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2) ¸®Æ¬°ú ACE¾ïÁ¦Á¦¸¦ º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â ¸®Æ¬µ¶¼ºÀÇ À§ÇèÀÌ ÀÖÀ¸¹Ç·Î Ç÷Áß ¸®Æ¬³óµµ¸¦ ½ÅÁßÈ÷ ¸ð´ÏÅ͸µÇÏ°í ¿ë·®À» Á¶ÀýÇÑ´Ù(¸®Æ¬ÀÇ ¹è¼³À» °¨¼Ò½ÃÄÑ Ç÷Á߸®Æ¬³óµµ°¡ Áõ°¡ÇÑ´Ù.). ¸®Æ¬°úÀÇ º´¿ëÀº ±ÇÀåµÇÁö ¾Ê´Â´Ù.
3) Àεµ¸ÞŸ½Å µîÀÇ ºñ½ºÅ×·ÎÀ̵å¼Ò¿°ÁøÅëÁ¦(NSAID) ¹× Ç×·ù¸¶Æ¼½º ¾à¹°°ú º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â ÀÌ ¾àÀÇ Ç÷¾Ð°ÇÏÀÛ¿ëÀÌ °¨¼ÒÇÒ ¼ö ÀÖÀ¸¹Ç·Î ÁÖÀÇÇÑ´Ù. ¶ÇÇÑ ºñ½ºÅ×·ÎÀ̵å¼Ò¿°ÁøÅëÁ¦¿Í ACE¾ïÁ¦Á¦´Â Ç÷û Ä®·ý ³óµµ Áõ°¡¿¡ »ó°¡ÀÛ¿ëÀ» ³ªÅ¸³»´Â ÇÑÆí ½Å±â´ÉÀº °¨¼ÒµÉ ¼ö ÀÖ´Â °ÍÀ¸·Î ¾Ë·ÁÁ³´Ù. ÀÌ·¯ÇÑ ÀÛ¿ëÀº ÀϹÝÀûÀ¸·Î °¡¿ªÀûÀ̸ç, ƯÈ÷ ½ÅÀå±â´ÉÀÌ ÀúÇÏµÈ È¯ÀÚ¿¡¼ ³ªÅ¸³´Ù. ȯÀÚ¿¡°Ô ¼öºÐÀ» ÃæºÐÈ÷ °ø±ÞÇϰí Ä¡·á Ãʱ⿡ ½ÅÀå ±â´ÉÀ» °üÂûÇÑ´Ù.
4) º£Å¸Â÷´ÜÁ¦, ¸ÞÆ¿µµÆÄ, Ä®½·Ã¤³ÎÂ÷´ÜÁ¦, ÀÌ´¢Á¦ µî ´Ù¸¥ Ç÷¾Ð°ÇÏÁ¦¿Í º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â Ç÷¾Ð°ÇÏÀÛ¿ëÀÌ Áõ°¡µÉ ¼ö ÀÖ´Ù.
5) ¸é¿ª¿ªÁ¦Á¦, ¼¼Æ÷Áõ½Ä¾ïÁ¦Á¦, ¾Ë·ÎǪ¸®³î, ÄÚ¸£Æ¼ÄÚÀÌµå ¶Ç´Â ÇÁ·ÎÄ«Àξƹ̵å¿Í º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â Ç÷±¸¼öÀÇ º¯È(¹éÇ÷±¸°¨¼ÒÁõÀÇ À§Ç輺 Áõ°¡)°¡ ³ªÅ¸³ª¹Ç·Î ÁÖÀÇÇÑ´Ù.
6) ¾ËÄڿðú º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â ¾ËÄÚ¿Ã ÀÛ¿ëÀÌ »ó½ÂÇÒ ¼ö ÀÖ°í ¾ËÄÚ¿ÃÀÌ Ç÷¾Ð°ÇÏ ÀÛ¿ëÀ» °È½Ãų ¼ö ÀÖÀ¸¹Ç·Î ÁÖÀÇÇÑ´Ù.
