드러그인포 약품요약정보

허가정보

항목

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청구코드(KD코드)
비급여점검코드
상한금액

비급여
[상병코드조회]
[질병코드조회]

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요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

갈색의 분말이 든 상부 쵸코렛색 하부 담홍색의 경질캅셀제 [제형정보 확인]

용법용량

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[처방약어]
성인 1회 1캅셀을 1일 2회 아침, 저녁 식후 복용

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

금기

상기가 강하고 안면홍조인 체력이 건실한 사람

신중투여

설사하기 쉬운 사람
임신부 또는 임신하고 있다고 사료되는 사람
의사의 치료를 받고 있는 사람

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	한방제제
ATC 코드	Other immunostimulants / L03AX [코드분류상세설명] [ATC코드예측]
복지부분류코드	329 (기타의 자양강장변질제 )
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	비급여 [상병코드조회] [질병코드집 다운로드]
제품성상	갈색의 분말이 든 상부 쵸코렛색 하부 담홍색의 경질캅셀제 [제형정보 확인]

복약정보

항목	내용
LACTmed 바로가기	[바로가기]
병용금기 및 연령대금기 근거조회	[병용금기 및 연령대금기 근거조회]
보관상 주의
조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
Mechanism of Action	Candicidin에 대한 Mechanism_Of_Action 정보 Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of Candicidin. Candicidin binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane.
Pharmacology	Candicidin에 대한 Pharmacology 정보 Candicidin is a polyene antifungal antibiotic produced by a strain of Streptomyces griseus. It is especially effective against Candida albicans (more effective than amphotericin B), and is administered intravaginally in the treatment of vulvovaginal candidiasis.
Metabolism	Candicidin에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Not Available
Protein Binding	Candicidin에 대한 단백결합 정보 Not Available
Half-life	Candicidin에 대한 반감기 정보 Not Available
Absorption	Candicidin에 대한 Absorption 정보 Not Available
Biotransformation	Candicidin에 대한 Biotransformation 정보 Not Available
Toxicity	Candicidin에 대한 Toxicity 정보 Not Available
Drug Interactions	Candicidin에 대한 Drug_Interactions 정보 Altretamine Risk of severe hypotensionAtazanavir Atazanavir increases the effect and toxicity of tricyclicsCarbamazepine The tricyclic increases the effect of carbamazepineCimetidine Cimetidine increases the effect of tricyclic agentCisapride Increased risk of cardiotoxicity and arrhythmiasClonidine The tricyclic decreases the effect of clonidineDihydroquinidine barbiturate Quinidine increases the effect of tricyclic agentDobutamine The tricyclic increases the sympathomimetic effectDonepezil Possible antagonism of actionDopamine The tricyclic increases the sympathomimetic effectDuloxetine Possible increase in the levels of this agent when used with duloxetineEphedra The tricyclic increases the sympathomimetic effectEphedrine The tricyclic increases the sympathomimetic effectEpinephrine The tricyclic increases the sympathomimetic effectFenoterol The tricyclic increases the sympathomimetic effectFluoxetine Fluoxetine increases the effect and toxicity of tricyclicsFluvoxamine Fluvoxamine increases the effect and toxicity of tricyclicsGalantamine Possible antagonism of actionGrepafloxacin Increased risk of cardiotoxicity and arrhythmiasGuanethidine The tricyclic decreases the effect of guanethidineIsocarboxazid Possibility of severe adverse effectsIsoproterenol The tricyclic increases the sympathomimetic effectMephentermine The tricyclic increases the sympathomimetic effectMetaraminol The tricyclic increases the sympathomimetic effectMethoxamine The tricyclic increases the sympathomimetic effectMoclobemide Possible severe adverse reaction with this combinationNorepinephrine The tricyclic increases the sympathomimetic effectOrciprenaline The tricyclic increases the sympathomimetic effectPhenelzine Possibility of severe adverse effectsPhenylephrine The tricyclic increases the sympathomimetic effectPhenylpropanolamine The tricyclic increases the sympathomimetic effectPirbuterol The tricyclic increases the sympathomimetic effectProcaterol The tricyclic increases the sympathomimetic effectPseudoephedrine The tricyclic increases the sympathomimetic effectQuinidine Quinidine increases the effect of tricyclic agentQuinidine barbiturate Quinidine increases the effect of tricyclic agentRasagiline Possibility of severe adverse effectsRifabutin The rifamycin decreases the effect of tricyclicsRifampin The rifamycin decreases the effect of tricyclicsRitonavir Ritonavir increases the effect and toxicity of tricyclicsRivastigmine Possible antagonism of actionSalbutamol The tricyclic increases the sympathomimetic effectSibutramine Increased risk of CNS adverse effectsSparfloxacin Increased risk of cardiotoxicity and arrhythmiasTerbinafine Terbinafine increases the effect and toxicity of the tricyclicTerbutaline The tricyclic increases the sympathomimetic effectTerfenadine Increased risk of cardiotoxicity and arrhythmiasTranylcypromine Possibility of severe adverse effects
CYP450 Drug Interaction	[CYP450 Table직접조회]
Food Interaction	Candicidin에 대한 Food Interaction 정보 Not Available
Drug Target	[Drug Target]
Description	Candicidin에 대한 Description 정보 Candicidin is an antibiotic obtained from a streptomyces (Streptomyces griseus) and active against some fungi of the genus Candida (C. albicans). Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis.
Dosage Form	Candicidin에 대한 Dosage_Form 정보 Not Available
Drug Category	Candicidin에 대한 Drug_Category 정보 Anti-Bacterial AgentsAntifungal Agents
Smiles String Canonical	Candicidin에 대한 Smiles_String_canonical 정보 CC(CC(C)C1OC(=O)CC(=O)CCCC(=O)CC(O)CC(O)CC(O)CC2(O)CC(O)C(C(CC(OC3OC(C)C(O)C(N)C3O)C=CC=CC=CC=CC=CC=CC=CC1C)O2)C(O)=O)C(O)CC(=O)C1=CC=C(N)C=C1
Smiles String Isomeric	Candicidin에 대한 Smiles_String_isomeric 정보 C[C@@H](C[C@H](C)[C@H]1OC(=O)CC(=O)CCCC(=O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@]2(O)C[C@@H](O)[C@H]([C@@H](C[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/[C@@H]1C)O2)C(O)=O)[C@@H](O)CC(=O)C1=CC=C(N)C=C1
InChI Identifier	Candicidin에 대한 InChI_Identifier 정보 InChI=1/C59H84N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-46(77-58-55(72)53(61)54(71)38(4)76-58)31-50-52(57(73)74)49(69)34-59(75,79-50)33-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)30-51(70)78-56(35)37(3)26-36(2)47(67)32-48(68)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,43-47,49-50,52-56,58,64-67,69,71-72,75H,17,19-20,26-34,60-61H2,1-4H3,(H,73,74)/b6-5-,9-7-,10-8-,13-11-,14-12-,18-15-,21-16-/t35?,36?,37?,38-,43?,44?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,58?,59?/m1/s1/f/h73H
Chemical IUPAC Name	Candicidin에 대한 Chemical_IUPAC_Name 정보 (19E,21E,23E,25E,27E,29E,31E)-33-[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-17-[7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl]-1,3,5,7,37-pentahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

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