| 항목 |
내용 |
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| 독성정보 |
Ibuprofen에 대한 독성정보 : 정보보기
출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do |
| Mechanism of Action |
Ibuprofen에 대한 Mechanism_Of_Action 정보
The exact mechanisms of action of Ibuprofen is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
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| Pharmacology |
Ibuprofen에 대한 Pharmacology 정보
Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.
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| Metabolism |
Ibuprofen에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Cytochrome P450 2C9 (CYP2C9)Monoamine oxidase type B (MAO-B)
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| Protein Binding |
Ibuprofen에 대한 단백결합 정보
99%
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| Half-life |
Ibuprofen에 대한 반감기 정보
1.8-2.0 hours
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| Absorption |
Ibuprofen에 대한 Absorption 정보
rapidly absorbed
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| Pharmacokinetics |
Ibuprofen의 약물동력학자료
- 진통효과 발현시간 : 30-60분
- 작용지속시간 : 4-6 시간
- 항염효과 발현시간 : 7일까지
- 최대 항염효과 발현시간 : 1-2주
- 흡수 : 경구 : 신속하게 흡수됨 (85%)
- 단백결합 : 90-99%
- 대사 : 간에서 산화대사
- 반감기 : 2-4 시간 (말기 신질환에서도 반감기는 변화하지 않음)
- 혈중최고농도 도달시간 : 1-2 시간 이내
- 소실 : 신배설(미변화체로는 1% 미만), 일부 담즙배설도 일어남
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| Biotransformation |
Ibuprofen에 대한 Biotransformation 정보
Hepatic
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| Toxicity |
Ibuprofen에 대한 Toxicity 정보
Abdominal pain, breathing difficulties, coma, drowsiness, headache, irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD50=1255mg/kg(orally in mice)
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| Drug Interactions |
Ibuprofen에 대한 Drug_Interactions 정보
Acebutolol Risk of inhibition of renal prostaglandinsAtenolol Risk of inhibition of renal prostaglandinsBetaxolol Risk of inhibition of renal prostaglandinsBevantolol Risk of inhibition of renal prostaglandinsBisoprolol Risk of inhibition of renal prostaglandinsCarteolol Risk of inhibition of renal prostaglandinsCarvedilol Risk of inhibition of renal prostaglandinsEsmolol Risk of inhibition of renal prostaglandinsLabetalol Risk of inhibition of renal prostaglandinsNadolol Risk of inhibition of renal prostaglandinsMetoprolol Risk of inhibition of renal prostaglandinsOxprenolol Risk of inhibition of renal prostaglandinsPenbutolol Risk of inhibition of renal prostaglandinsPindolol Risk of inhibition of renal prostaglandinsPractolol Risk of inhibition of renal prostaglandinsPropranolol Risk of inhibition of renal prostaglandinsSotalol Risk of inhibition of renal prostaglandinsTimolol Risk of inhibition of renal prostaglandinsWarfarin The NSAID increases the anticoagulant effectAcenocoumarol The NSAID increases the anticoagulant effectDicumarol The NSAID increases the anticoagulant effectAnisindione The NSAID increases the anticoagulant effectEthacrynic acid The NSAID decreases the diuretic and antihypertensive effect of the loop diureticFurosemide The NSAID decreases the diuretic and antihypertensive effect of the loop diureticTorasemide The NSAID decreases the diuretic and antihypertensive effect of the loop diureticBumetanide The NSAID decreases the diuretic and antihypertensive effect of the loop diureticAspirin Ibuprofen reduces ASA cardioprotective effectsMethotrexate The NSAID increases the effect and toxicity of methotrexateAlendronate Increased risk of gastric toxicityCyclosporine Monitor for nephrotoxicityLithium The NSAID increases serum levels of lithium
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CYP450
Drug Interaction |
[CYP450 Table직접조회]
Ibuprofen에 대한 P450 table
SUBSTRATES
CYP 2C9
NSAIDs:
diclofenac
**ibuprofen**
piroxicam
Oral Hypoglycemic Agents:
tolbutamide
glipizide
Angiotensin II Blockers:
NOT candesartan
irbesartan
losartan
NOT valsartan
celecoxib
fluvastatin naproxen
phenytoin
sulfamethoxazole
tamoxifen
tolbutamide
torsemide
warfarin
INHIBITORS
CYP 2C9
amiodarone
fluconazole
isoniazid
INDUCERS
CYP 2C9
rifampin
secobarbital
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| Food Interaction |
Ibuprofen에 대한 Food Interaction 정보
Avoid alcohol.Take with food to reduce irritation.
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| Drug Target |
[Drug Target]
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| Description |
Ibuprofen에 대한 Description 정보
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis. [PubChem]
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| Dosage Form |
Ibuprofen에 대한 Dosage_Form 정보
Capsule OralSuspension OralTablet OralTablet, chewable Oral
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| Drug Category |
Ibuprofen에 대한 Drug_Category 정보
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents, Non-SteroidalAnti-inflammatory AgentsCyclooxygenase InhibitorsNonsteroidal Antiinflammatory Agents (NSAIDs)
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| Smiles String Canonical |
Ibuprofen에 대한 Smiles_String_canonical 정보
CC(C)CC1=CC=C(C=C1)C(C)C(O)=O
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| Smiles String Isomeric |
Ibuprofen에 대한 Smiles_String_isomeric 정보
CC(C)CC1=CC=C(C=C1)[C@@H](C)C(O)=O
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| InChI Identifier |
Ibuprofen에 대한 InChI_Identifier 정보
InChI=1/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/f/h14H
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| Chemical IUPAC Name |
Ibuprofen에 대한 Chemical_IUPAC_Name 정보
2-[4-(2-methylpropyl)phenyl]propanoic acid
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| Drug-Induced Toxicity Related Proteins |
IBUPROFEN 의 Drug-Induced Toxicity Related Protein정보
Replated Protein:Myeloperoxidase
Drug:ibuprofen
Toxicity:increase the incidence of ventricular fibrillation.
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Replated Protein:Myeloperoxidase
Drug:ibuprofen
Toxicity:increase the incidence of haemorrhagic infarction.
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Replated Protein:Arylamine N-acetyltransferase 2
Drug:ibuprofen
Toxicity:ibuprofen inhibition.
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전문/일반
