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                    ¸ð³ª½ÅG¿¬°í  MONASIN G OINT.[Calcium pantothenate , Pyridoxine HCl , Testosterone]  
                    
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                     ÀϹÝÀǾàǰ | ºñ±Þ¿©  
                        
                    	
                    
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                      ¾Ë¸²:  | 
                      µå·°ÀÎÆ÷¿¡¼´Â ÀǾàǰ ÀÎÅÍ³Ý ÆÇ¸Å¸¦ ÇÏÁö ¾Ê½À´Ï´Ù. | 
                     
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        À¯·áȸ¿ø °áÀç½Ã¿¡´Â º¸´Ù ´Ù¾çÇÑ ¾à¹°Á¤º¸¸¦
        ÀÌ¿ëÇÏ½Ç ¼ö ÀÖ½À´Ï´Ù.
        À¯·áÁ¤º¸¸ñ·ÏÀº Àü¹®È¸¿øÀ¸·Î
        ·Î±×ÀÎ ÇϽøé È®ÀÎ °¡´ÉÇÕ´Ï´Ù.
       
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    | Ç׸ñ | 
    ³»¿ë | 
   
  
  
  
  
   
    û±¸ÄÚµå(KDÄÚµå) ºñ±Þ¿©Á¡°ËÄÚµå  »óÇÑ±Ý¾× | 
    
      
      
            ºñ±Þ¿©
          
        
      
    
    
    
      
     [»óº´ÄÚµåÁ¶È¸]
      
      [Áúº´ÄÚµåÁ¶È¸]
     
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    | ºü¸¥Á¶È¸ | 
    
      
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    | Á¦Ç°¼º»ó | 
    ¹é»ö-Ȳ¹é»ö ¹æÇ⼺ ¿¬°íÁ¦  [Á¦ÇüÁ¤º¸ È®ÀÎ] |   
   
  
  
  
  
  
   
    | Æ÷À塤À¯Åë´ÜÀ§ | 
    50g, 500g | 
   
  
  
  
  
  
  
  
 
  
  
    
  
  
  
  
  
  
  
  
  
  
 
  
  
  
 
  
  
  
  
  
  
  
     
  
  
  
   
    | È¿´ÉÈ¿°ú | 
    
    [ÀûÀÀÁõ º° °Ë»ö] 
     
    
     
	 
      ü¸ð¹«¸ðÁõ, ºó¸ðÁõ(¾È¸é, »çÁö, ü¸ð µî)ÀÇ ¹ß¸ðÃËÁø 
[Drugbank ÀÇ ¼ººÐÁ¤º¸¿¶÷] [Testosterone][Vitamin B6 (Pyridoxine)]
      
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    | ¿ë¹ý¿ë·® | 
    
      * Àý´ë ÀÓÀǺ¹¿ëÇÏÁö ¸¶½Ã°í ¹Ýµå½Ã ÀÇ»ç ¶Ç´Â ¾à»ç¿Í »ó´ãÇϽñ⠹ٶø´Ï´Ù. 
    
     
      
      
      [󹿾à¾î] 
       1ÀÏ 1~¼öȸ ȯºÎ¿¡ Àû´ç·®À» ¹Ù¸¥´Ù. 
[Á¦Çüº°º¹¾àÁöµµ]     
      	
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    | ½ÅÁßÅõ¿© | 
    ¾àÀ̳ª ÈÀåǰ µî¿¡ ÀÇÇÑ ¾Ë·¹¸£±â Áõ»ó(¹ßÁø, ¹ßÀû, °¡·Á¿òÁõ, ¿Ì µî¿¡ ÀÇÇÑ ÇǺο° µî)ÀÌ ³ªÅ¸³ ÀûÀÌ ÀÖ´Â »ç¶÷ | 
   
  
    
  
  
  
  
  
   
    | ÀÌ»ó¹ÝÀÀ | 
    
      ÀÌ ¾àÀÇ »ç¿ëÀ¸·Î ÀÎÇØ ¹ßÁø, ¹ßÀû, °¡·Á¿ò µîÀÇ Áõ»óÀÌ ³ªÅ¸³ª´Â °æ¿ì¿¡´Â »ç¿ëÀ» ÁßÁöÇÏ°í ¾à»ç ¶Ç´Â ÀÇ»ç¿Í »óÀÇÇÒ °Í.
      
