드러그인포 약품요약정보

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

[A06703411] [보험코드에 따른 약품기본정보 직접조회]
\0 원/18g/1포(2004.01.01)(현재약가)
\137 원/18g/1포(2003.10.01)(변경전약가)
[상병코드조회]
[질병코드조회]

빠른조회


요약정보	[효능] [용법] [금기] [신중투여] [이상반응]

상세정보	[효능] [용법] [경고] [금기] [신중투여] [이상반응] [일반주의] [상호작용] [임산부] [수유부] [소아] [고령자] [신장애환자] [간장애환자] [적용주의] [과량투여] [임상검사치] [보관] [기타]

제품성상

연한 미황색의 산제 [제형정보 확인]

포장·유통단위

6,20GRANS

효능효과

[적응증 별 검색]

감기제증상(콧물, 코막힘, 재채기, 인후통, 기침, 오한, 발열, 두통, 관절염, 근육통)의 완화

[질환별 복약지도]

약물음식간 상호작용

[조회]

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
[주성분코드:355600APD 에 따른 심사지침열람]
보통 성인(15세이상)의 경우 1일 3회, 1회 1포씩 온수에 녹여 복용한다. 1일 최대 4포를 초과하여 복용하지 말 것.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

주요약물 상호작용

[조회]

금기

15세 미만의 어린이
본인, 양친 또는 형제등이 두드러기, 접촉성피부염, 기관지 천식,알레르기성비염, 편두통, 음식물 알레르기 등을 일으키기 쉬운 체질을 갖고 있는 사람
지금까지 약에 의해 과민증상(예를 들면, 발진, 발적, 부종(후두, 눈꺼풀, 입술 등), 관절통, 천식, 가려움증 등)을 일으킨 적이 있는 사람
간장, 신장, 갑상선질환, 당뇨병, 고혈압 등이 있는 사람, 몸이 약한 사람 또는 고열이 있는 사람
심장에 장애가 있는 사람 또는 고령자
녹내장(예 :눈의 통증, 눈의 침침함 등)이 있는 사람, 배뇨곤란이 있는 사람
MAO저해제를 투여중이거나 투여를 중지한 지 2주 이내인 사람
폐기종이나 만성기관지염과 같은 호흡기 질환을 앓고 있는 사람
임부 또는 임신하고 있을 가능성이 있는 부인, 수유부
의사 또는 치과의사의 치료를 받고 있는 사람
수두 또는 인플루엔자에 감염되어 있거나 감염이 의심되는 환자
알콜중독자
지금까지 이 약 또는 다른 감기약, 해열진통제를 사용하여 천식이 나타난 적이 있는 사람

상호작용

바르비탈계 약물, 삼환계 항우울제 및 알코올을 투여한 환자는 다량의 아세트 아미노펜을 대사시키는 능력이 감소되어 아세트아미노펜의 혈장 반감기를 증가 시킬 수 있다. 알코올은 아세트아미노펜 과량투여의 간독성을 증가시킬 수 있다.

