드러그인포 약품요약정보

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

비급여
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

특이한 냄새가 있는 무색-담황색의 투명한 액 [제형정보 확인]

포장·유통단위

40G

효능효과

[적응증 별 검색]

습진, 피부염, 땀띠, 옻 등에 의한 피부염, 가려움, 벌레물린데, 두드러기

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
1일 수회(여러 차례) 환부(질환부위)에 적당량을 바른다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

금기

30개월 이하의 유아

신중투여

1) 지금까지 약이나 화장품 등에 의한 알레르기증상(예를 들면 발진ㆍ발적(충혈되어 붉어짐), 가려움, 옻 등에 의한 피부염 등)이 나타난 적이 있는 환자
2) 본인 또는 가족이 알레르기 체질인 환자
3) 습윤(습기 참)이나 미란(짓무름)이 심한 환자
4) 의사의 치료를 받고 있는 환자
5) 소아(경련을 유발할 수 있다)

이상반응

이 약의 사용으로 인해 발진ㆍ발적(충혈되어 붉어짐), 가려움, 부종(부기) 등의 증상이 나타나는 경우에는 사용을 중지하고 의사 또는 약사와 상의한다.

[주요 이상반응정보]

Related FDA Approved Drug

기준 성분:DIPHENHYDRAMINE
ADVIL PM (DIPHENHYDRAMINE CITRATE; IBUPROFEN)
AMBENYL (BROMODIPHENHYDRAMINE HYDROCHLORIDE; CODEINE PHOSPHATE)
AMBODRYL (BROMODIPHENHYDRAMINE HYDROCHLORIDE)
ANTITUSSIVE (DIPHENHYDRAMINE HYDROCHLORIDE)
BELDIN (DIPHENHYDRAMINE HYDROCHLORIDE)
BELIX (DIPHENHYDRAMINE HYDROCHLORIDE)
BENADRYL (DIPHENHYDRAMINE HYDROCHLORIDE)
BENADRYL PRESERVATIVE FREE (DIPHENHYDRAMINE HYDROCHLORIDE)
BENYLIN (DIPHENHYDRAMINE HYDROCHLORIDE)
BROMANYL (BROMODIPHENHYDRAMINE HYDROCHLORIDE; CODEINE PHOSPHATE)
BROMODIPHENHYDRAMINE HYDROCHLORIDE AND CODEINE PHOSPHATE (BROMODIPHENHYDRAMINE HYDROCHLORIDE; CODEINE PHOSPHATE)
DIBENIL (DIPHENHYDRAMINE HYDROCHLORIDE)
DIPHEN (DIPHENHYDRAMINE HYDROCHLORIDE)
DIPHENHYDRAMINE HYDROCHLORIDE PRESERVATIVE FREE (DIPHENHYDRAMINE HYDROCHLORIDE)
HYDRAMINE (DIPHENHYDRAMINE HYDROCHLORIDE)
IBUPROFEN AND DIPHENHYDRAMINE CITRATE (DIPHENHYDRAMINE CITRATE; IBUPROFEN)
SILPHEN (DIPHENHYDRAMINE HYDROCHLORIDE)
VICKS FORMULA 44 (DIPHENHYDRAMINE HYDROCHLORIDE)
기준 성분:DIBUCAINE HYDROCHLORIDE
HEAVY SOLUTION NUPERCAINE (DIBUCAINE HYDROCHLORIDE)
기준 성분:CROTAMITON
CROTAN (CROTAMITON)
EURAX (CROTAMITON)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	항히스타민/항소양제 (Antihistamins/Antipruritics)
ATC 코드	ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. / D04A [코드분류상세설명] [ATC코드예측]
복지부분류코드	264 (진통·진양·수렴·소염제 )
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	비급여 [상병코드조회] [질병코드집 다운로드]
제품성상	특이한 냄새가 있는 무색-담황색의 투명한 액 [제형정보 확인]
포장·유통단위	40G
보관방법	기밀용기,실온보관

복약정보

항목

내용

LACTmed 바로가기

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약리작용

유료정보입니다.

복약지도

유료정보입니다.

임부에대한투여

*	전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.

