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아미날캅셀 AMINAL CAPS.[Aminophylline , Diphenhydramine HCl , Ephedrine HCl , Papaverine HCl , Phenobarbital]
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전문의약품 | 삭제
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알림: |
드럭인포에서는 의약품 인터넷 판매를 하지 않습니다. |
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유료회원 결재시에는 보다 다양한 약물정보를
이용하실 수 있습니다.
유료정보목록은 전문회원으로
로그인 하시면 확인 가능합니다.
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 | 허가정보 |
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| 항목 |
내용 |
청구코드(KD코드)
비급여점검코드
상한금액 |
[A23401031]
[보험코드에 따른 약품기본정보 직접조회]
\0 원/1캅셀(2005.06.01)(현재약가)
\29 원/1캅셀(2002.07.01)(변경전약가)
[상병코드조회]
[질병코드조회]
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| 빠른조회 |
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| 제품성상 |
내용물은 적, 황, 백의 과립이 충진된 상부는 적색, 하부는 무색의 캅셀. [제형정보 확인] |
| 포장·유통단위 |
100,200,500,1000CAPS |
| 효능효과 |
[적응증 별 검색]
기침, 천식, 가래
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| 용법용량 |
* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.
[처방약어]
[주성분코드:268500ACH 에 따른 심사지침열람]
[TDM 대상약물]
Anticonvulsants
Phenobarbital
유효혈청농도: 15~40 ㎍/㎖
1회 1캅셀 1일 3-4회 식후복용
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| 주요약물 상호작용 |
[조회]
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| 금기 |
크산틴계 약물에 대한 심한 부작용 병력 환자. |
| 신중투여 |
- 본인 또는 양친, 형제 등이 두드러기, 접촉성피부염, 알레르기성비염, 편두통, 음식물 알레르기등을 일으키기 쉬운 체질을 갖고 있는 사람.
- 지금까지 약에 의해 알레르기증상(예:
발열, 발진, 관절염, 가려움증 등)을 일으킨 일이 있는 사람 - 간장, 신장, 갑상선질환, 당뇨병 등 병이 있는 사람, 몸이 약한 사람, 또는 고열이 있는 사람.
- 심장에 장해가 있는 사람, 혈압이 높은 사람, 또는 고령자(염산페닐프로파놀아민, 염산메톡시페나민, 염산메칠에페드린, 염산슈도에페드린을 함유하는 제제)
- 임부 또는 임신하고 있다고 생각되는 부인, 수유부.
- 의사의 치료를 받고 있는 사람
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| 상호작용 |
- 다른 크산틴(Xanthine)계 약물 또는 중추신경흥분제와 병용투여시 과도한 중추신경 자극작용이 나타날 수 있으므로 이러한 약물들과 병용하지 않는 것이 바람직하다.
- 에리스로마이신, 트리아세틸올레안도마이신, 트리암시놀론, 시메티딘, 에녹사신, 시프로플록사신, 토수플록사신, 염산티클로피딘등의 약물과의 병용 투여에 의해 아미노필린의 혈증농도가 상승한다는 보고가 있으므로 이러한 경우에는 신중히 투여한다.
- 다음 약들과 동시에 복용하지 말 것
- 다른 진해거담약, 감기약, 항히스타민제, 진정제 등
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| Off-label Usage |
[조회]
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| Related FDA Approved Drug |
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| 정보요약 |
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드럭인포 의약품 요약/상세정보
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| 코드 및 분류정보 |
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| 항목 |
내용 |
| BIT 약효분류 |
기관지확장제 (Respiratory Relaxants)
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| ATC 코드 |
Adrenergics and other drugs for obstructive airway diseases / R03CK
[코드분류상세설명]
[ATC코드예측]
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| 복지부분류코드 |
222 (진해거담제 )
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| 의약품 바코드정보 |
내용보기
8806103900290//PTP//1 단위/수량: 100
8806103900306//병//1 단위/수량: 1000
8806103990291//PTP//10 단위/수량: 1000
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주성분코드 분석 및
중복처방 검토 |
[주성분코드 분석 및 중복처방 검토]
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| Drugs By Indication |
[전체보기]
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| Drugs By Classification |
[전체보기]
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| 제품정보 |
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| 복약정보 |
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| 항목 |
내용 |
| LACTmed 바로가기 |
[바로가기]
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| 약리작용 |
유료정보입니다.