Related FDA Approved Drug

기준 성분:PSEUDOEPHEDRINE HYDROCHLORIDE
ACTAHIST (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
ACTIFED (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
ACTIFED W/ CODEINE (CODEINE PHOSPHATE; PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
ADVIL ALLERGY SINUS (CHLORPHENIRAMINE MALEATE; IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
ADVIL COLD AND SINUS (IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
ALEVE-D SINUS & COLD (NAPROXEN SODIUM; PSEUDOEPHEDRINE HYDROCHLORIDE)
ALLEGRA D 24 HOUR (FEXOFENADINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
ALLEGRA-D 12 HOUR (FEXOFENADINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
ALLERFED (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
BENYLIN (DIPHENHYDRAMINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
BROMANATE DM (BROMPHENIRAMINE MALEATE; DEXTROMETHORPHAN HYDROBROMIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
BROMFED-DM (BROMPHENIRAMINE MALEATE; DEXTROMETHORPHAN HYDROBROMIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
CETIRIZINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE (CETIRIZINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
CHILDREN'S ADVIL ALLERGY SINUS (CHLORPHENIRAMINE MALEATE; IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
CHILDREN'S ADVIL COLD (IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
CHILDREN'S MOTRIN COLD (IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
CODIMAL-L.A. 12 (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
CORPHED (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
DIMETANE-DX (BROMPHENIRAMINE MALEATE; DEXTROMETHORPHAN HYDROBROMIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
EFIDAC 24 PSEUDOEPHEDRINE HYDROCHLORIDE/BROMPHENIRAMINE MALEATE (BROMPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
FEXOFENADINE HCL; PSEUDOEPHEDRINE HCL (FEXOFENADINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE (FEXOFENADINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
HISTAFED (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE (IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
IBUPROHM COLD AND SINUS (IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
ISOCLOR (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
MUCINEX D (GUAIFENESIN; PSEUDOEPHEDRINE HYDROCHLORIDE)
MYFED (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE (NAPROXEN SODIUM; PSEUDOEPHEDRINE HYDROCHLORIDE)
NOVAFED (PSEUDOEPHEDRINE HYDROCHLORIDE)
PSEUDOEPHEDRINE HYDROCHLORIDE (PSEUDOEPHEDRINE HYDROCHLORIDE)
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
PSEUDOEPHEDRINE HYDROCHLORIDE AND TRIPROLIDINE HYDROCHLORIDE (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
SEMPREX-D (ACRIVASTINE; PSEUDOEPHEDRINE HYDROCHLORIDE)
SINE-AID IB (IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
SUDAFED 12 HOUR (PSEUDOEPHEDRINE HYDROCHLORIDE)
SUDAFED 24 HOUR (PSEUDOEPHEDRINE HYDROCHLORIDE)
TAVIST ALLERGY/SINUS/HEADACHE (ACETAMINOPHEN; CLEMASTINE FUMARATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
TRIACIN-C (CODEINE PHOSPHATE; PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
TRILITRON (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
TRIPHED (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
TRIPROLIDINE AND PSEUDOEPHEDRINE (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
TRIPROLIDINE AND PSEUDOEPHEDRINE HYDROCHLORIDES (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
TRIPROLIDINE AND PSEUDOEPHEDRINE HYDROCHLORIDES W/ CODEINE (CODEINE PHOSPHATE; PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
TRIPROLIDINE HCL, PSEUDOEPHEDRINE HCL AND CODEINE PHOSPHATE (CODEINE PHOSPHATE; PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
TRIPROLIDINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE (PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE)
ZYRTEC-D 12 HOUR (CETIRIZINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE)
기준 성분:DEXTROMETHORPHAN HBR
