ Áõ»óÀÌ ³ªÅ¸³ª´Â °æ¿ì Åõ¿©¸¦ ÁßÁöÇϰí ÀûÀýÇÑ Ã³Ä¡¸¦ ÇÑ´Ù.
14) Åõ¿©ºÎÀ§¿¡ µû¸¥ ÀÌ»ó¹ÝÀÀ
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1) ¹Ù¸£ºñÅ»°è ¾à¹°(Æä³ë¹Ù¸£ºñÅ»), Æä´ÏÅäÀÎ, ¸®ÆÊÇǽÅ, Ä«¸£¹Ù¸¶Á¦ÇÉ, ÇÁ¸®¹Ìµ·, ¾Æ¹Ì³ë±Û·çÅ×Ä¡¹Ìµå, ¸®ÆÄºÎƾ°ú º´¿ëÅõ¿©¿¡ ÀÇÇØ ÀÌ ¾àÀÇ ÀÛ¿ëÀÌ °¨¼ÒµÉ ¼ö ÀÖÀ¸¹Ç·Î º´¿ëÅõ¿©½Ã ¿ë·®¿¡ ÁÖÀÇÇÑ´Ù.
2) ºñ½ºÅ×·ÎÀ̵å¼Ò¿°ÁøÅëÁ¦(NSAID)¿Í º´¿ëÅõ¿©½Ã À§Àå°ü ±Ë¾çÀÇ À§ÇèÀ» Áõ°¡½Ãų ¼ö ÀÖÀ¸¸ç, ¾Æ½ºÇǸ°°ú º´¿ëÅõ¿©½Ã ¾Æ½ºÇǸ°ÀÇ ½Åû¼ÒÀ²À» Áõ°¡½ÃÄÑ »ì¸®½Ç»ê¿°ÀÇ Ç÷Áß ³óµµ¸¦ °¨¼Ò½ÃŰ°Å³ª ÀÌ ¾àÀ» Áß´ÜÇßÀ» ¶§ »ì¸®½Ç»ê¿°ÀÇ µ¶¼ºÀ» Áõ°¡½Ãų ¼ö ÀÖÀ¸¹Ç·Î ¿ë·®¿¡ ÁÖÀÇÇÑ´Ù. ƯÈ÷ ÀúÇÁ·ÎÆ®·ÒºóÇ÷Áõ ȯÀÚ¿¡¼ ÀÌ ¾à°ú ¾Æ½ºÇǸ°À» º´¿ëÅõ¿©½Ã ÁÖÀÇÇÑ´Ù.
3) Ç÷¾×ÀÀ°íÀúÁöÁ¦, Ç÷´ç°ÇÏÁ¦ÀÇ °æ¿ì ÄÚ¸£Æ¼ÄÚÀ̵å¿ÍÀÇ º´¿ëÅõ¿©¿¡ ÀÇÇØ ±× ÀÛ¿ëÀÌ ¾à鵃 ¼ö ÀÖÀ¸¹Ç·Î ¿ë·®Á¶ÀýÀÌ ÇÊ¿äÇÏ´Ù.
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| Related FDA Approved Drug |
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 FDA : Cµî±Þ
(prednisolone; )
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»ó±â ÀÓºÎÅõ¿©¿¡ ´ëÇÑ Á¤º¸´Â Àü»êó¸® µÇ¸é¼ ÀÔ·Â ¿À·ù °¡´É¼ºÀÌ Á¸ÀçÇÕ´Ï´Ù. ¿À·ù °¡´É¼ºÀ» ÃÖ¼ÒÈÇϱâ À§ÇÏ¿© ¸¹Àº ³ë·ÂÀ» ±â¿ïÀ̰í ÀÖÀ¸³ª, ±× Á¤È®¼º¿¡ ´ëÇÏ¿© È®½ÅÀ» µå¸± ¼ö ¾ø½À´Ï´Ù. ÀÌ¿¡ ´ëÇØ ȸ»ç´Â Ã¥ÀÓÀ» ÁöÁö ¾Ê½À´Ï´Ù.
