드러그인포 약품요약정보 - 리나펜엘릭실3.2%(아세트아미노펜)

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

642001490[A30602391] [보험코드에 따른 약품기본정보 직접조회]
\0 원/1ml(2008.06.01)(현재약가)
\7 원/1ml(2000.07.01)(변경전약가)
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

딸기향이 있는 적색의 엘릭실제 [제형정보 확인]

포장·유통단위

1ELIXIR

허가사항 원문조회

[허가사항 원문조회]

효능효과

[적응증 별 검색]

1. 주효능 효과
감기로 인한 발열 및 동통, 두통, 신경통, 근육통, 월경통, 염좌통
2. 다음 질환에도 사용할 수 있다.
치통, 관절통, 류마티양 동통

[Acetaminophen]

약물음식간 상호작용

[조회]

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
[주성분코드:101304AEL 에 따른 심사지침열람]

용법용량
(경구 : 300mg, 325mg, 500mg )
성인 : 아세트아미노펜으로서 1회 0.3-1.0g 1일 3-4회 경구투여한다.
1일최고 4g까지 투여할 수 있다.
연령, 질환, 증상에 따라 적절히 증감한다.
(어린이용 : 80mg, 160mg )
다음 1회 용량을 1일 3-4회 경구투여한다.
                          (160mg) (80mg)
      11-14세 :200-400mg (2정)   (4정)
       7-10세 :150-300mg (1-2정) (2-4정)
       3- 6세 :100-200mg (1정)   (2정)
       1- 2세 : 60-120mg         (1정)
   3개월-1세미만: 30-60mg
(어린이용 : 액제, 현탁액, 엘릭서제 )
소아 : 이 약은 1회 10~15mg/kg의 용량을 4~6시간 간격으로 필요시 복용하며, 1일 최대 5회 (75mg/kg)를넘지 않는다. 이 약 1회 용량은 몸무게 또는 나이에 따라다음과 같다.
(몸무게를 아는 경우에는 몸무게에 따른 용량으로 복용하는 것이 더 적절하다.)

연령	몸무게(kg)	아세트아미노펜으로서 용량	1회용량
만 12세	43kg 이상	640mg	20ml
만 11세	38.0~42.9kg	480mg	15ml
만 9-10세	30.0~37.9kg	400mg	12.5ml
만 6-8세	21.0~29.9kg	320mg	10ml
만 4-5세	16.0~20.9kg	240mg	7.5ml
만 2-3세	12.0~15.9kg	160mg	5ml
12-23개월	10.0~11.9kg	120mg	3.5ml
4-11개월	7.0~ 9.9kg	80mg	2.5ml

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

[피해야 할 음식] [복용을 잊은 경우 대처법]

금기

   1) 이 약에 과민증 환자
   2) 소화성궤양 환자
   3) 심한 혈액이상 환자
   4) 심한 간장애 환자
   5) 심한 신장애 환자
   6) 심한 심기능부전 환자
   7) 아스피린 천식(비스테로이드성소염진통제에 의한 천식발작 유발) 또는 그 병력이 있는 환자

신중투여

   1) 간장애 또는 그 병력이 있는 환자
   2) 신장애 또는 그 병력이 있는 환자
   3) 소화성궤양의 병력이 있는 환자
   4) 혈액이상 또는 그 병력이 있는 환자
   5) 출혈경향이 있는 환자 (혈소판기능이상이 나타날 수 있다.)
   6) 심기능이상이 있는 환자
   7) 과민증의 병력이 있는 환자
   8) 기관지 천식 환자
   9) 고령자

이상반응

   1) 쇽 : 쇽및 아나필락시양 증상(호흡곤란, 전신조홍, 혈관부종, 두드러기 등)이나타날 수 있으므로 충분히 관찰하여, 이상이 나타나는 경우에는 투여를 중지하고 적절한 처치를 할 것. 이 약은 천식발작을 유발할 수 있다.
   2) 혈액 : 드물게혈소판감소, 과립구감소, 용혈성빈혈, 메트헤모글로빈혈증, 혈소판기능저하(출혈시간연장) 등이 나타날 수 있으므로 관찰을 충분히 하고 이러한 증상이 나타날 경우에는 투여를 중지한다. 또한 청색증이 나타날 수 있다.
   3) 과민증 : 과민증상(안면부종, 호흡곤란, 발한, 저혈압, 쇽)이 나타날경우에는 투여를 중지한다.
   4) 소화기계 : 때때로구역, 구토, 식욕부진 등의 증상이 나타날 수 있으며 장기투여시위장관에 대한 부작용 특히 위장출혈, 소화성궤양 및 천공이 나타날 수 있다.
   5) 피부 : 드물게발진, 다른 알레르기 반응이 나타날 수 있다. 드물게 피부점막안증후군(스티븐스-존슨 증후군), 중독성표피괴사증(리엘 증후군)이나타날 수 있으므로 충분히 관찰하여 이러한 증상이 나타나는 경우에는 투여를 중지하고 적절한 처치를 할 것.
   6) 과량투여 : 간장신장심근의 괴사를 일으켰다는 보고가 있다.
   7) 기타 : 장기투여시만성간괴사, 급성췌장염, 만성간염, 신독성이 나타날 수 있다.

