드러그인포 약품요약정보

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

[A00802081] [보험코드에 따른 약품기본정보 직접조회]

\0 원/1정(2002.01.01)(현재약가)
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

흑갈색의 원형 당의정 [제형정보 확인]

포장·유통단위

10정 * 50, 200정, 1000정

효능효과

[적응증 별 검색]

두드러기, 습진, 피부염, 약물진, 가려움증, 소아 구진성 두드러기, 땀띠, 비염, 기타 알레르기 질환
[Drugbank 의 성분정보열람]
[Biotin][Chlorpheniramine][Vitamin B2 (Riboflavin)][Vitamin B6 (Pyridoxine)]

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
[주성분코드:261400ATB 에 따른 심사지침열람]
성인 1회 2정, 7~14세 1회 1정씩 1일 3회 식후 복용한다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

금기

녹내장 환자
전립선비대등의 하부요로에 폐쇄성 질환이 있는 환자

이상반응

전해질대사: 저칼륨혈증, 혈압상승, 나트륨 및 체액의 저류, 부종, 요량감소, 체중증가 등의 알도스테론증이 나타날 수 있으므로 혈청칼륨치를 측정하는 등 관찰을 충분히 하여 이상이 나타나는 경우에는 투여를 중지한다.
과민증: 발진 등의 과민증상이 나타날 수 있으므로 이러한 증상이 나타나는 경우에는 투여를 중지한다.
비뇨기계: 다뇨, 배뇨곤란 등의 증상이 나타날 수 있다.
정신신경계: 신경과민, 두통, 초조감, 복시, 졸음 등이 나타날 수 있다.
소화기계: 구갈, 흉통 등의 증상이 나타날 수 있다.

혈액계: 드물게 혈소판감소, 무과립구증, 재생불량성 빈혈 등의 증상이 나타날 수 있으므로 관찰을 충분히 하여 이러한 증상이 나타나는 경우에는 투여를 중지한다.

[주요 이상반응정보]

상호작용

중추신경억제제, MAO 저해제 등의 의약품과 병용하거나 알콜섭취에 의해 상호작용이 증강될 수 있으므로 이러한 의약품과의 병용시에는 감량하는 등 신중히 투여한다.

Related FDA Approved Drug

기준 성분:CHLORPHENIRAMINE MALEATE
ADVIL ALLERGY SINUS (CHLORPHENIRAMINE MALEATE; IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
ANTAGONATE (CHLORPHENIRAMINE MALEATE)
CHILDREN'S ADVIL ALLERGY SINUS (CHLORPHENIRAMINE MALEATE; IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
CHLOROHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE)
CHLORPHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CHLOR-TRIMETON (CHLORPHENIRAMINE MALEATE)
CODIMAL-L.A. 12 (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
COLD CAPSULE IV (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
COLD CAPSULE V (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CONTAC (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CONTAC 12 HOUR (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
DEMAZIN (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
DEXCHLORPHENIRAMINE MALEATE (DEXCHLORPHENIRAMINE MALEATE)
DRIZE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
EFIDAC 24 CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE)
ISOCLOR (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
KLOROMIN (CHLORPHENIRAMINE MALEATE)
ORNADE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
PHENETRON (CHLORPHENIRAMINE MALEATE)
PHENYLPROPANOLAMINE HYDROCHLORIDE W/ CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
POLARAMINE (DEXCHLORPHENIRAMINE MALEATE)
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
PYRIDAMAL 100 (CHLORPHENIRAMINE MALEATE)
TELDRIN (CHLORPHENIRAMINE MALEATE)
TRIAMINIC-12 (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
기준 성분:BIOTIN
BEROCCA PN (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN E)
CERNEVIT-12 (ALPHA-TOCOPHEROL; ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; FOLIC ACID; NIACINAMIDE; PANTOTHENIC ACID; PYRIDOXINE; RIBOFLAVIN; THIAMINE; VITAMIN A)
INFUVITE ADULT (ALPHA-TOCOPHEROL ACETATE; ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAM

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	항히스타민 & 항알러지약 (Antihistamines & antiallergics)
복지부분류코드	141 (항히스타민제 )
의약품 바코드정보	내용보기 8806104418466//병//1 단위/수량: 1000 8806104428465//PTP//1 단위/수량: 200 8806104438464//병//1 단위/수량: 200 8806104448463//PTP//1 단위/수량: 10 18806104418463//병//10 단위/수량: 10000 18806104428462//PTP//10 단위/수량: 2000 8806104458462//PTP//50 단위/수량: 500
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	[A00802081] [보험코드에 따른 약품기본정보 직접조회] \0 원/1정(2002.01.01)(최신약가) [상병코드조회] [질병코드집 다운로드]
제품성상	흑갈색의 원형 당의정 [제형정보 확인]
포장·유통단위	10정 * 50, 200정, 1000정
동일주성분코드 검색순위	유료정보입니다.