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¹Ýµå½Ã °ø½Å·Â ÀÖ´Â ¹®ÇåÀ» ´Ù½Ã Çѹø Âü°í ÇϽñ⠹ٶó¸ç ÀÇ»ç ¶Ç´Â ¾à»çÀÇ ÆÇ´Ü¿¡ µû¶ó Åõ¿©¿©ºÎ°¡ °áÁ¤µÇ¾î¾ß ÇÕ´Ï´Ù.
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| º¸°ü»ó ÁÖÀÇ |
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| DUR (ÀǾàǰ»ç¿ëÆò°¡) |
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| Mechanism of Action |
Prednisolone¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Glucocorticoids such as Prednisolone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisolone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.
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| Pharmacology |
Prednisolone¿¡ ´ëÇÑ Pharmacology Á¤º¸ Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Prednisolone is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.
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| Metabolism |
Prednisolone¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Cytochrome P450 3A4 (CYP3A4)
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| Protein Binding |
Prednisolone¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ Very high (>90%)
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| Half-life |
Prednisolone¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 2-3 hours
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| Absorption |
Prednisolone¿¡ ´ëÇÑ Absorption Á¤º¸ Readily absorbed by gastrointestinal tract, peak plasma concentration is reached 1-2 hours after administration.
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| Pharmacokinetics |
Prednisolone sodium succinateÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á
- ´Ü¹é°áÇÕ : 65¡91% (¿ë·® ÀÇÁ¸Àû)
- ´ë»ç : ÀÏÂ÷ÀûÀ¸·Î °£¿¡¼ ´ë»çµÇ³ª ´ëºÎºÐÀÇ Á¶Á÷¿¡¼µµ ´ë»ç°¡ ÀϾ¸ç ºñȰ¼ºÇü ´ë»çü°¡ »ý¼ºµÈ´Ù.
- ¹Ý°¨±â : 3.6½Ã°£
- »ý¸®Àû ¹Ý°¨±â : 18-36½Ã°£
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- ¼Ò½Ç : ´ëºÎºÐ glucuronides, sulfates Æ÷ÇÕü³ª ºñÆ÷ÇÕ ´ë»çü·Î ½Å¹è¼³ µÈ´Ù.
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| Biotransformation |
Prednisolone¿¡ ´ëÇÑ Biotransformation Á¤º¸ Excreted in the urine as either free or glucoconjugate.
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| Toxicity |
Prednisolone¿¡ ´ëÇÑ Toxicity Á¤º¸ LD50=500 mg/kg (oral, rat), short-term side effects include high blood glucose levels and fluid retention. Long term side effects include Cushing's syndrome, weight gain, osteoporosis, glaucoma, type II diabetes and adrenal suppression.
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| Drug Interactions |
Prednisolone¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Ambenonium The corticosteroid decreases the effect of anticholinesterasesEdrophonium The corticosteroid decreases the effect of anticholinesterasesNeostigmine The corticosteroid decreases the effect of anticholinesterasesPyridostigmine The corticosteroid decreases the effect of anticholinesterasesWarfarin The corticosteroid alters the anticoagulant effectAcenocoumarol The corticosteroid alters the anticoagulant effectDicumarol The corticosteroid alters the anticoagulant effectAnisindione The corticosteroid alters the anticoagulant effectMidodrine Increased arterial pressureAspirin The corticosteroid decreases the effect of salicylatesBismuth Subsalicylate The corticosteroid decreases the effect of salicylatesSalicylate-magnesium The corticosteroid decreases the effect of salicylatesSalicylate-sodium The corticosteroid decreases the effect of salicylatesSalsalate The corticosteroid decreases the effect of salicylatesTrisalicylate-choline The corticosteroid decreases the effect of salicylatesTalbutal The barbiturate decreases the effect of the corticosteroidSecobarbital The barbiturate decreases the effect of the corticosteroidQuinidine barbiturate The barbiturate decreases the effect of the corticosteroidPrimidone The barbiturate decreases the effect of the corticosteroidPhenobarbital The barbiturate decreases the effect of the corticosteroidPentobarbital The barbiturate decreases the effect of the corticosteroidMethylphenobarbital The barbiturate decreases the effect of the corticosteroidMethohexital The barbiturate decreases the effect of the corticosteroidHexobarbital The barbiturate decreases the