[Human Liver Adverse Effects Database]

[간기능이상 약물 및 주의사항] [신기능이상 약물 및 주의사항]

[주요 이상반응정보] [즉시 알려야 하는 이상반응]

상호작용

   1) 바르비탈계 약물,삼환계 항우울제 및 알코올을 투여한 환자는 다량의 아세트아미노펜을 대사시키는 능력이 감소되어 아세트아미노펜의 혈장 반감기를 증가시킬수 있다. 알코올은 아세트아미노펜 과량투여의 간독성을 증가시킬수 있다.
   2) 다른 비스테로이드성 소염진통제(인도메타신, 이부프로펜 등)를리튬과 병용투여시 리튬의 혈중농도를 상승시켜 리튬독성이 나타났다는 보고가 있으므로 병용투여하는 경우에는 관찰을 충분히 하고 신중히 투여한다.
   3) 다른 비스테로이드성 소염진통제(인도메타신 등)가 치아짓계 이뇨제의 작용을 감소시킨다는 보고가 있다.

Related FDA Approved Drug

기준 성분:ACETAMINOPHEN
ACEPHEN (ACETAMINOPHEN)
ACETAMINOPHEN (ACETAMINOPHEN)
ACETAMINOPHEN AND CODEINE PHOSPHATE (ACETAMINOPHEN; CODEINE PHOSPHATE)
ACETAMINOPHEN AND HYDROCODONE BITARTRATE (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ACETAMINOPHEN AND PENTAZOCINE HYDROCHLORIDE (ACETAMINOPHEN; PENTAZOCINE HYDROCHLORIDE)
ACETAMINOPHEN, ASPIRIN AND CAFFEINE (ACETAMINOPHEN; ASPIRIN; CAFFEINE)
ACETAMINOPHEN, ASPIRIN, AND CODEINE PHOSPHATE (ACETAMINOPHEN; ASPIRIN; CODEINE PHOSPHATE)
ACETAMINOPHEN, BUTALBITAL AND CAFFEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
ACETAMINOPHEN, CAFFEINE, AND DIHYDROCODEINE BITARTRATE (ACETAMINOPHEN; CAFFEINE; DIHYDROCODEINE BITARTRATE)
ALLAY (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANEXSIA (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANEXSIA 5/325 (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANEXSIA 7.5/325 (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANEXSIA 7.5/650 (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANOQUAN (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
BANCAP (ACETAMINOPHEN; BUTALBITAL)
BANCAP HC (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
BUCET (ACETAMINOPHEN; BUTALBITAL)
BUTALBITAL ACETAMINOPHEN AND CAFFEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
BUTALBITAL AND ACETAMINOPHEN (ACETAMINOPHEN; BUTALBITAL)
BUTALBITAL, ACETAMINOPHEN AND CAFFEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
BUTALBITAL, ACETAMINOPHEN, AND CAFFEINE WITH CODEINE PHOSPHATE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE)
BUTALBITAL, ACETAMINOPHEN, CAFFEINE AND CODEINE PHOSPHATE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE)
BUTALBITAL; ACETAMINOPHEN; CAFFEINE; CODEINE (BUTALBITAL; ACETAMINOPHEN; CAFFEINE; CODEINE PHOSPHATE)
BUTAPAP (ACETAMINOPHEN; BUTALBITAL)
CAPITAL AND CODEINE (ACETAMINOPHEN; CODEINE PHOSPHATE)
CODEINE, ASPIRIN, APAP FORMULA NO. 2 (ACETAMINOPHEN; ASPIRIN; CODEINE PHOSPHATE)
CODEINE, ASPIRIN, APAP FORMULA NO. 3 (ACETAMINOPHEN; ASPIRIN; CODEINE PHOSPHATE)
CODEINE, ASPIRIN, APAP FORMULA NO. 4 (ACETAMINOPHEN; ASPIRIN; CODEINE PHOSPHATE)
CODRIX (ACETAMINOPHEN; CODEINE PHOSPHATE)
CO-GESIC (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
DARVOCET (ACETAMINOPHEN; PROPOXYPHENE HYDROCHLORIDE)
DARVOCET A500 (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
DARVOCET-N 100 (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
DARVOCET-N 50 (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
DHC PLUS (ACETAMINOPHEN; CAFFEINE; DIHYDROCODEINE BITARTRATE)
DOLENE AP-65 (ACETAMINOPHEN; PROPOXYPHENE HYDROCHLORIDE)
DRIXORAL PLUS (ACETAMINOPHEN; DEXBROMPHENIRAMINE MALEATE; PSEUDOEPHEDRINE SULFATE)
DURADYNE DHC (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
EMPRACET W/ CODEINE PHOSPHATE #3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
EMPRACET W/ CODEINE PHOSPHATE #4 (ACETAMINOPHEN; CODEINE PHOSPHATE)
ESGIC (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
ESGIC-PLUS (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
EXCEDRIN (MIGRAINE) (ACETAMINOPHEN; ASPIRIN; CAFFEINE)
FEMCET (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
FIORICET (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
