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                    ¼Ò¸íÁ¤Ä°¼¿  SOMUYNGJUNG[Bezoar , Cervi Parvum Cornu Powder , Pyridoxine HCl , Riboflavin , Royal jelly , Thiamine disulfide , White Ginseng   
                    
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                     ÀϹÝÀǾàǰ | ¹Ì»ý»ê  
                        
                    	
                    
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                      ¾Ë¸²:  | 
                      µå·°ÀÎÆ÷¿¡¼´Â ÀǾàǰ ÀÎÅÍ³Ý ÆÇ¸Å¸¦ ÇÏÁö ¾Ê½À´Ï´Ù. | 
                     
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    Ȳ»öÀÇ ºÐ¸» ¶Ç´Â  °ú¸³»óÀÌ µç »óÇÏ´Ü Àû»öÀÇ Ä°¼¿Á¦  [Á¦ÇüÁ¤º¸ È®ÀÎ] |   
   
  
  
  
  
  
  
  
  
  
  
  
 
  
  
    
  
  
  
  
  
  
  
  
  
  
 
  
  
  
 
  
  
  
  
  
  
  
     
  
  
  
   
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    [ÀûÀÀÁõ º° °Ë»ö] 
     
    
     
	 
      ÀÚ¾ç°Àå, Çã¾àüÁú,  À°Ã¼ÇÇ·Î, º´Áß º´ÈÄ, ¿µ¾çÀåÇØ, ¹ß¿¼º¼Ò¸ð¼ºÁúȯµîÀÇ ¿µ¾çº¸±Þ
      
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      * Àý´ë ÀÓÀǺ¹¿ëÇÏÁö ¸¶½Ã°í ¹Ýµå½Ã ÀÇ»ç ¶Ç´Â ¾à»ç¿Í »ó´ãÇϽñ⠹ٶø´Ï´Ù. 
    
     
      
      
      [󹿾à¾î] 
      ¼ºÀÎ (15¼¼ ÀÌ»ó) 1ȸ 1ݼ¿, 1ÀÏ 2ȸ º¹¿ëÇÑ´Ù.     
      	
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    | ½ÅÁßÅõ¿© | 
    - 1¼¼ ¹Ì¸¸ÀÇ À¯¾Æ
 - ÀÇ»çÀÇ Ä¡·á¸¦ ¹Þ°í ÀÖ´Â »ç¶÷
 
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    | Off-label Usage | 
    
      
	[Á¶È¸]    
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    | Related FDA Approved Drug | 
    
      
      ±âÁØ ¼ººÐ: RIBOFLAVINBEROCCA PN (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN E) 
CERNEVIT-12 (ALPHA-TOCOPHEROL; ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; FOLIC ACID; NIACINAMIDE; PANTOTHENIC ACID; PYRIDOXINE; RIBOFLAVIN; THIAMINE; VITAMIN A) 
INFUVITE ADULT (ALPHA-TOCOPHEROL ACETATE; ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN K) 
INFUVITE PEDIATRIC (ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K) 
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE) (ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K) 
M.V.C. 9+3 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
M.V.I. ADULT (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K) 
M.V.I. ADULT (PHARMACY BULK PACKAGE) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K) 
M.V.I. PEDIATRIC (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
M.V.I.-12 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
M.V.I.-12 (WITHOUT VITAMIN K) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
M.V.I.-12 LYOPHILIZED (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE; VITAMIN A; VITAMIN E) 
MVC PLUS (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
VITAPED (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PANTOTHENIC ACID; PHYTONADIONE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; VITAMIN A PALMITATE; VITAMIN E) 
±âÁØ ¼ººÐ: PYRIDOXINE HYDROCHLORIDEBENDECTIN (DOXYLAMINE SUCCINATE; PYRIDOXINE HYDROCHLORIDE) 
HEXA-BETALIN (PYRIDOXINE HYDROCHLORIDE) 
PYRIDOXINE HYDROCHLORIDE (PYRIDOXINE HYDROCHLORIDE) 
TPN (NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; TYROSINE) 
±âÁØ ¼ººÐ: CERVI PARVUM CORNU POWDER±âÁØ ¼ººÐ: BEZOAR
        