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| 복약지도 |
유료정보입니다.
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| 임부에대한투여 |
| * |
전체임신 기간별로 여러등급이 존재할 수 있으며 가장 위험도가 높은 정보만 보여집니다. 단, 복합제의 경우 모든 복합제성분에 대한 임부투여등급이 표시된것은 절대 아니며 표시된것중에 가장 위험도가 높은 정보만 나타납니다.
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FDA : D등급
(phenobarbital; )
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상기 임부투여에 대한 정보는 전산처리 되면서 입력 오류 가능성이 존재합니다. 오류 가능성을 최소화하기 위하여 많은 노력을 기울이고 있으나, 그 정확성에 대하여 확신을 드릴 수 없습니다. 이에 대해 회사는 책임을 지지 않습니다.
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반드시 공신력 있는 문헌을 다시 한번 참고 하시기 바라며 의사 또는 약사의 판단에 따라 투여여부가 결정되어야 합니다.
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신장애, 간장애시
용량조절 |
유료정보입니다.
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| Pharmacokinetics |
유료정보입니다.
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| 병용금기 및 연령대금기 근거조회 |
[병용금기 및 연령대금기 근거조회]
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| 보관상 주의 |
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| 조제시 주의 |
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| 심사정보 |
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| 학술정보 |
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| 항목 |
내용 |
| DUR (의약품사용평가) |
병용금기 :
고시된 병용금기 내용은 없습니다.
[상호작용/병용금기검색]
연령대금기 :
고시된 연령금기 내용은 없습니다.
[연령대금기상세검색]
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| 독성정보 |
Diphenhydramine에 대한 독성정보 : 정보보기
Ephedrine에 대한 독성정보 : 정보보기
Phenobarbital에 대한 독성정보 : 정보보기
출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do |
| Mechanism of Action |
Aminophylline에 대한 Mechanism_Of_Action 정보
Theophylline is structurally related to theobromine and caffeine. The precise mechanism of action of theophylline is not known.
Diphenhydramine에 대한 Mechanism_Of_Action 정보
Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
Ephedrine에 대한 Mechanism_Of_Action 정보
Ephedrine is a sympathomimetic amine - that is, its principal mechanism of action relies on its direct and indirect actions on the adrenergic receptor system, which is part of the sympathetic nervous system. Ephedrine increases post-synaptic noradrenergic receptor activity by (weakly) directly activating post-synaptic 慣-receptors and 棺-receptors, but the bulk of its effect comes from the pre-synaptic neuron being unable to distinguish between real adrenaline or noradrenaline from ephedrine. The ephedrine, mixed with noradrenaline, is transported through the noradrenaline reuptake complex and packaged (along with real noradrenaline) into vesicles that reside at the terminal button of a nerve cell. Ephedrine's action as an agonist at most major noradrenaline receptors and its ability to increase the release of both dopamine and to a lesser extent, serotonin by the same mechanism is presumed to have a major role in its mechanism of action.
Papaverine에 대한 Mechanism_Of_Action 정보
Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy.
Phenobarbital에 대한 Mechanism_Of_Action 정보
Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal.
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| Pharmacology |
Aminophylline에 대한 Pharmacology 정보
Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi, produces diuresis, and causes an increase in gastric secretion.
Diphenhydramine에 대한 Pharmacology 정보
Diphenhydramine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, diphenhydramine competes with free histamine for binding at HA-receptor sites. Diphenhydramine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of diphenhydramine. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.
Papaverine에 대한 Pharmacology 정보
Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Papaverine are exerted on cardiac and smooth muscle. Like qathidine, Papaverine acts directly on the heart muscle to depress conduction and prolong the refractory period. Papaverine relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by Papaverine and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one, and unrelated to muscle innervation. Papaverine is practically devoid of effects on the central nervous system. Papaverine relaxes the smooth musculature of the larger blood vessels, especially coronary, systemic peripheral, and pulmonary arteries.
Phenobarbital에 대한 Pharmacology 정보
Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal).