FIORICET W/ CODEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE)
HYDROCODONE BITARTRATE AND ACETAMINOPHEN (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
HY-PHEN (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
INFANTS' FEVERALL (ACETAMINOPHEN)
INJECTAPAP (ACETAMINOPHEN)
LORCET-HD (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
LORTAB (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
MEDIGESIC PLUS (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
NEOPAP (ACETAMINOPHEN)
NORCET (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
NORCO (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
OXYCET (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
OXYCODONE 2.5/APAP 500 (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
OXYCODONE 5/APAP 500 (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
OXYCODONE AND ACETAMINOPHEN (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
PAPA-DEINE #3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PAPA-DEINE #4 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PERCOCET (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
PHENAPHEN W/ CODEINE NO. 2 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PHENAPHEN W/ CODEINE NO. 3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PHENAPHEN W/ CODEINE NO. 4 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PHENAPHEN-650 W/ CODEINE (ACETAMINOPHEN; CODEINE PHOSPHATE)
PHRENILIN (ACETAMINOPHEN; BUTALBITAL)
PHRENILIN FORTE (ACETAMINOPHEN; BUTALBITAL)
PHRENILIN WITH CAFFEINE AND CODEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE)
PROPACET 100 (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
PROPOXYPHENE HYDROCHLORIDE AND ACETAMINOPHEN (ACETAMINOPHEN; PROPOXYPHENE HYDROCHLORIDE)
PROPOXYPHENE NAPSYLATE AND ACETAMINOPHEN (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
PROVAL #3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
ROXICET (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
ROXICET 5/500 (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
ROXILOX (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
SEDAPAP (ACETAMINOPHEN; BUTALBITAL)
SYNALGOS-DC-A (ACETAMINOPHEN; CAFFEINE; DIHYDROCODEINE BITARTRATE)
TALACEN (ACETAMINOPHEN; PENTAZOCINE HYDROCHLORIDE)
TAVIST ALLERGY/SINUS/HEADACHE (ACETAMINOPHEN; CLEMASTINE FUMARATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
TENCON (ACETAMINOPHEN; BUTALBITAL)
TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (ACETAMINOPHEN; TRAMADOL HYDROCHLORIDE)
TRIAD (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
TRIAPRIN (ACETAMINOPHEN; BUTALBITAL)
TYCOLET (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
TYLENOL (ACETAMINOPHEN)
TYLENOL (CAPLET) (ACETAMINOPHEN)
TYLENOL (GELTAB) (ACETAMINOPHEN)
TYLENOL W/ CODEINE (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLENOL W/ CODEINE NO. 1 (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLENOL W/ CODEINE NO. 2 (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLENOL W/ CODEINE NO. 3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLENOL W/ CODEINE NO. 4 (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLOX (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
TYLOX-325 (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
ULTRACET (ACETAMINOPHEN; TRAMADOL HYDROCHLORIDE)
VICODIN (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
VICODIN ES (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
VICODIN HP (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
WYGESIC (ACETAMINOPHEN; PROPOXYPHENE HYDROCHLORIDE)
ZYDONE (ACETAMINOPHEN; HYDROCODONE BITARTRATE)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
대표코드	8806420014908