기준 성분:CHLORPHENIRAMINE MALEATE
ANTAGONATE (CHLORPHENIRAMINE MALEATE)
CHLOROHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE)
CHLORPHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CHLOR-TRIMETON (CHLORPHENIRAMINE MALEATE)
COLD CAPSULE IV (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
COLD CAPSULE V (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CONTAC (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CONTAC 12 HOUR (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
DEMAZIN (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
DEXCHLORPHENIRAMINE MALEATE (DEXCHLORPHENIRAMINE MALEATE)
DRIZE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
EFIDAC 24 CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE)
KLOROMIN (CHLORPHENIRAMINE MALEATE)
ORNADE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
PHENETRON (CHLORPHENIRAMINE MALEATE)
PHENYLPROPANOLAMINE HYDROCHLORIDE W/ CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
POLARAMINE (DEXCHLORPHENIRAMINE MALEATE)
PYRIDAMAL 100 (CHLORPHENIRAMINE MALEATE)
TELDRIN (CHLORPHENIRAMINE MALEATE)
TRIAMINIC-12 (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
기준 성분:ACETAMINOPHEN
ACEPHEN (ACETAMINOPHEN)
ACETAMINOPHEN (ACETAMINOPHEN)
ACETAMINOPHEN AND CODEINE PHOSPHATE (ACETAMINOPHEN; CODEINE PHOSPHATE)
ACETAMINOPHEN AND HYDROCODONE BITARTRATE (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ACETAMINOPHEN AND PENTAZOCINE HYDROCHLORIDE (ACETAMINOPHEN; PENTAZOCINE HYDROCHLORIDE)
ACETAMINOPHEN, ASPIRIN AND CAFFEINE (ACETAMINOPHEN; ASPIRIN; CAFFEINE)
ACETAMINOPHEN, ASPIRIN, AND CODEINE PHOSPHATE (ACETAMINOPHEN; ASPIRIN; CODEINE PHOSPHATE)
ACETAMINOPHEN, BUTALBITAL AND CAFFEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
ACETAMINOPHEN, CAFFEINE, AND DIHYDROCODEINE BITARTRATE (ACETAMINOPHEN; CAFFEINE; DIHYDROCODEINE BITARTRATE)
ALLAY (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANEXSIA (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANEXSIA 5/325 (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANEXSIA 7.5/325 (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANEXSIA 7.5/650 (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
ANOQUAN (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
BANCAP (ACETAMINOPHEN; BUTALBITAL)
BANCAP HC (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
BUCET (ACETAMINOPHEN; BUTALBITAL)
BUTALBITAL ACETAMINOPHEN AND CAFFEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
BUTALBITAL AND ACETAMINOPHEN (ACETAMINOPHEN; BUTALBITAL)
BUTALBITAL, ACETAMINOPHEN AND CAFFEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
BUTALBITAL, ACETAMINOPHEN, AND CAFFEINE WITH CODEINE PHOSPHATE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE)
BUTALBITAL, ACETAMINOPHEN, CAFFEINE AND CODEINE PHOSPHATE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE)
BUTALBITAL; ACETAMINOPHEN; CAFFEINE; CODEINE (BUTALBITAL; ACETAMINOPHEN; CAFFEINE; CODEINE PHOSPHATE)
BUTAPAP (ACETAMINOPHEN; BUTALBITAL)
CAPITAL AND CODEINE (ACETAMINOPHEN; CODEINE PHOSPHATE)
CODEINE, ASPIRIN, APAP FORMULA NO. 2 (ACETAMINOPHEN; ASPIRIN; CODEINE PHOSPHATE)
CODEINE, ASPIRIN, APAP FORMULA NO. 3 (ACETAMINOPHEN; ASPIRIN; CODEINE PHOSPHATE)
CODEINE, ASPIRIN, APAP FORMULA NO. 4 (ACETAMINOPHEN; ASPIRIN; CODEINE PHOSPHATE)
CODRIX (ACETAMINOPHEN; CODEINE PHOSPHATE)
CO-GESIC (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
DARVOCET (ACETAMINOPHEN; PROPOXYPHENE HYDROCHLORIDE)
DARVOCET A500 (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
DARVOCET-N 100 (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
DARVOCET-N 50 (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
DHC PLUS (ACETAMINOPHEN; CAFFEINE; DIHYDROCODEINE BITARTRATE)
DOLENE AP-65 (ACETAMINOPHEN; PROPOXYPHENE HYDROCHLORIDE)
DRIXORAL PLUS (ACETAMINOPHEN; DEXBROMPHENIRAMINE MALEATE; PSEUDOEPHEDRINE SULFATE)
DURADYNE DHC (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
EMPRACET W/ CODEINE PHOSPHATE #3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