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    | Off-label Usage | 
    
      
	[Á¶È¸]    
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    | Related FDA Approved Drug | 
    
      
      ±âÁØ ¼ººÐ: TESTOSTERONEANDRODERM (TESTOSTERONE) 
ANDROGEL (TESTOSTERONE) 
ANDROID 10 (METHYLTESTOSTERONE) 
ANDROID 25 (METHYLTESTOSTERONE) 
ANDROID 5 (METHYLTESTOSTERONE) 
DELATESTRYL (TESTOSTERONE ENANTHATE) 
DEPO-TESTADIOL (ESTRADIOL CYPIONATE; TESTOSTERONE CYPIONATE) 
DEPO-TESTOSTERONE (TESTOSTERONE CYPIONATE) 
DITATE-DS (ESTRADIOL VALERATE; TESTOSTERONE ENANTHATE) 
METANDREN (METHYLTESTOSTERONE) 
METHYLTESTOSTERONE (METHYLTESTOSTERONE) 
ORETON (METHYLTESTOSTERONE) 
ORETON METHYL (METHYLTESTOSTERONE) 
STRIANT (TESTOSTERONE) 
TESTIM (TESTOSTERONE) 
TESTODERM (TESTOSTERONE) 
TESTODERM TTS (TESTOSTERONE) 
TESTOSTERONE (TESTOSTERONE) 
TESTOSTERONE CYPIONATE (TESTOSTERONE CYPIONATE) 
TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE (ESTRADIOL CYPIONATE; TESTOSTERONE CYPIONATE) 
TESTOSTERONE ENANTHATE (TESTOSTERONE ENANTHATE) 
TESTOSTERONE ENANTHATE AND ESTRADIOL VALERATE (ESTRADIOL VALERATE; TESTOSTERONE ENANTHATE) 
TESTOSTERONE PROPIONATE (TESTOSTERONE PROPIONATE) 
TESTRED (METHYLTESTOSTERONE) 
VIRILON (METHYLTESTOSTERONE) 
±âÁØ ¼ººÐ: PYRIDOXINE HYDROCHLORIDEBENDECTIN (DOXYLAMINE SUCCINATE; PYRIDOXINE HYDROCHLORIDE) 
BEROCCA PN (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN E) 
HEXA-BETALIN (PYRIDOXINE HYDROCHLORIDE) 
INFUVITE ADULT (ALPHA-TOCOPHEROL ACETATE; ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A PALMITATE; VITAMIN K) 
M.V.C. 9+3 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
M.V.I. ADULT (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K) 
M.V.I. ADULT (PHARMACY BULK PACKAGE) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E; VITAMIN K) 
M.V.I. PEDIATRIC (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
M.V.I.-12 (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
M.V.I.-12 (WITHOUT VITAMIN K) (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
MVC PLUS (ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E) 
PYRIDOXINE HYDROCHLORIDE (PYRIDOXINE HYDROCHLORIDE) 
TPN (NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; TYROSINE) 
±âÁØ ¼ººÐ: CALCIUM PANTOTHENATE
        
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    | LACTmed ¹Ù·Î°¡±â | 
    
      
        [¹Ù·Î°¡±â]
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    | ¾à¸®ÀÛ¿ë | 
    
       
      À¯·áÁ¤º¸ÀÔ´Ï´Ù.
       