BIT 약효분류	기타 진통제 (Other Analgesics & Antipyretics)
ATC 코드	Paracetamol / N02BE01 [코드분류상세설명] [ATC코드예측]
복지부분류코드	114 (해열·진통·소염제 )
의약품 바코드정보	내용보기 리나펜엘릭실3.2%(아세트아미노펜)/A30602391 제품규격:/제품수량:/제형: 폼목기준코드:198601882 /대표코드:8806420014908/표준코드:8806420014908 구바코드:-/비고:식약청허가 취하 품목(20070827)
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	642001490[A30602391] [보험코드에 따른 약품기본정보 직접조회] \0 원/1ml(2008.06.01)(최신약가) \7 원/1ml(2000.07.01)(변경전약가) [상병코드조회] [질병코드집 다운로드]
제품성상	딸기향이 있는 적색의 엘릭실제 [제형정보 확인]
포장·유통단위	1ELIXIR
동일주성분코드 검색순위	유료정보입니다.
Brandname 정보	Acetaminophen Brand Names/Synonyms APAP Abenol Abensanil Acamol Accu-Tap Acephen Aceta Elixir Aceta Tablets Acetagesic Acetalgin Acetaminofen Actamin Actimol Algotropyl Allay Alpiny Alpinyl Alvedon Amadil Aminofen Anacin Anacin-3 Anaflon Anapap Anelix Anexsia Anhiba Anoquan Apacet Apadon Apamid Apamide Apo-Acetaminophen Atasol Bancap Banesin Bayer Select Bickie-mol Bucet Butapap Calpol Captin Cetadol Clixodyne Co-Gesic Conacetol Dafalgan Dapa Dapa X-S Darvocet Datril DHC Plus Dimindol Dirox Disprol Dolene AP-65 Doliprane Dolprone Drixoral Plus Dularin Duradyne DHC Dymadon Dypap Elixodyne Enelfa Eneril Esgic Esgic-Plus Eu-Med Excedrin Exdol Febridol Febrilix Febrinol Febro-Gesic Febrolin Femcet Fendon Feverall Fevor Finimal Fioricet Gelocatil Genapap Genebs Hedex Homoolan Hy-Phen Hydrocet Injectapap Janupap Korum Lestemp Liquagesic Liquiprin Lonarid Lorcet-Hd Lortab Lyteca Medigesic Plus Momentum Multin NAPA Napafen Napap Naprinol Nealgyl Nebs Neopap Neotrend Nobedon Norcet Norco Oraphen-PD Ortensan Oxycet Pacemo Painex Paldesic Panadol Panaleve Panasorb Panets Panex Panofen Papa-Deine Paracet Paracetamol Paracetamolo Paracetanol Parapan Paraspen Parelan Parmol Pasolind Pasolind N Pedric Percocet Phenaphen Phenaphen Caplets Phendon Phrenilin Phrenilin Forte Prompt Propacet 100 Proval #3 Pyrinazine Redutemp Rivalgyl Robigesic Rounox Roxicet Roxilox SK-Apap Salzone Sedapap Servigesic Snaplets-FR St. Joseph Fever Reducer Suppap Synalgos-Dc-A Tabalgin Talacen Tapanol Tapar Tavist Allergy/Sinus/Headache Temlo Tempanal Tempra Tencon Tibinide Tibizide Tisin Tisiodrazida Tizide Tralgon Triad Triaprin Tussapap Tycolet Tylenol Tylox Tylox-325 Ultracet Valadol Valgesic Valorin Valorin Extra Vicodin Vicodin Es Vicodin Hp Wygesic Brand Name Mixtures Amacodone (acetaminophen + hydrocodone bitartrate) Anexsia (acetaminophen + hydrocodone bitartrate) Anodynos (acetaminophen + hydrocodone bitartrate) Anolor (acetaminophen + butalbital + caffeine) Bancap (acetaminophen + hydrocodone bitartrate) CoGesic (acetaminophen + hydrocodone bitartrate) Dolacet (acetaminophen + hydrocodone bitartrate) Duradyne (acetaminophen + hydrocodone bitartrate) Endolor (acetaminophen + butalbital + caffeine) Esgic (acetaminophen + butalbital + caffeine) Fioricet (acetaminophen + butalbital + caffeine) Hydrocet (acetaminophen + hydrocodone bitartrate) Hydrogesic (acetaminophen + hydrocodone bitartrate) Margesic (acetaminophen + hydrocodone bitartrate) Lorcet (acetaminophen + hydrocodone bitartrate) Lortab (acetaminophen + hydrocodone bitartrate) Norcet (acetaminophen + hydrocodone bitartrate) Oxycet (acetaminophen + oxycodone hydrochloride) Percocet (acetaminophen + oxycodone hydrochloride) Roxicet (acetaminophen + oxycodone hydrochloride) Roxilox (acetaminophen + oxycodone hydrochloride) Stagesic (acetaminophen + hydrocodone bitartrate) TGesic (acetaminophen + hydrocodone bitartrate) Tylox (acetaminophen + oxycodone hydrochloride) Vicodin (acetaminophen + hydrocodone bitartrate) Zebutal (acetaminophen + butalbital + caffeine) Zydone (acetaminophen + hydrocodone bitartrate) Chemical IUPAC Name N-(4-hydroxyphenyl)acetamide