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| Metabolism |
Aminophylline에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Not Available
Diphenhydramine에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Cytochrome P450 2D6 (CYP2D6)Cytochrome P450 3A4 (CYP3A4)
Papaverine에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Xanthine dehydrogenase/oxidase
Phenobarbital에 대한 Metabolism 정보
# Phase_1_Metabolizing_Enzyme:Cytochrome P450 2C19 (CYP2C19)
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| Protein Binding |
Aminophylline에 대한 단백결합 정보
60%
Diphenhydramine에 대한 단백결합 정보
98 to 99%
Papaverine에 대한 단백결합 정보
~90%
Phenobarbital에 대한 단백결합 정보
20 to 45%
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| Half-life |
Aminophylline에 대한 반감기 정보
7-9 hours
Diphenhydramine에 대한 반감기 정보
1-4 hours
Papaverine에 대한 반감기 정보
0.5-2 hours
Phenobarbital에 대한 반감기 정보
53 to 118 hours (mean 79 hours)
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| Absorption |
Aminophylline에 대한 Absorption 정보
Not Available
Diphenhydramine에 대한 Absorption 정보
Quickly absorbed with maximum activity occurring in approximately one hour.
Papaverine에 대한 Absorption 정보
Not Available
Phenobarbital에 대한 Absorption 정보
Absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach.
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| Pharmacokinetics |
Ephedrine HCl의 약물동력학자료
- 경구투여시
- 작용발현시간 : 0.25-1시간 이내
- 작용지속시간 : 3-6 시간
- 분포 : 태반 통과, 유즙 분비
- 대사 : 간대사를 거의 받지 않음
- 반감기 : 2.5-3.6 시간
- 소실 : 24시간내에 투여량의 60-77%가 미변화체로 뇨를 통해 배설됨
Phenobarbital의 약물동력학자료
- 경구 :
- 수면효과 발현시간 : 20-60분 이내
- 작용지속시간 : 6-10 시간
- 정맥투여 :
- 작용발현시간 : 5분 이내
- 최대효과 발현시간 : 30분 이내
- 작용지속시간 : 4-10 시간
- 흡수 : 경구 : 70-90%
- 단백결합 : 20-45%, 신생아에서는 감소됨
- 대사 : 간에서 hydroxylation되고 glucuronide 포합됨
- 반감기 :
- 신생아 : 45-500 시간
- 영아 : 20-133 시간
- 소아 : 37-73 시간
- 성인 : 53-140 시간
- 혈중최고농도 도달시간 : 경구 : 1-6 시간 이내
- 소실 : 20-50%가 소변으로 미변화 배설됨
Aminophylline의 약물동력학자료
1.분포 Vd = 0.45L/kg
2.모유로 거의 혈중농도와 같은 정도로 분포하며 태반도 통과
3.대사 : 간에서 demethylation, oxidation
4.반감기 : 나이, 간 기능, 심 기능, 폐 질환, 흡연력에 따라 매우 다양
■ Aminophylline의 반감기
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환자군 |
반감기(hr) |
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신생아 |
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미숙아 |
30 |
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정상분만 |
24 |
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영아 |
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4-52주 |
4-30 |
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소아/청소년 |
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1-9세 |
2-10 (평균4) |
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9-16세 |
4-16 |
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성인 |
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비흡연자 |
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흡연자 |
4.4 |
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심질환,간부전 |
20-30 |
■ Aminophylline의 역동학/약력학
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제형 |
최고혈중농도 도달시간 |
투여 간격 |
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나정/시럽 |
2시간 |
6시간 |
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장용정 |
5시간 |
12시간 |
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츄잉정 |
1-1.5시간 |
6시간 |
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서방정 |
4-7시간 |
12시간 |
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주사제 |
30분이하 |
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5.소실 : 소변
6.성인은 10%가 미변화체로 배설되고 신생아는 더 많은 양(50%까지)이 미변화체로 신배설된다.