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    | ÀӺο¡´ëÇÑÅõ¿© | 
    
      
      
        
	      
	      
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	          ÀüüÀӽŠ±â°£º°·Î ¿©·¯µî±ÞÀÌ Á¸ÀçÇÒ ¼ö ÀÖÀ¸¸ç °¡Àå À§Çèµµ°¡ ³ôÀº Á¤º¸¸¸ º¸¿©Áý´Ï´Ù. ´Ü, º¹ÇÕÁ¦ÀÇ °æ¿ì ¸ðµç º¹ÇÕÁ¦¼ººÐ¿¡ ´ëÇÑ ÀÓºÎÅõ¿©µî±ÞÀÌ Ç¥½ÃµÈ°ÍÀº Àý´ë ¾Æ´Ï¸ç Ç¥½ÃµÈ°ÍÁß¿¡ °¡Àå À§Çèµµ°¡ ³ôÀº Á¤º¸¸¸ ³ªÅ¸³³´Ï´Ù. 
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	      FDA : Xµî±Þ 
				        
				         (testosterone; )
				        
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	          »ó±â ÀÓºÎÅõ¿©¿¡ ´ëÇÑ Á¤º¸´Â Àü»êó¸® µÇ¸é¼ ÀÔ·Â ¿À·ù °¡´É¼ºÀÌ Á¸ÀçÇÕ´Ï´Ù. ¿À·ù °¡´É¼ºÀ» ÃÖ¼ÒÈÇϱâ À§ÇÏ¿© ¸¹Àº ³ë·ÂÀ» ±â¿ïÀ̰í ÀÖÀ¸³ª, ±× Á¤È®¼º¿¡ ´ëÇÏ¿© È®½ÅÀ» µå¸± ¼ö ¾ø½À´Ï´Ù. ÀÌ¿¡ ´ëÇØ ȸ»ç´Â Ã¥ÀÓÀ» ÁöÁö ¾Ê½À´Ï´Ù.
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	          ¹Ýµå½Ã °ø½Å·Â ÀÖ´Â ¹®ÇåÀ» ´Ù½Ã Çѹø Âü°í ÇϽñ⠹ٶó¸ç ÀÇ»ç ¶Ç´Â ¾à»çÀÇ ÆÇ´Ü¿¡ µû¶ó Åõ¿©¿©ºÎ°¡ °áÁ¤µÇ¾î¾ß ÇÕ´Ï´Ù.
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      | Pharmacokinetics | 
      
       
      À¯·áÁ¤º¸ÀÔ´Ï´Ù.
      
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    | º´¿ë±Ý±â ¹× ¿¬·É´ë±Ý±â ±Ù°ÅÁ¶È¸ | 
    
      [º´¿ë±Ý±â ¹× ¿¬·É´ë±Ý±â ±Ù°ÅÁ¶È¸]
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    | Á¦Çüº° º¹¾àÁöµµ | 
    [¿¬°í] | 
   
  
  
   
    | º¸°ü»ó ÁÖÀÇ | 
    
      
    	
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    | Á¶Á¦½Ã ÁÖÀÇ | 
    
      
    	
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    | Ç׸ñ | 
    ³»¿ë | 
   
  
    | DUR (ÀǾàǰ»ç¿ëÆò°¡) | 
    º´¿ë±Ý±â :
     
	 °í½ÃµÈ º´¿ë±Ý±â ³»¿ëÀº ¾ø½À´Ï´Ù.
	 
	  [»óÈ£ÀÛ¿ë/º´¿ë±Ý±â°Ë»ö]										
	  ¿¬·É´ë±Ý±â :
      °í½ÃµÈ ¿¬·É±Ý±â ³»¿ëÀº ¾ø½À´Ï´Ù.
      
       [¿¬·É´ë±Ý±â»ó¼¼°Ë»ö]
       
       
        
        
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    | µ¶¼ºÁ¤º¸ | 
    Calcium¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
Pyridoxine¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
Testosterone¿¡ ´ëÇÑ µ¶¼ºÁ¤º¸ : Á¤º¸º¸±â 
  Ãâó: ±¹¸³µ¶¼º°úÇпø µ¶¼º¹°ÁúÁ¤º¸DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do  | 
   
  
   
    | Mechanism of Action | 
    
       Calcium¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium.   The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium.  Low calcium intake may also be a risk factor in the development of osteoporosis.  The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.
  Pyridoxine¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
  Testosterone¿¡ ´ëÇÑ Mechanism_Of_Action Á¤º¸ The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5¥á-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5¥á-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. 
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    | Pharmacology | 
     