7) ¸¶¾à, Á¤½Åº´Ä¡·áÁ¦¿Í º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â ±â¸³ÀúÇ÷¾ÐÀÇ À§ÇèÀÌ Áõ°¡µÉ ¼ö ÀÖ´Ù.
8) Àν¶¸° ¶Ç´Â °æ±¸¿ë Ç÷´ç°ÇÏÁ¦¿Í º´¿ëÅõ¿©ÇÏ´Â °æ¿ì¿¡´Â Ç÷´ç°ÇÏÀÛ¿ëÀÌ Áõ°¡µÈ´Ù´Â º¸°í°¡ ÀÖÀ¸¹Ç·Î ÁÖÀÇÇÑ´Ù.
9) ¼ö¸éÁ¦, ¸¶ÃëÁ¦ µîÀº Ç÷¾ÐÀÇ ÇöÀúÇÑ °¨¼Ò¸¦ ³ªÅ¸³¾ ¼ö ÀÖÀ¸¹Ç·Î ÁÖÀÇÇÑ´Ù.
10) Á¦»êÁ¦¿Í º´¿ëÅõ¿©½Ã ACE¾ïÁ¦Á¦ÀÇ »ýü³» ÀÌ¿ë·üÀÌ °¨¼ÒµÉ ¼ö ÀÖ´Ù.
11) ±³°¨½Å°æÀÛ¿ëÁ¦, ¿°È³ªÆ®·ýÀº ÀÌ ¾àÀÇ È¿°ú¸¦ °¨¼Ò½Ãų ¼ö ÀÖ´Ù.
12) ÁÖ»ç¿ë ±Ý(Sodium aurothiomalate)°ú ACE¾ïÁ¦Á¦·Î º´¿ë Ä¡·áÇÑ È¯Àڵ鿡¼ µå¹°°Ô ¾ÆÁú»ê¿°¾ç ¹ÝÀÀ(nitritoid reaction : ¾ó±¼È«Á¶, ±¸¿ª, ±¸Åä ¹× ÀúÇ÷¾ÐÀ» µ¿¹ÝÇÑ Áõ»ó)ÀÌ º¸°íµÇ¾ú´Ù.
13) ¿¡½ºÆ®¶ó¹«½ºÆ¾ : Ç÷°üºÎÁ¾ÀÇ ÀÌ»ó¹ÝÀÀ À§ÇèÀ» Áõ°¡½Ãų ¼ö ÀÖÀ¸¹Ç·Î, ÀÌ ¾à°úÀÇ º´¿ëÀº ±ÇÀåµÇÁö ¾Ê´Â´Ù.
14) ¹ÙŬ·ÎÆæ : Ç÷¾Ð °ÇÏ È¿°ú¸¦ Áõ°¡½ÃŲ´Ù. Ç÷¾ÐÀÇ ¸ð´ÏÅ͸µ°ú Ç÷¾Ð°ÇÏÁ¦ÀÇ ¿ë·®Á¶ÀýÀÌ ÇÊ¿äÇÏ´Ù.