Papaverine HCl의 약물동력학자료
- 작용발현시간 : 경구 : 신속
- 단백결합 : 90%
- 대사 : 간에서 신속히 대사
- 반감기 : 0.5-1.5시간
- 소실 : 뇨를 통해 주로 대사체로 배설
Diphenhydramine HCl의 약물동력학자료
- 최고 진정 효과 : 1-3 시간
- 작용지속시간 : 4-7 시간
- 흡수 : 초회통과효과가 있어서 40 - 60 % 정도가 전신순환으로 들어감
- 대사 : 대부분 간대사, 일부는 폐와 신장에서도 대사
- 단백결합 : 78%
- 최고혈중농도 도달시간 : 2-4 시간
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| Biotransformation |
Aminophylline에 대한 Biotransformation 정보
Not Available
Diphenhydramine에 대한 Biotransformation 정보
Hepatic and renal
Papaverine에 대한 Biotransformation 정보
Not Available
Phenobarbital에 대한 Biotransformation 정보
Hepatic (mostly via CYP2C19).
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| Toxicity |
Aminophylline에 대한 Toxicity 정보
Not Available
Diphenhydramine에 대한 Toxicity 정보
LD50=500 mg/kg (orally in rats). Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death.
Papaverine에 대한 Toxicity 정보
Not Available
Phenobarbital에 대한 Toxicity 정보
CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.
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| Drug Interactions |
Aminophylline에 대한 Drug_Interactions 정보
Aciclovir Acyclovir increases the effect and toxicity of theophyllineAdenosine This xanthine decreases the effect of adenosineButabarbital The barbiturate decreases the effect of theophyllineButalbital The barbiturate decreases the effect of theophyllineDihydroquinidine barbiturate The barbiturate decreases the effect of theophyllineAtracurium Theophylline decreases the effect of muscle relaxantCarbamazepine Carbamazepine increases or decreases the effect of theophyllineCarteolol Antagonism of action and increased effect of theophyllineCimetidine Cimetidine increases the effect of theophyllineCiprofloxacin The quinolone increases the effect of theophyllineClarithromycin Clarithromycin increases the effect amd toxicity of theophyllineDisulfiram Disulfiram increases the effect and toxicity of theophyllineDoxacurium Theophylline decreases the effect of muscle relaxantEnoxacin The quinolone increases the effect of theophyllineErythromycin The macrolide increases the effect and toxicity of theophyllineEthinyl Estradiol The contraceptive increases the effect and toxicity of theophyllineEthotoin Decreased effect of both productsFluvoxamine Fluvoxamine increases the effect and toxicity of theophyllineFosphenytoin Decreased effect of both productsGallamine Triethiodide Theophylline decreases the effect of muscle relaxantGrepafloxacin The quinolone increases the effect of theophyllineHalothane Increased risk of cardiac arrhythmiaInterferon Alfa-2a, Recombinant Interferon increases the effect and toxicity of theophyllineInterferon Alfa-2b, Recombinant Interferon increases the effect and toxicity of theophyllineInterferon alfa-n1 Interferon increases the effect and toxicity of theophyllineIsoniazid Isoniazid increases the effect and toxicity of theophhyllineJosamycin The macrolide increases the effect and toxicity of theophyllineMephenytoin Decreased effect of both productsMethohexital The barbiturate decreases the effect of theophyllineMetocurine Theophylline decreases the effect of muscle relaxantMexiletine Mexiletine increases the effect and toxicity of theophyllineMivacurium Theophylline decreases the effect of muscle relaxantNadolol Antagonism of action and increased effect of theophyllineNorfloxacin The quinolone increases the effect of theophyllinePancuronium Theophylline decreases the effect of muscle relaxantPefloxacin The quinolone increases the effect of theophyllinePeginterferon alfa-2a Interferon increases the effect and toxicity of theophyllinePeginterferon alfa-2b Interferon increases the effect and toxicity of theophyllinePentobarbital The barbiturate decreases the effect of theophyllinePentoxifylline Pentoxyfylline increases the effect and toxicity of theophyllinePhenytoin Decreased effect of both productsPindolol Antagonism of action and increased effect of theophyllinePrimidone The barbiturate decreases the effect of