EMPRACET W/ CODEINE PHOSPHATE #4 (ACETAMINOPHEN; CODEINE PHOSPHATE)
ESGIC (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
ESGIC-PLUS (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
EXCEDRIN (MIGRAINE) (ACETAMINOPHEN; ASPIRIN; CAFFEINE)
FEMCET (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
FIORICET (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
FIORICET W/ CODEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE)
HYDROCODONE BITARTRATE AND ACETAMINOPHEN (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
HY-PHEN (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
INFANTS' FEVERALL (ACETAMINOPHEN)
INJECTAPAP (ACETAMINOPHEN)
LORCET-HD (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
LORTAB (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
MEDIGESIC PLUS (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
NEOPAP (ACETAMINOPHEN)
NORCET (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
NORCO (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
OXYCET (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
OXYCODONE 2.5/APAP 500 (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
OXYCODONE 5/APAP 500 (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
OXYCODONE AND ACETAMINOPHEN (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
PAPA-DEINE #3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PAPA-DEINE #4 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PERCOCET (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
PHENAPHEN W/ CODEINE NO. 2 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PHENAPHEN W/ CODEINE NO. 3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PHENAPHEN W/ CODEINE NO. 4 (ACETAMINOPHEN; CODEINE PHOSPHATE)
PHENAPHEN-650 W/ CODEINE (ACETAMINOPHEN; CODEINE PHOSPHATE)
PHRENILIN (ACETAMINOPHEN; BUTALBITAL)
PHRENILIN FORTE (ACETAMINOPHEN; BUTALBITAL)
PHRENILIN WITH CAFFEINE AND CODEINE (ACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE)
PROPACET 100 (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
PROPOXYPHENE HYDROCHLORIDE AND ACETAMINOPHEN (ACETAMINOPHEN; PROPOXYPHENE HYDROCHLORIDE)
PROPOXYPHENE NAPSYLATE AND ACETAMINOPHEN (ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE)
PROVAL #3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
ROXICET (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
ROXICET 5/500 (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
ROXILOX (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
SEDAPAP (ACETAMINOPHEN; BUTALBITAL)
SYNALGOS-DC-A (ACETAMINOPHEN; CAFFEINE; DIHYDROCODEINE BITARTRATE)
TALACEN (ACETAMINOPHEN; PENTAZOCINE HYDROCHLORIDE)
TENCON (ACETAMINOPHEN; BUTALBITAL)
TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (ACETAMINOPHEN; TRAMADOL HYDROCHLORIDE)
TRIAD (ACETAMINOPHEN; BUTALBITAL; CAFFEINE)
TRIAPRIN (ACETAMINOPHEN; BUTALBITAL)
TYCOLET (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
TYLENOL (ACETAMINOPHEN)
TYLENOL (CAPLET) (ACETAMINOPHEN)
TYLENOL (GELTAB) (ACETAMINOPHEN)
TYLENOL W/ CODEINE (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLENOL W/ CODEINE NO. 1 (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLENOL W/ CODEINE NO. 2 (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLENOL W/ CODEINE NO. 3 (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLENOL W/ CODEINE NO. 4 (ACETAMINOPHEN; CODEINE PHOSPHATE)
TYLOX (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
TYLOX-325 (ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE)
ULTRACET (ACETAMINOPHEN; TRAMADOL HYDROCHLORIDE)
VICODIN (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
VICODIN ES (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
VICODIN HP (ACETAMINOPHEN; HYDROCODONE BITARTRATE)
WYGESIC (ACETAMINOPHEN; PROPOXYPHENE HYDROCHLORIDE)
ZYDONE (ACETAMINOPHEN; HYDROCODONE BITARTRATE)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
BIT 약효분류	종합감기약(Drugs to Relieve Common Cold)
ATC 코드	COUGH AND COLD PREPARATIONS / R05 [코드분류상세설명] [ATC코드예측]