15) ÀÌ´¢Á¦ : °©ÀÛ½º·± Ç÷¾Ð °ÇÏ ¹×/ȤÀº ÁßÁõÀÇ ½ÅºÎÀü À§ÇèÀÌ ÀÖ´Ù. ACE¾ïÁ¦Á¦¿¡ ÀÇÇÑ Ä¡·á¸¦ ½ÃÀÛÇϱâ Àü¿¡ ÀÌ´¢Á¦¸¦ Áß´ÜÇϰí Â÷Ãû ÇÊ¿äÇÑ °æ¿ì, ÀúÄ®·ýÇ÷Áõ ÀÌ´¢Á¦¸¦ ´Ù½Ã »ç¿ëÇϰųª ACE¾ïÁ¦Á¦ÀÇ Ãʱ⠿뷮À» °¨¼Ò½ÃÄÑ Ã³¹æÇÏ°í ¿ë·®À» ´Ü°èÀûÀ¸·Î Áõ°¡½ÃÄÑ¾ß ÇÑ´Ù. ÀÌ´¢Á¦ Ä¡·á¹ÞÀº ¿ïÇ÷ ½ÉºÎÀüÀÇ °æ¿ì, ACE¾ïÁ¦Á¦¸¦ ¼Ò·®À¸·Î Åõ¿© ½ÃÀÛÇϰí, Ä¡·á¸¦ ½ÃÀÛÇÑ ¸î ÁÖ ÀÌÈÄ¿¡ ½Å±â´É(Å©·¹¾ÆÆ¼´Ñ)À» È®ÀÎÇÑ´Ù. ÀÌ ¾à Åõ¿©½Ã °úµµÇÑ Ç÷¾Ð °ÇÏ(ƯÈ÷, ÃÖ±Ù ÀÌ´¢Á¦ Ä¡·á¸¦ ½ÃÀÛÇÑ È¯ÀÚ)°¡ º¸°íµÈ ¹Ù ÀÖ´Ù. ÀÌ ¾à º¹¿ë½Ã ÀúÇ÷¾ÐÀÇ °¡´É¼ºÀº ÀÌ´¢Á¦¸¦ Áß´ÜÇϰųª ȤÀº ÀÌ ¾à Ä¡·á ½ÃÀÛÇϱ⠸çÄ¥ Àü ºÎÅÍ ¿° ¼·Ãë·®À» Áõ°¡½ÃŰ´Â °Í¿¡ ÀÇÇØ ÃÖ¼ÒÈÇÒ ¼ö ÀÖ´Ù.
16) ¾Æ¹ÌÆ÷½ºÆ¾ : Ç÷¾Ð°ÇÏÈ¿°ú Áõ°¡½ÃŲ´Ù.
17) »ïȯ°èÇ׿ì¿ï¾à, ½Å°æÀÌ¿ÏÁ¦ : Ç÷¾Ð°ÇÏÈ¿°ú ¹× ±â¸³ ÀúÇ÷¾ÐÀÇ À§ÇèÀ» Áõ°¡½ÃŲ´Ù.
18) ºÎ½ÅÇÇÁúÈ£¸£¸ó, Åׯ®¶óÄÚ»èŸÀ̵å : Ç÷¾Ð°ÇÏÈ¿°ú¸¦ °¨¼Ò½ÃŲ´Ù.
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| Mechanism of Action |
Moexipril¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Moexipril is a prodrug for moexiprilat, which inhibits ACE in humans and animals. The mechanism through which moexiprilat lowers blood pressure is believed to be primarily inhibition of ACE activity. ACE is a peptidyl dipeptidase that catalyzes the conversion of the inactive decapeptide angiotensin I to the vasoconstrictor substance angiotensin II. Angiotensin II is a potent peripheral vasoconstrictor that also stimulates aldosterone secretion by the adrenal cortex and provides negative feedback on renin secretion. ACE is identical to kininase II, an enzyme that degrades bradykinin, an endothelium-dependent vasodilator. Moexiprilat is about 1000 times as potent as moexipril in inhibiting ACE and kininase II. Inhibition of ACE results in decreased angiotensin II formation, leading to decreased vasoconstriction, increased plasma renin activity, and decreased aldosterone secretion. The latter results in diuresis and natriuresis and a small increase in serum potassium concentration (mean increases of about 0.25 mEq/L were seen when moexipril was used alone). Whether increased levels of bradykinin, a potent vasodepressor peptide, play a role in the therapeutic effects of moexipril remains to be elucidated. Although the principal mechanism of moexipril in blood pressure reduction is believed to be through the renin-angiotensin-aldosterone system, ACE inhibitors have some effect on blood pressure even in apparent low-renin hypertension.