       Pyridoxine¿¡ ´ëÇÑ Pharmacology Á¤º¸ Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
  Testosterone¿¡ ´ëÇÑ Pharmacology Á¤º¸ Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females although small amounts are secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty times the amount of testosterone than an adult female's body does. 
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    | Metabolism | 
    
       Pyridoxine¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Methylenetetrahydrofolate reductase
  Testosterone¿¡ ´ëÇÑ Metabolism Á¤º¸ # Phase_1_Metabolizing_Enzyme:Cytochrome P450 3A4 (CYP3A4)Cytochrome P450 19 (Aromatase)Monoamine oxidase type A (MAO-A)Cytochrome P450 11A1 (CYP11A1) 
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    | Protein Binding | 
    
       Pyridoxine¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ 22%
  Testosterone¿¡ ´ëÇÑ ´Ü¹é°áÇÕ Á¤º¸ 40% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound and the rest is bound to albumin and other proteins. 
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    | Half-life | 
    
       Pyridoxine¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 15-20 days
  Testosterone¿¡ ´ëÇÑ ¹Ý°¨±â Á¤º¸ 10-100 minutes 
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    | Absorption | 
    
       Pyridoxine¿¡ ´ëÇÑ Absorption Á¤º¸ The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
  Testosterone¿¡ ´ëÇÑ Absorption Á¤º¸ Approximately 10% of the testosterone dose applied on the skin surface is absorbed into systemic circulation 
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    | Pharmacokinetics | 
    
       Calcium pantothenateÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
- Èí¼ö : °æ±¸ : Àß Èí¼öµÈ´Ù.
 - ¼Ò½Ç : ¾à 70%´Â ¹Ìº¯Èü·Î ¼Òº¯À» ÅëÇØ, ¾à 30%´Â ´ëº¯À» ÅëÇØ ¹è¼³µÈ´Ù.
  
 Pyridoxine HClÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
- Èí¼ö : À§Àå°üÀ¸·ÎºÎÅÍ Àß Èí¼öµÈ´Ù.
 - ´ë»ç : °£¿¡¼ 4-pyridoxic acid·Î ´ë»çµÈ´Ù.
 - ¹Ý°¨±â : 15-20ÀÏ
 - Ç÷ÁßÃÖ°í³óµµ µµ´Þ½Ã°£ : °æ±¸ : 1.25 ½Ã°£
 - ¼Ò½Ç : 4-pyridoxic acid·Î ½Å¹è¼³µÇ¸ç, ¼Ò·® (¾à 2%)Àº ´ãÁóÀ» ÅëÇØ ¹è¼³µÈ´Ù.
  
 TestosteroneÀÇ ¾à¹°µ¿·ÂÇÐÀÚ·á 
 
- 	ÃÖ´ëÈ¿°ú ¹ßÇö½Ã°£ : 
 
 - 	ÀÛ¿ëÁö¼Ó½Ã°£ : Åõ¿© °æ·Î ¹× ¿° Á¾·ù¿¡ µû¶ó ´Ù¸£´Ù.
 
- 	   Testosterone cypionate, Testosterone enanthate : ±ÙÀ°ÁÖ»ç : 2-4ÁÖ
 
   
 - 	Èí¼ö : 
 
- 	   °æ±¸ : À§Àå°ü, ±¸° Á¡¸·À¸·ÎºÎÅÍ Èí¼öµÇ³ª ÃÊȸÅë°úÈ¿°ú°¡ ¸Å¿ì Å©´Ù.
 
 - 	   ±ÙÀ°ÁÖ»ç : ¼¼È÷ Èí¼öµÈ´Ù.
 
   
 - 	ºÐÆ÷ : ÅÂ¹Ý Åë°ú, À¯Áó ºÐºñ
 
 - 	´Ü¹é°áÇÕ : 98% (transcortin ¹× albumin¿¡ °áÇÕÇÑ´Ù.)
 
