| 항목 |
내용 |
| DUR (의약품사용평가) |
병용금기 :
고시된 병용금기 내용은 없습니다.
[상호작용/병용금기검색]
연령대금기 :
고시된 연령금기 내용은 없습니다.
[연령대금기상세검색]
|
| 독성정보 |
Potassium에 대한 독성정보 : 정보보기
출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do |
| Mechanism of Action |
Sulfamethoxazole에 대한 Mechanism_Of_Action 정보
Sulfonamides inhibit bacterial dihydrofolate synthetase, causing interference in the conversion of p-aminobenzoic acid (PABA) into folic acid. As folic acid is a coenzyme responsible for the transport of one-carbon fragments from one molecule to another, it is an essential component of bacterial development. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, the immediate next step, and therefore act synergistically with the sulfonamides.
|
| Pharmacology |
Sulfamethoxazole에 대한 Pharmacology 정보
Sulfamethoxazole is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). Sulfamethoxazole is normally given in combination with Trimethoprim (a dihydrofolate reductase inhibitor). Studies have shown that bacterial resistance develops more slowly with the combination of the two drugs than with either Trimethoprim or Sulfamethoxazole alone.
|
| Metabolism |
Sulfamethoxazole에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Cytochrome P450 2C9 (CYP2C9)
|
| Protein Binding |
Sulfamethoxazole에 대한 단백결합 정보
70%
|
| Half-life |
Sulfamethoxazole에 대한 반감기 정보
10 hours
|
| Absorption |
Sulfamethoxazole에 대한 Absorption 정보
Rapidly absorbed following oral administration.
|
| Pharmacokinetics |
Sulfamethoxazole sodium의 약물동력학자료
- 생체내이용률 : 경구 : 90%
- 분포 : 태반통과, 뇌척수액으로 용이하게 확산
- 단백결합 : 70%
- 대사 : 일차적으로 간대사, 10-20%는 혈액에서 N-acetylation된다.
- 반감기 : 9-12 시간, 신장애시 연장
- 혈중최고농도 도달시간 : 3-4 시간 이내
- 소실 : 20%는 미변화체로, 나머지는 대사체로 신배설
|
| Biotransformation |
Sulfamethoxazole에 대한 Biotransformation 정보
Hepatic. The metabolism of sulfamethoxazole occurs predominately by N4-acetylation, although the glucuronide conjugate has been identified.
|
| Toxicity |
Sulfamethoxazole에 대한 Toxicity 정보
Not Available
|
| Drug Interactions |
Sulfamethoxazole에 대한 Drug_Interactions 정보
Not Available
|
CYP450
Drug Interaction |
[CYP450 Table직접조회]
Sulfamethoxazole에 대한 P450 table
SUBSTRATES
CYP 2C9
NSAIDs:
diclofenac
ibuprofen
piroxicam
Oral Hypoglycemic Agents:
tolbutamide
glipizide
Angiotensin II Blockers:
NOT candesartan
irbesartan
losartan
NOT valsartan
celecoxib
fluvastatin naproxen
phenytoin
**sulfamethoxazole**
tamoxifen
tolbutamide
torsemide
warfarin
INHIBITORS
CYP 2C9
amiodarone
fluconazole
isoniazid
INDUCERS
CYP 2C9
rifampin
secobarbital
|
| Food Interaction |
Sulfamethoxazole에 대한 Food Interaction 정보
Take on empty stomach: 1 hour before or 2 hours after meals.Take with a full glass of water.Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.
|
| Drug Target |
[Drug Target]
|
| Description |
Sulfamethoxazole에 대한 Description 정보
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
|
| Dosage Form |
Sulfamethoxazole에 대한 Dosage_Form 정보
Tablet Oral
|
| Drug Category |
Sulfamethoxazole에 대한 Drug_Category 정보
Anti-Infective AgentsAnti-InfectivesSulfonamides
|
| Smiles String Canonical |
Sulfamethoxazole에 대한 Smiles_String_canonical 정보
CC1=CC(NS(=O)(=O)C2=CC=C(N)C=C2)=NO1
|
| Smiles String Isomeric |
Sulfamethoxazole에 대한 Smiles_String_isomeric 정보
CC1=CC(NS(=O)(=O)C2=CC=C(N)C=C2)=NO1
|
| InChI Identifier |
Sulfamethoxazole에 대한 InChI_Identifier 정보
InChI=1/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)/f/h13H
|
| Chemical IUPAC Name |
Sulfamethoxazole에 대한 Chemical_IUPAC_Name 정보
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
|
| Drug-Induced Toxicity Related Proteins |
SULFAMETHOXAZOLE 의 Drug-Induced Toxicity Related Protein정보
Replated Protein:Myeloperoxidase
Drug:sulfamethoxazole
Toxicity:agranulocytosis.
[바로가기]
Replated Protein:Myeloperoxidase
Drug:sulfamethoxazole
Toxicity:lupus.
[바로가기]
|
전문/일반