theophyllinePropafenone Propafenone increases the effect of theophyllinePropranolol Antagonism of action and increased effect of theophyllineQuinidine barbiturate The barbiturate decreases the effect of theophyllineRifampin Rifampin decreases the effect of theophyllineRitonavir Ritonavir decreases the effect of theophyllineRofecoxib Rofecoxib increases the effect and toxicity of theophyllineSecobarbital The barbiturate decreases the effect of theophyllineSotalol Antagonism of action and increased effect of theophyllineSt. John's Wort St. John's Wort decreases the effect of theophyllineTacrine Tacrine increases the effect and toxicity of theophyllineTalbutal The barbiturate decreases the effect of theophyllineTerbinafine Terbinafine increases the effect and toxicity of theophyllineThiabendazole Thiabendazole increases the effect and toxicity of theophyllineTiclopidine Ticlopidine increases the effect and toxicity of theophyllineTimolol Antagonism of action and increased effect of theophyllineTubocurarine Theophylline decreases the effect of muscle relaxantVecuronium Theophylline decreases the effect of muscle relaxantZileuton Zileuton increases the effect and toxicity of theophyllineVerapamil Verapamil increases the effect of theophyllineAmobarbital The barbiturate decreases the effect of theophyllineAprobarbital The barbiturate decreases the effect of theophyllineButethal The barbiturate decreases the effect of theophyllineHeptabarbital The barbiturate decreases the effect of theophyllineHexobarbital The barbiturate decreases the effect of theophyllineLithium Theophylline decreases serum levels of lithiumMestranol The contraceptive increases the effect and toxicity of theophyllineMethylphenobarbital The barbiturate decreases the effect of theophyllinePenbutolol Antagonism of action and increased effect of theophyllinePhenobarbital The barbiturate decreases the effect of theophyllineTroleandomycin The macrolide increases the effect and toxicity of theophylline
Diphenhydramine에 대한 Drug_Interactions 정보
Atomoxetine The CYP2D6 inhibitor could increases the effect and toxicity of atomoxetineDonepezil Possible antagonism of actionGalantamine Possible antagonism of actionMesoridazine Increased risk of cardiotoxicity and arrhythmiasRivastigmine Possible antagonism of actionThioridazine Increased risk of cardiotoxicity and arrhythmias
Papaverine에 대한 Drug_Interactions 정보
Probenecid Probenecid increases the antibiotic's level
Phenobarbital에 대한 Drug_Interactions 정보
Aminophylline The barbiturate decreases the effect of theophyllineDyphylline The barbiturate decreases the effect of theophyllineOxtriphylline The barbiturate decreases the effect of theophyllineTheophylline The barbiturate decreases the effect of theophyllineAnisindione The barbiturate decreases the anticoagulant effectAcenocoumarol The barbiturate decreases the anticoagulant effectDicumarol The barbiturate decreases the anticoagulant effectWarfarin The barbiturate decreases the anticoagulant effectBetamethasone The barbiturate decreases the effect of the corticosteroidCortisone acetate The barbiturate decreases the effect of the corticosteroidCyclosporine The barbiturate decreases the effect of cyclosporineDasatinib Decreased levels/efficacy of ddasatinibDelavirdine The anticonvulsant decreases the effect of delavirdineDexamethasone The barbiturate decreases the effect of the corticosteroidDisopyramide Phenobarbital decreases levels of disopyramideDoxycycline The anticonvulsant decreases the effect of doxycyclineFelbamate Felbamate increases the effect and toxicity of phenobarbital/primidoneFelodipine The barbiturate decreases the effect of felodipineFludrocortisone The barbiturate decreases the effect of the corticosteroidFolic Acid Folic acid decreases the effect of anticonvulsantGefitinib This CYP3A4 inducer may reduce gefitinib plasma concentrations and pharmacological effectsGriseofulvin The barbiturate decreases the effect of griseofulvinHydrocortisone