 
 - 	´ë»ç : 
 
- 	   °æ±¸ Åõ¿©½Ã °ÅÀÇ ´ëºÎºÐÀÌ ÃÊȸÅë°ú ´ë»ç¸¦ ¹Þ´Â´Ù.
 
 - 	   °£¿¡¼ ´Ù¾çÇÑ 17-ketosteroids ¹× Æ÷ÇÕü·Î ´ë»çµÈ´Ù.
   
 - 	¹Ý°¨±â : 10-100ºÐ
 
- 	   À¯¸®Çü testosteroneÀÇ ¾ç¿¡ µû¶ó ¹Ý°¨±â°¡ º¯ÇϹǷΠÅõ¿© °æ·Î ¹× ¿° Á¾·ù¿¡ µû¶ó ´Ù¸£´Ù.
 
 - 	   Testosterone cypionate : ±ÙÀ°ÁÖ»ç : ¹Ý°¨±â°¡ ¾à 8ÀÏÀ̶ó°í º¸°íµÇ¾ú´Ù.
   
 - 	¼Ò½Ç : 90%´Â ÁÖ·Î ´ë»çü·Î¼ ´¢¸¦ ÅëÇØ, ¾à 10%´Â ´ãÁóÀ» °ÅÃÄ ´ëº¯À» ÅëÇØ ¹è¼³µÈ´Ù.
 
 
  
 
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    | Biotransformation | 
    
       Testosterone¿¡ ´ëÇÑ Biotransformation Á¤º¸ Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT). 
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    | Toxicity | 
    
       Pyridoxine¿¡ ´ëÇÑ Toxicity Á¤º¸ Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
  Testosterone¿¡ ´ëÇÑ Toxicity Á¤º¸ Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation. 
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    | Drug Interactions | 
    
       Calcium¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Alendronate	Formation of non-absorbable complexesAmprenavir	The antiacid decreases the absorption of amprenavirAtazanavir	This gastric pH modifier decreases the levels/effects of atazanavirChloroquine	The antiacid decreases the absorption of chloroquineCiprofloxacin	Formation of non-absorbable complexesDapsone	Formation of non-absorbable complexesDelavirdine	The antiacid decreases the effect of delavirdineDemeclocycline	Formation of non-absorbable complexesDoxycycline	Formation of non-absorbable complexesEnoxacin	Formation of non-absorbable complexesFosamprenavir	The antiacid decreases the absorption of amprenavirGrepafloxacin	Formation of non-absorbable complexesIbandronate	Formation of non-absorbable complexesIndinavir	The antiacid decreases the absorption of indinavirItraconazole	The antacid decreases the effect of the imidazoleKetoconazole	The antacid decreases the effect of the imidazoleLevofloxacin	Formation of non-absorbable complexesLevothyroxine	Calcium decreases absorption of levothyroxineLomefloxacin	Formation of non-absorbable complexesMethacycline	Formation of non-absorbable complexesMinocycline	Formation of non-absorbable complexesMoxifloxacin	Formation of non-absorbable complexesNorfloxacin	Formation of non-absorbable complexesOfloxacin	Formation of non-absorbable complexesOxytetracycline	Formation of non-absorbable complexesPefloxacin	Formation of non-absorbable complexesPolystyrene sulfonate	Formation of non-absorbable complexesRisedronate	Formation of non-absorbable complexesTetracycline	Formation of non-absorbable complexesTrovafloxacin	Formation of non-absorbable complexesClodronate	Formation of non-absorbable complexesEtidronic acid	Formation of non-absorbable complexesMycophenolate mofetil	Formation of non-absorbable complexesTemafloxacin	Formation of non-absorbable complexes
  Pyridoxine¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available
  Testosterone¿¡ ´ëÇÑ Drug_Interactions Á¤º¸ Not Available 
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    CYP450  Drug Interaction | 
    
      [CYP450 TableÁ÷Á¢Á¶È¸] 
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    | Food Interaction | 
    
       Testosterone¿¡ ´ëÇÑ Food Interaction Á¤º¸ Not Available 
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    | Drug Target | 
    