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| Pharmacology |
Moexipril¿¡ ´ëÇÑ Pharmacology Á¤º¸ Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
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| Metabolism |
Moexipril¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Liver carboxylesterase
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| Protein Binding |
Moexipril¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ Moexiprilat is about 50% protein bound.
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| Half-life |
Moexipril¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ Moexipril elimination half-life is approximately 1 hour. Moexiprilat elimination half-life is 2 to 9 hours.
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| Absorption |
Moexipril¿¡ ´ëÇÑ Absorption Á¤º¸ Moexipril is incompletely absorbed, with bioavailability as moexiprilat of about 13% compared to intravenous (I.V.) moexipril (both measuring the metabolite moexiprilat), and is markedly affected by food, which reduces Cmax and AUC by about 70% and 40% respectively after the ingestion of a low-fat breakfast or by 80% and 50% respectively after the ingestion of a high-fat breakfast.
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| Pharmacokinetics |
Moexipril HClÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á
- Ç÷ÁßÃÖ°í³óµµ µµ´Þ½Ã°£ : 1.5 ½Ã°£
- Èí¼ö : À½½Ä¹°Àº »ýü³»ÀÌ¿ëÀ²À» °¨¼Ò½ÃÅ´. (AUC ¾à 40% °¨¼Ò)
- »ýü³»ÀÌ¿ëÀ² : moexiprilat : 13%
- ºÐÆ÷
- ºÐÆ÷¿ëÀû : moexiprilat : 180 L
- ´Ü¹é°áÇÕ
- moexipril : 90%
- moexiprilat : 50-70%
- ´ë»ç : °£, ¼ÒÀå¿¡¼ moexiprilat·Î ´ë»çµÊ. Moexiprilat´Â moexiprilº¸´Ù 1000¹è È¿´ÉÀÌ ´õ Å©´Ù.
- ¹Ý°¨±â : moexipril : 1½Ã°£. moexiprilat : 2-10 ½Ã°£
- ¼Ò½Ç : 50%´Â ´ëº¯À¸·Î ¹è¼³µÊ.
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| Biotransformation |
Moexipril¿¡ ´ëÇÑ Biotransformation Á¤º¸ Rapidly converted to moexiprilat, the active metabolite. Conversion to the active metabolite is thought to require carboxyesterases and is likely to occur in organs or tissues, other than the gastrointestinal tract, in which carboxyesterases occur. The liver is thought to be one site of conversion, but not the primary site.
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| Toxicity |
Moexipril¿¡ ´ëÇÑ Toxicity Á¤º¸ Human overdoses of moexipril have not been reported. In case reports of overdoses with other ACE inhibitors, hypotension has been the principal adverse effect noted. Single oral doses of 2 g/kg moexipril were associated with significant lethality in mice. Rats, however, tolerated single oral doses of up to 3 g/kg.
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| Drug Interactions |
Moexipril¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available
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CYP450 Drug Interaction |
[CYP450 TableÁ÷Á¢Á¶È¸]
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| Food Interaction |
Moexipril¿¡ ´ëÇÑ Food Interaction Á¤º¸ Take moexipril one hour before meals.
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| Drug Target |
[Drug Target]
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| Description |
Moexipril¿¡ ´ëÇÑ Description Á¤º¸ Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
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| Dosage Form |
Moexipril¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Tablet, coated Oral
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| Drug Category |
Moexipril¿¡ ´ëÇÑ Drug_Category Á¤º¸ Angiotensin-converting Enzyme Inhibitors
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| Smiles String Canonical |
Moexipril¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N1CC2=CC(OC)=C(OC)C=C2CC1C(O)=O
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| Smiles String Isomeric |
Moexipril¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CC2=CC(OC)=C(OC)C=C2C[C@H]1C(O)=O
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| InChI Identifier |
Moexipril¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C27H34N2O7/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32)/t17-,21-,22-/m0/s1/f/h31H
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| Chemical IUPAC Name |
Moexipril¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
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º» ¼öÁ¤ÀÏ Á¤º¸´Â Çã°¡Á¤º¸ ÀÌ¿ÜÀÇ ±âŸÁ¤º¸ ¼öÁ¤ÀÏÀ» ÀǹÌÇϹǷÎ, Çã°¡Á¤º¸¼öÁ¤ÀÏÀº º»¹®¿¡ Ç¥±âµÈ ³¯Â¥¸¦ ÂüÁ¶ÇϽñ⠹ٶø´Ï´Ù.