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	          ÀüüÀӽŠ±â°£º°·Î ¿©·¯µî±ÞÀÌ Á¸ÀçÇÒ ¼ö ÀÖÀ¸¸ç °¡Àå À§Çèµµ°¡ ³ôÀº Á¤º¸¸¸ º¸¿©Áý´Ï´Ù. ´Ü, º¹ÇÕÁ¦ÀÇ °æ¿ì ¸ðµç º¹ÇÕÁ¦¼ººÐ¿¡ ´ëÇÑ ÀÓºÎÅõ¿©µî±ÞÀÌ Ç¥½ÃµÈ°ÍÀº Àý´ë ¾Æ´Ï¸ç Ç¥½ÃµÈ°ÍÁß¿¡ °¡Àå À§Çèµµ°¡ ³ôÀº Á¤º¸¸¸ ³ªÅ¸³³´Ï´Ù. 
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	      FDA : Aµî±Þ 
				        
				         (pyridoxine;riboflavin;thiamine; )
				        
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	          »ó±â ÀÓºÎÅõ¿©¿¡ ´ëÇÑ Á¤º¸´Â Àü»êó¸® µÇ¸é¼ ÀÔ·Â ¿À·ù °¡´É¼ºÀÌ Á¸ÀçÇÕ´Ï´Ù. ¿À·ù °¡´É¼ºÀ» ÃÖ¼ÒÈÇϱâ À§ÇÏ¿© ¸¹Àº ³ë·ÂÀ» ±â¿ïÀ̰í ÀÖÀ¸³ª, ±× Á¤È®¼º¿¡ ´ëÇÏ¿© È®½ÅÀ» µå¸± ¼ö ¾ø½À´Ï´Ù. ÀÌ¿¡ ´ëÇØ ȸ»ç´Â Ã¥ÀÓÀ» ÁöÁö ¾Ê½À´Ï´Ù.
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	          ¹Ýµå½Ã °ø½Å·Â ÀÖ´Â ¹®ÇåÀ» ´Ù½Ã Çѹø Âü°í ÇϽñ⠹ٶó¸ç ÀÇ»ç ¶Ç´Â ¾à»çÀÇ ÆÇ´Ü¿¡ µû¶ó Åõ¿©¿©ºÎ°¡ °áÁ¤µÇ¾î¾ß ÇÕ´Ï´Ù.
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      [º´¿ë±Ý±â ¹× ¿¬·É´ë±Ý±â ±Ù°ÅÁ¶È¸]
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    | º¸°ü»ó ÁÖÀÇ | 
    
      
    	
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    | Á¶Á¦½Ã ÁÖÀÇ | 
    
      
    	
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    | DUR (ÀǾàǰ»ç¿ëÆò°¡) | 
    º´¿ë±Ý±â :
     
	 °í½ÃµÈ º´¿ë±Ý±â ³»¿ëÀº ¾ø½À´Ï´Ù.
	 
	  [»óÈ£ÀÛ¿ë/º´¿ë±Ý±â°Ë»ö]										
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    | µ¶¼ºÁ¤º¸ | 
    Ethanol¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
Pyridoxine¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
Riboflavin¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
  Ãâó: ±¹¸³µ¶¼º°úÇпø µ¶¼º¹°ÁúÁ¤º¸DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do  | 
   
  
   
    | Mechanism of Action | 
    
       Pyridoxine¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
  Riboflavin¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.
  Thiamine¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux.
  Ginseng¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes. 
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    | Pharmacology | 
     