복약정보

항목

내용

LACTmed 바로가기

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약리작용

유료정보입니다.

축약복약지도

유료정보입니다.

복약지도

유료정보입니다.

임부에대한투여

*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : B등급

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

Pharmacokinetics

유료정보입니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Biotin에 대한 독성정보 : 정보보기 Calcium에 대한 독성정보 : 정보보기 Chlorpheniramine에 대한 독성정보 : 정보보기 Pyridoxine에 대한 독성정보 : 정보보기 Riboflavin에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Biotin에 대한 Mechanism_Of_Action 정보 Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids. Chlorpheniramine에 대한 Mechanism_Of_Action 정보 Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. calcium에 대한 Mechanism_Of_Action 정보 Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available. Pyridoxine에 대한 Mechanism_Of_Action 정보 Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA). Riboflavin에 대한 Mechanism_Of_Action 정보 Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.
Pharmacology	Biotin에 대한 Pharmacology 정보 Biotin is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is used in cell growth, the production of fatty acids, metabolism of fats, and amino acids. It plays a role in the Kreb cycle, which is the process in which energy is released from food. Biotin not only assists in various metabolic chemical conversions, but also helps with the transfer of carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequenty, it is found in many cosmetic and health products for the hair and skin. Biotin deficiency is a rare nutritional disorder caused by a deficiency of biotin. Initial symptoms of biotin deficiency include: Dry skin, Seborrheic dermatitis, Fungal infections, rashes including erythematous periorofacial macular rash, fine and brittle hair, and hair loss or total alopecia. If left untreated, neurological symptoms can develop, including mild depression, which may progress to profound lassitude and, eventually, to somnolence; changes in mental status, generalized muscular pains (myalgias), hyperesthesias and paresthesias. The treatment for biotin deficiency is to simply start taking some biotin supplements. A lack of biotin in infants will lead to a condition called seborrheic dermatitis or "cradle cap". Biotin deficiencies are extremely rare in adults but if it does occur, it will lead to anemia, depression, hair loss, high blood sugar levels, muscle pain, nausea, loss of appetite and inflamed mucous membranes. Chlorpheniramine에 대한 Pharmacology 정보 In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. Pyridoxine에 대한 Pharmacology 정보 Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities. Riboflavin에 대한 Pharmacology 정보 Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts.
Metabolism	Chlorpheniramine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 3A4 (CYP3A4)Cytochrome P450 2D6 (CYP2D6) Pyridoxine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Methylenetetrahydrofolate reductase Riboflavin에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Monoamine oxidase type A (MAO-A)Methylenetetrahydrofolate reductase
Protein Binding	Chlorpheniramine에 대한 단백결합 정보 72% Pyridoxine에 대한 단백결합 정보 22% Riboflavin에 대한 단백결합 정보 60%
Half-life	Chlorpheniramine에 대한 반감기 정보 21-27 hours Pyridoxine에 대한 반감기 정보 15-20 days Riboflavin에 대한 반감기 정보 66-84 minutes
Absorption	Biotin에 대한 Absorption 정보 Systemic - approximately 50% Chlorpheniramine에 대한 Absorption 정보 Well absorbed in the gastrointestinal tract. Pyridoxine에 대한 Absorption 정보 The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum. Riboflavin에 대한 Absorption 정보 Vitamin B2 is readily absorbed from the upper gastrointestinal tract.