      
      [Drug Target]
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    | Description | 
    
       Calcium¿¡ ´ëÇÑ Description Á¤º¸ Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium.  Low calcium intake may also be a risk factor in the development of osteoporosis.  The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
  Pyridoxine¿¡ ´ëÇÑ Description Á¤º¸ The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.  Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). [PubChem]
  Testosterone¿¡ ´ëÇÑ Description Á¤º¸ A potent androgenic steroid and major product secreted by the leydig cells of the testis. Its production is stimulated by luteinizing hormone from the pituitary gland. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to dihydrotestosterone or estradiol. [PubChem] 
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    | Dosage Form | 
    
       Calcium¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Capsule	OralLiquid	DentalLiquid	IntravenousLiquid	OralLiquid	SublingualPaste	DentalPowder	OralPowder, for solution	OralSolution	IntramuscularSolution	IntravenousSolution	OralSolution / drops	OralSyrup	OralTablet	OralTablet, chewable	Oral
  Pyridoxine¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Liquid	IntramuscularSolution	IntramuscularSolution / drops	OralTablet	Oral
  Testosterone¿¡ ´ëÇÑ Dosage_Form Á¤º¸ Capsule	OralGel	TopicalLiquid	IntramuscularPatch	TransdermalSolution	Intramuscular 
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    | Drug Category | 
    
       Pyridoxine¿¡ ´ëÇÑ Drug_Category Á¤º¸ Anti-inflammatory AgentsEssential VitaminVitamin B ComplexVitamins (Vitamin B Complex)
  Testosterone¿¡ ´ëÇÑ Drug_Category Á¤º¸ Androgens 
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    | Smiles String Canonical | 
    
       Calcium¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ Not Available
  Pyridoxine¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CC1=NC=C(CO)C(CO)=C1O
  Testosterone¿¡ ´ëÇÑ Smiles_String_canonical Á¤º¸ CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2O 
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    | Smiles String Isomeric | 
    
       Calcium¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ Not Available
  Pyridoxine¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ CC1=NC=C(CO)C(CO)=C1O
  Testosterone¿¡ ´ëÇÑ Smiles_String_isomeric Á¤º¸ C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O 
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    | InChI Identifier | 
    
       Calcium¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ Not Available
  Pyridoxine¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
  Testosterone¿¡ ´ëÇÑ InChI_Identifier Á¤º¸ InChI=1/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 
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    | Chemical IUPAC Name | 
    
       Calcium¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ Not Available
  Pyridoxine¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
  Testosterone¿¡ ´ëÇÑ Chemical_IUPAC_Name Á¤º¸ (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one 
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                ÃÖ±ÙÁ¤º¸¼öÁ¤ÀÏ 2012-03-02
              
 
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                 º» ¼öÁ¤ÀÏ Á¤º¸´Â Çã°¡Á¤º¸ ÀÌ¿ÜÀÇ ±âŸÁ¤º¸ ¼öÁ¤ÀÏÀ» ÀǹÌÇϹǷÎ, Çã°¡Á¤º¸¼öÁ¤ÀÏÀº º»¹®¿¡ Ç¥±âµÈ ³¯Â¥¸¦ ÂüÁ¶ÇϽñ⠹ٶø´Ï´Ù.
                
              
     
             
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                      µå·°ÀÎÆ÷ ÀǾàÇмúÁ¤º¸´Â ½ÄǰÀǾàǰ¾ÈÀüóÀÇ Á¦Ç°Çã°¡»çÇ×, Çмú¹®Çå, Á¦¾àȸ»ç Á¦°øÁ¤º¸ µîÀ» ±Ù°Å·Î ÀÛ¼ºµÈ Âü°í Á¤º¸ÀÔ´Ï´Ù. 
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                            ¹Ýµå½Ã Á¦Á¶¡¤¼öÀÔ»ç, ÆÇ¸Å»ç, ÀÇ»ç, ¾à»ç¿¡°Ô ÃÖÁ¾ÀûÀ¸·Î È®ÀÎÇϽñ⠹ٶø´Ï´Ù.
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