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병용금기 및 연령대금기 근거조회

[병용금기 및 연령대금기 근거조회]

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DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

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항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
화학구조 및 물성	[Acetaminophen] [Acetaminophen] CAS number/103-90-2 ATC code/N02 BE01 PubChem/1983 DrugBank/APRD00252 Formula/C₈H₉N O₂ Mol. mass/151.17 g/mol Bioavailability/almost 100% Metabolism/90 to 95% Hepatic Excretion/Renal Pregnancy cat./ A(AU) B(US) safe Legal status/ Unscheduled(AU) GSL(UK) OTC(US) Routes/Oral, rectal, intravenous Solubility/1.4쟥/100쟭l or 14쟭g/mL (20젾C)
독성정보	Acetaminophen에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Acetaminophen에 대한 Mechanism_Of_Action 정보 Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1 and COX-2, enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works.
Pharmacology	Acetaminophen에 대한 Pharmacology 정보 Acetaminophen (USAN) or Paracetamol (INN) is a popular analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or accidental overdoses are not uncommon. Acetaminophen, unlike other common analgesics such as aspirin and ibuprofen, has no anti-inflammatory properties or effects on platelet function, and so it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs or NSAIDs. In normal doses acetaminophen does not irritate the lining of the stomach nor affect blood coagulation, the kidneys, or the fetal ductus arteriosus (as NSAIDs can). Like NSAIDs and unlike opioid analgesics, acetaminophen does not cause euphoria or alter mood in any way. Acetaminophen and NSAIDs have the benefit of being completely free of problems with addiction, dependence, tolerance and withdrawal. Acetaminophen is used on its own or in combination with pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, doxylamine, codeine, hydrocodone, or oxycodone.
Metabolism	Acetaminophen에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 1A2 (CYP1A2)Cytochrome P450 2E1 (CYP2E1)
Half-life	Acetaminophen에 대한 반감기 정보 1 to 4 hours
Absorption	Acetaminophen에 대한 Absorption 정보 Rapid and almost complete
Pharmacokinetics	Acetaminophen의 약물동력학자료 단백결합 : 20-50% 대사 : 상용량에서 : 간에서 sulfate와 glucuronide 포합체로 대사되며, 소량은 microsomal mixed function oxidases에 의해 반응성이 매우 높은 중간대사체(acetylimidoquinone)로 대사된 후 glutathione 포합으로 비활성화된다. 중독량에서 (4g을 단 하루 복용한 정도까지도 포함된다) : glutathione 포합이 점점 불충분하게 되어 acetylimidoquinone 농도가 증가하게 되며 이것이 간세포 괴사를 유발하는 것으로 여겨지고 있다. 반감기 신생아 : 2-5 시간 성인 정상 신기능 : 1-3 시간 말기 신질환 : 1-3 시간 최대혈중농도 도달시간 경구 : 상용량 복용시 10-60분, 급성 중독량 복용시 지연될 수 있다.
Biotransformation	Acetaminophen에 대한 Biotransformation 정보 Approximately 90 to 95% of a dose is metabolized in the liver via the cytochrome P450 enzyme pathways (primarily by conjugation with glucuronic acid, sulfuric acid, and cysteine). An intermediate metabolite is hepatotoxic and most likely nephrotoxic and can accumulate after the primary metabolic pathways have been saturated.
Toxicity	Acetaminophen에 대한 Toxicity 정보 Oral, mouse: LD₅₀ = 338 mg/kg; Oral, rat: LD₅₀ = 1944 mg/kg. Acetaminophen is metabolized primarily in the liver, where most of it is converted to inactive compounds by conjugation with sulfate and glucuronide, and then excreted by the kidneys. Only a small portion is metabolized via the hepatic cytochrome P450 enzyme system. The toxic effects of acetaminophen are due to a minor alkylating metabolite (N-acetyl-p-benzo-quinone imine), not acetaminophen itself nor any of the major metabolites. This toxic metabolite reacts with sulfhydryl groups. At usual doses, it is quickly detoxified by combining irreversibly with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is eventually excreted by the kidneys. The toxic dose of paracetamol is highly variable. In adults, single doses above 10 grams or 140 mg/kg have a reasonable likelihood of causing toxicity. In adults, single doses of more than 25 grams have a high risk of lethality.