Pharmacokinetics	Biotin의 약물동력학자료 흡수 : 위장관에서 신속히 흡수됨 단백결합 : 높음, avidin에 결합하면 불활성화됨 분포 : 유즙분비됨 배설 : 과도하게 투여된 경우 biotin 자체 또는 대사체로 뇨배설됨 Pyridoxine HCl의 약물동력학자료 흡수 : 위장관으로부터 잘 흡수된다. 대사 : 간에서 4-pyridoxic acid로 대사된다. 반감기 : 15-20일 혈중최고농도 도달시간 : 경구 : 1.25 시간 소실 : 4-pyridoxic acid로 신배설되며, 소량 (약 2%)은 담즙을 통해 배설된다. Riboflavin의 약물동력학자료 흡수 : 위장관으로부터 잘 흡수된다. 음식물에 의해 흡수양이 증가한다. 간염, 간경화, 담관폐색이 있는 환자에서 흡수가 감소한다. 분포 : 체내 모든 조직에 널리 분포한다. 반감기 : 초기 상 : 1.4 시간 말기 상 : 14시간 소실 : 미변화체로 신배설되는 양은 약 9%이다. Precipitated calcium carbonate의 약물동력학자료 흡수 : 위장관을 통해 이온화 형태로 흡수되며 비타민 D가 필요;산성에서 흡수증가 생체내이용률 : 4-45 % 음식물의 영향 : 칼슘흡수(10-30 %)증가 섬유소가 많은 음식은 위장관 배출시간을 지체시켜 칼슘흡수를 저하시킴 분포 : 태반통과; 유즙분비 체내 99%가 뼈에 저장 단백결합 : 45 % 소실 : 흡수되지 않은 칼슘은 주로 변으로 배설 신배설 : 20 % (50-300 mg/day) Dibasic calcium phosphate의 약물동력학자료 흡수 : 위장관을 통해 이온화 형태로 흡수되며 비타민 D가 필요 ; 산성에서 흡수증가 생체내이용률 : 4-45 % ; 제제마다 다르다. 음식물의 영향 : 칼슘흡수(10-30 %)증가 섬유소가 많은 음식은 위장관 배출시간을 지체시켜 칼슘흡수를 저하시킴 분포 : 태반통과; 유즙분비 체내 99%가 뼈에 저장 단백결합 : 45 % 소실 : 흡수되지 않은 칼슘은 주로 변으로 배설 신배설 : 20 % (50-300 mg/day) Chlorpheniramine Maleate의 약물동력학자료 단백결합 : 69-72% 대사 : 간대사 반감기 : 20-24 시간 소실 : 대사체, 약물(3-4%)이 신배설되며, 48시간내에 전체의 35%가 소실된다.
Biotransformation	Biotin에 대한 Biotransformation 정보 Not Available Chlorpheniramine에 대한 Biotransformation 정보 Primarily hepatic via Cytochrome P450 (CYP450) enzymes. Riboflavin에 대한 Biotransformation 정보 Hepatic.
Toxicity	Biotin에 대한 Toxicity 정보 Prolonged skin contact may cause irritation. Chlorpheniramine에 대한 Toxicity 정보 LD₅₀ = 306 mg/kg in humans, mild reproductive toxin to women of childbearing age. Pyridoxine에 대한 Toxicity 정보 Oral Rat LD₅₀ = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness. Riboflavin에 대한 Toxicity 정보 Not Available
Drug Interactions	Biotin에 대한 Drug_Interactions 정보 Not Available Chlorpheniramine에 대한 Drug_Interactions 정보 Donepezil Possible antagonism of actionGalantamine Possible antagonism of actionRivastigmine Possible antagonism of actionEthotoin The antihistamine increases the effect of hydantoinFosphenytoin The antihistamine increases the effect of hydantoinMephenytoin The antihistamine increases the effect of hydantoinPhenytoin The antihistamine increases the effect of hydantoin calcium에 대한 Drug_Interactions 정보 Alendronate Formation of non-absorbable complexesAmprenavir The antiacid decreases the absorption of amprenavirAtazanavir This gastric pH modifier decreases the levels/effects of atazanavirChloroquine The antiacid decreases the absorption of chloroquineCiprofloxacin Formation of non-absorbable complexesDapsone Formation of non-absorbable complexesDelavirdine The antiacid decreases the effect of delavirdineDemeclocycline Formation of non-absorbable complexesDoxycycline Formation of non-absorbable complexesEnoxacin Formation of non-absorbable complexesFosamprenavir The antiacid decreases the absorption of amprenavirGrepafloxacin Formation of non-absorbable complexesIbandronate Formation of non-absorbable complexesIndinavir The antiacid decreases the absorption of indinavirItraconazole The antacid decreases the effect of the imidazoleKetoconazole The antacid decreases the effect of the imidazoleLevofloxacin Formation of non-absorbable complexesLevothyroxine Calcium decreases absorption of levothyroxineLomefloxacin Formation of non-absorbable complexesMethacycline Formation of non-absorbable complexesMinocycline Formation of non-absorbable complexesMoxifloxacin Formation of non-absorbable complexesNorfloxacin Formation of non-absorbable complexesOfloxacin Formation of non-absorbable complexesOxytetracycline Formation of non-absorbable complexesPefloxacin Formation of non-absorbable complexesPolystyrene sulfonate Formation of non-absorbable complexesRisedronate Formation of non-absorbable complexesTetracycline Formation of non-absorbable complexesTrovafloxacin Formation of non-absorbable complexesClodronate Formation of non-absorbable complexesEtidronic acid Formation of non-absorbable complexesMycophenolate mofetil Formation of non-absorbable complexesTemafloxacin Formation of non-absorbable complexes Pyridoxine에 대한 Drug_Interactions 정보 Not Available Riboflavin에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회] Chlorpheniramine에 대한 P450 table SUBSTRATES CYP 2D6 Beta Blockers: S-metoprolol propafenone timolol Antidepressants: amitriptyline clomipramine desipramine imipramine paroxetine Antipsychotics: haloperidol risperidone thioridazine aripiprazole codeine dextromethorphan duloxetine flecainide mexiletine ondansetron tamoxifen tramadol venlafaxine INHIBITORS CYP 2D6 amiodarone buproprion chlorpheniramine cimetidine clomipramine duloxetine fluoxetine haloperidol methadone mibefradil paroxetine quinidine ritonavir INDUCERS CYP 2D6 N/A