복지부분류코드	114 (해열·진통·소염제 )
주성분코드 분석 및 중복처방 검토	[주성분코드 분석 및 중복처방 검토]
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청구코드(KD코드) 비급여점검코드 상한금액	[A06703411] [보험코드에 따른 약품기본정보 직접조회] \0 원/18g/1포(2004.01.01)(최신약가) \137 원/18g/1포(2003.10.01)(변경전약가) [상병코드조회] [질병코드집 다운로드]
제품성상	연한 미황색의 산제 [제형정보 확인]
포장·유통단위	6,20GRANS
보관방법	기밀용기, 건냉암소에 보관
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항목	내용
DUR 관련 고시	[병용연령금기 의약품 / 임부금기 의약품 / 비용효과적 함량 의약품 / 안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Acetaminophen에 대한 독성정보 : 정보보기 Chlorpheniramine에 대한 독성정보 : 정보보기 Dextromethorphan에 대한 독성정보 : 정보보기 Ephedrine에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Acetaminophen에 대한 Mechanism_Of_Action 정보 Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1 and COX-2, enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. Chlorpheniramine에 대한 Mechanism_Of_Action 정보 Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Dextromethorphan에 대한 Mechanism_Of_Action 정보 Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan. Pseudoephedrine에 대한 Mechanism_Of_Action 정보 Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect.
Pharmacology	Acetaminophen에 대한 Pharmacology 정보 Acetaminophen (USAN) or Paracetamol (INN) is a popular analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or accidental overdoses are not uncommon. Acetaminophen, unlike other common analgesics such as aspirin and ibuprofen, has no anti-inflammatory properties or effects on platelet function, and so it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs or NSAIDs. In normal doses acetaminophen does not irritate the lining of the stomach nor affect blood coagulation, the kidneys, or the fetal ductus arteriosus (as NSAIDs can). Like NSAIDs and unlike opioid analgesics, acetaminophen does not cause euphoria or alter mood in any way. Acetaminophen and NSAIDs have the benefit of being completely free of problems with addiction, dependence, tolerance and withdrawal. Acetaminophen is used on its own or in combination with pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, doxylamine, codeine, hydrocodone, or oxycodone. Chlorpheniramine에 대한 Pharmacology 정보 In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. Dextromethorphan에 대한 Pharmacology 정보 Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. Pseudoephedrine에 대한 Pharmacology 정보 Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa).
Metabolism	Acetaminophen에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 1A2 (CYP1A2)Cytochrome P450 2E1 (CYP2E1) Chlorpheniramine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 3A4 (CYP3A4)Cytochrome P450 2D6 (CYP2D6) Dextromethorphan에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 2D6 (CYP2D6) Pseudoephedrine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Monoamine oxidase type A (MAO-A)
Protein Binding	Chlorpheniramine에 대한 단백결합 정보 72% Pseudoephedrine에 대한 단백결합 정보 Pseudoephedrine does not bind to human plasma proteins over the concentration range of 50 to 2000 ng/mL
Half-life	Acetaminophen에 대한 반감기 정보 1 to 4 hours Chlorpheniramine에 대한 반감기 정보 21-27 hours Dextromethorphan에 대한 반감기 정보 3-6 hours Pseudoephedrine에 대한 반감기 정보 9-16 hours
Absorption	Acetaminophen에 대한 Absorption 정보 Rapid and almost complete Chlorpheniramine에 대한 Absorption 정보 Well absorbed in the gastrointestinal tract. Dextromethorphan에 대한 Absorption 정보 Rapidly absorbed from the gastrointestinal tract. Pseudoephedrine에 대한 Absorption 정보 Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
Pharmacokinetics	Pseudoephedrine HCl의 약물동력학자료 비충혈제거 효과의 발현시간 (경구투여시) : 15-30분 작용지속시간 : 4-6 시간 (서방형 제제는 12시간 지속) 대사 : 간에서 일부 대사 반감기 : 9-16 시간 소실 : 투여량의 70-90%가 미변화체로, 1-6%가 norpseudoephedrine으로 소변으로 배설됨. 신배설은 뇨 pH와 뇨량에 의해 변화되며 알칼리뇨는 pseudoephedrine의 신배설을 감소시킴. Dextromethorphan HBr의 약물동력학자료 진해작용 발현시간 : 15~30분 이내 작용지속시간 : 6시간까지 대사 : 간대사 소실 : 주로 신배설 Acetaminophen의 약물동력학자료 단백결합 : 20-50% 대사 : 상용량에서 : 간에서 sulfate와 glucuronide 포합체로 대사되며, 소량은 microsomal mixed function oxidases에 의해 반응성이 매우 높은 중간대사체(acetylimidoquinone)로 대사된 후 glutathione 포합으로 비활성화된다. 중독량에서 (4g을 단 하루 복용한 정도까지도 포함된다) : glutathione 포합이 점점 불충분하게 되어 acetylimidoquinone 농도가 증가하게 되며 이것이 간세포 괴사를 유발하는 것으로 여겨지고 있다. 반감기 신생아 : 2-5 시간 성인 정상 신기능 : 1-3 시간 말기 신질환 : 1-3 시간 최대혈중농도 도달시간 경구 : 상용량 복용시 10-60분, 급성 중독량 복용시 지연될 수 있다. Chlorpheniramine Maleate의 약물동력학자료 단백결합 : 69-72% 대사 : 간대사 반감기 : 20-24 시간 소실 : 대사체, 약물(3-4%)이 신배설되며, 48시간내에 전체의 35%가 소실된다.