FDA : C등급
(crotamiton; )

*	상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
*	반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.

Pharmacokinetics

유료정보입니다.

병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

보관상 주의

조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Camphor에 대한 독성정보 : 정보보기 Diphenhydramine에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Crotamiton에 대한 Mechanism_Of_Action 정보 Crotamiton relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your body's attention away from the itching. Dibucaine에 대한 Mechanism_Of_Action 정보 Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Diphenhydramine에 대한 Mechanism_Of_Action 정보 Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Menthol에 대한 Mechanism_Of_Action 정보 Menthol is classified as a calcium channel blocker. Calcium channel blockers are a class of drugs with effects on many excitable cells of the body, like the muscle of the heart, smooth muscles of the vessels or neuron cells. Calcium channel blockers work by blocking voltage-sensitive calcium channels in the heart and in the blood vessels. This prevents calcium levels from increasing as much in the cells when stimulated, leading to less contraction.
Pharmacology	Crotamiton에 대한 Pharmacology 정보 Crotamiton is usually used to treat pruritis (itching of the skin) caused by scabies or sunburn. Crotamiton relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your body's attention away from the itching. Due to this cooling effect it is also effective for the relief of sunburn. The drug is also believed to kill scabies through an unknown mechanism. Dibucaine에 대한 Pharmacology 정보 Dibucaine is an amide-type local anesthetic, similar to lidocaine. Diphenhydramine에 대한 Pharmacology 정보 Diphenhydramine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, diphenhydramine competes with free histamine for binding at HA-receptor sites. Diphenhydramine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of diphenhydramine. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. Menthol에 대한 Pharmacology 정보 Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Menthol's ability to chemically trigger cold-sensitive receptors in the skin is responsible for the well known cooling sensation that it provokes when inhalated, eaten, or applied to the skin. It should be noted that menthol does not cause an actual drop in temperature.
Metabolism	Crotamiton에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Not Available Dibucaine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 1A2 (CYP1A2)Cytochrome P450 2D6 (CYP2D6)Cholinesterase Diphenhydramine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 2D6 (CYP2D6)Cytochrome P450 3A4 (CYP3A4)
Protein Binding	Crotamiton에 대한 단백결합 정보 Not Available Dibucaine에 대한 단백결합 정보 Not Available Diphenhydramine에 대한 단백결합 정보 98 to 99% Menthol에 대한 단백결합 정보 Not Available
Half-life	Crotamiton에 대한 반감기 정보 Not Available Dibucaine에 대한 반감기 정보 Not Available Diphenhydramine에 대한 반감기 정보 1-4 hours Menthol에 대한 반감기 정보 Not Available
Absorption	Crotamiton에 대한 Absorption 정보 10 % absorbed when applied locally. Dibucaine에 대한 Absorption 정보 In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation. Diphenhydramine에 대한 Absorption 정보 Quickly absorbed with maximum activity occurring in approximately one hour. Menthol에 대한 Absorption 정보 Not Available
Pharmacokinetics	Menthol의 약물동력학자료 소실 : 흡수된 약물은 glucuronide 포합체로서 소변 및 담즙을 통해 배설된다. Dibucaine HCl의 약물동력학자료 작용발현시간 : 15분 이내 작용지속시간 : 2-4 시간 흡수 : 손상되지 않은 피부에 적용시 흡수는 매우 적지만, 점막이나 손상된 피부로부터는 잘 흡수된다. Diphenhydramine의 약물동력학자료 최고 진정 효과 : 1-3 시간 작용지속시간 : 4-7 시간 흡수 : 초회통과효과가 있어서 40 - 60 % 정도가 전신순환으로 들어감 대사 : 대부분 간대사, 일부는 폐와 신장에서도 대사 단백결합 : 78% 최고혈중농도 도달시간 : 2-4 시간
Biotransformation	Crotamiton에 대한 Biotransformation 정보 Not Available Dibucaine에 대한 Biotransformation 정보 Primarily hepatic. Diphenhydramine에 대한 Biotransformation 정보 Hepatic and renal