Food Interaction	Chlorpheniramine에 대한 Food Interaction 정보 Take with food.Avoid alcohol.
Drug Target	[Drug Target]
Description	Biotin에 대한 Description 정보 A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. [PubChem] Chlorpheniramine에 대한 Description 정보 A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem] calcium에 대한 Description 정보 Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. Pyridoxine에 대한 Description 정보 The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). [PubChem] Riboflavin에 대한 Description 정보 Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]
Dosage Form	Biotin에 대한 Dosage_Form 정보 Powder, for solution OralTablet Oral Chlorpheniramine에 대한 Dosage_Form 정보 Syrup OralTablet OralTablet, extended release Oral calcium에 대한 Dosage_Form 정보 Capsule OralLiquid DentalLiquid IntravenousLiquid OralLiquid SublingualPaste DentalPowder OralPowder, for solution OralSolution IntramuscularSolution IntravenousSolution OralSolution / drops OralSyrup OralTablet OralTablet, chewable Oral Pyridoxine에 대한 Dosage_Form 정보 Liquid IntramuscularSolution IntramuscularSolution / drops OralTablet Oral Riboflavin에 대한 Dosage_Form 정보 Not Available
Drug Category	Biotin에 대한 Drug_Category 정보 Dietary supplementMicronutrientVitamin B ComplexVitamins (Vitamin B Complex) Chlorpheniramine에 대한 Drug_Category 정보 Anti-Allergic AgentsAntihistaminesAntipruriticsHistamine H1 Antagonists Pyridoxine에 대한 Drug_Category 정보 Anti-inflammatory AgentsEssential VitaminVitamin B ComplexVitamins (Vitamin B Complex) Riboflavin에 대한 Drug_Category 정보 Photosensitizing AgentsRadiation-Sensitizing AgentsVitamin B ComplexVitamins (Vitamin B Complex)
Smiles String Canonical	Biotin에 대한 Smiles_String_canonical 정보 OC(=O)CCCCC1SCC2NC(=O)NC12 Chlorpheniramine에 대한 Smiles_String_canonical 정보 CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1 calcium에 대한 Smiles_String_canonical 정보 Not Available calcium에 대한 Smiles_String_canonical 정보 Not Available Pyridoxine에 대한 Smiles_String_canonical 정보 CC1=NC=C(CO)C(CO)=C1O Riboflavin에 대한 Smiles_String_canonical 정보 CC1=CC2=C(C=C1C)N(CC(O)C(O)C(O)CO)C1=NC(=O)NC(=O)C1=N2
Smiles String Isomeric	Biotin에 대한 Smiles_String_isomeric 정보 OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 Chlorpheniramine에 대한 Smiles_String_isomeric 정보 CN(C)CC[C@H](C1=CC=C(Cl)C=C1)C1=CC=CC=N1 calcium에 대한 Smiles_String_isomeric 정보 Not Available Pyridoxine에 대한 Smiles_String_isomeric 정보 CC1=NC=C(CO)C(CO)=C1O Riboflavin에 대한 Smiles_String_isomeric 정보 CC1=CC2=C(C=C1C)N(C[C@@H](O)[C@@H](O)[C@@H](O)CO)C1=NC(=O)NC(=O)C1=N2
InChI Identifier	Biotin에 대한 InChI_Identifier 정보 InChI=1/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1/f/h11-13H Chlorpheniramine에 대한 InChI_Identifier 정보 InChI=1/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 calcium에 대한 InChI_Identifier 정보 Not Available Pyridoxine에 대한 InChI_Identifier 정보 InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3 Riboflavin에 대한 InChI_Identifier 정보 InChI=1/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m1/s1/f/h20H
Chemical IUPAC Name	Biotin에 대한 Chemical_IUPAC_Name 정보 5-[(3aR,6S,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]pentanoic acid Chlorpheniramine에 대한 Chemical_IUPAC_Name 정보 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine calcium에 대한 Chemical_IUPAC_Name 정보 Not Available Pyridoxine에 대한 Chemical_IUPAC_Name 정보 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol Riboflavin에 대한 Chemical_IUPAC_Name 정보 7,8-dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione
Drug-Induced Toxicity Related Proteins	MALEATE 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Intercellular adhesion molecule 1 Drug:maleate Toxicity:hepatic injury. [바로가기]

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