The barbiturate decreases the effect of the corticosteroidItraconazole The barbiturate decreases the effect of itraconazoleMethadone The barbiturate decreases the effect of methadoneMethylprednisolone The barbiturate decreases the effect of the corticosteroidPrednisolone The barbiturate decreases the effect of the corticosteroidPrednisone The barbiturate decreases the effect of the corticosteroidParamethasone The barbiturate decreases the effect of the corticosteroidTriamcinolone The barbiturate decreases the effect of the corticosteroidVoriconazole The barbiturate decreases the effect of voriconazoleVerapamil The barbiturate decreases the effect of the calcium channel blockerSunitinib Possible decrease in sunitinib levelsPropranolol The barbiturate decreases the effect of the metabolized beta-blockerMetoprolol The barbiturate decreases the effect of the metabolized beta-blockerMethoxyflurane The barbiturate increases the renal toxicity of methoxyfluraneMetronidazole The barbiturate decreases the effect of metronidazoleNifedipine The barbiturate decreases the effect of the calcium channel blockerQuinidine The anticonvulsant decreases the effect of quinidineDivalproex sodium Valproic acid increases the effect of barbiturateChlorotrianisene The enzyme inducer decreases the effect of hormonesClomifene The enzyme inducer decreases the effect of hormonesDiethylstilbestrol The enzyme inducer decreases the effect of hormonesEstradiol The enzyme inducer decreases the effect of hormonesEstriol The enzyme inducer decreases the effect of hormonesConjugated Estrogens The enzyme inducer decreases the effect of hormonesEstrone The enzyme inducer decreases the effect of hormonesEstropipate The enzyme inducer decreases the effect of hormonesImatinib Phenobarbital decreases levels of imatinibLevonorgestrel Phenobarbital decreases the effect of levonorgestrelMedroxyprogesterone The enzyme inducer decreases the effect of hormonesMegestrol The enzyme inducer decreases the effect of hormonesQuinestrol The enzyme inducer decreases the effect of hormonesNorethindrone This product may cause a slight decrease of contraceptive effectMestranol This product may cause a slight decrease of contraceptive effectEthinyl Estradiol This product may cause a slight decrease of contraceptive effect
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CYP450
Drug Interaction |
[CYP450 Table직접조회]
Phenobarbital에 대한 P450 table
SUBSTRATES
CYP 2B6
bupropion
cyclophosphamide
efavirenz
ifosfamide
methadone
INHIBITORS
CYP 2B6
thiotepa
ticlopidine
INDUCERS
CYP 2B6
**phenobarbital**
phenytoin
rifampin
SUBSTRATES
CYP 3A4/3A5/3A7
Macrolide antibiotics:
clarithromycin
erythromycin
NOT azithromycin
telithromycin
Anti-arrhythmics:
quinidine
Benzodiazepines:
alprazolam
diazepam
midazolam
triazolam
Immune Modulators:
cyclosporine
tacrolimus (FK506)
HIV Protease Inhibitors:
indinavir
ritonavir
saquinavir
Prokinetic:
cisapride
Antihistamines:
astemizole
chlorpheniramine
Calcium Channel Blockers:
amlodipine
diltiazem
felodipine
nifedipine
nisoldipine
nitrendipine
verapamil
HMG CoA Reductase Inhibitors:
atorvastatin
cerivastatin
lovastatin
NOT pravastatin
simvastatin
aripiprazole
buspirone
gleevec
haloperidol (in part)
methadone
pimozide
quinine
NOT rosuvastatin
sildenafil
tamoxifen
trazodone
vincristine
INHIBITORS
CYP 3A4/3A5/3A7
HIV Protease Inhibitors:
indinavir
nelfinavir
ritonavir
amiodarone
NOT azithromycin
cimetidine
clarithromycin
diltiazem
erythromycin
fluvoxamine
grapefruit juice
itraconazole
ketoconazole
mibefradil
nefazodone
troleandomycin
verapamil
INDUCERS
CYP 3A4/3A5/3A7
carbamazepine
**phenobarbital**
phenytoin
rifabutin
rifampin
St. John's wort
troglitazone
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| Food Interaction |
Aminophylline에 대한 Food Interaction 정보
Take with food.Limit caffeine intake.Vitamin B6 needs increased, supplement recommended.
Diphenhydramine에 대한 Food Interaction 정보
Avoid alcohol.Take with food.