Biotransformation	Acetaminophen에 대한 Biotransformation 정보 Approximately 90 to 95% of a dose is metabolized in the liver via the cytochrome P450 enzyme pathways (primarily by conjugation with glucuronic acid, sulfuric acid, and cysteine). An intermediate metabolite is hepatotoxic and most likely nephrotoxic and can accumulate after the primary metabolic pathways have been saturated. Chlorpheniramine에 대한 Biotransformation 정보 Primarily hepatic via Cytochrome P450 (CYP450) enzymes. Dextromethorphan에 대한 Biotransformation 정보 Hepatic. Rapidly and extensively metabolized to dextrorphan (active metabolite). One well known metabolic catalyst involved is a specific cytochrome P450 enzyme known as 2D6, or CYP2D6. Pseudoephedrine에 대한 Biotransformation 정보 Hepatic.
Toxicity	Acetaminophen에 대한 Toxicity 정보 Oral, mouse: LD₅₀ = 338 mg/kg; Oral, rat: LD₅₀ = 1944 mg/kg. Acetaminophen is metabolized primarily in the liver, where most of it is converted to inactive compounds by conjugation with sulfate and glucuronide, and then excreted by the kidneys. Only a small portion is metabolized via the hepatic cytochrome P450 enzyme system. The toxic effects of acetaminophen are due to a minor alkylating metabolite (N-acetyl-p-benzo-quinone imine), not acetaminophen itself nor any of the major metabolites. This toxic metabolite reacts with sulfhydryl groups. At usual doses, it is quickly detoxified by combining irreversibly with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is eventually excreted by the kidneys. The toxic dose of paracetamol is highly variable. In adults, single doses above 10 grams or 140 mg/kg have a reasonable likelihood of causing toxicity. In adults, single doses of more than 25 grams have a high risk of lethality. Chlorpheniramine에 대한 Toxicity 정보 LD₅₀ = 306 mg/kg in humans, mild reproductive toxin to women of childbearing age. Dextromethorphan에 대한 Toxicity 정보 Not Available Pseudoephedrine에 대한 Toxicity 정보 Common adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness.
Drug Interactions	Acetaminophen에 대한 Drug_Interactions 정보 Anisindione Acetaminophen increases the anticoagulant effectWarfarin Acetaminophen increases the anticoagulant effectImatinib Increased hepatic toxicity of both agentsIsoniazid Risk of hepatotoxicityDicumarol Acetaminophen increases the anticoagulant effectDicumarol Increases the anticoagulant effectAcenocoumarol Increases the anticoagulant effect Chlorpheniramine에 대한 Drug_Interactions 정보 Donepezil Possible antagonism of actionGalantamine Possible antagonism of actionRivastigmine Possible antagonism of actionEthotoin The antihistamine increases the effect of hydantoinFosphenytoin The antihistamine increases the effect of hydantoinMephenytoin The antihistamine increases the effect of hydantoinPhenytoin The antihistamine increases the effect of hydantoin Dextromethorphan에 대한 Drug_Interactions 정보 Dihydroquinidine barbiturate Quinidine increases the toxicity of dextromethorphanQuinidine Quinidine increases the toxicity of dextromethorphanQuinidine barbiturate Quinidine increases the toxicity of dextromethorphanFluoxetine Combination associated with possible serotoninergic syndromeIsocarboxazid Possible severe adverse reactionMemantine Increased risk of CNS adverse effectsMoclobemide Increased CNS toxicityParoxetine Combination associated with possible serotoninergic syndromePhenelzine Possible severe adverse reactionRasagiline Possible severe adverse reactionSelegiline Combination associated with possible serotoninergic syndromeSibutramine Combination associated with possible serotoninergic syndromeTerbinafine