       Pyridoxine¿¡ ´ëÇÑ Pharmacology Á¤º¸ Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
  Riboflavin¿¡ ´ëÇÑ Pharmacology Á¤º¸ Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts.
  Thiamine¿¡ ´ëÇÑ Pharmacology Á¤º¸ Thiamine is a vitamin with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiamine has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiamine deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiamine has been shown to inhibit this effect of glucose on endothelial cells.
  Ginseng¿¡ ´ëÇÑ Pharmacology Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ Pharmacology Á¤º¸ Alcohol produces injury to cells by dehydration and precipitation of the cytoplasm or protoplasm. This accounts for its bacteriocidal and antifungal action. When alcohol is injected in close proximity to nerve tissues, it produces neuritis and nerve degeneration (neurolysis). Ninety to 98% of ethanol that enters the body is completely oxidized. Ethanol is also used as a cosolvent to dissolve many insoluble drugs and to serve as a mild sedative in some medicinal formulations. 
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    | Metabolism | 
    
       Pyridoxine¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Methylenetetrahydrofolate reductase
  Riboflavin¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Monoamine oxidase type A (MAO-A)Methylenetetrahydrofolate reductase
  Ginseng¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Cytochrome P450 1A1 (CYP1A1)
  ethanol¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Cytochrome P450 2E1 (CYP2E1) 
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    | Protein Binding | 
    
       Pyridoxine¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ 22%
  Riboflavin¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ 60%
  Thiamine¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ 90-94% 
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    | Half-life | 
    
       Pyridoxine¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 15-20 days
  Riboflavin¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 66-84 minutes
  Ginseng¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ Not Available 
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    | Absorption | 
    
       Pyridoxine¿¡ ´ëÇÑ Absorption Á¤º¸ The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
  Riboflavin¿¡ ´ëÇÑ Absorption Á¤º¸ Vitamin B2 is readily absorbed from the upper gastrointestinal tract.
  Thiamine¿¡ ´ëÇÑ Absorption Á¤º¸ Absorbed mainly from duodenum, by both active and passive processes
  Ginseng¿¡ ´ëÇÑ Absorption Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ Absorption Á¤º¸ Rapidly absorbed. 
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    | Pharmacokinetics | 
    
       Thiamine disulfideÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
- Èí¼ö : 
-    °æ±¸ : ÃÖ´ëÈí¼ö·® : 8-15 mg/day
 
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 RiboflavinÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
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	- À§Àå°üÀ¸·ÎºÎÅÍ Àß Èí¼öµÈ´Ù.
	
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 - ºÐÆ÷ : ü³» ¸ðµç Á¶Á÷¿¡ ³Î¸® ºÐÆ÷ÇÑ´Ù.
 - ¹Ý°¨±â : 
	
	- Ãʱ⠻ó : 1.4 ½Ã°£
	
 - ¸»±â »ó : 14½Ã°£
	
  
 - ¼Ò½Ç : ¹Ìº¯Èü·Î ½Å¹è¼³µÇ´Â ¾çÀº ¾à 9%ÀÌ´Ù.
  
 Pyridoxine HClÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
- Èí¼ö : À§Àå°üÀ¸·ÎºÎÅÍ Àß Èí¼öµÈ´Ù.
 - ´ë»ç : °£¿¡¼ 4-pyridoxic acid·Î ´ë»çµÈ´Ù.
 - ¹Ý°¨±â : 15-20ÀÏ
 - Ç÷ÁßÃÖ°í³óµµ µµ´Þ½Ã°£ : °æ±¸ : 1.25 ½Ã°£
 - ¼Ò½Ç : 4-pyridoxic acid·Î ½Å¹è¼³µÇ¸ç, ¼Ò·® (¾à 2%)Àº ´ãÁóÀ» ÅëÇØ ¹è¼³µÈ´Ù.
  