Papaverine에 대한 Food Interaction 정보
Not Available
Phenobarbital에 대한 Food Interaction 정보
Avoid alcohol.Avoid excessive quantities of coffee or tea (Caffeine).Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.Take on an empty stomach for quicker absorption
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| Drug Target |
[Drug Target]
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| Description |
Aminophylline에 대한 Description 정보
Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio. [Wikipedia]
Diphenhydramine에 대한 Description 정보
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
Ephedrine에 대한 Description 정보
An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem]
Papaverine에 대한 Description 정보
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels. [PubChem]
Phenobarbital에 대한 Description 정보
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. [PubChem]
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| Dosage Form |
Aminophylline에 대한 Dosage_Form 정보
Solution IntravenousTablet OralTablet, extended release Oral
Diphenhydramine에 대한 Dosage_Form 정보
Capsule OralCream TopicalElixir OralLiquid IntramuscularLiquid IntravenousLiquid OralLozenge OralStrip OralSyrup OralTablet OralTablet, chewable Oral
Ephedrine에 대한 Dosage_Form 정보
Capsule OralLiquid IntramuscularLiquid IntravenousPowder OralSolution IntramuscularTablet Oral
Papaverine에 대한 Dosage_Form 정보
Liquid Intravenous
Phenobarbital에 대한 Dosage_Form 정보
Elixir OralSolution IntramuscularTablet Oral
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| Drug Category |
Aminophylline에 대한 Drug_Category 정보
Bronchodilator AgentsCardiotonic AgentsPhosphodiesterase InhibitorsRespiratory Smooth Muscle Relaxants
Diphenhydramine에 대한 Drug_Category 정보
AnestheticsAnesthetics, LocalAnti-Allergic AgentsAntidyskineticsAntiemeticsAntiparkinson AgentsAntipruriticsAntitussivesEthanolamine DerivativesHistamine H1 AntagonistsHypnotics and Sedatives
Ephedrine에 대한 Drug_Category 정보
Adrenergic AgentsCentral Nervous System StimulantsSympathomimeticsVasoconstrictor Agents
Papaverine에 대한 Drug_Category 정보
Phosphodiesterase InhibitorsVasodilator Agents
Phenobarbital에 대한 Drug_Category 정보
AnticonvulsantsExcitatory Amino Acid AntagonistsGABA ModulatorsHypnotics and Sedatives
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| Smiles String Canonical |
Aminophylline에 대한 Smiles_String_canonical 정보
NCCN.CN1C(=O)N(C)C2=C(NC=N2)C1=O.CN1C(=O)N(C)C2=C(NC=N2)C1=O
Diphenhydramine에 대한 Smiles_String_canonical 정보
CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1
Ephedrine에 대한 Smiles_String_canonical 정보
CNC(C)C(O)C1=CC=CC=C1
Papaverine에 대한 Smiles_String_canonical 정보
COC1=C(OC)C=C(CC2=NC=CC3=CC(OC)=C(OC)C=C23)C=C1
Phenobarbital에 대한 Smiles_String_canonical 정보
CCC1(C(=O)NC(=O)NC1=O)C1=CC=CC=C1
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| Smiles String Isomeric |
Aminophylline에 대한 Smiles_String_isomeric 정보
NCCN.CN1C(=O)N(C)C2=C(NC=N2)C1=O.CN1C(=O)N(C)C2=C(NC=N2)C1=O
Diphenhydramine에 대한 Smiles_String_isomeric 정보
CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1
Ephedrine에 대한 Smiles_String_isomeric 정보
CN[C@@H](C)[C@H](O)C1=CC=CC=C1
Papaverine에 대한 Smiles_String_isomeric 정보
COC1=C(OC)C=C(CC2=NC=CC3=CC(OC)=C(OC)C=C23)C=C1
Phenobarbital에 대한 Smiles_String_isomeric 정보
CCC1(C(=O)NC(=O)NC1=O)C1=CC=CC=C1
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| InChI Identifier |
Aminophylline에 대한 InChI_Identifier 정보
InChI=1/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2/f/h2*8H;
Diphenhydramine에 대한 InChI_Identifier 정보
InChI=1/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
Ephedrine에 대한 InChI_Identifier 정보
InChI=1/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
Papaverine에 대한 InChI_Identifier 정보
InChI=1/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
Phenobarbital에 대한 InChI_Identifier 정보
InChI=1/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17)/f/h13-14H
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| Chemical IUPAC Name |
Aminophylline에 대한 Chemical_IUPAC_Name 정보
1,3-dimethyl-7H-purine-2,6-dione; 1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
Diphenhydramine에 대한 Chemical_IUPAC_Name 정보
2-[di(phenyl)methoxy]-N,N-dimethylethanamine
Ephedrine에 대한 Chemical_IUPAC_Name 정보
(1R,2S)-2-methylamino-1-phenylpropan-1-ol
Papaverine에 대한 Chemical_IUPAC_Name 정보
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline
Phenobarbital에 대한 Chemical_IUPAC_Name 정보
5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione
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최근정보수정일 2016-05-10
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