Terbinafine increases dextromethorphan levelsTranylcypromine Possible severe adverse reaction Pseudoephedrine에 대한 Drug_Interactions 정보 Alseroxylon Increased arterial pressureIsocarboxazid Increased arterial pressureLinezolid Possible increase of arterial pressureMethyldopa Increased arterial pressureBromocriptine The sympathomimetic increases the toxicity of bromocriptineTranylcypromine Increased arterial pressureMidodrine Increased arterial pressureMoclobemide Moclobemide increases the sympathomimetic effectPargyline Increased arterial pressurePhenelzine Increased arterial pressureRasagiline Increased arterial pressureReserpine Increased arterial pressureTrimipramine The tricyclic increases the sympathomimetic effectProtriptyline The tricyclic increases the sympathomimetic effectNortriptyline The tricyclic increases the sympathomimetic effectAmitriptyline The tricyclic increases the sympathomimetic effectAmoxapine The tricyclic increases the sympathomimetic effectClomipramine The tricyclic increases the sympathomimetic effectImipramine The tricyclic increases the sympathomimetic effectDesipramine The tricyclic increases the sympathomimetic effectDoxepin The tricyclic increases the sympathomimetic effectDeserpidine Increased arterial pressureGuanethidine The agent decreases the effect of guanethidine
CYP450 Drug Interaction	[CYP450 Table직접조회] Dextromethorphan에 대한 P450 table Chlorpheniramine에 대한 P450 table Acetaminophen에 대한 P450 table SUBSTRATES CYP 2E1 acetaminophen chlorzoxazone ethanol INHIBITORS CYP 2E1 disulfiram INDUCERS CYP 2E1 ethanol isoniazid SUBSTRATES CYP 2D6 Beta Blockers: S-metoprolol propafenone timolol Antidepressants: amitriptyline clomipramine desipramine imipramine paroxetine Antipsychotics: haloperidol risperidone thioridazine aripiprazole codeine dextromethorphan duloxetine flecainide mexiletine ondansetron tamoxifen tramadol venlafaxine INHIBITORS CYP 2D6 amiodarone buproprion chlorpheniramine cimetidine clomipramine duloxetine fluoxetine haloperidol methadone mibefradil paroxetine quinidine ritonavir INDUCERS CYP 2D6 N/A SUBSTRATES CYP 2D6 Beta Blockers: S-metoprolol propafenone timolol Antidepressants: amitriptyline clomipramine desipramine imipramine paroxetine Antipsychotics: haloperidol risperidone thioridazine aripiprazole codeine dextromethorphan duloxetine flecainide mexiletine ondansetron tamoxifen tramadol venlafaxine INHIBITORS CYP 2D6 amiodarone buproprion chlorpheniramine cimetidine clomipramine duloxetine fluoxetine haloperidol methadone mibefradil paroxetine quinidine ritonavir INDUCERS CYP 2D6 N/A
Food Interaction	Acetaminophen에 대한 Food Interaction 정보 Take without regard to meals.Avoid alcohol (may increase risk of hepatotoxicity). Chlorpheniramine에 대한 Food Interaction 정보 Take with food.Avoid alcohol. Pseudoephedrine에 대한 Food Interaction 정보 Take without regard to meals.
Drug Target	[Drug Target]
SNP 정보	Name:Dextromethorphan (DB00514) Interacting Gene/Enzyme:Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 SNP(s):CYP2D66 rs5030655 (T deletion, homozygote) Effect:Poor drug metabolizer, lower dose requirements Reference(s):*Bradford LD, Gaedigk A, Leeder JS: High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data. Psychopharmacol Bull. 1998;34(4):797-804. [PubMed]
Description	Acetaminophen에 대한 Description 정보 Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. [PubChem] Chlorpheniramine에 대한 Description 정보 A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem] Dextromethorphan에 대한 Description 정보 The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. [PubChem] Pseudoephedrine에 대한 Description 정보 An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem]
Dosage Form	Acetaminophen에 대한 Dosage_Form 정보 Capsule OralElixir OralLiquid OralSolution OralSolution / drops OralSuppository RectalSuspension OralSyrup OralTablet OralTablet, effervescent OralTablet, extended release Oral Chlorpheniramine에 대한 Dosage_Form 정보 Syrup OralTablet OralTablet, extended release Oral Dextromethorphan에 대한 Dosage_Form 정보 Capsule OralLiquid OralLozenge OralStrip OralSuspension OralSyrup OralTablet Oral Pseudoephedrine에 대한 Dosage_Form 정보 Liquid OralSyrup OralTablet OralTablet, extended release Oral