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µå·°ÀÎÆ÷ ÀǾàÇмúÁ¤º¸´Â ½ÄǰÀǾàǰ¾ÈÀüóÀÇ Á¦Ç°Çã°¡»çÇ×, Çмú¹®Çå, Á¦¾àȸ»ç Á¦°øÁ¤º¸ µîÀ» ±Ù°Å·Î ÀÛ¼ºµÈ Âü°í Á¤º¸ÀÔ´Ï´Ù.
Á¤º¸ÀÇ Á¤È®¼ºÀ» À§ÇØ ³ë·ÂÇϰí ÀÖÀ¸³ª ÆíÁý»óÀÇ ¿À·ù, Çã°¡»çÇ× º¯°æ, Ãß°¡ÀûÀÎ Çмú¿¬±¸ ¶Ç´Â Àӻ󿬱¸ ¹ßÇ¥ µîÀ¸·Î ÀÎÇØ ¹ß»ýÇÏ´Â ¹®Á¦¿¡ ´ëÇØ µå·°ÀÎÆ÷´Â
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¹Ýµå½Ã Á¦Á¶¡¤¼öÀÔ»ç, ÆÇ¸Å»ç, ÀÇ»ç, ¾à»ç¿¡°Ô ÃÖÁ¾ÀûÀ¸·Î È®ÀÎÇϽñ⠹ٶø´Ï´Ù.
ÀüÈ: 02-3486-1061 ¤Ó À̸ÞÀÏ: webmaster@druginfo.co.kr
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The database contains the following fields: The generic name of each chemical For module A10 (liver enzyme composite module): Overall activity category for each compound (A for active, M for marginally active, or I for inactive) based on the number of active and marginally active scores for each compound at the five individual endpoints (see research article for full description of method) Number of endpoints at which each compound is marginally active (M) Number of endpoints at which each compound is active (A) For modules A11 to A15 (alkaline phosphatase increased, SGOT increased, SGPT increased, LDH increased, and GGT increased, respectively): Overall activity category for each compound (A for active, M for marginally active, or I for inactive) based on the RI and ADR values (see the research article for full description of method) Number of ADR reports for each compound, given as <4 or ¡Ã4 Reporting Index value for each compound, except where no shipping units were available (NSU) Group 1 comprises of compounds for which ADR data were available for the first five years of marketing, so when no ADR reports were listed during this period the compounds were evaluated as inactive. Group 2 comprises of compounds for which a 'steady state' period of ADR data were available (1992-1996). In cases where no ADR reports were filed during this period, the compounds were scored as 'NA' (data not available) since they may have had one or more ADR reports during their first five years of marketing which should not be negated by a lack of ADR reports during the steady-state period. MOEXIPRIL[GGT Increase][Composite Activity](Score) I(Marginal) 0(Active) 0[Alkaline Phosphatase Increase](Activity Score) I(Number of Rpts) <4(Index value) 0[SGOT Increase](Activity Score) I(Number of Rpts) <4(Index value) 1.3[SGPT Increase](Activity Score) I(Number of Rpts) <4(Index value) 1.3[LDH Increase](Activity Score) I(Number of Rpts) <4(Index value) 0[GGT Increase](Activity Score) I(Number of Rpts) <4(Index value) 0
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