Drug Interactions	Acetaminophen에 대한 Drug_Interactions 정보 Anisindione Acetaminophen increases the anticoagulant effectWarfarin Acetaminophen increases the anticoagulant effectImatinib Increased hepatic toxicity of both agentsIsoniazid Risk of hepatotoxicityDicumarol Acetaminophen increases the anticoagulant effectDicumarol Increases the anticoagulant effectAcenocoumarol Increases the anticoagulant effect
CYP450 Drug Interaction	[CYP450 Table직접조회] Acetaminophen에 대한 P450 table SUBSTRATES CYP 2E1 acetaminophen chlorzoxazone ethanol INHIBITORS CYP 2E1 disulfiram INDUCERS CYP 2E1 ethanol isoniazid
Food Interaction	Acetaminophen에 대한 Food Interaction 정보 Take without regard to meals.Avoid alcohol (may increase risk of hepatotoxicity).
Drug Target	[Drug Target]
Description	Acetaminophen에 대한 Description 정보 Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. [PubChem]
Dosage Form	Acetaminophen에 대한 Dosage_Form 정보 Capsule OralElixir OralLiquid OralSolution OralSolution / drops OralSuppository RectalSuspension OralSyrup OralTablet OralTablet, effervescent OralTablet, extended release Oral
Drug Category	Acetaminophen에 대한 Drug_Category 정보 Analgesics, Non-NarcoticAntipyretics
Smiles String Canonical	Acetaminophen에 대한 Smiles_String_canonical 정보 CC(=O)NC1=CC=C(O)C=C1
Smiles String Isomeric	Acetaminophen에 대한 Smiles_String_isomeric 정보 CC(=O)NC1=CC=C(O)C=C1
InChI Identifier	Acetaminophen에 대한 InChI_Identifier 정보 InChI=1/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)/f/h9H
Chemical IUPAC Name	Acetaminophen에 대한 Chemical_IUPAC_Name 정보 N-(4-hydroxyphenyl)acetamide
Drug-Induced Toxicity Related Proteins	ACETAMINOPHEN 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Alpha-2A adrenergic receptor Drug:acetaminophen Toxicity:hepatic injury . [바로가기] Replated Protein:Myeloperoxidase Drug:acetaminophen Toxicity:respiratory burst. [바로가기] Replated Protein:Glucose-6-phosphate 1-dehydrogenase Drug:acetaminophen Toxicity:drug-induced hemolysis. [바로가기] Replated Protein:Ornithine decarboxylase Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Lactate dehydrogenase Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Transcription factor AP-1(JUN) Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Haptoglobin Drug:acetaminophen Toxicity:drug-induced hemolysis. [바로가기] Replated Protein:Alanine aminotransferase Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Beta-glucuronidase Drug:acetaminophen Toxicity:hepatotoxin-induced effects. [바로가기] Replated Protein:CYP2E1 Drug:Acetaminophen Toxicity:idiosyncratic hepatotoxicity. [바로가기] Replated Protein:Cytochrome P450 2E1 Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Sulfotransferase family cytosolic Drug:acetaminophen Toxicity:chronic hypoxia. [바로가기] Replated Protein:Cytochrome P450 3A4 Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Caspase recruitment domain-containing protein Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Cytochrome P450 1A2 Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] ACETAMINOPHEN (APAP) 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Cytochrome P450 Drug:acetaminophen (APAP) Toxicity:renal functional changes, strain-dependent histopathological changes. [바로가기]

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Acetaminophen

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