effect of the corticosteroidHeptabarbital The barbiturate decreases the effect of the corticosteroidDihydroquinidine barbiturate The barbiturate decreases the effect of the corticosteroidButethal The barbiturate decreases the effect of the corticosteroidButalbital The barbiturate decreases the effect of the corticosteroidButabarbital The barbiturate decreases the effect of the corticosteroidAprobarbital The barbiturate decreases the effect of the corticosteroidAmobarbital The barbiturate decreases the effect of the corticosteroidChlorotrianisene The estrogenic agent increases the effect of the corticosteroidClomifene The estrogenic agent increases the effect of the corticosteroidDiethylstilbestrol The estrogenic agent increases the effect of the corticosteroidEstradiol The estrogenic agent increases the effect of the corticosteroidEstriol The estrogenic agent increases the effect of the corticosteroidConjugated Estrogens The estrogenic agent increases the effect of the corticosteroidEstrone The estrogenic agent increases the effect of the corticosteroidEstropipate The estrogenic agent increases the effect of the corticosteroidEthinyl Estradiol The estrogenic agent increases the effect of the corticosteroidMestranol The estrogenic agent increases the effect of the corticosteroidQuinestrol The estrogenic agent increases the effect of the corticosteroidEthotoin The enzyme inducer decreases the effect of the corticosteroidFosphenytoin The enzyme inducer decreases the effect of the corticosteroidMephenytoin The enzyme inducer decreases the effect of the corticosteroidPhenytoin The enzyme inducer decreases the effect of the corticosteroidRifampin The enzyme inducer decreases the effect of the corticosteroidItraconazole The imidazole increases the effect and toxicity of the corticosteroidKetoconazole The imidazole increases the effect and toxicity of the corticosteroid
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CYP450 Drug Interaction |
[CYP450 TableÁ÷Á¢Á¶È¸]
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| Food Interaction |
Prednisolone¿¡ ´ëÇÑ Food Interaction Á¤º¸ Take with food to reduce gastric irritation.Avoid alcohol. Avoid caffeine.
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| Drug Target |
[Drug Target]
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| Description |
Prednisolone¿¡ ´ëÇÑ Description Á¤º¸ A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. [PubChem]
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| Dosage Form |
Prednisolone¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Liquid OralSolution OralSolution / drops OphthalmicSuspension OphthalmicTablet Oral
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| Drug Category |
Prednisolone¿¡ ´ëÇÑ Drug_Category Á¤º¸ Adrenergic AgentsAnti-inflammatory AgentsAntineoplastic AgentsAntineoplastic Agents, HormonalGlucocorticoids
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| Smiles String Canonical |
Prednisolone¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CC12CC(O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO
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| Smiles String Isomeric |
Prednisolone¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
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| InChI Identifier |
Prednisolone¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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| Chemical IUPAC Name |
Prednisolone¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
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| Drug-Induced Toxicity Related Proteins |
PREDNISOLONE ÀÇ Drug-Induced Toxicity Related ProteinÁ¤º¸ Replated Protein:DNA topoisomerase 1 Drug:prednisolone Toxicity:appearance of apoptotic cells. [¹Ù·Î°¡±â]
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µå·°ÀÎÆ÷ ÀǾàÇмúÁ¤º¸´Â ½ÄǰÀǾàǰ¾ÈÀüóÀÇ Á¦Ç°Çã°¡»çÇ×, Çмú¹®Çå, Á¦¾àȸ»ç Á¦°øÁ¤º¸ µîÀ» ±Ù°Å·Î ÀÛ¼ºµÈ Âü°í Á¤º¸ÀÔ´Ï´Ù.
Á¤º¸ÀÇ Á¤È®¼ºÀ» À§ÇØ ³ë·ÂÇϰí ÀÖÀ¸³ª ÆíÁý»óÀÇ ¿À·ù, Çã°¡»çÇ× º¯°æ, Ãß°¡ÀûÀÎ Çмú¿¬±¸ ¶Ç´Â Àӻ󿬱¸ ¹ßÇ¥ µîÀ¸·Î ÀÎÇØ ¹ß»ýÇÏ´Â ¹®Á¦¿¡ ´ëÇØ µå·°ÀÎÆ÷´Â
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ÀüÈ: 02-3486-1061 ¤Ó À̸ÞÀÏ: webmaster@druginfo.co.kr
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