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    | Biotransformation | 
    
       Riboflavin¿¡ ´ëÇÑ Biotransformation Á¤º¸ Hepatic.
  Thiamine¿¡ ´ëÇÑ Biotransformation Á¤º¸ Hepatic
  Ginseng¿¡ ´ëÇÑ Biotransformation Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ Biotransformation Á¤º¸ Hepatic. Metabolized by cytochrome P450 enzyme CYP2E1. 
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    | Toxicity | 
    
       Pyridoxine¿¡ ´ëÇÑ Toxicity Á¤º¸ Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
  Riboflavin¿¡ ´ëÇÑ Toxicity Á¤º¸ Not Available
  Thiamine¿¡ ´ëÇÑ Toxicity Á¤º¸ Thiamine toxicity is uncommon; as excesses are readily excreted, although long-term supplementation of amounts larger than 3 gram have been known to cause toxicity. Oral mouse LD50 = 8224 mg/kg, oral rat LD50 = 3710 mg/kg.
  Ginseng¿¡ ´ëÇÑ Toxicity Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ Toxicity Á¤º¸ Oral, rat LD50: 5628 mg/kg. Symptoms and effects of overdose include nausea, vomiting, CNS depression, acute respiratory failure or death and with chronic use, severe health problems, such as liver and brain damage. 
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    | Drug Interactions | 
    
       Pyridoxine¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available
  Riboflavin¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available
  Thiamine¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available
  Ginseng¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Amphetamine	Decreased anorexic effect, may increase psychotic symptomsBenzphetamine	Decreased anorexic effect, may increase psychotic symptomsDexfenfluramine	Decreased anorexic effect, may increase psychotic symptomsDiethylpropion	Decreased anorexic effect, may increase psychotic symptomsFenfluramine	Decreased anorexic effect, may increase psychotic symptomsMazindol	Decreased anorexic effect, may increase psychotic symptomsMethamphetamine	Decreased anorexic effect, may increase psychotic symptomsPhendimetrazine	Decreased anorexic effect, may increase psychotic symptomsDextroamphetamine	Decreased anorexic effect, may increase psychotic symptomsPhenmetrazine	Decreased anorexic effect, may increase psychotic symptomsPhentermine	Decreased anorexic effect, may increase psychotic symptomsPhenylpropanolamine	Decreased anorexic effect, may increase psychotic symptomsTranylcypromine	Possible severe adverse reaction with this combinationPhenelzine	Possible severe adverse reaction with this combinationIsocarboxazid	Possible severe adverse reaction with this combinationPargyline	Possible severe adverse reaction with this combinationBromocriptine	The phenothiazine decreases the effect of bromocriptineCisapride	Increased risk of cardiotoxicity and arrhythmiasGatifloxacin	Increased risk of cardiotoxicity and arrhythmiasGrepafloxacin	Increased risk of cardiotoxicity and arrhythmiasGuanethidine	he agent decreases the effect of guanethidineLevofloxacin	Increased risk of cardiotoxicity and arrhythmiasTerfenadine	Increased risk of cardiotoxicity and arrhythmiasSparfloxacin	Increased risk of cardiotoxicity and arrhythmiasRivastigmine	Possible antagonism of actionDonepezil	Possible antagonism of actionGalantamine	Possible antagonism of actionMetrizamide	Increased risk of convulsions
  ethanol¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available 
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    CYP450  Drug Interaction | 
    
      [CYP450 TableÁ÷Á¢Á¶È¸] ethanol¿¡ ´ëÇÑ P450 table
  SUBSTRATES 
CYP 2E1 
acetaminophen 
chlorzoxazone 
**ethanol** 
 INHIBITORS 
CYP 2E1 
disulfiram 
 INDUCERS 
CYP 2E1 
**ethanol** 
isoniazid 
  SUBSTRATES 
CYP 2E1 
acetaminophen 
chlorzoxazone 
**ethanol** 
 INHIBITORS 
CYP 2E1 
disulfiram 
 INDUCERS 
CYP 2E1 
**ethanol** 
isoniazid 
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    | Food Interaction | 
    
       Ginseng¿¡ ´ëÇÑ Food Interaction Á¤º¸ Not Available 
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    | Drug Target | 
    
      
      [Drug Target]
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    | Description | 
    
       Pyridoxine¿¡ ´ëÇÑ Description Á¤º¸ The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.  Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). [PubChem]
  Riboflavin¿¡ ´ëÇÑ Description Á¤º¸ Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]
  Thiamine¿¡ ´ëÇÑ Description Á¤º¸ 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride. [PubChem]
  Ginseng¿¡ ´ëÇÑ Description Á¤º¸ Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens.
  ethanol¿¡ ´ëÇÑ Description Á¤º¸ A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. [PubChem] 
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    | Dosage Form | 
    