Toxicity	Crotamiton에 대한 Toxicity 정보 Not Available Dibucaine에 대한 Toxicity 정보 Subcutaneous LD₅₀ in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest. Diphenhydramine에 대한 Toxicity 정보 LD₅₀=500 mg/kg (orally in rats). Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death. Menthol에 대한 Toxicity 정보 Menthol, DL: ORAL (LD50): Acute: 2900 mg/kg [Rat], 3100 mg/kg [Mouse]. DERMAL (LD50): Acute: 5001 mg/kg [Rabbit].
Drug Interactions	Crotamiton에 대한 Drug_Interactions 정보 Acetohexamide The beta-blocker decreases the symptoms of hypoglycemiaChlorpropamide The beta-blocker decreases the symptoms of hypoglycemiaCimetidine Cimetidine increases the effect of the beta-blockerClonidine Increased hypertension when clonidine stoppedDisopyramide The beta-blocker increases toxicity of disopyramideGliclazide The beta-blocker decreases the symptoms of hypoglycemiaGlipizide The beta-blocker decreases the symptoms of hypoglycemiaGlisoxepide The beta-blocker decreases the symptoms of hypoglycemiaGlibenclamide The beta-blocker decreases the symptoms of hypoglycemiaGlycodiazine The beta-blocker decreases the symptoms of hypoglycemiaInsulin The beta-blocker decreases the symptoms of hypoglycemiaLidocaine The beta-blocker increases the effect and toxicity of lidocainePropafenone Propafenone increases the effect of beta-blockerRepaglinide The beta-blocker decreases the symptoms of hypoglycemiaRifampin Rifampin decreases the effect of the metabolized beta-blockerTelithromycin Telithromycin may possibly increase metoprolol effectTolazamide The beta-blocker decreases the symptoms of hypoglycemiaTolbutamide The beta-blocker decreases the symptoms of hypoglycemiaAmobarbital The barbiturate decreases the effect of metabolized beta-blockerAprobarbital The barbiturate decreases the effect of metabolized beta-blockerButalbital The barbiturate decreases the effect of metabolized beta-blockerButabarbital The barbiturate decreases the effect of metabolized beta-blockerButethal The barbiturate decreases the effect of metabolized beta-blockerDihydroquinidine barbiturate The barbiturate decreases the effect of metabolized beta-blockerHeptabarbital The barbiturate decreases the effect of metabolized beta-blockerHexobarbital The barbiturate decreases the effect of metabolized beta-blockerMethohexital The barbiturate decreases the effect of metabolized beta-blockerMethylphenobarbital The barbiturate decreases the effect of metabolized beta-blockerPentobarbital The barbiturate decreases the effect of metabolized beta-blockerPhenobarbital The barbiturate decreases the effect of metabolized beta-blockerPrimidone The barbiturate decreases the effect of metabolized beta-blockerQuinidine barbiturate The barbiturate decreases the effect of metabolized beta-blockerSecobarbital The barbiturate decreases the effect of metabolized beta-blockerTalbutal The barbiturate decreases the effect of metabolized beta-blockerCitalopram The SSRI increases the effect of the beta-blockerEscitalopram The SSRI increases the effect of the beta-blockerFluoxetine The SSRI increases the effect of the beta-blockerSertraline The SSRI increases the effect of the beta-blockerParoxetine The SSRI increases the effect of the beta-blockerDihydroergotamine Ischemia with risk of gangreneDihydroergotoxine Ischemia with risk of gangreneErgonovine Ischemia with risk of gangreneErgotamine Ischemia with risk of gangreneMethysergide Ischemia with risk of gangreneVerapamil Increased effect of both drugsHydralazine Increased effect of both drugsDiltiazem Increased risk of bradycardiaEpinephrine Hypertension, then bradycardiaFenoterol AntagonismFormoterol AntagonismIsoproterenol AntagonismOrciprenaline AntagonismPirbuterol AntagonismPrazosin Risk of hypotension at the beginning of therapyProcaterol AntagonismSalbutamol AntagonismSalmeterol AntagonismTerbutaline AntagonismIbuprofen