Drug Category	Acetaminophen에 대한 Drug_Category 정보 Analgesics, Non-NarcoticAntipyretics Chlorpheniramine에 대한 Drug_Category 정보 Anti-Allergic AgentsAntihistaminesAntipruriticsHistamine H1 Antagonists Dextromethorphan에 대한 Drug_Category 정보 Analgesics, OpioidAntitussive AgentsExcitatory Amino Acid Antagonists Pseudoephedrine에 대한 Drug_Category 정보 Adrenergic AgentsBronchodilator AgentsCentral Nervous System AgentsNasal DecongestantsSympathomimeticsVasoconstrictor Agents
Smiles String Canonical	Acetaminophen에 대한 Smiles_String_canonical 정보 CC(=O)NC1=CC=C(O)C=C1 Chlorpheniramine에 대한 Smiles_String_canonical 정보 CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1 Dextromethorphan에 대한 Smiles_String_canonical 정보 COC1=CC2=C(CC3C4CCCCC24CCN3C)C=C1 Pseudoephedrine에 대한 Smiles_String_canonical 정보 CNC(C)C(O)C1=CC=CC=C1
Smiles String Isomeric	Acetaminophen에 대한 Smiles_String_isomeric 정보 CC(=O)NC1=CC=C(O)C=C1 Chlorpheniramine에 대한 Smiles_String_isomeric 정보 CN(C)CC[C@H](C1=CC=C(Cl)C=C1)C1=CC=CC=N1 Dextromethorphan에 대한 Smiles_String_isomeric 정보 COC1=CC2=C(C[C@H]3[C@H]4CCCC[C@@]24CCN3C)C=C1 Pseudoephedrine에 대한 Smiles_String_isomeric 정보 CN[C@@H](C)[C@@H](O)C1=CC=CC=C1
InChI Identifier	Acetaminophen에 대한 InChI_Identifier 정보 InChI=1/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)/f/h9H Chlorpheniramine에 대한 InChI_Identifier 정보 InChI=1/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 Dextromethorphan에 대한 InChI_Identifier 정보 InChI=1/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18-/m1/s1 Pseudoephedrine에 대한 InChI_Identifier 정보 InChI=1/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
Chemical IUPAC Name	Acetaminophen에 대한 Chemical_IUPAC_Name 정보 N-(4-hydroxyphenyl)acetamide Chlorpheniramine에 대한 Chemical_IUPAC_Name 정보 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine Dextromethorphan에 대한 Chemical_IUPAC_Name 정보 Not Available Pseudoephedrine에 대한 Chemical_IUPAC_Name 정보 (1S,2S)-2-methylamino-1-phenylpropan-1-ol
Drug-Induced Toxicity Related Proteins	ACETAMINOPHEN 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Alpha-2A adrenergic receptor Drug:acetaminophen Toxicity:hepatic injury . [바로가기] Replated Protein:Myeloperoxidase Drug:acetaminophen Toxicity:respiratory burst. [바로가기] Replated Protein:Glucose-6-phosphate 1-dehydrogenase Drug:acetaminophen Toxicity:drug-induced hemolysis. [바로가기] Replated Protein:Ornithine decarboxylase Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Lactate dehydrogenase Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Transcription factor AP-1(JUN) Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Haptoglobin Drug:acetaminophen Toxicity:drug-induced hemolysis. [바로가기] Replated Protein:Alanine aminotransferase Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Beta-glucuronidase Drug:acetaminophen Toxicity:hepatotoxin-induced effects. [바로가기] Replated Protein:CYP2E1 Drug:Acetaminophen Toxicity:idiosyncratic hepatotoxicity. [바로가기] Replated Protein:Cytochrome P450 2E1 Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Sulfotransferase family cytosolic Drug:acetaminophen Toxicity:chronic hypoxia. [바로가기] Replated Protein:Cytochrome P450 3A4 Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Caspase recruitment domain-containing protein Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] Replated Protein:Cytochrome P450 1A2 Drug:acetaminophen Toxicity:hepatotoxicity. [바로가기] ACETAMINOPHEN (APAP) 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Cytochrome P450 Drug:acetaminophen (APAP) Toxicity:renal functional changes, strain-dependent histopathological changes. [바로가기] MALEATE 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Intercellular adhesion molecule 1 Drug:maleate Toxicity:hepatic injury. [바로가기]

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