       Pyridoxine¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Liquid	IntramuscularSolution	IntramuscularSolution / drops	OralTablet	Oral
  Riboflavin¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Not Available
  Thiamine¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Liquid	IntramuscularLiquid	IntravenousSolution	IntravenousTablet	Oral
  Ginseng¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Capsule	OralLiquid	OralSolution / drops	OralTablet	Oral
  ethanol¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Aerosol	TopicalGel	TopicalLiquid	IntramuscularLiquid	IntravenousLiquid	OralLiquid	TopicalLotion	TopicalSolution	TopicalSolution / drops	OralSpray	Topical 
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    | Drug Category | 
    
       Pyridoxine¿¡ ´ëÇÑ Drug_Category Á¤º¸ Anti-inflammatory AgentsEssential VitaminVitamin B ComplexVitamins (Vitamin B Complex)
  Riboflavin¿¡ ´ëÇÑ Drug_Category Á¤º¸ Photosensitizing AgentsRadiation-Sensitizing AgentsVitamin B ComplexVitamins (Vitamin B Complex)
  Thiamine¿¡ ´ëÇÑ Drug_Category Á¤º¸ Anti-inflammatory AgentsEssential VitaminVitamin B ComplexVitamins (Vitamin B Complex)
  Ginseng¿¡ ´ëÇÑ Drug_Category Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ Drug_Category Á¤º¸ Anti-Infective Agents, LocalCentral Nervous System DepressantsDisinfectantsSolvents 
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    | Smiles String Canonical | 
    
       Pyridoxine¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CC1=NC=C(CO)C(CO)=C1O
  Riboflavin¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CC1=CC2=C(C=C1C)N(CC(O)C(O)C(O)CO)C1=NC(=O)NC(=O)C1=N2
  Thiamine¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CC1=NC=C(C[N+]2=CSC(CCO)=C2C)C(N)=N1
  Ginseng¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CCO 
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    | Smiles String Isomeric | 
    
       Pyridoxine¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CC1=NC=C(CO)C(CO)=C1O
  Riboflavin¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CC1=CC2=C(C=C1C)N(C[C@@H](O)[C@@H](O)[C@@H](O)CO)C1=NC(=O)NC(=O)C1=N2
  Thiamine¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CC1=NC=C(C[N+]2=CSC(CCO)=C2C)C(N)=N1
  Ginseng¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CCO 
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    | InChI Identifier | 
    
       Pyridoxine¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
  Riboflavin¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m1/s1/f/h20H
  Thiamine¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1/f/h13H2
  Ginseng¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ Not Available 
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    | Chemical IUPAC Name | 
    
       Pyridoxine¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
  Riboflavin¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ 7,8-dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione
  Thiamine¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol
  Ginseng¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ Not Available
  ethanol¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ ethanol 
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    | Drug-Induced Toxicity Related Proteins | 
    
      ETHANOL ÀÇ Drug-Induced Toxicity Related ProteinÁ¤º¸ Replated Protein:Proenkephalin  Drug:ethanol Toxicity:ethanol narcosis.  [¹Ù·Î°¡±â] Replated Protein:Insulin receptor substrate 1 Drug:Ethanol  Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.  [¹Ù·Î°¡±â] Replated Protein:Phosphatidylinositol-4-phosphate 3-kinase Drug:Ethanol  Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.  [¹Ù·Î°¡±â] Replated Protein:Insulin receptor substrate 2 Drug:Ethanol  Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.  [¹Ù·Î°¡±â] Replated Protein:Mitogen-activated protein kinase(Erk2) Drug:Ethanol  Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.  [¹Ù·Î°¡±â] Replated Protein:Mitogen-activated protein kinase  Drug:Ethanol  Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.  [¹Ù·Î°¡±â] 
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