| 항목 |
내용 |
| DUR (의약품사용평가) |
병용금기 :
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연령대금기 :
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| 독성정보 |
Ethanol에 대한 독성정보 : 정보보기
출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do |
| Mechanism of Action |
Ethanol에 대한 Mechanism_Of_Action 정보
The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes.
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| Pharmacology |
Ethanol에 대한 Pharmacology 정보
Alcohol produces injury to cells by dehydration and precipitation of the cytoplasm or protoplasm. This accounts for its bacteriocidal and antifungal action. When alcohol is injected in close proximity to nerve tissues, it produces neuritis and nerve degeneration (neurolysis). Ninety to 98% of ethanol that enters the body is completely oxidized. Ethanol is also used as a cosolvent to dissolve many insoluble drugs and to serve as a mild sedative in some medicinal formulations.
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| Metabolism |
Ethanol에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Cytochrome P450 2E1 (CYP2E1)
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| Half-life |
Ethanol에 대한 반감기 정보
Not Available
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| Absorption |
Ethanol에 대한 Absorption 정보
Rapidly absorbed.
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| Pharmacokinetics |
Ethanol의 약물동력학자료
- 흡수 : 약 20%는 위에서, 80%는 소장에서 흡수된다. 증기 상태로는 폐로도 흡수될 수 있다.
- 분포 :
- 태반을 신속하게, 잘 통과하며, 유즙으로도 신속하게 분비된다.
- 체내 모든 조직과 체액에 골고루 균등하게 분포한다.
- 분포용적 : 0.53 L/kg (만성 섭취시 남성에서는 증가함)
- 대사 :
- 90-98%는 간에서 alcohol dehydrogenase, aldehyde dehydrogenase에 의해 acetaldehyde, acetyl-CoA로 차례대로 대사된 후 citric acid cycle을 통해 산화된다. 특히 이 경로의 대사과정은 0차 반응속도를 따른다.
- 일부는 간의 sER (smooth endoplasmic reticulum)의 cytochrome P-450 효소계에 의해 산화된다.
- 반감기 : 용량의존적
- 소실 : 주로 신배설 (2-10%는 미변화체로 신배설)되며, 일부는 폐를 통해 배설된다.
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| Biotransformation |
Ethanol에 대한 Biotransformation 정보
Hepatic. Metabolized by cytochrome P450 enzyme CYP2E1.
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| Toxicity |
Ethanol에 대한 Toxicity 정보
Oral, rat LD50: 5628 mg/kg. Symptoms and effects of overdose include nausea, vomiting, CNS depression, acute respiratory failure or death and with chronic use, severe health problems, such as liver and brain damage.
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| Drug Interactions |
Ethanol에 대한 Drug_Interactions 정보
Not Available
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CYP450
Drug Interaction |
[CYP450 Table직접조회]
Ethanol에 대한 P450 table
SUBSTRATES
CYP 2E1
acetaminophen
chlorzoxazone
**ethanol**
INHIBITORS
CYP 2E1
disulfiram
INDUCERS
CYP 2E1
**ethanol**
isoniazid
SUBSTRATES
CYP 2E1
acetaminophen
chlorzoxazone
**ethanol**
INHIBITORS
CYP 2E1
disulfiram
INDUCERS
CYP 2E1
**ethanol**
isoniazid
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| Drug Target |
[Drug Target]
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| Description |
Ethanol에 대한 Description 정보
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. [PubChem]
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| Drug Category |
Ethanol에 대한 Drug_Category 정보
Anti-Infective Agents, LocalCentral Nervous System DepressantsDisinfectantsSolvents
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| Smiles String Canonical |
Ethanol에 대한 Smiles_String_canonical 정보
CCO
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| Smiles String Isomeric |
Ethanol에 대한 Smiles_String_isomeric 정보
CCO
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| InChI Identifier |
Ethanol에 대한 InChI_Identifier 정보
Not Available
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| Chemical IUPAC Name |
Ethanol에 대한 Chemical_IUPAC_Name 정보
ethanol
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| Drug-Induced Toxicity Related Proteins |
ETHANOL 의 Drug-Induced Toxicity Related Protein정보
Replated Protein:Proenkephalin
Drug:ethanol
Toxicity:ethanol narcosis.
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Replated Protein:Insulin receptor substrate 1
Drug:Ethanol
Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.
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Replated Protein:Phosphatidylinositol-4-phosphate 3-kinase
Drug:Ethanol
Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.
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Replated Protein:Insulin receptor substrate 2
Drug:Ethanol
Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.
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Replated Protein:Mitogen-activated protein kinase(Erk2)
Drug:Ethanol
Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.
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Replated Protein:Mitogen-activated protein kinase
Drug:Ethanol
Toxicity:impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation.
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