Risk of inhibition of renal prostaglandinsIndomethacin Risk of inhibition of renal prostaglandinsPiroxicam Risk of inhibition of renal prostaglandins Dibucaine에 대한 Drug_Interactions 정보 Methotrexate The NSAID increases the effect and toxicity of methotrexateLithium The NSAID increases serum levels of lithiumAcenocoumarol The NSAID increases the anticoagulant effect Diphenhydramine에 대한 Drug_Interactions 정보 Atomoxetine The CYP2D6 inhibitor could increases the effect and toxicity of atomoxetineDonepezil Possible antagonism of actionGalantamine Possible antagonism of actionMesoridazine Increased risk of cardiotoxicity and arrhythmiasRivastigmine Possible antagonism of actionThioridazine Increased risk of cardiotoxicity and arrhythmias Menthol에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회]
Food Interaction	Crotamiton에 대한 Food Interaction 정보 Not Available Diphenhydramine에 대한 Food Interaction 정보 Avoid alcohol.Take with food.
Drug Target	[Drug Target]
Description	Crotamiton에 대한 Description 정보 Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol. Dibucaine에 대한 Description 정보 A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006) Diphenhydramine에 대한 Description 정보 A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects. Menthol에 대한 Description 정보 Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (-)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation.
Dosage Form	Crotamiton에 대한 Dosage_Form 정보 Cream Topical Dibucaine에 대한 Dosage_Form 정보 Ointment Rectal Diphenhydramine에 대한 Dosage_Form 정보 Capsule OralCream TopicalElixir OralLiquid IntramuscularLiquid IntravenousLiquid OralLozenge OralStrip OralSyrup OralTablet OralTablet, chewable Oral Menthol에 대한 Dosage_Form 정보 Cream TopicalGel TopicalLiquid NasalLiquid OralLiquid TopicalLozenge OralOintment TopicalPatch TopicalPowder TopicalSolution / drops OralSpray Topical
Drug Category	Crotamiton에 대한 Drug_Category 정보 Antiparasitic AgentsAntipruriticsPesticidesScabicides Dibucaine에 대한 Drug_Category 정보 Anesthetics, Local Diphenhydramine에 대한 Drug_Category 정보 AnestheticsAnesthetics, LocalAnti-Allergic AgentsAntidyskineticsAntiemeticsAntiparkinson AgentsAntipruriticsAntitussivesEthanolamine DerivativesHistamine H1 AntagonistsHypnotics and Sedatives Menthol에 대한 Drug_Category 정보 Antipruritics
Smiles String Canonical	Crotamiton에 대한 Smiles_String_canonical 정보 CCN(C(=O)C=CC)C1=CC=CC=C1C Dibucaine에 대한 Smiles_String_canonical 정보 CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC Diphenhydramine에 대한 Smiles_String_canonical 정보 CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1 Menthol에 대한 Smiles_String_canonical 정보 CC(C)C1CCC(C)CC1O
Smiles String Isomeric	Crotamiton에 대한 Smiles_String_isomeric 정보 CCN(C(=O)\C=C\C)C1=CC=CC=C1C Dibucaine에 대한 Smiles_String_isomeric 정보 CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC Diphenhydramine에 대한 Smiles_String_isomeric 정보 CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1 Menthol에 대한 Smiles_String_isomeric 정보 CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
InChI Identifier	Crotamiton에 대한 InChI_Identifier 정보 InChI=1/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3 Dibucaine에 대한 InChI_Identifier 정보 InChI=1/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)/f/h21H Diphenhydramine에 대한 InChI_Identifier 정보 InChI=1/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3 Menthol에 대한 InChI_Identifier 정보 InChI=1/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
Chemical IUPAC Name	Crotamiton에 대한 Chemical_IUPAC_Name 정보 N-ethyl-N-(2-methylphenyl)but-2-enamide Dibucaine에 대한 Chemical_IUPAC_Name 정보 2-butoxy-N-(2-diethylaminoethyl)quinoline-4-carboxamide Diphenhydramine에 대한 Chemical_IUPAC_Name 정보 2-[di(phenyl)methoxy]-N,N-dimethylethanamine Menthol에 대한 Chemical_IUPAC_Name 정보 (1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol

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